"H" Keywords - 72 Result(s)

 H

[Haptic interface]

Robot Technology for Achieving Secure Society

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特徴・独自性
  • Tadokoro Laboratory developed ‘Active Scope Camera,' a world-unique rescue robot that can search deep in rubble piles of collapsed structures through a gap of a few cm wide. It also developed ‘Quince,' a world-unique unmanned ground vehicle that could survey the second to fifth floors of Nuclear Reactor Buildings of Fukushima-Daiichi Nuclear Power Plant. Its technologies was applied industries, including unmanned transfer vehicle for outdoors under ice and snow environment being actually used in a factory of Toyota Motor East Japan, and ‘Robo-Scope' for debris inspection in collaboration with Shimizu Corporation.
実用化イメージ

We have a policy of education through and research for solution to actual problems. Current nearly ten collaborative researches focuses on outdoor investigation, infrastructure/plant inspection, and remote/autonomous task execution by robots.

Researchers

Graduate School of Information Sciences

Satoshi Tadokoro

[Hardware Algorithms]

Cyber Physical Systems Security and Its Applications

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特徴・独自性
  • Our study focuses on information security technologies for the next-generation ICT society fusing real-world and cyber-space computing. We are now conducting the research and development of ultra-high-speed, ultra-low power LSI computing to perform security functions such as encryption and secure computing, secure implementation technologies to protect systems from various physical attacks (attacks carried out by physical access to the system), and security optimization technologies tailored to the system usage environment and application area.
実用化イメージ

We can provide collaboration and information exchange services in the fields of information security. In particular, we have experiences of domestic/international collaborative researches on embedded security with some companies, universities, and governmental institutes.

Researchers

Research Institute of Electrical Communication

Naofumi Homma

[Hardware Security]

Cyber Physical Systems Security and Its Applications

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特徴・独自性
  • Our study focuses on information security technologies for the next-generation ICT society fusing real-world and cyber-space computing. We are now conducting the research and development of ultra-high-speed, ultra-low power LSI computing to perform security functions such as encryption and secure computing, secure implementation technologies to protect systems from various physical attacks (attacks carried out by physical access to the system), and security optimization technologies tailored to the system usage environment and application area.
実用化イメージ

We can provide collaboration and information exchange services in the fields of information security. In particular, we have experiences of domestic/international collaborative researches on embedded security with some companies, universities, and governmental institutes.

Researchers

Research Institute of Electrical Communication

Naofumi Homma

[head and neck cancer]

Development of an intranodal administration method

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特徴・独自性
  • (1) The amount of anticancer drug required to treat one metastatic lymph node is 1/1,000 to 1/10,000 of the systemic dose.
  • (2) The drug can be administered into the lymph node under ultrasound guidance.
  • (3) An international patent has been filed for the solvent of the administered drug.
実用化イメージ

1. Treatment and prophylactic therapy of affiliated lymph nodes in head and neck cancer, breast cancer, etc.
2. Pharmaceutical companies aiming to develop drugs by drug repositioning and generics
3. Medical device manufacturers aiming to develop a dosing system

Researchers

Graduate School of Biomedical Engineering

Tetsuya KODAMA

[health]

Development of Wearable Motion Measurement System for Motor Rehabilitation and Healthcare

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特徴・独自性
  • In order to realize wealthy and vibrant local communities, it is desired that people in the community are healthy. However, the amount of the daily activity decreases as they get older, which increases the risks of the fall by weakened lower limb muscles and of the cerebrovascular disease, and so on. Therefore, for the elderly people, there is increased need of the walking training and the movement assistance in daily life, and of the rehabilitation aid.
  • In this study, focusing on the motor function of the lower limbs that is important for independent activities of daily living and that relates to the health maintenance, development of assistive technologies for decreased gait ability or for dysfunction of lower limbs are performed based on the technologies of electronics and signal processing. Especially, the wearable sensor system using gyroscopes and accelerometers are developed to measure kinetic information, and then the evaluation system for the gait ability and the lower limbs motor function is developed in this study.
実用化イメージ

The goal of this study is to realize simple and convenient measurement and accumulation of various information of gait, to visualize the obtained data for determination of training effect and evaluation of motor function, and to provide appropriate training program for each subject.

Researchers

Graduate School of Biomedical Engineering

Takashi Watanabe

[health sciences]

Functional and Molecular Imaging with Positron Emission Tomography (PET)

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特徴・独自性
  • Using positron emission tomography (PET), we can measure the regional metabolism, perfusion and signal transmission between neurotransmitters and receptors in various organ systems of living humans and animals, such as the brain and heart. Recent technical developments have shown that the mind, or at least some parts of it, can be demonstrated by "imaging".
実用化イメージ

Our group has had considerable achievements in clinical research on drug effects and side effects, elucidation of underlying mechanism of alternative and complementary therapies, as well as exercise physiology.

Researchers

Cyclotron and Radioisotope Center

Manabu Tashiro

[Healthcare]

Development of Biomedical Micro/Nano Integrated System Using LSI Technology

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特徴・独自性
  • Semiconductor neural engineering is a discipline that uses semiconductor process/device/circuit technologies to further understand properties of neural systems and to create novel fusion systems of living body and machine.
実用化イメージ

One of the goals in this laboratory is to establish semiconductor neural engineering and develop biomedical micro/nano integrated systems.
Another goal is to educate the next generation of leaders in biomedical engineering through research including:
1. Intelligent Si neural probe and biomedical signal processing LSI
2. Fully-implantable retinal prosthesis system
3. Bio/nano technology and novel Bio-FET sensor
4. 3-dimensional integration technology and analog/digital LSI design

Researchers

Graduate School of Biomedical Engineering

Tetsu Tanaka

Minimally Invasive Medical Devices and Healthcare Devices Using Micro/Nano Machining Technology

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特徴・独自性
  • Medical devices and healthcare devices which have several functions with small size have been developed using precise micromachining technology and MEMS (Microelectromechanical systems) technology. More precise and safe diagnostics and therapy, as well as novel diagnostics and treatment can be realized by developing high-functionalized endoscopes and catheters and developing novel medical devices. Healthcare without restriction of location and time is aimed by developing thin, light and high-functionalized new healthcare devices.
実用化イメージ

Besides of basic research, we are working in cooperation with clinicians and medical device companies for practical use. We founded a university-launched venture company for bridge-building between university and company and collaborative researches have been performed.

Researchers

Graduate School of Biomedical Engineering

Yoichi Haga

[Healthy Aging]

Smart Ageing Initiative

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特徴・独自性
  • In Japan, the percentage of elderly people aged 65 years or over was 23.1% in 2010. It is no doubt that Japan is the world's first super-aging society. In such a super-aging environment, it is necessary to form a society in which each individual can play an active role even as one becomes older in order to maintain and improve the quality of life of all people and to maintain a healthy society. In advanced brain science, research from the fields of brain function imaging, cognitive science, and psychology has been utilized with the aim of realizing a healthy aging society. Up to date information on various new technologies and related discoveries has been disseminated so that individuals can live a healthy life with peace of mind at every stage of aging, while maintaining and improving the health of their brain and mind in a diverse and complex society.
実用化イメージ

We believe to overcome super-aging environments is not only an object of public concern but also big business chances to create new industries.

Researchers

Institute of Development, Aging and Cancer

Ryuta Kawashima

[healthy life]

The Novel Ultrasound Irradiation Device

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特徴・独自性
  • Dr. Katsunori Nonogaki has developed the novel ultrasound irradiation device, which can improve the autonomic nervous system activity and peripheral circulation. In addition, the ultrasoud device can improve hypertension and hyperglycemia within 20 min in subjects with drug-resistant hypertension and diabetes. Our initial device was approved in Japan (226AIBZX00028000). This device will be avaliable for the treatment of 1) muscle pain, 2) the autonomic neural dysfunction and stress-related disorders, 3) hypertention, and 4) diabetes. Moreover, the device will be usefull for your healthy life and aging care.
実用化イメージ

Our aims are to export the device internationally. We seek the investment and international business partners.

Researchers

Cyclotron and Radioisotope Center

Katsunori Nonogaki

[heart rate variability]

Quantitative Evaluation of the Baroreflex Sensitivity of the Heart and Artery

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特徴・独自性
  • Metabolic syndrome is an important view point, when we consider the preventive medicine. Hypertension is one of the most important points to prevent the cardiovascular events. However, there is no method to measure the baroreflex sensitivity of the artery in the patients with hypertension. Tohoku University had invented the new method to evaluate the baroreflex sensitivity of the heart and artery (JP Patent No.4789203).
実用化イメージ

By the use of this machine, the baroreflex sensitivity of an artery in the patients can easily be measured noninvasively. It enables to predict the occurrence of hypertension and evaluate the therapy of hypertension easily, while allowing prevention of the cardiovascular events.

Researchers

Institute of Development, Aging and Cancer

Tomoyuki Yambe

[Heart Wall]

Noninvasive Ultrasonic Measurement of Dynamic Properties of Heart and Arteries

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特徴・独自性
  • Complexity of the cardiac contraction sequence is still not fully understood because the dynamic mechanical excitation process, which directly correlates with contraction, cannot be accurately measured by CT, MRI, SPECT, or conventional ultrasound. By developing a noninvasive novel imaging modality with high temporal and spatial resolutions (US patent 5840028), we have detected the minute mechanical response (velocity component) to the propagation of the action potential in the human heart or to detect the propagation of the vibrations along the heart wall caused by the valve closure (Fig. 2).
  • By applying the same procedure to the human arteries, the regional change in wall thickness caused during one cardiac cycle can be measured with high spatial resolution (Fig. 1). From the measurement, the regional elasticity of tissue surrounding atherosclerotic plaque can be determined. By comparing the pathological findings with the distribution of elasticity, elasticity of lipid and that of fibrous tissue were determined. Thus, each point inside the plaque is classified into lipid or fibrous tissue using transcutaneous ultrasound (Fig. 3).
実用化イメージ

This novel method offers potential as a diagnostic technique for detection of plaque vulnerability with high spatial resolution.
We are prepared to provide academic consultations to companies interested in our research.

Researchers

Graduate School of Engineering

Hiroshi Kanai

[heat stroke]

Prediction and evaluation of future thermal and wind environments based on CFD, and planning of urban environments adaptable to future climate

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特徴・独自性
  • Numerical simulations of the physical environment of urban outdoor spaces are conducted to predict the physical environment, such as temperature, humidity, wind, and pollutant concentration, and field measurements are conducted to understand the actual physical environment. In addition, the future outdoor environments and heat stroke risks due to global warming are predicted and evaluated.
    Furthermore, the impacts of urban morphology (building shape and layout, street trees, etc.) on the adaptation to severe heat in summer and rare typhoons and floods are evaluated quantitatively.
実用化イメージ

Numerical analysis is used to quantitatively evaluate the "merits and demerits" of designing buildings, planning city blocks and urban areas, and introducing various heat control technologies on the wider thermal environment and the formation of wind ventilation paths, as well as the adverse effects of typhoons and other disasters. The materials for making decisions on whether or not to introduce these technologies are provided.

Researchers

Graduate School of Engineering

Yasuyuki Ishida

[Heat Transfer]

Molecular Dynamics Analysis of Coating and Surface Modification

特徴・独自性
  • Molecular-scale mechanism of solid-liquid affinity, wettability, thermal boundary resistance and molecular deposition are analyzed by molecular dynamics simulations toward its control. With a background of heat and mass transport and interfacial thermodynamics, transport phenomena of various scales ranging from spin coating of photoresist to SAM (self-assembled monolayer) and hydrophobic/hydrophilic treatment by attaching some molecular basis are studied. Futhermore, the molecular-scale mechanisms which determine thermophysical properties and the molecular structure that realizes desired thermophysical properties are studied. We can conduct effective collaboration and provide academic consultations to companies interested in our research.
実用化イメージ

Researchers

Tohoku Medical Megabank Organization

Taku Obara

[heatresistant material]

Precipitation Hardened Co-based Alloy

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特徴・独自性
  • The high-temperature strength in Co-based alloys is inferior to that in Ni-based superalloys due to no available ’ phase for strengthening Co-based alloys. We have found a new intermetallic compound Co3(Al,W) ’ phase, and /’ Co-Al-W-based wrought and cast alloys show excellent high-temperature strength. The /’ Ir-Al-W-based alloys are also available for high-temperature uses at over 1100 °C. The Co-based alloys also have good wear resistance. For example, friction stir welding (FSW) of high-softening-temperature materials such as steels and titanium alloys is possible using a Co-based alloy tool. We hope to conduct collaborative research with willing company for a practical application of the Co- or Ir-based alloys for high-temperature uses including FSW applications.
実用化イメージ

Researchers

Graduate School of Engineering

Toshihiro Omori

[hepatocyte growth factor]

Development of a Novel Therapy for Amyotrophic Lateral Sclerosis (ALS) Using Hepatocyte Growth Factor (HGF)

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特徴・独自性
  • Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by systematic motor neuron degeneration. Approximately 20% cases of familial ALS are caused by mutations in the superoxide dismutase 1 (SOD1) gene. We developed transgenic rats that express a human SOD1 gene with two different ALS-linked mutations (G93A or H46R) showing progressive motor neuron degeneration and paralysis. The larger size of the rat ALS models as compared with existing mouse models will facilitate studies on neuroprotective and neuro-regenerative strategy involving manipulations of cerebrospinal fluid and spinal cord.
実用化イメージ

Hepatocyte growth factor (HGF) is one of the most potent survival-promoting factors for motor neurons. Continuous intrathecal infusion of human recombinant HGF (hrHGF) attenuated loss of spinal motor neurons, astrocytosis, and microglial activation, leading to prolonged survival in the ALS rats. Safety and toxicology testing of the hrHGF protein in non-human primates should prompt further clinical trials in human ALS patients.

Researchers

Graduate School of Medicine

Masashi Aoki

[hereditary includion body myopathy (hIBM)]

Amyotrophic lateral sclerosis (ALS),Muscular dystrophy,Distal myopathy with rimmed vacuoles (DMRV)/ hereditary inclusion body myopathy (hIBM)

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特徴・独自性
  • Distal myopathy with rimmed vaculoles (DMRV) / hereditary inclusion body myopathy (hIBM) is an autosomal recessive disorder characterized clinically by the preferential involvement of the tibialis anterior muscle. It is known that the disease gene underlying DMRV is GNE, encoding glucosamine (UDP-N-acetyl)-2- epimerase and N-acetylmannosamine kinase, two essential enzymes in sialic acid biosynthesis. Decreased sialic acid production causes muscle degeneration. Muscle atrophy and weakness are completely prevented in a mouse model of DMRV after treatment with sialic acid metabolites orally.
  • The aim of this study is to investigate pharmacokinetics and safety of N-acetylneuraminic acid (figure) in patients with DMRV. N-acetylneuraminic acid and N-glycolylneuraminic acid in serum and urine are measured before and after oral administration of N-acetylneuraminic acid. We are prepared to provide academic consultations to companies interested in our research.
実用化イメージ

Researchers

Graduate School of Medicine

Masashi Aoki

[heterologous protein]

Development of Production System of Valuable Proteins Using a Koji-Mold, Aspergillus Oryzae, as a Host

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特徴・独自性
  • Because a koji-mold, Aspergillus oryzae, has an ability to secret a higher amount of proteins and is regarded as a safe microorganism, it has been expected as a promising host for production of useful proteins derived from plants and animals. However, Aspergillus oryzae produces various proteolytic enzymes that could degrade heterologous proteins produced, and hence we constructed mutant strains in which a transcription factor gene involved in proteolytic enzyme production was disrupted. In addition, codon optimization of heterologous gene resulted in a significant increase in the stability of heterologous gene transcripts. These attempts would lead to an increase in the amount of valuable proteins produced.
実用化イメージ

The technology could be applied to the high-level production of pharmaceutical proteins and industrially useful enzymes. We look forward to developing the collaborative project with enzyme and pharmaceutical industries.

Researchers

Graduate School of Agricultural Science

Katsuya Gomi

[Heusler alloy]

Development of High Sensitive Magnetic Sensor Operating at Room Temperature with Tunnel Magnetoresistance Devices

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特徴・独自性
  • Recently, many tunnel magnetoresistance devices with high magnetoresistance effect are reported. These are expected to be applied to high sensitive magnetic sensors. There are many magnetic sensors with variety of the mechanism, in order to meet the demand of the very wide range of sensing magnetic field. However, there is no magnetic sensor which has high sensitivity, easy to use, operation at room temperature and low cost. Only a magnetic sensor with tunnel magnetoresistance devices can satisfy all the demand in principle. As the device has very wide range of the sensing magnetic field, it can be designed for any demand to the sensors.
実用化イメージ

For example, this device can sense a bio-magnetic field easily at room temperature, so that it could be replaced SQUID device, which is popular now but is very expensive and not easy to use personally. Therefore, by using this device, we expect we can conduct effective collaborative research in medical field.

Researchers

Graduate School of Engineering

Yasuo Ando

[HGF]

Development of a Novel Therapy for Amyotrophic Lateral Sclerosis (ALS) Using Hepatocyte Growth Factor (HGF)

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特徴・独自性
  • Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by systematic motor neuron degeneration. Approximately 20% cases of familial ALS are caused by mutations in the superoxide dismutase 1 (SOD1) gene. We developed transgenic rats that express a human SOD1 gene with two different ALS-linked mutations (G93A or H46R) showing progressive motor neuron degeneration and paralysis. The larger size of the rat ALS models as compared with existing mouse models will facilitate studies on neuroprotective and neuro-regenerative strategy involving manipulations of cerebrospinal fluid and spinal cord.
実用化イメージ

Hepatocyte growth factor (HGF) is one of the most potent survival-promoting factors for motor neurons. Continuous intrathecal infusion of human recombinant HGF (hrHGF) attenuated loss of spinal motor neurons, astrocytosis, and microglial activation, leading to prolonged survival in the ALS rats. Safety and toxicology testing of the hrHGF protein in non-human primates should prompt further clinical trials in human ALS patients.

Researchers

Graduate School of Medicine

Masashi Aoki