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Development of New Reactions Using Organocatalyst

update:2015-10-15
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Features
Organocatalyst is a synthetically useful catalyst in synthetic organic chemistry, because of the several merits. We have been investigating the development of new and efficient organocatalysts derived from proline. We have already reported the diphenylprolinol silyl ether, which is called as a Jorgensen-Hayashi catalyst, and siloxyproline, which is effective in the presence of water. We have also developed several practical asymmetric catalytic reactions based on the organocatalysts. We also applied these reactions to the total synthesis of natural products and drugs. We have already synthesized Tamiflu in one-pot reaction, and prostaglandin E1 methyl ester via three one-pot procedure.

Targeted Application(s)/Industry
Our newly developed reactions using organocatalysis can be widely used for synthesis of medicines, agrichemicals, and chemical products.

Researchers

Department of Chemistry, Graduate School of Science

HAYASHI, Yujiro , Professor
Doctor of Science

Keywords

Related Information

Publications
1) High-Yielding Synthesis of the Anti-Influenza Neuramidase Inhibitor (-)-Oseltamivir by Three “One-Pot” Operations, H. Ishikawa, T. Suzuki, Y. Hayashi, Angew. Chem. Int. Ed., 48, 1304-1307 (2009).

2) Diphenylprolinol Silyl Ethers as Efficient Organocatalysts for the Asymmetric Michael Reaction of Aldehydes and Nitroalkenes, Y. Hayashi, H. Gotoh, T. Hayashi, M. Shoji, Angew. Chem. Int. Ed., 44, 4212-4215 (2005).
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