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A tomato with a high serotonin content a day keeps the doctor away

update:2018-12-10
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Features
Serotonin (5-hydroxytryptamine: 5-HT) has two independent systems, one in the brain and the other in the periphery. As the highest serotonin levels were found in cherry tomato in 38 fruits and vegetables in Japan. Peripheral serotonin plays important roles in regulating glucose and lipid metabolism through the increasing of bile acids concentration in circulation. The intraperitoneal injection of serotonin to mice inhibits weight gain, hyperglycemia and insulin resistance, and completely prevented the enlargement of intra-abdominal adipocytes when on a high fat diet, but not on a chow diet. This novel metabolic effect of peripheral serotonin is critically related to a shift in the profile of muscle fiber type from fast/glycolytic to slow/oxidative in soleus muscle.

Targeted Application(s)/Industry
The foods with a high serotonin content may represent excellent dietary sources of serotonin, and serotonin action may well offer new drug strategies for developing therapeutic drugs for the treatment of metabolic diseases such as hyperlipidemia, hypercholesterolemia, diabetes and obesity.

Researchers

Graduate School of Agricultural Science

ASO, Hisashi , Professor
Doctor of Medicine

Keywords

Related Information

Watanabe H, Akasaka D, Ogasawara H, Sato K, Miyake M, Saito K, Kanaya T, Takakura I, Chao G, Rose MT, Ohwada S, Watanabe K, Yamaguchi T, Aso H, Peripheral serotonin enhances lipid metabolism by accelerating bile acid turnover. Endocrinology 151 (10): 4776-4786, 2010.
Watanabe H, Rose MT, Aso H, Role of peripheral serotonin in glucose and lipid metabolism. Current Opinion in Lipidology 22:186–191, 2011.
Watanabe H, Nakano T, Saito R, Akasaka D, Saito K, Ogasawara H, Minashima T, Miyazawa K, Kanaya T, Takakura I, Inoue N, Ikeda I, Chen X, Miyake M, Kitazawa H, Shirakawa H, Sato K, Tahara T, Nagasawa N, Rose MT, Ohwada S, Watanabe K, Aso H, Serotonin improves high fat diet induced obesity in mice. PLoS ONE 11(1): e0147143, 2015.
Islam J, Shirakawa H, Nguyen TK, Aso H, Komai M, Simultaneous analysis of serotonin, tryptophan and tryptamine levels in common fresh fruits and vegetables in Japan using fluorescence HPLC. Food Bioscience, 13, 56-59, 2016.
Hano S, Shibuya T, Imoto N, Ito A, Imanishi S, Aso H, Kanayama Y, Serotonin content in fresh and processed tomatoes and its accumulation during fruit development. Scientia Horticulturae 214: 107–113, 2017.
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