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Researchers 287 Result(s), Themes 265 Result(s)

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Visualization of supply chain risks from the resource logistics perspective

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特徴・独自性
  • With the increased global concerns of resource and environmental constraints of recent years, the role of mining, as a constituent of social responsibility associated with resource extraction and usage, is becoming increasingly important in the science, technology, and innovation policy. Under increasing public and shareholders' concerns of social and environmental sustainability, the fabrication industries require careful attention owing to their own risks related to the resources and materials that are used in their products and services. The Material Flow Analysis tool and Input output technique provide useful perspectives and valuable evidences for avoiding or minimizing the social and environmental risks related to the demand of resources.
実用化イメージ

Our developed model evaluates the risk weighted flow analysis by combining the resource logistics database and Global Link Input Output model. The estimated results shed light on how resource logistics prepares policy makers and R&D engineers to confront the risks behind resource usage and how the information should be shared among the stakeholders.

Researchers

Graduate School of Environmental Studies

Kazuyo Matsubae

IVR (Interventional Radiology) Treatment of Hypertention: Minimally Invasive Treatment of Primary Aldosteronism Based on the Adrenal Vein Sampling Technology

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特徴・独自性
  • Primary aldosteronism is a leading cause of secondary hypertension accounting for approximately 10 % of hypertensive patients; 4 million patients potentially exist in Japan. We aim to optimize the method of ablating aldosterone producing adenoma using newly developed bipolar radiofrequency ablation system with 300-400kHz high-frequency current and electric power of 40W (Celon Prosurge Applicator), and establish a less invasive interventional radiological treatment of primary aldosteronism.
実用化イメージ

Collaboration with medical equipment manufacture and universities are expected to develop new devices enabling ablation of aldosterone producing adenoma. Flexible guide-wire-type ablation system and rapid aldosterone assay system should be co-developed to tread aldosterone producing microadenoma which is difficult to detect due to its small diameter of less than 5mm.

Researchers

Graduate School of Medicine

Kei Takase

Monomer-Recycle System of Biodegradable Plastics by Industrial Fungal Fermentation and Application of Fungal Biosurfactant Proteins to Nanoparticles for Medical Use

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特徴・独自性
  • In Japan, solid-phase fungal fermentation systems using the industrial fungus Aspergillus oryzae have been extensively used for producing fermented foods such as soy sauce and sake; the annual production volume of the products is over one million tons. The efficient enzymatic hydrolyzing systems are expected to be applicable to biological recycling of biodegradable plastics. We found that A. oryzae can effectively degrade polybutylene succinate-coadipate (PBSA) by the combination with an esterase (cutinase) CutL1 and novel surfactant proteins, RolA and HsbA that are attached to the surface of PBSA and then recruit CutL1. The recruitment of Cutl1 by the surfactants stimulated PBSA degradation.
実用化イメージ

The fungal biosurfactant protein is applicable to industrial recycling of biodegradable plastics and to production of immune-response free nano-particles for medical use.

Researchers

Graduate School of Agricultural Science

Keietsu Abe

Development of Entangled Photon Sources

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特徴・独自性
  • The quantum information and communication technology (QICT) is expected to overcome the difficulties that classical information technology is confronted with. Quantum entanglement carried by photons is one of the most fundamental resources in QICT. We have been developing efficient, high-quality entangled photon sources utilizing semiconductor materials and quasi-phase-matched optical nonlinear devices, with a number of patents awarded.
実用化イメージ

We hope to conduct collaborative research with a willing company for a practical application of this technology.

Researchers

Research Institute of Electrical Communication

Keiichi Edamatsu

Development of a Novel Quantification Method for Diarrhetic Schell Fish Poisoning

特徴・独自性
  • We have investigated isolation and structure determination of natural products and evaluated mode of their actions. We have especially focused on marine natural products causative for a food poisoning, diarrheic shellfish poisoning (DSP), which has spread worldwide and threatened regional fishery industry. Dinophysistoxin produced by the dinoflagellate Dinophysis spp. and okadaic acid, are thought to be responsible for DSP. Acute toxicity test using mice has been the primary method for detection of DSP in the fish market, though an alternative method to quantify DSP without sacrificing mice has been requested. We isolated OABP2, a novel okadaic acid binding protein, from the marine sponge Halichondria okadai and succeeded in expression of the recombinant OABP2 in E. coli, which eventually showed high affinity to the DSP toxins.
実用化イメージ

We are now working on visualization of OA by utilizing OABP2 in order to provide an easy and quick quantification method for DSP.

Researchers

Graduate School of Agricultural Science

Keiichi Konoki

Development of catalytic reaction system for direct synthesis from CO2 and diols

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特徴・独自性
  • We found an effective catalyst system composed of CeO2 and 2-cyanopyridine for direct and catalytic polycarbonate formation reaction from CO2 and diols. CeO2 acted as an activator for CO2 and diols, and 2-cyanopyridine shifted the equilibrium in favor of the product side by hydration of 2-cyanopyridine, promoting the reaction. Green polycarbonates can be synthesized by combination of the catalyst system with a technique of diol syntheses from biomass.
実用化イメージ

This catalyst system is effective for direct transformation of CO2, contributing to the effective utilization and emission reduction of CO2. Combination of the catalyst system with a concentration technique of CO2 will bring about much advantage.

Researchers

Graduate School of Engineering

Keiichi Tomishige

Regulation of ABC Transporters in Colorectal Cancer

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特徴・独自性
  • Colorectal cancer (CRC) is one of the most common types of cancer worldwide. Surgical resection is the only curative treatment available for primary CRC. We determined the gene expression profiles for ATP binding cassette (ABC) transporters by RNA sequencing in matched colon cancer and normal colon tissue specimens in order to provide insight into the regulatory mechanisms underlying expression of transporters related to colon carcinogenesis. The expression of ABCC3 was repressed by Wnt signaling pathway, suggesting downregulation of ABCC3 might contribute oncogenesis.
実用化イメージ

Recently, we easily obtain comprehensive data including transcriptome and other omics data. These data are expected to help find a target for drug development, expecting that pharmaceutical industry interpret and extract new knowledge from them.

Researchers

Graduate School of Medicine

Keiko Nakayama

Elucidation of oncogenesis by Fbxw7

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特徴・独自性
  • In life science research field, it is noteworthy issue how information in genome is interpreted and is transferred to functional molecules. However, during these 10 years, we convinced that the amount of proteins, final functional molecules was regulated by not only by production but also by degradation. For examples, the amount of c-Myc, which promotes cell cycle and inhibits cell death, increase in many types of cancer by failure of protein degradation.
  • We have generated model mice in which function of Fbxw7, inducer of c-Myc degradation is suppressed. We observed promotion of oncogenesis in these mice, suggesting that Fbxw7 is oncosuppressor gene. In other words, Fbxw7 has a great potential to regulate oncogenesis or progress of cancer. These molecules specified the target proteins for proteolysis suggesting that modification of these molecules leads to develop oncosuppressive therapy. We hope to conduct collaborative research with a willing company for a practical application of this knowledge in industry.
実用化イメージ

Researchers

Graduate School of Medicine

Keiko Nakayama

Nonlinear Aeroelastic and Multibody Dynamic Analysis for Floating Wind Turbine and Next-Generation Aircraft

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概要

Floating wind turbine and next-generation aircraft have high-aspect-ratio blade and wing that undergo nonlinear aeroelastic deformation. We have developed a nonlinear aeroelastic analysis framework with absolute nodal coordinate formulation (ANCF). This nonlinear aeroelastic deformation is coupled with multibody dynamics. We are also developing a novel analysis framework for this coupling dynamics.

従来技術との比較

By using the nonlinear analysis method proposed in this study, it is possible to handle the reduction in flutter speed due to large deformations and the coupled phenomenon of deformation and flight behavior that cannot be captured using conventional linear analysis methods.

特徴・独自性
  • Straightforward nonlinear structural analysis method that does not use any rotational coordinates
  • Highly efficient unsteady fluid calculation method for large deformations
  • Multibody dynamics that captures the relative motion between bodies, such as rotating blades and control surfaces
実用化イメージ

Dynamic, aeroelastic, structural, vibration, aerodynamic analyses for Aeroelastic Multibody Systems:
1. Floating wind turbine
2. High altitude platform station (HAPS), high-aspect-ratio-wing commercial jet
3. Helicopter, drone
4. Robot, crane

Researchers

Graduate School of Engineering

Keisuke Otsuka

Development of Compound Semiconductor Radiation Detectors

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特徴・独自性
  • The main research subject of our group is developing material purification methods, crystal growth methods and detector fabrication technologies for compound semiconductor radiation detectors. Our group intensely studies a compound semiconductor, thallium bromide (TlBr), for fabrication of gamma-ray detectors for the advanced radiation applications. The attractive physical properties of TlBr lie in its high atomic number (Tl: 81, Br: 35), high density (7.56 g/cm3) and wide bandgap (2.68 eV). Due to the high atomic number and high density, TlBr exhibits high photon stopping power. The wide bandgap of TlBr permits the device low-noise operation at and above room temperatures.
実用化イメージ

Our group focuses on development of compound semiconductor radiation detectors for advanced radiation applications including ultra-high resolution PET systems, ultra-high resolution SPECT systems, photon counting CT systems and Compton cameras. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Researchers

Graduate School of Engineering

Keitaro Hitomi

newQuantitative analysis of microstructure in nuclear materials by week-beam scanning transmission electron microscopy

概要

We have developed a technique for quantitative analysis of microstructures (e.g., dislocations and irradiation defect aggregates) of activated and nuclear-burned specimens in the context of the Week Beam Scanning Transmission Electron Microscope (WB-STEM) method, which boasts extremely high measurement accuracy as a quantitative analysis method for lattice defects.
In combination with a dedicated heated sample holder with fully automated temperature measurement and current control in a cartridge-type heating furnace, changes in dislocation microstructure can be dynamically measured in-situ along with a highly reliable temperature history.

従来技術との比較

Conventional TEM methods require expertise in reciprocal space and dislocation theory, but our WB-STEM method is equipped with automatic analysis software for film thickness measurement and dislocation loop feature extraction, making it possible to analyze irradiation defects easily and precisely.

特徴・独自性
  • Since its design, the WB-STEM method has been developed for implementation and on-site repair in radiation controlled areas where nuclear materials are handled, with special aperture and diffraction disc selection equipment, control and analysis software.
  • WB-STEM accepts irradiation defect analysis of activated specimens from all over the world, including RPV monitoring specimens from European reactors and neutron-irradiated materials from US research reactors.
  • It is also used to analyze the properties of iron-containing nuclear fuel simulated debris in decommissioning projects.
実用化イメージ

We support research organizations that currently use transmission electron microscopy to observe microstructures to introduce the WB-STEM method by special modification. We will instruct researchers who have no experience using transmission electron microscopy in the procedure for dislocation analysis.

Researchers

Institute for Materials Research

Kenta Yoshida

Natural Language Processing for Semantic Analysis of Big Data

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特徴・独自性
  • This lab conducts fundamental research for deep natural language processing (NLP) and NLP-oriented information organization such as classification, extraction, and summarization of language information. Our activities also cover a broad range of applied research including NLP-based information and knowledge mining, information credibility analysis, and resilient ICT through the maximal use of Big Data.
実用化イメージ

(i) Analysis of market trend or research trend through intelligent text mining, (ii) Discovery of potential needs and risks from opinions in social media, (iii) Management of knowledge in a company by analyzing internal documents, etc.

Researchers

Center for Language AI Research

Kentaro Inui

Hands-On Access Fabrication Facility –Open Facility for MEMS and Semiconductor Prototyping–

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概要

We offer shared facility for the development of semiconductor prototypes equipped with 4-inch, 6-inch and some 8-inch wafer fabrication tools available on an hourly basis. Know-how accumulated at Tohoku University is available, and staff provide maximum support for prototyping. The service is performed at the 1,200 m2 Super Clean Room on the second floor of the Junichi Nishizawa Memorial Research Centre at Tohoku University. For information on equipment and fees, see our website.

従来技術との比較

More than 10 experienced technical staff assist customer's usages. Standard process conditions for each process, such as etching and deposition, are provided. allowing customers to start prototyping immediately. Various materials other than silicon can also be supported.

特徴・独自性
  • We support the development of devices and semiconductor materials such as MEMS, optical elements and RF components.
  • Technical consultation on devices and processes before and during prototyping is also available.
  • A
  • 'Prototype lab' for device packaging is also available.
  • The museums where you can learn about the history of semiconductors, measuring instruments and sensors are open.
  • As part of Technology Co-creation for Semiconductor of Tohoku University, we promote R&D of semiconductors and the development of human resources.
  • On-demand semiconductor human resource development programs for students and engineers are available.
  • As a member of the MEXT's Advanced Research Infrastructure for Materials (ARIM) program, we are involved in sharing facility and data.
実用化イメージ

More than 310 companies have used our shared facility since its launch in 2010, not only from device manufacturers such as MEMS, but also from manufacturers of materials, mechanical components and equipment. To date, we have successfully supported the commercialization of about 10 devices.

Researchers

Micro System Integration Center

Kentaro Totsu

Molecular studies on new resources for hybrid rice breeding

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特徴・独自性
  • F1 hybrid breeding is one of the most advanced techniques for production of cultivars with higher yield and desirable traits of both parents. Most of hybrid rice utilize cytoplasmic male sterility (CMS) and fertility restoration system. We develop a Tohoku University-original CW-type CMS and fertility restorer line and study their molecular mechanism. The CW-type cytoplasm enables indica rice cultivars to be CMS, which could not be achieved by other known cytoplasm.
実用化イメージ

Hybrid rice has an average 30% yield advantage over inbred lines, and is cultivated on 13% of the world rice fields. Our study provides a new and original resource for hybrid rice breeding for globalization of rice industry.

Researchers

Graduate School of Agricultural Science

Kinya Toriyama

Philosophy of Science and Technology, Science and Technology Studies (STS)

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特徴・独自性
  • My research area is mainly phenomenology, philosophy of technology, and applied ethics (engineering ethics etc.). Technological Artifacts mediate human activities. So designing artifacts is in itself an ethical behavior. Analysing the ontological structure of the artifacts, describing the epistemological propcess of desingning activities, evaluating the social and ethical influence of artifacts are main issues in philosophy of technology. On the basis of such philosophical investigations, we can develope ethical studies concerining how engineerss, companies can recognize ethical issues in a networks of meanings , how they can make ethical decision among engineers and users.
実用化イメージ

I hope to conduct cooperative research on ethical education of engineers, as well as on human-machine interaction.

Researchers

Graduate School of Arts and Letters

Kiyotaka Naoe

Advanced Vision System with Less Calibration

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特徴・独自性
  • The difficulties of introducing robot systems in production line are maintenance of environment and teaching of robot motion. Environ recognition and motion teaching using vision system will greatly improve the difficulties. However, calibration of vision-robot system is tedious and troublesome. Feedback control using vision sensor information will allow robustness against environment and teach by showing. This technique is called visual servo.
実用化イメージ

Visual servo will allow flexible camera setting, calibration-less system setting, and easy teaching.

Researchers

Graduate School of Information Sciences

Koichi Hashimoto

High Sensitivity Radioactivity Measurement at Ultra-Low Radioactivity Environment

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特徴・独自性
  • Research Center for Neutrino Science established ultra-low radioactivity environment (trillion times lower than natural environment) with 1200 cubic-meter organic scintillator detector at 1000m underground where very stable temperature/humidity and low vibration are maintained. We are pursuing high sensitivity measurements, especially neutrino observation, and are also developing purification system for ultra-low radioactivity and high performance radioactivity detectors.
実用化イメージ

The established ultra-low radioactivity environment is suitable for rare phenomena study and is also applicable for high sensitivity radio-impurity measurement. It may also apply to investigation of biological influence of low radioactivity irradiation. The other applications such as neutrino detection technique for monitoring nuclear reactors and medical use of high sensitivity radioactivity detectors may also be considered.

Researchers

Research Center for Neutrino Science

Kunio Inoue

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Exercising "Cultured" Myotubes!

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特徴・独自性
  • We succeeded in generating highly developed cultured C2C12 myotubes by manipulating intracellular Ca2+ transients with electric pulse stimulation (EPS), that are endowed with similar properties to in vivo skeletal muscle in terms of (1) excitation-induced contractile activity as a result of de novo sarcomere formation, (2) higher energy expenditure (as assessed by AMPK activation), and (3) improved insulin responsiveness (as assessed by exofacial myc-GLUT4 translocation assay).
実用化イメージ

Taking advantage of our “in vitro Exercise Model", our innovation will be an excellent alternative for the animal experimentation that can be applicable for a wide array of skeletal muscle research including drug screen.

Researchers

Graduate School of Biomedical Engineering

Makoto Kanzaki

Electrical Spin Generation and Manipulation in Semiconductors

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特徴・独自性
  • Since spin orbit interactions caused by the structural inversion asymmetry and the bulk inversion asymmetry induce an effective magnetic field in III-Vsemiconductor heterostructures, it is possible to realize the new functional devices based on the electrical control of the spin precession. We study the electrical spin generation by using spatial modulation of spin orbit interaction, which demonstrates Stern-Gerlach spin filter in semiconductors, and research ultra-fast spin dynamics by using time resolved Kerr rotation microscopy. We also investigate a spin MOSFET based on the perpendicular magnetic materials and electric-field induced magnetization control. We can reduce the leak current and the signal delay in the logic circuit. With the non-volatility of the ferromagnetic source and drain electrodes, random access memory is also enabled by using the spin MOSFET structure.
実用化イメージ

Target application will be low power logic devices and non-volatile memory based on electron spins and also future metal-based spintronic devices.

Researchers

Graduate School of Engineering

Makoto Koda