"R" Theme - 10 Result(s)

 R

R&D in Semiconductor Materials and their Device Applications Bringing System Evolutions

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特徴・独自性
  • 1. Development of Distributed Feedback (DFB) Laser Diodes (LD) widely used in optical communications systems realizing a highly information-based society. This LD increases the transmission capacity by 25,000 times per fiber which means the bit rate of 10Tb/s.
  • 2. Nitride semiconductors famous for blue light emitting diodes.
  • (a) Proposal of InGaAlN system considering device applications in 1989
  • (b) Success in growth of single crystalline InGaN by metalorganic vapor phase epitaxy (MOVPE) in 1989
  • (c) Prediction of band-gap energy (Eg) of InN much smaller than the values reported in 1980s and its   experimental confirmation in 2002
  • (d) Observation of photoluminescence from InGaN in 1991
  • (e) Prediction of phase separation in InGaAlN in 1997
実用化イメージ

DFB-LD: Fabrication of periodic structure with submicron scale, Epitaxial growth of semiconductor films on the substrate with fine structures, LD fabrication process, device evaluation, and device simulation

Nitride Semiconductors: MOVPE growth, N-polar growth, Evaluation of semiconductor materials, Fabrication of light-emitting devices, solar cells, and high-power transistors

Researchers

New Industry Creation Hatchery Center

Takashi Matsuoka

Radiological Medical Infomatics

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特徴・独自性
  • PET and SPECT have very high sensitivity to detect molecule by means of radiation detection, and are considered to be excellent tools for molecular imaging. We are studying and developing data analysis techniques for PET and SPECT data. Using our approaches, we can analyze data in quantitative manner, and obtain physiological functions in living organism.
実用化イメージ

Pharmaceutical companies who are interested in using PET to evaluate efficacy of new drug. Companies which are related to medical informatics, medical equipments.

Researchers

Cyclotron and Radioisotope Center

Hiroshi Watabe

Regulation of ABC Transporters in Colorectal Cancer

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特徴・独自性
  • Colorectal cancer (CRC) is one of the most common types of cancer worldwide. Surgical resection is the only curative treatment available for primary CRC. We determined the gene expression profiles for ATP binding cassette (ABC) transporters by RNA sequencing in matched colon cancer and normal colon tissue specimens in order to provide insight into the regulatory mechanisms underlying expression of transporters related to colon carcinogenesis. The expression of ABCC3 was repressed by Wnt signaling pathway, suggesting downregulation of ABCC3 might contribute oncogenesis.
実用化イメージ

Recently, we easily obtain comprehensive data including transcriptome and other omics data. These data are expected to help find a target for drug development, expecting that pharmaceutical industry interpret and extract new knowledge from them.

Researchers

Graduate School of Medicine

Keiko Nakayama

Regulation of Angiogenesis

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特徴・独自性
  • Angiogenesis, i.e., the formation of new capillaries, takes place under pathophysiological conditions including cancers, ocular neovascular diseases and atherosclerosis. Anti-angiogenic drugs have been developed, and are now in clinical use. However, because of side effects due to the damage to vascular endothelial cells, the development of anti-angiogenic drugs with different modalities is anticipated. We have isolated vasohibin-1 (VASH1) as a novel angiogenesis inhibitor expressed by endothelial cells (ECs), and vasohibin-2 (VASH2) as its homologue having pro-angiogenic activity.
実用化イメージ

We are planning to develop strategies of VASH1 potentiation and VASH2 inhibition. For VASH1 potentiation, we are planning to use recombinant VASH1 protein or search low molecular weight substances having VASH1 like activity. For VASH2 inhibition, we are succeeded in the development of neutralizing anti-human VASH2 monoclonal antibody.

Researchers

New Industry Creation Hatchery Center

Yasufumi Sato

Regulation of TSLP Production in Keratinocytes

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特徴・独自性
  • Thymic stromal lymphopoietin(TSLP)has been focused as a master switch for allergy. We established a mouse keratinocyte cell line which constitutively and highly produces TSLP. This cell line will be useful to find the inhibitor of TSLP production and to study biochemical features of production and action of TSLP. The inhibitor of TSLP production might be used as an external or an inhalation drug, indicating low probability of causing a decrease in immune competence.
実用化イメージ

By using this cell line, we expect we can conduct effective collaborative research in medical fields. For examples, the cell line is useful for analysis of TSLP production and functions, development of inhibitors of TSLP production, and detection of immunotoxic compounds.

Researchers

Graduate School of Pharmaceutical Sciences

Noriyasu Hirasawa

Religion, language, society, and life in ancient India

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特徴・独自性
実用化イメージ

Researchers

Graduate School of Arts and Letters

Naoko Nishimura

Resarch and development for maintaining and improving brain and mental health

特徴・独自性
  • The Smart Aging International Research Center (SAIRC) was founded on 1 October 2009. This Center proposes the creation of a new field to produce well-rounded personnel who have gained “totally comprehensive intelligence” from their experience, in order to cope with various problems associated with the diverse and complex super-aging society. To this end, the Center will promote interdisciplinary cooperative research, international collaborative research projects, and research collaborations with industry, as well as disseminate and exchange information by holding international conferences and symposia.  The SAIRC is designed to develop an approach for maintaining and improving brain and mental health in a diverse and complex society from the standpoints of brain science, with the aim of maintaining and improving brain functions; cognitive neuroscience and psychology, with the aim of maintaining a healthy and tranquil state of mind at each aging stage; and philosophy, phenomenology and ethics that provide a radical reconsideration of the concept of the “mind.” We welcome collaborative researches with companies, and academic consultations.
実用化イメージ

Researchers

Institute of Development, Aging and Cancer

Ryuta Kawashima

Research and Development of Space Exploration Robots

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特徴・独自性
  • We study and develop mobile robotics technology for lunar and planetary exploration. Our technology is featured by rich experience in locomotion mechanisms for highly rough terrain and advanced slippage control in loose soil environment. Also by 3D map building technology using a laser scanner for autonomous collision avoidance and for operator assistance in remote control/tele-operation. We also contributed to the design and development of Hayabusa and Hayabusa-2, which are sample-return probes developed and operated by Japanese space agency JAXA.
実用化イメージ

These technologies are also applied to terrestrial robots for such as surveillance or disaster response.

Researchers

Graduate School of Engineering

Kazuya Yoshida

Robot Technology for Achieving Secure Society

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特徴・独自性
  • Tadokoro Laboratory developed ‘Active Scope Camera,' a world-unique rescue robot that can search deep in rubble piles of collapsed structures through a gap of a few cm wide. It also developed ‘Quince,' a world-unique unmanned ground vehicle that could survey the second to fifth floors of Nuclear Reactor Buildings of Fukushima-Daiichi Nuclear Power Plant. Its technologies was applied industries, including unmanned transfer vehicle for outdoors under ice and snow environment being actually used in a factory of Toyota Motor East Japan, and ‘Robo-Scope' for debris inspection in collaboration with Shimizu Corporation.
実用化イメージ

We have a policy of education through and research for solution to actual problems. Current nearly ten collaborative researches focuses on outdoor investigation, infrastructure/plant inspection, and remote/autonomous task execution by robots.

Researchers

Graduate School of Information Sciences

Satoshi Tadokoro

Room temperature bonding using thin metal films (Atomic Diffusion Bonding)

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特徴・独自性
  • Atomic diffusion bonding of two flat wafers with thin metal films is a promising process to achieve wafer bonding at room temperature. High surface energies of metal films and a large atomic diffusion coefficient at the grain boundaries and film surfaces enable bonding at room temperature without unusually high loading pressure. This technique, which enables bonding of any mirror-polished wafer, is gaining wider use for fabricating optical and electrical devices. Moreover, bonding of mirror polished metals and polymer sheets can be achieved, which further extends the application of this bonding technique.
実用化イメージ

Optical, power and electrical devices, MEMS, bonding of polymer sheets, metals, and ceramics for precision mechanical equipments.

Researchers

Frontier Research Institute for Interdisciplinary Sciences

Takehito Shimatsu