Research Profiles

JP

"M" Keywords - 143 Result(s)

M
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 M

[modeling]

Mathematical Biology

 
 
 
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特徴・独自性
  • Principal subject of our study is the mathematical model analysis to make clear or present the point at issue for scientific discussion about real biological/social phenomena, or to promote the advanced theoretical research: what theoretical problem about target phenomenon is treated, how the problem is mathematically modeled, what mathematical analysis is applied for the model, and how the mathematical result is lead to the discussion in biological/social science.
実用化イメージ

Researchers

Graduate School of Information Sciences

Hiromi Seno

[mold]

Indentation modulus 8.4 GPa! Resin replica mold more solid than polyimide

概要

Light curing high strength resin mold
https://www.t-technoarch.co.jp/data/anken_en/T11-053.pdf

特徴・独自性
実用化イメージ

Researchers

Institute of Multidisciplinary Research for Advanced Materials

Masaru Nakagawa

[Molecular Architecture Chemistry]

Development of Nano-Interface Chemistry for Materials Sciences Using Surface Forces Measurement

 
 
 
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特徴・独自性
  • Our research aims at developing methods, including instrumentation, for characterizing surface (or interface) at the nano-meter level. Most of our research subjects are related to the surface forces measurement, which can directly monitor the interaction between two surfaces. We study phenomena occurring at the solid-liquid interface such as adsorption and structuring of liquids. We have developed the resonance shear measurement which is a sensitive method for evaluating properties of confined liquid for nano-rheology and tribology. Twin-path surface forces apparatus we developed enabled us to study wide variety of samples such as metals, ceramics and plastics.
実用化イメージ

These methods are applicable for characterizing lubricants, nano-materials, paints, sealants, and cosmetics. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Researchers

New Industry Creation Hatchery Center

Kazue Kurihara

[Molecular dynamics]

Quantum and Molecular Dynamic Simulations of Transport Phenomena in Fuel Cell

 
 
 
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特徴・独自性
  • It is necessary to grasp nanoscale transport phenomena of materials in polymer electrolyte fuel cell to improve its performance. In our laboratory, nanoscale transport phenomena are analyzed by large scale molecular dynamics simulations using a supercomputer system. As the present theme, the dependence of the materials or structures of polymer electrolyte membrane on the ability of proton transfer(Fig. 1), the ability of proton transfer or oxygen permeability of ionomer in catalyst layer(Fig. 2), and the mechanism of transport phenomena of a water droplet in a nano pore in gas diffusion layer or micro porous layer(Fig. 3), are analyzed in detail.
実用化イメージ

These research can be applied to the analysis of flow field in devices which have nanoscale structure, for instance, fabrication process of semiconductor, friction phenomena of such nanoscale devices or next generation batteries, as well as the field of fuel cell.

Researchers

Institute of Fluid Science

Takashi Tokumasu

Molecular Dynamics Analysis of Coating and Surface Modification

特徴・独自性
  • Molecular-scale mechanism of solid-liquid affinity, wettability, thermal boundary resistance and molecular deposition are analyzed by molecular dynamics simulations toward its control. With a background of heat and mass transport and interfacial thermodynamics, transport phenomena of various scales ranging from spin coating of photoresist to SAM (self-assembled monolayer) and hydrophobic/hydrophilic treatment by attaching some molecular basis are studied. Futhermore, the molecular-scale mechanisms which determine thermophysical properties and the molecular structure that realizes desired thermophysical properties are studied. We can conduct effective collaboration and provide academic consultations to companies interested in our research.
実用化イメージ

Researchers

Tohoku Medical Megabank Organization

Taku Obara

[Molecular Electronics]

Synthesis and material characterization of new organic ferroelectric materials, molecular semiconductors, molecular magnets.

 
 
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特徴・独自性
  • Multifunctional molecular-assemblies and hybrid organic - inorganic materials are examined from the viewpoint of structural freedom of organic molecules. The spin and electronic states of molecular-assemblies are designed in terms of electrical conductivity, magnetism, and ferroelectricity. Diverse molecular assemblies from single crystal, plastic crystal, liquid crystal, gel, to Langmuir-Blodgett film are our research targets, which were hybridized with inorganic gigantic clusters and metal nanoparticles. We are prepared to provide academic consultations to companies interested in our research.
実用化イメージ

Researchers

Institute of Multidisciplinary Research for Advanced Materials

Tomoyuki Akutagawa

[molecular evolutionary engineering]

Peptide and Protein Designs for Unexplored Fileds

 
 
 
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特徴・独自性
  • I am proposing methodologies to design recombinant peptides and proteins with appropriate structures and functions in the medicinal, environmental, material, and nanotechnological fields, with molecular evolutional and domain shuffling engineering. At present, we have constructed the methodologies for efficient renaturation of functional proteins from inclusion bodies expressed in bacteria, generation of peptides and proteins with the function of biomineralization, generation of peptides and proteins with affinity for inorganic materials to spontaneously make linkages between various nanomaterials, and high enhancement of cellulolytic enzyme activity induced by nanoclustering design on nanomaterials.
実用化イメージ

We hope the business partners in the in the medicinal, environmental, material, and nanotechnological fields would be interested in my approaches and we could conduct effective collaboration research with them.

Researchers

Graduate School of Engineering

Mitsuo Umetsu

[Molecular Magnet]

Synthesis and material characterization of new organic ferroelectric materials, molecular semiconductors, molecular magnets.

 
 
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特徴・独自性
  • Multifunctional molecular-assemblies and hybrid organic - inorganic materials are examined from the viewpoint of structural freedom of organic molecules. The spin and electronic states of molecular-assemblies are designed in terms of electrical conductivity, magnetism, and ferroelectricity. Diverse molecular assemblies from single crystal, plastic crystal, liquid crystal, gel, to Langmuir-Blodgett film are our research targets, which were hybridized with inorganic gigantic clusters and metal nanoparticles. We are prepared to provide academic consultations to companies interested in our research.
実用化イメージ

Researchers

Institute of Multidisciplinary Research for Advanced Materials

Tomoyuki Akutagawa

[Molecular Science]

Visualization of Electron Motion in Matter by Means of Electron Compton Scattering

 
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特徴・独自性
  • Properties of matter, such as reactivity and functionality, are determined by the motion of the constituent electrons. For this reason we aim at developing new spectroscopic methods, by using electron Compton scattering, that would visualize the electron motion for stable species and most importantly the change of electron motion in transient species, which is the driving force behind any chemical reactions;
  • (1) development of molecular frame electron momentum spectroscopy for momentum-space imaging of molecular orbitals in the three-dimensional form,
  • (2) developments of multiparameter coincidence techniques for studies on stereo-dynamics in electron-molecule collisions,
  • (3) development of time-resolved electron momentum spectroscopy for visualization of the change of electron motion in transient species.
  • We hope to conduct collaborative research with a willing company for a practical application of this technology in industry, and we are also prepared to provide academic consultations to companies interested in our research.
実用化イメージ

Researchers

Institute of Multidisciplinary Research for Advanced Materials

Masahiko Takahashi

[Momentum Space Wave Function]

Visualization of Electron Motion in Matter by Means of Electron Compton Scattering

 
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特徴・独自性
  • Properties of matter, such as reactivity and functionality, are determined by the motion of the constituent electrons. For this reason we aim at developing new spectroscopic methods, by using electron Compton scattering, that would visualize the electron motion for stable species and most importantly the change of electron motion in transient species, which is the driving force behind any chemical reactions;
  • (1) development of molecular frame electron momentum spectroscopy for momentum-space imaging of molecular orbitals in the three-dimensional form,
  • (2) developments of multiparameter coincidence techniques for studies on stereo-dynamics in electron-molecule collisions,
  • (3) development of time-resolved electron momentum spectroscopy for visualization of the change of electron motion in transient species.
  • We hope to conduct collaborative research with a willing company for a practical application of this technology in industry, and we are also prepared to provide academic consultations to companies interested in our research.
実用化イメージ

Researchers

Institute of Multidisciplinary Research for Advanced Materials

Masahiko Takahashi

[monoclonal antibody]

Production of Tumor-Specific Monoclonal Antibodies

 
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特徴・独自性
  • Podoplanin (PDPN/Aggrus/T1α), a platelet aggregation-inducing mucin-like sialoglycoprotein, is highly expressed in many cancers and normal tissues. A neutralizing monoclonal antibody (mAb; NZ-1) can block the association between podoplanin and C-type lectin-like receptor-2 (CLEC-2) and inhibit podoplanin-induced cancer metastasis, but NZ-1 reacts with podoplanin-expressing normal cells such as lymphatic endothelial cells. Recently, we established a platform to produce cancer-specific mAbs (CasMabs). The newly established LpMab-2 mAb reacted with podoplanin-expressing cancer cells but not with normal cells, as shown by flow cytometry and immunohistochemistry; therefore, LpMab-2 is an anti-podoplanin CasMab that is expected to be useful for molecular targeting therapy against podoplanin-expressing cancers.
実用化イメージ

We can produce cancer-specific mAbs (CasMabs) against all membranous proteins. CasMabs are expected to be useful for molecular targeting therapy without side effects.

Researchers

Graduate School of Medicine

Yukinari Kato

[Motion Analysis]

High-Speed Vision for Real-Time Motion Analysis

 
 
 
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特徴・独自性
  • We are investigating high-speed vision systems that enable real-time image acquisition and visual processing at frame rates substantially higher than the standard video rate.
実用化イメージ

High-speed vision systems are useful for fast measurement and control of dynamic systems in general. When combined with external facilities such as high-speed projectors or acceleration sensors, they enable further wider applications including fast 3D measurement or object identification.

Researchers

Graduate School of Information Sciences

Shingo Kagami

[motion capture system]

Clinical Applications of Motion Capture System for Living Body

 
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特徴・独自性
  • We have developed a wireless motion capture system for living body that could non-invasively measure various biological movements without any contact. By utilizing the LC resonant magnetic marker due to the latest magnetic engineering technology, we have achieved a magnetic wireless system which could be used even in a shielded space such as oral cavity by applying a magnetic field from outside the body. By using the infrared reflective markers of small and light, we have also succeeded in developing an optical system capable of synchronous real-time measurement at up to 50 locations at 250 hertz.
実用化イメージ

This new system can three dimensionally analyze various biological movements and can be applied to such diagnostic and medical equipment that requires a motion analysis non-invasively without any contact. It is possible to specialize this system to suit the required conditions, so I would like to joint research with companies and organizations that want to take advantage of this system.

Researchers

Graduate School of Dentistry

Hiroyasu Kanetaka

[Motion Stereo Vision]

Hardware Development of Brain Computer and its Application to Visual Information Processing

 
 
 
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特徴・独自性
  • Toward realizing a high-performance neuromorphic vision processing system, our research involves a neural network model of spatial perception based on motion-stereo vision and its implementation on a very large scale integrated circuit (VLSI). Important parameters for spatial perception such as time-to-contact, orientation, and the shortest distance to plane surfaces of a target object are recognized by using the model without knowing moving direction and velocity of the object. We have developed a VLSI capable of performing visual perception based on the model with low power consumption, reduced less than 1/100 compared with a commercial CPU.
実用化イメージ

Targeted applications include a drone flying autonomously equipped with collision avoidance system by visual perception. Targeted industry includes infrastructure inspection, agriculture, logistics, and so on.

Researchers

Research Institute of Electrical Communication

Shigeo Sato

[motor neuron]

Development of a Novel Therapy for Amyotrophic Lateral Sclerosis (ALS) Using Hepatocyte Growth Factor (HGF)

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特徴・独自性
  • Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by systematic motor neuron degeneration. Approximately 20% cases of familial ALS are caused by mutations in the superoxide dismutase 1 (SOD1) gene. We developed transgenic rats that express a human SOD1 gene with two different ALS-linked mutations (G93A or H46R) showing progressive motor neuron degeneration and paralysis. The larger size of the rat ALS models as compared with existing mouse models will facilitate studies on neuroprotective and neuro-regenerative strategy involving manipulations of cerebrospinal fluid and spinal cord.
実用化イメージ

Hepatocyte growth factor (HGF) is one of the most potent survival-promoting factors for motor neurons. Continuous intrathecal infusion of human recombinant HGF (hrHGF) attenuated loss of spinal motor neurons, astrocytosis, and microglial activation, leading to prolonged survival in the ALS rats. Safety and toxicology testing of the hrHGF protein in non-human primates should prompt further clinical trials in human ALS patients.

Researchers

Graduate School of Medicine

Masashi Aoki

[movement]

Development of Wearable Motion Measurement System for Motor Rehabilitation and Healthcare

 
 
 
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特徴・独自性
  • In order to realize wealthy and vibrant local communities, it is desired that people in the community are healthy. However, the amount of the daily activity decreases as they get older, which increases the risks of the fall by weakened lower limb muscles and of the cerebrovascular disease, and so on. Therefore, for the elderly people, there is increased need of the walking training and the movement assistance in daily life, and of the rehabilitation aid.
  • In this study, focusing on the motor function of the lower limbs that is important for independent activities of daily living and that relates to the health maintenance, development of assistive technologies for decreased gait ability or for dysfunction of lower limbs are performed based on the technologies of electronics and signal processing. Especially, the wearable sensor system using gyroscopes and accelerometers are developed to measure kinetic information, and then the evaluation system for the gait ability and the lower limbs motor function is developed in this study.
実用化イメージ

The goal of this study is to realize simple and convenient measurement and accumulation of various information of gait, to visualize the obtained data for determination of training effect and evaluation of motor function, and to provide appropriate training program for each subject.

Researchers

Graduate School of Biomedical Engineering

Takashi Watanabe

[MRI]

Brain Development and Aging Using Large Brain MRI Database

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特徴・独自性
  • We have revealed relationships among brain structure, brain function, lifestyle, genetic factor, and cognitive function using brain magnetic resonance imaging (MRI) database. The goal of our project is to prevent several diseases and disorders such as dementia by performing personalized medicine using the large brain MRI database.
実用化イメージ

Our research is related with several industrial fields such as food, sleep, and other lifestyle industries. In addition, our research is also related with medical field such as preventing medicine and brain check-up.

Researchers

Smart-Aging Research Center

Yasuyuki Taki

[MRI monitoring]

Image Guided Local Drug Delivery for Central Nervous System Disorders

 
 
 
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特徴・独自性
  • Effective drug delivery to central nervous system is promising as a new therapeutic strategy against various central nervous system disorders. However, it represents a challenge because systemic delivery is always hindered by blood brain barrier, and local delivery cannot be effective because of the restricted distribution. Recently, local drug delivery system that can achieve robust distribution of the infusates by maintaining a pressure gradient at the tip of the infusion catheter during infusion has developed. Although this method is promising, there still exist several problems as loss of infusates by backflow through catheter tract or inconsistent distribution. We recently developed a method to deliver agents with this method under MRI guidance, and now performing clinical trial to treat recurrent gliomas.
実用化イメージ

Focal central nervous system disorders such as tumor, epilepsy, and parkinson's disease can be the target for application of this technique. Developments of the new catheters and pre-infusional similation systems are on their way. We are searching for effective collaborative research in this field.

Researchers

Administrative Staff

Teiji Tominaga

[MRI NIRS]

Application of Nuroimaging Technique to Interface Evaluation

 
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特徴・独自性
  • Nuclear power plants, chemical plants, ironworks and smelters, aircrafts and others that involve large-scale and complex systems yield many benefits to society and daily life, but a serious accident in such systems may result in dire consequences and significant damage. As long as there is human intervention of any kind, it is difficult to completely avoid human error. In light of this, it is crucial to have the mindset of "to err is human, (to forgive divine)." Takahashi Laboratory advocates the improvement of safety based on the harmonization of humans, machines and the environment. The object of our research is the human. Incorporating neuroscience approach and knowledge, we probe into human cognitive and behavioral traits and reflect our findings back into our research with the cooperation of this university's Institute of Development, Aging and Cancer as well as practicing specialists and technical experts. Through our broad vision, flexible mindset and creativity, we pioneer interfaces between humans and systems where safety is ingrained.
実用化イメージ

The core of our research is the examination and understanding of the human factor to be taken into account for the safe and efficient operation of large scale, complex systems, and we are involved in the research of a wide array of subjects not limited to nuclear energy systems but air traffic control operations, man-machine interfaces, cyber security, standardization of rules among others.

Researchers

Graduate School of Engineering

Makoto Takahashi

[MRL/lpr]

Development of McH-lpr/lpr-RA1 mouse, a study model that spontaneously develops severe autoimmune arthritis, vasculitis, and sialadenitis

 
 
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特徴・独自性
  • McH/lpr-RA1 mice are recombinant congenic mice descended from MRL/lpr and C3H/lpr mice and develop arthritis, vasculitis, and sialadenitis with high frequency and severity, with severe pannus formation similar to rheumatoid arthritis, polyarteritis nodosa, and Sjogren's syndrome. On the other hand, McH/lpr-RA1 mice do not develop systemic lymphadenopathy and severe nephritis as seen in MRL/lpr mice, so they are easy to breed and maintain and can be used for long-term drug administration experiments.
実用化イメージ

Development of diagnostic and therapeutic agents for collagen diseases. It can be applied to the elucidation of the mechanism of onset of immunological adverse events caused by immune checkpoint inhibitors and the development of drugs to prevent the onset of such events, etc. Industry-academia collaboration with pharmaceutical companies, test reagent companies, etc. is possible.

Researchers

Graduate School of Biomedical Engineering

Tetsuya KODAMA

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