Tohoku University. Research Profiles

LANGUAGE
  • Top
  • Life Sciences
  • Study of the Regulatory Mechanism of Socio-Sexual Behavior by Oxytocin and Oxytocin Receptor System

Study of the Regulatory Mechanism of Socio-Sexual Behavior by Oxytocin and Oxytocin Receptor System

update´╝Ü2018-12-18
  • JAPANESE
  • INQUIRY
  • PDF
  • seed-210-1-en.jpg
  • seed-210-2-en.jpg
  • seed-210-3-en.jpg
NEXT
PREV
Features
Oxytocin is synthesized in hypothalamus in brain, and by axonal projection and in a paracrine manner through the oxytocin receptors expressed in multiple types' neurons, it exerts various cellular and physiological reaction in animals. Generation of the mice lacking oxytocin receptor (oxtr) gene and analysis of them revealed that oxt/oxtr system was essential to control social and kizuna-behavior, such as maternal behavior, mother-infant relationship and so on. As genetic mutation in oxtr gene was found with a portion of autistic spectrum disorder (ASD) patients, and in addition, as the impaired social recognition was the typical symptom of ASD, existence of a possibly close relationship between the genetic mutation in oxt/oxtr genes and ASD was suspected. Analysis of Oxtr-venus knockin mice: After generation of oxtr-venus knockin mice, we analyzed various types' neurons, which expressed oxtr, and found that oxtr was expressed in a large portion of serotonergic neurons. Thus, we now suspect that oxt may exert its function in controlling socio-sexual behaviors by controlling 5-HT secretion.

Targeted Application(s)/Industry
Our study presents new strategy to cure depression, anxiety disorder and ASD patients using oxtr KO pathophysiologically model animals.

Researchers

Graduate School of Agricultural Science

NISHIMORI, Katsuhiko , Professor
Doctor of Agriculture

Keywords

List