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Monomer-Recycle System of Biodegradable Plastics by Industrial Fungal Fermentation and Application of Fungal Biosurfactant Proteins to Nanoparticles for Medical Use

update:2018-12-19
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Features
In Japan, solid-phase fungal fermentation systems using the industrial fungus Aspergillus oryzae have been extensively used for producing fermented foods such as soy sauce and sake; the annual production volume of the products is over one million tons. The efficient enzymatic hydrolyzing systems are expected to be applicable to biological recycling of biodegradable plastics. We found that A. oryzae can effectively degrade polybutylene succinate-coadipate (PBSA) by the combination with an esterase (cutinase) CutL1 and novel surfactant proteins, RolA and HsbA that are attached to the surface of PBSA and then recruit CutL1. The recruitment of Cutl1 by the surfactants stimulated PBSA degradation.

Targeted Application(s)/Industry
The fungal biosurfactant protein is applicable to industrial recycling of biodegradable plastics and to production of immune-response free nano-particles for medical use.

Researchers

Graduate School of Agricultural Science

ABE, Keietsu , Professor
Doctor of Agriculture

Keywords

Related Information

Publications
Abe K et al. Aspergillus, pp. 199-227, Caister Academic Press (2010)

Takahashi et al. Mol. Microbiol. 57:1780-1798 (2005)
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