Sorted by Keyword - 1938 word(s), 265 profile(s)

 B

[baroreflex sensitivity]

Quantitative Evaluation of the Baroreflex Sensitivity of the Heart and Artery

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特徴・独自性
  • Metabolic syndrome is an important view point, when we consider the preventive medicine. Hypertension is one of the most important points to prevent the cardiovascular events. However, there is no method to measure the baroreflex sensitivity of the artery in the patients with hypertension. Tohoku University had invented the new method to evaluate the baroreflex sensitivity of the heart and artery (JP Patent No.4789203).
実用化イメージ

By the use of this machine, the baroreflex sensitivity of an artery in the patients can easily be measured noninvasively. It enables to predict the occurrence of hypertension and evaluate the therapy of hypertension easily, while allowing prevention of the cardiovascular events.

Researchers

Institute of Development, Aging and Cancer

Tomoyuki Yambe

[Basal metabolic rates]

Development of New Drugs and Devices Regulating Inter-Organ Neural Network for Obesity Therapy

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特徴・独自性
  • Obesity induced the metabolic syndrome, which causes cardiovascular diseases. Obesity has now become a major health concern not only in developed countries but developing countries. However, diet and exercise are still major therapies. We discovered endogenous systems maintaining homeostasis of energy metabolism and revealed several neuronal networks among organs to be responsible for the regulation systems.
  • 1) Afferent neuronal signals from adipose tissue regulate appetite and prevent over-eating during obesity development (Cell Metab 2006)
  • 2) Neuronal network from the liver enhances basal metabolic rates to prevent obesity development when energy store is increasing (Science 2006) 3) Neuronal network from the liver suppresses adaptive thermogenesis in brown adipose tissue (Cell Metab 2012).
実用化イメージ

On the basis of these original discoveries, we are aiming at developing new drugs and/or building devices which regulate the inter-organ neuronal networks and hope to conduct collaborative research with a willing company for a practical application to obesity therapy.

Researchers

Graduate School of Medicine

Hideki Katagiri

[battery]

“HYDRIDE" Researches for Energy Applications

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特徴・独自性
  • This group is engaged in basic and applied researches of "hydrides" for practical use in hydrogen energy system. The main subject is the exploration of advanced hydrogen storage materials which support hydrogen energy technologies such as fuel cells. Currently, we synthesize a wide variety of novel hydrides composed of lightweight metals with specific nano-structures using advanced techniques for crystal and electronic structure analyses. In addition to the hydrogen storage, we develop the wide research fields related to hydrides, such as fast lithium ionic conductors.
実用化イメージ

Besides the contributions in industrial progress through the material development for future hydrogen energy system and next-generation secondary battery, we positively provide technical assistance to organizations and companies concerned about our findings.

Researchers

Advanced Institute for Materials Research

Shin-Ichi Orimo

[Bayes Modeling]

Data Analytics for Creation of Social Values

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特徴・独自性
  • My research field is a data analytics for creation of social values by data science approaches. In modern society, we can observe various data sets about our daily life, business or community. I aim to create new services for it using such data set and methods of Bayesian modeling, data mining or machine learning.
実用化イメージ

Researchers

Graduate School of Economics and Management

Tsukasa Ishigaki

[Bayesian Optimization]

Optimizing everything / Optimal Society

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特徴・独自性
  • Aiming at developing practical quantum optimization technology known as quantum annealing, we are working on exploring basic technologies that can overcome the limitations and applications in collaboration with multiple companies. The advantage of the method is that it can be used simply by formulating a cost function that draws the goal to be optimized once, but we are not limited to the original method. We extend it by considering a much easier problem, sequential optimization by learning, black box optimization, etc.. In particular, it is being applied to automated driving, logistics in factories, and evacuation guidance during disasters.
実用化イメージ

Applications to route search problems such as automatic driving of various vehicles, evacuation route guidance at the time of disaster, process scheduling and a large number of combination problems. We can provide a solution to combinatorial optimization in each industry. (Transportation / distribution, manufacturing, materials, drug discovery, etc.)

Researchers

Graduate School of Information Sciences

Masayuki Ohzeki

[BCP]

Business Continuity Management (BCM)

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特徴・独自性
  • Business continuity management (BCM) is a strategy of a company or a public organization to continue critical operations or recover them early even when they suffer serious damage from disasters, major accidents, terrorism, infectious diseases and so on. The plans for BCM is called BCPs. Japanese government and industry organizations actively promote introduction and improvement of BCM. My laboratory have studied how to spread and improve BCM. I participate in development of governmental guidelines for BCM. I also operate a BCM study group consist of companies, governmental organizations and research institutes in Sendai City.
実用化イメージ

I would be able to give an advice to companies or organizations which are going to introduce or improve their BCM and BCP at the request of them. In addition, collaboration with corporate groups can be assumed to promote or improve BCM practically.

Researchers

International Research Institute of Disaster Science

Hiroaki Maruya

[Beam Yielding Mechanism]

[Big Data]

Brain Development and Aging Using Large Brain MRI Database

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特徴・独自性
  • We have revealed relationships among brain structure, brain function, lifestyle, genetic factor, and cognitive function using brain magnetic resonance imaging (MRI) database. The goal of our project is to prevent several diseases and disorders such as dementia by performing personalized medicine using the large brain MRI database.
実用化イメージ

Our research is related with several industrial fields such as food, sleep, and other lifestyle industries. In addition, our research is also related with medical field such as preventing medicine and brain check-up.

Researchers

Smart-Aging Research Center

Yasuyuki Taki

Advanced Analysis of Socio-Economical Data for Capturing Social Needs

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特徴・独自性
  • We have proposed advanced methods of behavior analysis for public transport service.
  • They include a demand composition based on the automatically mesured traffic data, estimation of true demand partly unrealized by the congestion, and intense usage of geographical data. These methods may be applicable for behavior analysis besides transport service.
実用化イメージ

We welcome cooperative research on demand analysis of public services, as well as needs analysis for new goods and services.

Researchers

International Research Institute of Disaster Science

Makoto Okumura

[Bio-FET sensor]

Development of Biomedical Micro/Nano Integrated System Using LSI Technology

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特徴・独自性
  • Semiconductor neural engineering is a discipline that uses semiconductor process/device/circuit technologies to further understand properties of neural systems and to create novel fusion systems of living body and machine.
実用化イメージ

One of the goals in this laboratory is to establish semiconductor neural engineering and develop biomedical micro/nano integrated systems.
Another goal is to educate the next generation of leaders in biomedical engineering through research including:
1. Intelligent Si neural probe and biomedical signal processing LSI
2. Fully-implantable retinal prosthesis system
3. Bio/nano technology and novel Bio-FET sensor
4. 3-dimensional integration technology and analog/digital LSI design

Researchers

Graduate School of Biomedical Engineering

Tetsu Tanaka

[Bio-inspired materials]

Bio-inspired engineering for energy and biological applications

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特徴・独自性
  • Our goal is "bio-inspired engineering" to create new functions that exhibit functions beyond the nature systems by learning from their superior functions and incorporating them into creating materials and devices. For example, the development of surface treatment and adhesives learned from mussels, the development of anti-biofouling substrates learned from pitcher plants, the design of non-platinum catalysts for highly active fuel cells (hydrogen, enzymes, microbes, etc.) learned from hemoglobin, and needle-type biosensors learned from biological needles.
実用化イメージ

Based on electrochemistry and polymer chemistry, I provide technologies and expertise in the energy, biotechnology, and electrical and electronic fields, including metal-air batteries, fuel cells, surface treatment, adhesion, biosensors, etc.

Researchers

Frontier Research Institute for Interdisciplinary Sciences

Hiroya Abe

[Bio-inspired Robotics]

Understanding Biological Control Systems and its Application to Development of Life-Like Resilient Systems

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特徴・独自性
  • In contrast to artificial systems, living organisms exhibit astoundingly adaptive and resilient properties. One of the central research goals in our laboratory is to endow artificial systems with similar properties. To this end, we are particularly focusing on the concept of autonomous decentralized control. We have so far successfully developed various types of robots on the basis of decentralized control, including amoeboid robots, snake-like robots, legged robots etc., in collaboration with mathematicians and biologists.
実用化イメージ

Development of adaptive autonomous robotic system, Control of Large D.O.F. system

Researchers

Research Institute of Electrical Communication

Akio Ishiguro

[Bio-interface]

Creation of a high functional bio-interface using laser fabrication

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特徴・独自性
  •  Using laser fabrication, we are developing techniques to enhance material surface properties and functionality. For example, to create a functional interface, we aim to clarify, by way of simulation and experimentation, the phenomenon that occurs when the surface of a material is irradiated using a laser beam.
  •  We expect that the results of our research will be widely applicable, including biomedical devices.
  • ■ Creation of biocompatible surfaces
  •  Materials used for artificial organs, vessels, and other bio-implants require excellent tissue and cell biocompatibility. Therefore, we are exploring the creation of biocompatible surfaces using a new laser irradiation process in this study.
  •  We have succeeded in imparting a biologically active function to titanium-based materials by applying the laser irradiation technique. When such a material that has a biologically active function is inserted in a living body, hydroxyapatite (the principal constituent of bones and teeth) precipitates on the surface. Using the laser irradiation technique, we can manufacture bone-adherent implants, and we envisage their application to artificial joints or dental implants.
  •  This research aims to discover such breakthrough solutions for biomedical applications using the laser irradiation technique.
実用化イメージ

Researchers

Green Goals Initiative

Masayoshi Mizutani

[bio-magnetic sensor]

Development of High Sensitive Magnetic Sensor Operating at Room Temperature with Tunnel Magnetoresistance Devices

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特徴・独自性
  • Recently, many tunnel magnetoresistance devices with high magnetoresistance effect are reported. These are expected to be applied to high sensitive magnetic sensors. There are many magnetic sensors with variety of the mechanism, in order to meet the demand of the very wide range of sensing magnetic field. However, there is no magnetic sensor which has high sensitivity, easy to use, operation at room temperature and low cost. Only a magnetic sensor with tunnel magnetoresistance devices can satisfy all the demand in principle. As the device has very wide range of the sensing magnetic field, it can be designed for any demand to the sensors.
実用化イメージ

For example, this device can sense a bio-magnetic field easily at room temperature, so that it could be replaced SQUID device, which is popular now but is very expensive and not easy to use personally. Therefore, by using this device, we expect we can conduct effective collaborative research in medical field.

Researchers

Graduate School of Engineering

Yasuo Ando

[bio-organic chemistry]

Creation of cancer cell specific oligonucleotide therapeutics

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特徴・独自性
  • Focusing our reseach interest mostly on the recognition and complexation behavior control of bioplymrs, such as DNA/RNA, proteines and so on. Another topics are reaction control based on molecular recognition phenomena in both ground and electronically excited states, we are pursuing mechanistic and synthetic studies on asymmetric photochemistry with supramolecular biopolymers as chiral reaction fields.
実用化イメージ

Researchers

Institute of Multidisciplinary Research for Advanced Materials

Takehiko Wada

[Bio-related equipment]

IVR (Interventional Radiology) Treatment of Hypertention: Minimally Invasive Treatment of Primary Aldosteronism Based on the Adrenal Vein Sampling Technology

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特徴・独自性
  • Primary aldosteronism is a leading cause of secondary hypertension accounting for approximately 10 % of hypertensive patients; 4 million patients potentially exist in Japan. We aim to optimize the method of ablating aldosterone producing adenoma using newly developed bipolar radiofrequency ablation system with 300-400kHz high-frequency current and electric power of 40W (Celon Prosurge Applicator), and establish a less invasive interventional radiological treatment of primary aldosteronism.
実用化イメージ

Collaboration with medical equipment manufacture and universities are expected to develop new devices enabling ablation of aldosterone producing adenoma. Flexible guide-wire-type ablation system and rapid aldosterone assay system should be co-developed to tread aldosterone producing microadenoma which is difficult to detect due to its small diameter of less than 5mm.

Researchers

Graduate School of Medicine

Kei Takase

[bioactive]

Creation of a high functional bio-interface using laser fabrication

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特徴・独自性
  •  Using laser fabrication, we are developing techniques to enhance material surface properties and functionality. For example, to create a functional interface, we aim to clarify, by way of simulation and experimentation, the phenomenon that occurs when the surface of a material is irradiated using a laser beam.
  •  We expect that the results of our research will be widely applicable, including biomedical devices.
  • ■ Creation of biocompatible surfaces
  •  Materials used for artificial organs, vessels, and other bio-implants require excellent tissue and cell biocompatibility. Therefore, we are exploring the creation of biocompatible surfaces using a new laser irradiation process in this study.
  •  We have succeeded in imparting a biologically active function to titanium-based materials by applying the laser irradiation technique. When such a material that has a biologically active function is inserted in a living body, hydroxyapatite (the principal constituent of bones and teeth) precipitates on the surface. Using the laser irradiation technique, we can manufacture bone-adherent implants, and we envisage their application to artificial joints or dental implants.
  •  This research aims to discover such breakthrough solutions for biomedical applications using the laser irradiation technique.
実用化イメージ

Researchers

Green Goals Initiative

Masayoshi Mizutani

[Biochip]

Bio-Hybrid MEMS for Medical, Environmental and Food Engineering

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特徴・独自性
  • We have developed original manufacturing techniques for bio-hybrid MEMSs that utilize special functions of bio-elements, proteins and living cells, for molecular selective sensing and power generation from natural fuels.
  • (1) Conducting polymer electrodes printed on hydrogels (image 1)
  • (2) Dynamic control of bio-adhesion by electrochemical means (image 2)
  • (3) Micro Biofuel Cells with flexible enzyme electrode patches (image 3)
実用化イメージ

We hope to conduct collaborative research with a willing company for a practical application of these technologies in industry.

Researchers

Graduate School of Engineering

Matsuhiko Nishizawa

[biocompatibility]

Creation of a high functional bio-interface using laser fabrication

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特徴・独自性
  •  Using laser fabrication, we are developing techniques to enhance material surface properties and functionality. For example, to create a functional interface, we aim to clarify, by way of simulation and experimentation, the phenomenon that occurs when the surface of a material is irradiated using a laser beam.
  •  We expect that the results of our research will be widely applicable, including biomedical devices.
  • ■ Creation of biocompatible surfaces
  •  Materials used for artificial organs, vessels, and other bio-implants require excellent tissue and cell biocompatibility. Therefore, we are exploring the creation of biocompatible surfaces using a new laser irradiation process in this study.
  •  We have succeeded in imparting a biologically active function to titanium-based materials by applying the laser irradiation technique. When such a material that has a biologically active function is inserted in a living body, hydroxyapatite (the principal constituent of bones and teeth) precipitates on the surface. Using the laser irradiation technique, we can manufacture bone-adherent implants, and we envisage their application to artificial joints or dental implants.
  •  This research aims to discover such breakthrough solutions for biomedical applications using the laser irradiation technique.
実用化イメージ

Researchers

Green Goals Initiative

Masayoshi Mizutani

[biodegradable]

Multi-functionalization of composite materials by microstructure design

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特徴・独自性
  • For further social development, it is required the miniaturization, weight saving, high performance of various devices. We study on fiber, particle reinforced polymer, metal, ceramic matrices composite materials using our knowledge about materials mechanics and numerical simulation such as finite element method. We recently address to develop multi-functionalized composite materials, which have high strength, super lightweight, energy harvesting function, damage monitoring function, biodegradable at the same time.
実用化イメージ

Researchers

Graduate School of Environmental Studies

Hiroki Kurita