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Synthesis of Biologically Active Cyclodepsipeptide Natural Products

Features and Uniqueness
  • Cyclodepsipeptide natural products include optically active hydroxy acids as well as various unnatural amino acids and exhibit a variety of biological activity depending on the peptide sequence, chirality, and selection of the hydroxy acids. Structure-activity relationships of a synthetic library of natural products could give us significant information of not only biologically important moieties but also intact positions in the biologically active small molecules. On the basis of the former information, more potent compounds and/or peptide mimetics can be designed. The latter information can also be important for making a molecular probe that is used for exploration of a target molecule.
Practical Application

We study for combinatorial synthesis of natural product analogues using solid-phase.



Graduate School of Pharmaceutical Sciences

Takayuki Doi, Professor
Doctor of Engineering