Research Profiles

JP

"M" Keywords - 123 Result(s)

M
View Details

 M

[Motion Analysis]

High-Speed Vision for Real-Time Motion Analysis

 
 
 
NEXT
PREV
特徴・独自性
  • We are investigating high-speed vision systems that enable real-time image acquisition and visual processing at frame rates substantially higher than the standard video rate.
実用化イメージ

High-speed vision systems are useful for fast measurement and control of dynamic systems in general. When combined with external facilities such as high-speed projectors or acceleration sensors, they enable further wider applications including fast 3D measurement or object identification.

Researchers

Unprecedented-scale Data Analytics Center

Shingo Kagami

[motion capture system]

Clinical Applications of Motion Capture System for Living Body

 
NEXT
PREV
特徴・独自性
  • We have developed a wireless motion capture system for living body that could non-invasively measure various biological movements without any contact. By utilizing the LC resonant magnetic marker due to the latest magnetic engineering technology, we have achieved a magnetic wireless system which could be used even in a shielded space such as oral cavity by applying a magnetic field from outside the body. By using the infrared reflective markers of small and light, we have also succeeded in developing an optical system capable of synchronous real-time measurement at up to 50 locations at 250 hertz.
実用化イメージ

This new system can three dimensionally analyze various biological movements and can be applied to such diagnostic and medical equipment that requires a motion analysis non-invasively without any contact. It is possible to specialize this system to suit the required conditions, so I would like to joint research with companies and organizations that want to take advantage of this system.

Researchers

Graduate School of Dentistry

Hiroyasu Kanetaka

[motor neuron]

Specializes in clinical neurology, particularly neurodegenerative diseases and skeletal muscle diseases, and clinical genetics, and engaged in drug discovery and translational research for patients with intractable neuromuscular diseases.

NEXT
PREV
概要

Amyotrophic lateral sclerosis (ALS) is a representative intractable neurodegenerative disease, and the development of effective therapies is desired. A novel phase I trial of intrathecal administration of recombinant HGF protein was conducted at Tohoku University Hospital. Based on the results, a phase II trial (investigator-initiated clinical trial) to confirm efficacy and safety for ALS was conducted and completed at the Tohoku and Osaka University Hospital from 2016 to 2022. Although there was no statistically significant difference in the primary endpoint, additional analyses are currently ongoing. Clinical development of the same formulation for acute spinal cord injury is also underway.

従来技術との比較

Simultaneous development of a novel intrathecal formulation of recombinant HGF protein, and a medical device (a subcutaneous port with an intrathecal catheter) that enable repeated intrathecal administration for efficient and selective delivery to the central nervous system.

特徴・独自性
  • We developed a novel rat model of ALS model (Nagai M, et al. 2001)
  • Intrathecal continuous administration of HGF protein was confirmed to have a slowing effect on progression in this model
  • Phase I and II clinical trials have been completed, and the efficacy is currently being verified through additional analysis
実用化イメージ

We have been working with Kringle Pharma, Inc., Keio University (Prof. Hideyuki Okano and Prof. Masaya Nakamura), and Asahikawa Medical University (Prof. Hiroshi Funakoshi) to develop this drug. Phase I and II clinical trials for ALS have been completed. In addition, a phase III clinical trial for acute spinal cord injury is near completion. Additional collaboration with pharmaceutical companies is planned.

Researchers

Graduate School of Medicine

Masashi Aoki

[movement]

Development of Wearable Motion Measurement System for Motor Rehabilitation and Healthcare

 
 
 
NEXT
PREV
特徴・独自性
  • In order to realize wealthy and vibrant local communities, it is desired that people in the community are healthy. However, the amount of the daily activity decreases as they get older, which increases the risks of the fall by weakened lower limb muscles and of the cerebrovascular disease, and so on. Therefore, for the elderly people, there is increased need of the walking training and the movement assistance in daily life, and of the rehabilitation aid.
  • In this study, focusing on the motor function of the lower limbs that is important for independent activities of daily living and that relates to the health maintenance, development of assistive technologies for decreased gait ability or for dysfunction of lower limbs are performed based on the technologies of electronics and signal processing. Especially, the wearable sensor system using gyroscopes and accelerometers are developed to measure kinetic information, and then the evaluation system for the gait ability and the lower limbs motor function is developed in this study.
実用化イメージ

The goal of this study is to realize simple and convenient measurement and accumulation of various information of gait, to visualize the obtained data for determination of training effect and evaluation of motor function, and to provide appropriate training program for each subject.

Researchers

Graduate School of Biomedical Engineering

Takashi Watanabe

[MRI]

Brain Development and Aging Using Large Brain MRI Database

NEXT
PREV
特徴・独自性
  • We have revealed relationships among brain structure, brain function, lifestyle, genetic factor, and cognitive function using brain magnetic resonance imaging (MRI) database. The goal of our project is to prevent several diseases and disorders such as dementia by performing personalized medicine using the large brain MRI database.
実用化イメージ

Our research is related with several industrial fields such as food, sleep, and other lifestyle industries. In addition, our research is also related with medical field such as preventing medicine and brain check-up.

Researchers

Institute of Development, Aging and Cancer

Yasuyuki Taki

[MRI NIRS]

Application of Nuroimaging Technique to Interface Evaluation

 
NEXT
PREV
特徴・独自性
  • Nuclear power plants, chemical plants, ironworks and smelters, aircrafts and others that involve large-scale and complex systems yield many benefits to society and daily life, but a serious accident in such systems may result in dire consequences and significant damage. As long as there is human intervention of any kind, it is difficult to completely avoid human error. In light of this, it is crucial to have the mindset of "to err is human, (to forgive divine)." Takahashi Laboratory advocates the improvement of safety based on the harmonization of humans, machines and the environment. The object of our research is the human. Incorporating neuroscience approach and knowledge, we probe into human cognitive and behavioral traits and reflect our findings back into our research with the cooperation of this university's Institute of Development, Aging and Cancer as well as practicing specialists and technical experts. Through our broad vision, flexible mindset and creativity, we pioneer interfaces between humans and systems where safety is ingrained.
実用化イメージ

The core of our research is the examination and understanding of the human factor to be taken into account for the safe and efficient operation of large scale, complex systems, and we are involved in the research of a wide array of subjects not limited to nuclear energy systems but air traffic control operations, man-machine interfaces, cyber security, standardization of rules among others.

Researchers

Graduate School of Engineering

Makoto Takahashi

[MRL/lpr]

Development of McH-lpr/lpr-RA1 mouse, a study model that spontaneously develops severe autoimmune arthritis, vasculitis, and sialadenitis

 
 
NEXT
PREV
特徴・独自性
  • McH/lpr-RA1 mice are recombinant congenic mice descended from MRL/lpr and C3H/lpr mice and develop arthritis, vasculitis, and sialadenitis with high frequency and severity, with severe pannus formation similar to rheumatoid arthritis, polyarteritis nodosa, and Sjogren's syndrome. On the other hand, McH/lpr-RA1 mice do not develop systemic lymphadenopathy and severe nephritis as seen in MRL/lpr mice, so they are easy to breed and maintain and can be used for long-term drug administration experiments.
実用化イメージ

Development of diagnostic and therapeutic agents for collagen diseases. It can be applied to the elucidation of the mechanism of onset of immunological adverse events caused by immune checkpoint inhibitors and the development of drugs to prevent the onset of such events, etc. Industry-academia collaboration with pharmaceutical companies, test reagent companies, etc. is possible.

Researchers

Graduate School of Biomedical Engineering

Tetsuya Kodama

[MRL/lpr mouse]

Development of Recombinant Inbred Mice with a Genetic Predisposition to Collagen Disease

 
 
NEXT
PREV
特徴・独自性
  • Eleven strains of recombinant inbred (RI) mice derived from MRL/lpr and C3H/lpr mice were established. This RI is the only one in the world that randomly develops lesions such as nephritis, arthritis, sialadenitis, vasculitis, and production of autoantibodies in each strain. The genomes of the two strains of mice are randomly held in homozygous condition, and the phenotypes of each strain and the effects of administered drugs could be compared based on their genotype maps. It is possible to identify the regions of gene loci involved in the phenotype and drug sensitivity.
実用化イメージ

Development of diagnostic and therapeutic agents for autoimmune diseases. It can be applied to the elucidation of the mechanism of onset of immunological adverse events caused by immune checkpoint inhibitors and the development of drugs to prevent the onset of such events, and industry-academia collaboration with pharmaceutical companies, test reagent companies, etc. is possible.

Researchers

Graduate School of Biomedical Engineering

Tetsuya Kodama

[multi-function]

Performance enhancement and application development of energy harvesting materials by microstructure design

 
 
NEXT
PREV
特徴・独自性
  • To realize IoT society, it is required the sensors, which function without battery charge. We study on energy harvesting materials using our knowledge about materials mechanics and numerical simulation such as finite element method. We recently address to develop energy harvesting devices, which can recovery the unharnessed　energy around us as electrical energy.
実用化イメージ

Researchers

Graduate School of Environmental Studies

Fumio Narita

[Multi-physics analysis]

[multi-physics and multi-scale simulation]

Material Design for Solution of Energy and Environmental Problems by Multi-Physics and Multi-Scale Simulation

 
 
 
NEXT
PREV
特徴・独自性
  • In order to solve the energy and environmental problems, the development of the high-functional and high-performance materials is required in a wide variety of research fields such as fuel cell, Li-ion battery, tribology etc. Especially, the recent material technologies constitute of multi-physics and multi-scale phenomena including chemical reaction, friction, impact, stress, fluid, photon, electron, heat, electric and magnetic fields etc. on nano- and macro-scales. Therefore, Kubo laboratory is pioneering the development of multi-physics and multi-scale simulator on the basis of quantum chemistry and is utilizing supercomputers "Fugaku" and "MASAMUNE-IMR" for realizing the theoretical material design with high-accuracy.
実用化イメージ

We utilize our developed multi-physics and multi-scale simulation technology on the basis of quantum chemistry for acceelerating the material development in a wide variety of private companies of automotive, machinery, power, electronics, material, metal, chemistry etc. and then contribute to solving the energy and environmental problems.

Researchers

Institute for Materials Research

Momoji Kubo

[Multi-scale analysis]

[Multibody Dynamics]

Nonlinear Aeroelastic and Multibody Dynamic Analysis for Floating Wind Turbine and Next-Generation Aircraft

 
 
 
NEXT
PREV
概要

Floating wind turbine and next-generation aircraft have high-aspect-ratio blade and wing that undergo nonlinear aeroelastic deformation. We have developed a nonlinear aeroelastic analysis framework with absolute nodal coordinate formulation (ANCF). This nonlinear aeroelastic deformation is coupled with multibody dynamics. We are also developing a novel analysis framework for this coupling dynamics.

従来技術との比較

By using the nonlinear analysis method proposed in this study, it is possible to handle the reduction in flutter speed due to large deformations and the coupled phenomenon of deformation and flight behavior that cannot be captured using conventional linear analysis methods.

特徴・独自性
  • Straightforward nonlinear structural analysis method that does not use any rotational coordinates
  • Highly efficient unsteady fluid calculation method for large deformations
  • Multibody dynamics that captures the relative motion between bodies, such as rotating blades and control surfaces
実用化イメージ

Dynamic, aeroelastic, structural, vibration, aerodynamic analyses for Aeroelastic Multibody Systems:
1. Floating wind turbine
2. High altitude platform station (HAPS), high-aspect-ratio-wing commercial jet
3. Helicopter, drone
4. Robot, crane

Researchers

Graduate School of Engineering

Keisuke Otsuka

[Multicultural collaboration]

Multicultural collaboration and Human Rights Education

 
 
NEXT
PREV
特徴・独自性
  • In this research, students from various backgrounds study human rights together to see whether human rights could be the universal topic for students to start and developing their discussions. Thus, this research is trying to observe students' behavior and check their study outcome.
実用化イメージ

It would be great if I could collaborate with any researchers or associations to do comparative research under the topics of human rights or creating collaborative relationships among students from various backgrounds.

Researchers

Institute for Excellence in Higher Education

Mino Takamatsu

[multimedia materials]

Advanced Educational Environment with Interactive Instruction System IMPRESSION

 
 
 
NEXT
PREV
特徴・独自性
  • IMPRESSION is an interactive instruction system for both face-to-face lesson and distance education.
  • It was designed to facilitate teachers to plan and perform effective and attractive lessons with various multimedia materials, and help to evaluate performed lessons and improve them based on the double loop instructional design process, which is focusing on interaction between a teacher and students.
実用化イメージ

It could be used to perform advanced education with multimedia materials in schools, and also to design and implement training for employees at branch offices.

Researchers

Center for Data-driven Science and Artificial Intelligence

Takashi Mitsuishi

[Multiparameter Coincidence Spectroscopy]

Visualization of Electron Motion in Matter by Means of Electron Compton Scattering

 
NEXT
PREV
特徴・独自性
  • Properties of matter, such as reactivity and functionality, are determined by the motion of the constituent electrons. For this reason we aim at developing new spectroscopic methods, by using electron Compton scattering, that would visualize the electron motion for stable species and most importantly the change of electron motion in transient species, which is the driving force behind any chemical reactions;
  • (1) development of molecular frame electron momentum spectroscopy for momentum-space imaging of molecular orbitals in the three-dimensional form,
  • (2) developments of multiparameter coincidence techniques for studies on stereo-dynamics in electron-molecule collisions,
  • (3) development of time-resolved electron momentum spectroscopy for visualization of the change of electron motion in transient species.
  • We hope to conduct collaborative research with a willing company for a practical application of this technology in industry, and we are also prepared to provide academic consultations to companies interested in our research.
実用化イメージ

Researchers

Institute of Multidisciplinary Research for Advanced Materials

Masahiko Takahashi

[Multiphase flow]

Development of Sustainable Integrated Multiphase Energy System

 
 
 
NEXT
PREV
特徴・独自性
  • Our laboratory is focusing in the development of innovative multiphase fluid dynamic methods based on the multiscale integration of massively parallel supercomputing and advanced measurements, and research related to creation of environmentally conscious energy systems. Furthermore, we promote basic research for the creation of risk management science and associated new multiphase flow system directly linked to sustainable energy represented by a high-density hydrogen storage technology.
実用化イメージ

P2P Hydrogen supply chain, Elastohydrodynamic lubrication, Supercomputing of Laser melting and sputter particle formation, High pressure diecast computing / Automotive industry, Additive manufacturing

Researchers

Institute of Fluid Science

Jun Ishimoto

Development of integrated safety management technology for hydrogen energy systems

 
 
 
NEXT
PREV
特徴・独自性
  • To investigate the diffusion and combustion phenomena of reactive hydrogen gas leakage when a high-pressure hydrogen tank fails due to crack propagation caused by an initial defect, we have developed a coupled analysis method that simultaneously analyzes the material structure and reactive turbulent multiphase flow through an interdisciplinary research approach. Furthermore, we have developed a new numerical prediction method related to the diffusion flow characteristics and combustion limits of hydrogen leaking due to crack propagation failure of high-pressure tank bulkheads.
実用化イメージ

We contribute to the design of hydrogen storage containers for various types of transportation equipment and the development of safety guidelines and risk management for hydrogen station configurations.

Researchers

Institute of Fluid Science

Jun Ishimoto

Advanced die casting process computing with solidification phenomena

 
 
 
NEXT
PREV
特徴・独自性
  • Die casting is a method of mass-producing high-precision castings in a short time by filling the mold with molten metal at high pressure and high speed. Since solidification is completed quickly under high pressure, various defects peculiar to die casting occur. Significantly, the casting cavity has a high incidence in die casting, and it is a factor that hinders the quality. Therefore, a numerical approach to the die casting process is expected to prevent these problems, and the information obtained from the numerical analysis is expected to be reflected in the casting plan to reduce the number of prototypes, the lead time to product development, and the cost. In this study, a multiphase flow analysis with solidification phenomena of molten aluminum inside mold was conducted for a high-pressure die casting process of the throttle body.
実用化イメージ

Automotive industry, Automotive suppliers, Foundry industry

Researchers

Institute of Fluid Science

Jun Ishimoto

Development of a Numerical Prediction System for Sliding Part Wear and Seizure Occurrence Portions

 
NEXT
PREV
概要

Focusing on the lubricant film flow with phase change between the engine piston pin and connecting rod small end, we developed a new multiphase fluid-structure coupled analysis method that takes into account elastic deformation of the structure and flow path changes and developed a simulation prediction method for tribological properties under high load conditions. The simulation prediction method for tribological properties under high load conditions has been created. As a result, we succeeded in simulation prediction of the wear/seizure generating areas in sliding parts. We discovered that the peculiar deformation behavior of the components is the cause of wear/seizure.

従来技術との比較

It has been thought that computational prediction is impossible to verify the wear and seizure locations in fluid lubrication. Still, this study succeeded in the simulation prediction of wear and seizure locations in sliding parts.

特徴・独自性
  • Numerical prediction of the wear and seizure locations in the sliding parts of engine piston pins was successfully performed.
  • The bow-like deformation of the piston pin was identified as the cause of mechanical contact and seizure at the connecting rod edge.
  • A three-dimensional multiphase fluid-structure coupled analysis method has been successfully developed, considering the piston pin's elastic deformation and connecting rod and thin-film cavitation1 lubrication with unsteady flow path changes.
実用化イメージ

This research method applies to automotive engines and all sliding component elements using fluid lubrication. It contributes to damage prediction and the development of safety guidelines for transportation and industrial machinery components, enabling the optimal design of components.

Researchers

Institute of Fluid Science

Jun Ishimoto

Research Profiles

Fields

ENGLISH
Close