"H" Keywords - 72 Result(s)

 H

[Hydrogen Embrittlement]

Hydrogen embrittlement of high strength steels

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特徴・独自性
  • We are studying hydrogen embrittlement property of high strength steels from the aspects of both the effect of hydrogen on mechanical properties of high strength steels and hydrogen uptake behavior in corrosive environments. The topics of our study includes clarification of mechanism of hydrogen embrittlement of various steels, investigation of hydrogen entry caused by corrosion using electrochemical techniques, hydrogen visualization, proposing evaluation methods for hydrogen embrittlement property and so forth.
実用化イメージ

Collaborative research in the field of hydrogen embrittlement, for example, hydrogen embrittlement properties of high strength steels and the effects of metallographic structure and hydrogen traps, proposal of evaluation methods for hydrogen embrittlement property for some specific steel and for parts with specific shape, development of novel hydrogen visualization techniques.

Researchers

Institute for Materials Research

Eiji Akiyama

[Hydrogen energy]

Development of Sustainable Integrated Multiphase Energy System

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特徴・独自性
  • Our laboratory is focusing in the development of innovative multiphase fluid dynamic methods based on the multiscale integration of massively parallel supercomputing and advanced measurements, and research related to creation of environmentally conscious energy systems. Furthermore, we promote basic research for the creation of risk management science and associated new multiphase flow system directly linked to sustainable energy represented by a high-density hydrogen storage technology.
実用化イメージ

P2P Hydrogen supply chain, Elastohydrodynamic lubrication, Supercomputing of Laser melting and sputter particle formation, High pressure diecast computing / Automotive industry, Additive manufacturing

Researchers

Institute of Fluid Science

Jun Ishimoto

[Hydrogen Production]

Development of Solid-State-Ionics Materials for Energy Conversion, Storage and Utilization

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特徴・独自性
  • Our focus is on the development of solid-state-ionics materials to be used for a variety of energy conversion systems. To further improve the performance of fuel cells and lithium batteries, novel ionic conductors and mixed conductors with high ionic conductivity and chemical stability are highly demanded. We have been developing such the materials based on defect chemistry and thermodynamics of ceramics, and trying to apply those materials to actual energy conversion devices.
実用化イメージ

To date, a hydrogen production system utilizing oxygen permeable membranes and an all-solid-state battery have been prepared.

Researchers

Graduate School of Engineering

Hitoshi Takamura

[Hydrogen Storage]

“HYDRIDE" Researches for Energy Applications

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特徴・独自性
  • This group is engaged in basic and applied researches of "hydrides" for practical use in hydrogen energy system. The main subject is the exploration of advanced hydrogen storage materials which support hydrogen energy technologies such as fuel cells. Currently, we synthesize a wide variety of novel hydrides composed of lightweight metals with specific nano-structures using advanced techniques for crystal and electronic structure analyses. In addition to the hydrogen storage, we develop the wide research fields related to hydrides, such as fast lithium ionic conductors.
実用化イメージ

Besides the contributions in industrial progress through the material development for future hydrogen energy system and next-generation secondary battery, we positively provide technical assistance to organizations and companies concerned about our findings.

Researchers

Advanced Institute for Materials Research

Shin-Ichi Orimo

[hydrophobin]

Monomer-Recycle System of Biodegradable Plastics by Industrial Fungal Fermentation and Application of Fungal Biosurfactant Proteins to Nanoparticles for Medical Use

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特徴・独自性
  • In Japan, solid-phase fungal fermentation systems using the industrial fungus Aspergillus oryzae have been extensively used for producing fermented foods such as soy sauce and sake; the annual production volume of the products is over one million tons. The efficient enzymatic hydrolyzing systems are expected to be applicable to biological recycling of biodegradable plastics. We found that A. oryzae can effectively degrade polybutylene succinate-coadipate (PBSA) by the combination with an esterase (cutinase) CutL1 and novel surfactant proteins, RolA and HsbA that are attached to the surface of PBSA and then recruit CutL1. The recruitment of Cutl1 by the surfactants stimulated PBSA degradation.
実用化イメージ

The fungal biosurfactant protein is applicable to industrial recycling of biodegradable plastics and to production of immune-response free nano-particles for medical use.

Researchers

Graduate School of Agricultural Science

Keietsu Abe

[Hydrothermal technology]

Process development using chemical reactions in high temperature/high pressure water; Super/subcritical fluid extraction technology

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特徴・独自性
  • Most of my research to date have been related to hydrothermal technology (e.g., super/subcritical water technologies), supercritical fluid (CO₂) and subcritical fluid (DME) extraction technologies, inorganic materials synthesis, coal chemistry, biomass conversion, microalgae extraction, and waste recycling. And I have a lot of experimence on the practial application of chemical engineering. The current research themes include spent lithium-ion battery recycling, waste plastic recycling, and automation and intelligence of chemical experiments.
実用化イメージ

Spent lithium-ion battery recycling and waste plastic recycling

Researchers

Graduate School of Engineering

Qingxin Zheng

[hyperglycemia]

The Novel Ultrasound Irradiation Device

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特徴・独自性
  • Dr. Katsunori Nonogaki has developed the novel ultrasound irradiation device, which can improve the autonomic nervous system activity and peripheral circulation. In addition, the ultrasoud device can improve hypertension and hyperglycemia within 20 min in subjects with drug-resistant hypertension and diabetes. Our initial device was approved in Japan (226AIBZX00028000). This device will be avaliable for the treatment of 1) muscle pain, 2) the autonomic neural dysfunction and stress-related disorders, 3) hypertention, and 4) diabetes. Moreover, the device will be usefull for your healthy life and aging care.
実用化イメージ

Our aims are to export the device internationally. We seek the investment and international business partners.

Researchers

Cyclotron and Radioisotope Center

Katsunori Nonogaki

[hypertension]

The Novel Ultrasound Irradiation Device

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特徴・独自性
  • Dr. Katsunori Nonogaki has developed the novel ultrasound irradiation device, which can improve the autonomic nervous system activity and peripheral circulation. In addition, the ultrasoud device can improve hypertension and hyperglycemia within 20 min in subjects with drug-resistant hypertension and diabetes. Our initial device was approved in Japan (226AIBZX00028000). This device will be avaliable for the treatment of 1) muscle pain, 2) the autonomic neural dysfunction and stress-related disorders, 3) hypertention, and 4) diabetes. Moreover, the device will be usefull for your healthy life and aging care.
実用化イメージ

Our aims are to export the device internationally. We seek the investment and international business partners.

Researchers

Cyclotron and Radioisotope Center

Katsunori Nonogaki

IVR (Interventional Radiology) Treatment of Hypertention: Minimally Invasive Treatment of Primary Aldosteronism Based on the Adrenal Vein Sampling Technology

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特徴・独自性
  • Primary aldosteronism is a leading cause of secondary hypertension accounting for approximately 10 % of hypertensive patients; 4 million patients potentially exist in Japan. We aim to optimize the method of ablating aldosterone producing adenoma using newly developed bipolar radiofrequency ablation system with 300-400kHz high-frequency current and electric power of 40W (Celon Prosurge Applicator), and establish a less invasive interventional radiological treatment of primary aldosteronism.
実用化イメージ

Collaboration with medical equipment manufacture and universities are expected to develop new devices enabling ablation of aldosterone producing adenoma. Flexible guide-wire-type ablation system and rapid aldosterone assay system should be co-developed to tread aldosterone producing microadenoma which is difficult to detect due to its small diameter of less than 5mm.

Researchers

Graduate School of Medicine

Kei Takase

Quantitative Evaluation of the Baroreflex Sensitivity of the Heart and Artery

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特徴・独自性
  • Metabolic syndrome is an important view point, when we consider the preventive medicine. Hypertension is one of the most important points to prevent the cardiovascular events. However, there is no method to measure the baroreflex sensitivity of the artery in the patients with hypertension. Tohoku University had invented the new method to evaluate the baroreflex sensitivity of the heart and artery (JP Patent No.4789203).
実用化イメージ

By the use of this machine, the baroreflex sensitivity of an artery in the patients can easily be measured noninvasively. It enables to predict the occurrence of hypertension and evaluate the therapy of hypertension easily, while allowing prevention of the cardiovascular events.

Researchers

Institute of Development, Aging and Cancer

Tomoyuki Yambe

[hypoxia]

Development of anti-fibrotic therapies with a cell line from myofibroblasts of fibrotic kidneys

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特徴・独自性
  • There are serious unmet medical needs in kidney diseases. Since fibrosis is a common terminal pathology of various kidney diseases and closely related to renal failure, anti-fibrotic therapies are plausible strategies for kidney diseases. Kidney fibrosis progresses with the emergence of myofibroblasts which produce extracellular matrix. We demonstrated that myofibroblasts originate from renal interstitial fibroblasts, which produce the erythroid growth factor erythropoietin, and that the transformation is reversible. To elucidate mechanisms of kidney fibrosis, we have established a cell line derived from myofibroblasts of mouse kidneys. It has been demonstrated that epigenetic interventions restore the cells (Replic cells) to their original fibroblastic features.
実用化イメージ

Replic cells provide useful and precise strategies to identify anti-fibrotic drugs.

Researchers

New Industry Creation Hatchery Center

Norio Suzuki

[Hypoxia-Inducible Factor alpha, HIF-a]

Development of PHD-Targeted Drug for Ischemic Injury

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特徴・独自性
  • All the living organisms generate energy from molecular oxygen to maintain their own lives. Once the concentration of oxygen falls down, life activity gets severely hampered and it could sometimes cause death. Typical examples that are related to local hypoxia are ischemic heart disease, stroke and kidney disease.
  • We focus on the function of prolyl hydroxylase (PHD) as a sensor to detect the hypoxia, and we are developing drugs to treat ischemic injury by controlling hypoxia.
実用化イメージ

Currently, we have several compounds that inhibit the PHD. We want to commercialize in conjunction with pharmaceutical companies in Japan and overseas, advancing our non-clinical studies for clinical development.

Researchers

Graduate School of Medicine

Toshio Miyata