Research Profiles

JP

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 Y

[yeast]

Yeast models of familial Alzheimer disease to screen for gamma-secretase inhibitors and modulators

 
 
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特徴・独自性
  • Using the yeast transcriptional activator Gal4 system, we reconstituted the production of amyloid beta (Aβ), responsible for Alzheimer disease. Aβ production could be monitored by the positive growth in the selection media or by the reporter enzyme (β-Gal). Utilizing familial Alzheimer disease mutants, we established a system to screen for mutations and chemicals that modulate gamma secretase activity and reduce toxic Aβ42.
実用化イメージ

Our yeast system can be used to screen for chemicals, natural products, food ingredients, genes, and mutations that modulate γ-secretase activity and block Aβ42 production specifically. We hope to conduct collaboration research with a willing company for a practical application of this technology in industry.

Researchers

Graduate School of Agricultural Science

Eugene Futai

 Z

[Zero carbon society]

Integrated Design for Sustainable Energy Systems

 
 
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特徴・独自性
  • The concept of LCS (low carbon society) is a unique approach having multi-dimensional considerations such as social, economic and environmental dimensions. The LCS aims at an extensive restructuring of worldwide energy supply/demand network system by not only replacing the conventional parts with the new ones, but also integrating all the necessary components and designing absolutely different energy networks. An energy-economic model is a tool for decision making for a variety of purposes, such as energy security planning, climate policy analysis, and technology innovation assessment.
実用化イメージ

Provide local governments, participating companies, and consultants with databases related to local energy supply and demand to support data analysis and scenario design in planning smart cities and decarbonized regions.

Researchers

Graduate School of Engineering

Toshihiko Nakata

 O

[ Functional Brain Mapping]

Resarch and development for maintaining and improving brain and mental health

特徴・独自性
  • The Smart Aging International Research Center (SAIRC) was founded on 1 October 2009. This Center proposes the creation of a new field to produce well-rounded personnel who have gained “totally comprehensive intelligence” from their experience, in order to cope with various problems associated with the diverse and complex super-aging society. To this end, the Center will promote interdisciplinary cooperative research, international collaborative research projects, and research collaborations with industry, as well as disseminate and exchange information by holding international conferences and symposia.　 The SAIRC is designed to develop an approach for maintaining and improving brain and mental health in a diverse and complex society from the standpoints of brain science, with the aim of maintaining and improving brain functions; cognitive neuroscience and psychology, with the aim of maintaining a healthy and tranquil state of mind at each aging stage; and philosophy, phenomenology and ethics that provide a radical reconsideration of the concept of the “mind.” We welcome collaborative researches with companies, and academic consultations.
実用化イメージ

Researchers

Institute of Development, Aging and Cancer

Ryuta Kawashima

[ inhibitors]

Development and evaluation of various inhibitors and disinfectants for SARS-CoV-2

 
 
 
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特徴・独自性
  • Using the infectious SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2), we are evaluating and developing new therapeutic drug candidates as well as evaluating disinfectants. Further analyses such as mechanism of action and resistance may be applicable. Other pathogens, including influenza virus and drug-resistant bacteria, will be examined upon request and discussion. Through joint and collaborative research with domestic and overseas pharmaceutical companies and related companies, we have experience of their clinical application including basic research.
実用化イメージ

We support development and evaluation of various inhibitors and disinfectants for variants of SARS-CoV-2 as well as wild type.

Researchers

International Research Institute of Disaster Science

Eiichi Kodama

[ single crystal growth]

Development of Novel Scintillator and Piezoelectric Crystals

 
 
 
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特徴・独自性
  • Our research target is mainly focused on the topic of development of novel scintillator crystals, piezoelectric crystals, growth technology, characterization and its device application.
  • We design and synthesize new materials from a view point of Crystal Chemistry, and investigate their structure and physical properties. We also study on photo-detector, as suitable photo-detector fully contribute to get maximum signal from scintillator. This activity is very important to realize practical application of our developed materials. Recently, piezoelectric material and high melting temperature alloy project is also started.
実用化イメージ

For the purpose of "real" contribution to human culture, we are always carrying out our research activity considering the industrial application. This point is unique feature of our attitude toward science.

Researchers

Institute for Materials Research

Akira Yoshikawa

 3

[3D]

Interactive Content to Enrich Our Lives

 
 
 
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特徴・独自性
  • (1) Displays and Interactive Techniques
  • Designing original display systems to show visual information accurately and effectively, and interaction techniques to make better use of these display systems.
  • (2) Interactive Video Content
  • Creating new interactive content from real video taken by cameras and computer-generated animations.
  • (3) Modeling and Controlling the “Atmosphere” in a Conversation Space
  • Aiming to stimulate the “atmosphere” in a conversation space by supplying real-time feedback to the users, we are exploring means of sensing and analyzing change in the space.
  • (4) Designing and Evaluating Novel Interaction Techniques
  • Designing and evaluating novel interaction techniques on target selection for variety types of displays including large and touch displays.
実用化イメージ

Researchers

Research Institute of Electrical Communication

Yoshifumi Kitamura

[3D atom probe]

Analysis and Function Elucidation of Fine Clusters and Defects in Materials Invisible by Electron Microscopy

 
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特徴・独自性
  • It is well known that nano-scale impurity/solute clusters, defects, defect clusters and their complexes affect the mechanical and electrical properties in materials. However, it is very difficult to observe these objects even by state-of-the-art electron microscopes. We overcome the difficulty by employing noble two techniques: laser three-dimensional atom probe (3D-AP) technique and positron annihilation spectroscopy (PAS). Laser 3D-AP can map out each atom in various materials (metals, semiconductors, insulators) in three-dimensional real space with nearly atomic scale resolution. PAS can detect vacancy-type defects and defect-impurity complexes very sensitively.
実用化イメージ

By combining these methods, we are going to reveal the functions of the fine impurity clusters and defects to the materials: developments of new nano-structured materials, the mechanism of degradation of aged structural materials, the fall in the yield of semiconductor device production, and developments of quantum devices etc.

Researchers

Institute for Materials Research

Yasuyoshi Nagai

[3D Display]

Development of the high-quality and low-power display system for ultra-realistic communications

 
 
 
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特徴・独自性
  • Recently, with a spread of high definition video streaming services and ubiquitous network, development of high-quality, ultra-realistic and low-power display systems has been demanded. We have been studying physical properties of liquid crystal materials, precise control technique of polarization, high performance liquid crystal display (LCD) devices and its application to the advanced display systems for the realization of new media such as electric paper display and digital signage display, and low-energy society. We established a polarization control technology which realizes a precise control of polarization with liquid crystal materials. By using this world-leading technology, we have been studying the control of the surface alignment of liquid crystal molecules and developed a wide-viewing angle and fast switching liquid crystal display, ultra-high definition field-sequential-color display (Fig. 1), ultra-low power reflective full-color display (Fig. 2) and large-size high-quality display system.
  • We are also studying the ultra-realistic display systems such as a spatial 3D display and a multiple directional viewing display based on the precise light control technique as a next generation interactive communication technologies (Fig.3). We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.
実用化イメージ

Researchers

Graduate School of Engineering

Takahiro Ishinabe

[3D Integrated Circuit]

Novel-Concept Silicon Integrated Circuits Derived from the 3-Dimensional Device, Circuit and Architecture

 
 
 
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特徴・独自性
  • In recent year, facing the age of nanoscale engineering, the new technologies of device, circuit and architecture supported by novel physical guidance principles are highly expected, just as the similar situation as the predawn of semiconductor technology when Bardeen and Shockley discovered the secret of transistors. Therefore, in our research approach, the architectures, circuits, devices and CAD design tools for nanoscale LSI are systematically investigated in the following three main research subjects.
  • 1. Study on nanoscale device and circuit
  • Aiming at the nanoscale silicon semiconductor integrated circuit, we are mainly working on the following directions for new devices and circuits:
  • ①Analysis for novel physical phenomenon based on nanostructural effects
  • ②Device and circuit technology with new operating principle
  • ③Restraint technology for increasing variability of device characteristics
  • ④Architecture and circuit technology for robust information processing
  • 2. Study on the 3-dimention-structual device and circuit
  • The elementary element of recent LSI with planar-structural devices is coming close to the physical limitation of scaling. In order to break the limit and sustain the evolution of future LSI performance, we have started the research on the novel 3-dimension-structural devices and circuits.
  • 3. research on wireless integrated circuit (IC) based on information transmission
  • The ultracompact lightweight wireless IC is one of essential technologies for realizing the ubiquitous society which has the network available in anywhere, at anytime and from any surrounding items. For example, the IC tags for receiving information with reading function are getting close to the practical applications. In our laboratory, aiming at the automatic operating wireless IC with embedded power supply, we are systematically working on the following directions:
  • ①The electrical power generation and storage devices
  • ②Devices and circuits with Ultralow power consumption
  • ③Sensing devices
  • For all above subjects, We hope to conduct collaborative researches with companies interested in our research.
実用化イメージ

Researchers

Graduate School of Engineering

Tetsuo Endoh

[3D Measurement]

High-Speed Vision for Real-Time Motion Analysis

 
 
 
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特徴・独自性
  • We are investigating high-speed vision systems that enable real-time image acquisition and visual processing at frame rates substantially higher than the standard video rate.
実用化イメージ

High-speed vision systems are useful for fast measurement and control of dynamic systems in general. When combined with external facilities such as high-speed projectors or acceleration sensors, they enable further wider applications including fast 3D measurement or object identification.

Researchers

Graduate School of Information Sciences

Shingo Kagami

[3D printing]

Additive Manufacturing of Metallic Parts with Electron Beam Melting (EBM)

 
 
 
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特徴・独自性
  • Electron beam melting (EBM) is a type of additive manufacturing technologies. EBM uses electron beam as an energy source to melt metal powder and produce metal thin layers. This sequence is repeated in a layer-by-layer manner to fabricate three-dimensional (3D) components.
  • This technology can produce any kinds of structures based on 3D CAD models and is suitable for custom-made manufacturing.
  • In addition, our recent studies revealed that the unique microstructure, such as directional solidification and uniform dispersions of fine precipitates, are obtained by EBM; this technology is useful to realize advanced materials that cannot be obtained conventional manufacturing.
実用化イメージ

The EBM technology has received much attention for producing metal parts used in biomedical, aerospace and automotive industries.
Rapid prototyping / rapid tooling is one of the applications of this technology.

Researchers

New Industry Creation Hatchery Center

Akihiko Chiba

Advanced Nanotechnology for Critical metal free secondary battery

 
 
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特徴・独自性
  • Monoatomic layered materials of Graphene, Transition metal sulfide nanosheet, nanocrystalline active materials, nanoparticles and nanoporous materials are investigated for realizing high capacity, high power, high safety and low cost energy storage devices as a post- Lithium ion battery. Advanced chemistry of functional materials and device processes for All solid state battery, Magnesium battery, fuel cells, supercapacitor and wearable batteries are investigated.
実用化イメージ

Academia – Industry collaboration with manufacturing companies of functional materials, batteries, and also smart grid, renewable energy, electrical power companies are encouraged for developments of advanced energy materials and post-Lithium ion battery.

Researchers

Institute of Multidisciplinary Research for Advanced Materials

Itaru Homma

[3D-LSI/TSV]

Development of Biomedical Micro/Nano Integrated System Using LSI Technology

 
 
 
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特徴・独自性
  • Semiconductor neural engineering is a discipline that uses semiconductor process/device/circuit technologies to further understand properties of neural systems and to create novel fusion systems of living body and machine.
実用化イメージ

One of the goals in this laboratory is to establish semiconductor neural engineering and develop biomedical micro/nano integrated systems.
Another goal is to educate the next generation of leaders in biomedical engineering through research including:
1. Intelligent Si neural probe and biomedical signal processing LSI
2. Fully-implantable retinal prosthesis system
3. Bio/nano technology and novel Bio-FET sensor
4. 3-dimensional integration technology and analog/digital LSI design

Researchers

Graduate School of Biomedical Engineering

Tetsu Tanaka

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