Research Profiles

JP

"P" Keywords - 98 Result(s)

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 P

[probe synthesis]

Synthesis of Biologically Active Cyclodepsipeptide Natural Products

 
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特徴・独自性
  • Cyclodepsipeptide natural products include optically active hydroxy acids as well as various unnatural amino acids and exhibit a variety of biological activity depending on the peptide sequence, chirality, and selection of the hydroxy acids. Structure-activity relationships of a synthetic library of natural products could give us significant information of not only biologically important moieties but also intact positions in the biologically active small molecules. On the basis of the former information, more potent compounds and/or peptide mimetics can be designed. The latter information can also be important for making a molecular probe that is used for exploration of a target molecule.
実用化イメージ

We study for combinatorial synthesis of natural product analogues using solid-phase.

Researchers

Graduate School of Pharmaceutical Sciences

Takayuki Doi

[Probiotics]

Gastroenteritis virus-binding enteric bacteria for probiotics

 
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特徴・独自性
  • We have found enteric bacteria that can capture gastroenteritis viruses, such as norovirus and rotavirus, through histo-blood group antigen (HBGA)-like substances. These HBGA-positive bacteria give a significant impant on the ecology of gastroenteritis viruses in human body and in environments.
実用化イメージ

Since gastroenteritis virus-binding bacteria can affect the viral infection capability to host cells, these bacteria and produced HBGA-like substances are available in probiotics application.

Researchers

Graduate School of Engineering

Daisuke Sano

[Process equipment]

Development of Advanced Device and Process Technologies and New Image Sensors

 
 
 
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特徴・独自性
  • Toward the ultimate performances of image sensors, advanced research activities are being conducted that cover a wide range of technology fields from cleanroom infrastructure, materials, process equipment, process, device, circuit, assembly, signal processing, measurement/evaluation and reliability. Following technologies have been successfully commercialized:
  • A fast and accurate measurement technology of electrical characteristics for over 1 million transistors
  • A wide dynamic range CMOS image sensor technology capturing images over five decade brightness ranges
  • An ultra-fast CMOS image sensor technology with 10 million frames/sec
実用化イメージ

Followings are available for industry collaborators:
A. 200mm-diameter-wafer silicon device fabrication utilizing the ultra-clean facility including wafer mutual fabrication processing between device manufacturers.
B. Process technology development and various kinds of analyses.
C. Development of new image sensors.

Researchers

New Industry Creation Hatchery Center

Shigetoshi Sugawa

[product usability]

Food Palatability, Product Usability, and Preference; An Approach from Psychology and Neuroscience.

 
 
 
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特徴・独自性
  • My research interest is peoples' perception of external stimulus. Based on these researches and our knowledge, I can offer you an idea of the products that give consumers satisfaction. Also on the basis of psychological and neuro-scientifc experiences and knowledges, I can offer you a transdisciplinary approaches on human perception, cognition, emotion and decision making.
実用化イメージ

Marketing and developing of the products such as foods, beverages, fabric softeners, perfumes, body deodorants etc. The knowledges and research tools are also useful in regulating the malodor in the air pollution, in developing the public services and in elevating public quality of life.

Researchers

Graduate School of Arts and Letters

Nobuyuki Sakai

[productivity improvement]

Improvement of Seed Production by Using Reproductive Trait in Crops, Especially, Rice and Cruciferous Crops

 
 
 
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概要

The recent spate of extreme weather events is threatening to reduce crop seed and fruit production. We have identified a catalog of genes that respond under low and high temperature stress, and will construct a system that enables production under temperature stress through genome editing and other methods.

従来技術との比較

In addition to conventionally used genetic recombination methods, genome editing technology has made it possible to modify genes that can be used for practical purposes.

特徴・独自性
  • Crops are important for food, environment recovery, energy production, and amenity activity for human being. For improvement of crop seed production, the breeding of crops having environmental stress, is important. Especially the developmental stage from pollination to fertilization is quite weak for these environmental stresses. Thus, by breeding of reproductive trait, we will establish the high productivity and quality of crop seeds. From our research, we found several stress-tolerant genes. We already started the research by both basic and applied level.
実用化イメージ

For application, we evaluated by taking prize for application in 2001. And our basic data has been published in international Journal, "Nature" and "Science". If anyone is interested in these genes, we hope to conduct to collaborative research for establishing the useful breeding lines.

Researchers

Graduate School of Life Sciences

Masao Watanabe

[Programming Languages]

Programming Language Theory and Computation Models

 
 
 
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特徴・独自性
  • Our laboratory conducts leading research on programming language theory and high-level computation models. In particular, we focus on research and application of (general proof methods for) program equivalence, functional programing, and type systems (also known as lightweight formal methods), which are attracting revived interests in recent years. Our Japanese translation of "Types and Programming Languages" (Benjamin C. Pierce, University of Pennsylvania)---compiled in cooperation with engineers from top-level electronics and software companies in Japan---has become the 42nd bestseller (rather exceptional as an academic Publications) among new books in Amazon.co.jp. For more information, please see the Web page: http://www.kb.ecei.tohoku.ac.jp/~sumii
実用化イメージ

Our technology can be used for design and development of software artifacts, especially programming languages and tools including DSL (domain specific languages), as well as application of functional programming, type systems, or formal methods.

Researchers

Graduate School of Information Sciences

Eijiro Sumii

[Programming Models]

Supercomputing for enabling large-scale advanced simulations

 
 
 
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特徴・独自性
  • As modern supercomputers are getting larger and more complicated, it is not so easy to exploit their potential performance. It is necessary to develop a simulation code with considering various factors for both hardware and software reasons, and hence expert knowledge and experiences about supercomputing are often needed to achieve high actual performance. Our research interests focus on shaping future supercomputing systems and their applications, especially system software technologies for effectively using the future supercomputers. Also we are always exploring how to make good use of the state-of-the-art hardware and software technologies in order to enable unprecedented-scale and more advanced simulations.
  • From beginning (apply for use of our supercomputer) to end (get a solution), we can consistently support developing large-scale practical simulation, which is feasible only by using the supercomputer. As a supercomputing center, we have a long history of parallelizing and accelerating a lot of practical simulation programs. In addition, we are looking for research collaborators who are interested in streamlining and/or facilitating large-scale scientific software development.
実用化イメージ

Researchers

Cyberscience Center

Hiroyuki Takizawa

[Prolyl hydroxylase]

Development of PHD-Targeted Drug for Ischemic Injury

 
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特徴・独自性
  • All the living organisms generate energy from molecular oxygen to maintain their own lives. Once the concentration of oxygen falls down, life activity gets severely hampered and it could sometimes cause death. Typical examples that are related to local hypoxia are ischemic heart disease, stroke and kidney disease.
  • We focus on the function of prolyl hydroxylase (PHD) as a sensor to detect the hypoxia, and we are developing drugs to treat ischemic injury by controlling hypoxia.
実用化イメージ

Currently, we have several compounds that inhibit the PHD. We want to commercialize in conjunction with pharmaceutical companies in Japan and overseas, advancing our non-clinical studies for clinical development.

Researchers

Graduate School of Medicine

Toshio Miyata

[protein]

A novel crystal growth via controlling an energy relationship between crystal and melt with applying an electric field

 
 
 
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特徴・独自性
  • This lab is concerned with the novel approach mainly for the growth from melt by studying the relationship between the interface dynamics during growth and properties of grown crystals. Special interests lie in the growth of new crystals via the imposition of an interface-electric field. Nano-scaled control of crystal growth is executed in an electric double layer of ~nm thickness that is induced by applying an external electric field on the growth interface. Some of our growth results brought by applying an electric field are;
  • 1. Growth of Langasite-type crystals for the pressure sensor at high temperature by manipulating the energy relationship between crystal and melt.
  • 2. Easy nucleation of protein crystals that are normally hard to crystallize.
  • 3. Formation of Si crystals with desired structure by manipulating the interface instability of Si.
  • Crystals developed this way will widen an opportunity to collaborate with industries in the field of the piezoelectric, magnetic, optic and other fields related to the highly-networked information society.
実用化イメージ

Researchers

New Industry Creation Hatchery Center

Satoshi Uda

Imaging and photoregulation of biological functions

特徴・独自性
  • To properly understand the functions of biomolecules, it is essential to observe them under physiological conditions where the interactions with other biomolecules are preserved. Therefore, we are developing new functional molecules using both organic chemistry and protein science approaches, and working on the visualization and optical control of biomolecules and their functions. Especially, we have developed fluorescent probes that quantitate the concentration of biomolecules or ions in subcellular regions such as organelles and caged compounds and photoswitches that optically manipulate the biomolecular functions.
実用化イメージ

Researchers

Institute of Multidisciplinary Research for Advanced Materials

Shin Mizukami

[protein labeling]

Imaging and photoregulation of biological functions

特徴・独自性
  • To properly understand the functions of biomolecules, it is essential to observe them under physiological conditions where the interactions with other biomolecules are preserved. Therefore, we are developing new functional molecules using both organic chemistry and protein science approaches, and working on the visualization and optical control of biomolecules and their functions. Especially, we have developed fluorescent probes that quantitate the concentration of biomolecules or ions in subcellular regions such as organelles and caged compounds and photoswitches that optically manipulate the biomolecular functions.
実用化イメージ

Researchers

Institute of Multidisciplinary Research for Advanced Materials

Shin Mizukami

[Proton]

Quantum and Molecular Dynamic Simulations of Transport Phenomena in Fuel Cell

 
 
 
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特徴・独自性
  • It is necessary to grasp nanoscale transport phenomena of materials in polymer electrolyte fuel cell to improve its performance. In our laboratory, nanoscale transport phenomena are analyzed by large scale molecular dynamics simulations using a supercomputer system. As the present theme, the dependence of the materials or structures of polymer electrolyte membrane on the ability of proton transfer(Fig. 1), the ability of proton transfer or oxygen permeability of ionomer in catalyst layer(Fig. 2), and the mechanism of transport phenomena of a water droplet in a nano pore in gas diffusion layer or micro porous layer(Fig. 3), are analyzed in detail.
実用化イメージ

These research can be applied to the analysis of flow field in devices which have nanoscale structure, for instance, fabrication process of semiconductor, friction phenomena of such nanoscale devices or next generation batteries, as well as the field of fuel cell.

Researchers

Institute of Fluid Science

Takashi Tokumasu

[prototype]

Hands-On Access Fabrication Facility –Open Facility for MEMS and Semiconductor Prototyping–

 
 
 
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概要

We offer shared facility for the development of semiconductor prototypes equipped with 4-inch, 6-inch and some 8-inch wafer fabrication tools available on an hourly basis. Know-how accumulated at Tohoku University is available, and staff provide maximum support for prototyping. The service is performed at the 1,200 m2 Super Clean Room on the second floor of the Junichi Nishizawa Memorial Research Centre at Tohoku University. For information on equipment and fees, see our website.

従来技術との比較

More than 10 experienced technical staff assist customer's usages. Standard process conditions for each process, such as etching and deposition, are provided. allowing customers to start prototyping immediately. Various materials other than silicon can also be supported.

特徴・独自性
  • We support the development of devices and semiconductor materials such as MEMS, optical elements and RF components.
  • Technical consultation on devices and processes before and during prototyping is also available.
  • A
  • 'Prototype lab' for device packaging is also available.
  • The museums where you can learn about the history of semiconductors, measuring instruments and sensors are open.
  • As part of Technology Co-creation for Semiconductor of Tohoku University, we promote R&D of semiconductors and the development of human resources.
  • On-demand semiconductor human resource development programs for students and engineers are available.
  • As a member of the MEXT's Advanced Research Infrastructure for Materials (ARIM) program, we are involved in sharing facility and data.
実用化イメージ

More than 310 companies have used our shared facility since its launch in 2010, not only from device manufacturers such as MEMS, but also from manufacturers of materials, mechanical components and equipment. To date, we have successfully supported the commercialization of about 10 devices.

Researchers

Micro System Integration Center

Kentaro Totsu

[Pseudomonas aeruginosa]

Novel high-throughput screening systems for new antibiotics targeting bacterial virulence factors

 
 
 
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特徴・独自性
  • Chemotherapy toward bacterial infection, which dates back to the discovery of penicillin, opened up the golden era of antibiotics. Thereafter, various clinically important antibiotics were introduced into the clinic, and hence serious bacterial infectious diseases were eradicated. However, this ephemeral hope has been disappearing due to the emergence of antibiotic resistant pathogens toward every new antibiotics launched into the clinic, such as multidrug-resistant Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus (MRSA). To combat these life-threatening pathogens, there is a pressing need to develop new antibiotics. However, new antibiotics discovered in the future will be nullified by development of resistance to these antibiotics, since their targets are essential for bacterial survival. From this aspect in which inhibitors of the essential functions inevitably select resistant mutants, bacterial virulence could be a fascinating target for developing new antibiotics, because virulence attenuators are thought to be less likely to generate resistance. We focus on a novel protein translocation system, Tat, since this system appears to be involved in several aspects of bacterial virulence and is not present in mammalian cells, and iron-metabolism-associated system as novel targets for development of their inhibitors. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.
実用化イメージ

Researchers

Graduate School of Agricultural Science

Hiroshi Yoneyama

[public policy]

Economics of Aging

特徴・独自性
  • I investigate on the economics of aging, the optimal social welfare policy, low fertility and so on not based on the historical and systematic approach but based on the neo-classical economic theory. I also use econometric method and statistical approach. I often estimate the future projections of the population, public finance, magnitude of private markets, the results of public policies.
  • I also research on the comparative studies on East Asia (Japan, China, Korea, Taiwan) and European (especially Scandinavian countries). I provide statistic data and information on the economic and political systems on the aging in Japan.
実用化イメージ

The future estimation on the financial status , market caused by low fertility and aging. The effective management of the medical institutions, social welfare systems, gender equality societies for the central and local government, research institutions, public enterprises, and financial Institutions.

Researchers

Graduate School of Economics and Management

Hiroshi Yoshida

[pulse laser]

Spintronics Devices and Materials

 
 
 
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特徴・独自性
  • Spintronics is a technology utilizing electron spin which provided magnetic sensor, nonvolatile magnetic memory, and so on. Our studies are as below.
  • Noble & Rare-earth free magnetic films with large perpendicular magnetic anisotropy. We achieved to develop various Mn-bases alloy films exhibiting high perpendicular magnetic anisotropy (Fig.1 ).
  • THz range observation of magnetization motion. We achieved to detect a motion of magnetization using pulse laser in time domain (Fig. 2).
  • Novel organic spin devices. We achieved to fabricate hybrid junction consisting of an organic layer sandwiched by two inorganic magnetic layers and to observe magnetoresistance effect.
  • Tunnel Magnetoresistive devices: We are developing TMR devices with Mn-Ga alloys films (Fig.3 ).
実用化イメージ

Magnetic memory and storage. Microwave and Terahertz wave. Magnetic sensors.
We hope to conduct collaborative research with a willing company for a practical application of these devices and materials in industry.

Researchers

Advanced Institute for Materials Research

Shigemi Mizukami

[PVA]

Biomodel for Development of Endovascular Treatment

 
 
 
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特徴・独自性
  • We perform in-vitro or computational researches for development of medical devices. We develop a model of artery or bone to evaluate medical devices. And we apply optimization way for development of medical devices. Our main target is, currently, stent, or catheter.
実用化イメージ

Our collaboration company can be; medical equipment, device, medical image, MEMS, standardization, medical training, or polymer.

Researchers

Institute of Fluid Science

Makoto Ohta

[PVC]

Chemical Recycling of Problematic Polymeric Wastes

 
 
 
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特徴・独自性
  • The Yoshioka Laboratory works on the recycling of various polymers by thermal and wet processes. Plastics such as poly(ethylene terephthalate) (PET), polyvinyl chloride (PVC), and high impact polystyrene (HIPS) cause serious problems during their recycling for the recycling process and the environment. However, these materials can also be seen as a resource for new materials. The decarboxylation of PET results in high yields of benzene that can be used as a chemical feedstock. Another important feature is the dehalogenation of flame retarded plastics and PVC. Dechlorinated plastic waste can be an important source for hydrocarbons, which can be used as fuels and chemical feedstock. The chemical modification of PVC offers the possibility of new materials with new properties. Modified PVC can be used as antibacterial material or as a material with ion exchange properties. The removal of brominated flame retardants from HIPS leads to higher recovery rates of styrene during thermal processing. When a wet process is used, the resulting flame retardant free HIPS can be reused.
実用化イメージ

We are eager to help companies to overcome their problems during recycling and recovery, and provide solutions for the treatment of waste materials.

Researchers

Graduate School of Environmental Studies

Toshiaki Yoshioka

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