Tohoku University. Research Profiles

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"G" Keywords - 36 Result(s)

G

 g

[gait]

Development of Wearable Motion Measurement System for Motor Rehabilitation and Healthcare

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Features
In order to realize wealthy and vibrant local communities, it is desired that people in the community are healthy. However, the amount of the daily activity decreases as they get older, which increases the risks of the fall by weakened lower limb muscles and of the cerebrovascular disease, and so on. Therefore, for the elderly people, there is increased need of the walking training and the movement assistance in daily life, and of the rehabilitation aid.
In this study, focusing on the motor function of the lower limbs that is important for independent activities of daily living and that relates to the health maintenance, development of assistive technologies for decreased gait ability or for dysfunction of lower limbs are performed based on the technologies of electronics and signal processing. Especially, the wearable sensor system using gyroscopes and accelerometers are developed to measure kinetic information, and then the evaluation system for the gait ability and the lower limbs motor function is developed in this study.

Targeted Application(s)/Industry
The goal of this study is to realize simple and convenient measurement and accumulation of various information of gait, to visualize the obtained data for determination of training effect and evaluation of motor function, and to provide appropriate training program for each subject.

Graduate School of Biomedical Engineering
WATANABE, Takashi, Professor Doctor of Engineering

[gamma-secretase]

Yeast models of familial Alzheimer disease to screen for gamma-secretase inhibitors and modulators

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Features
Using the yeast transcriptional activator Gal4 system, we reconstituted the production of amyloid beta (Aβ), responsible for Alzheimer disease. Aβ production could be monitored by the positive growth in the selection media or by the reporter enzyme (β-Gal). Utilizing familial Alzheimer disease mutants, we established a system to screen for mutations and chemicals that modulate gamma secretase activity and reduce toxic Aβ42.

Targeted Application(s)/Industry
Our yeast system can be used to screen for chemicals, natural products, food ingredients, genes, and mutations that modulate γ-secretase activity and block Aβ42 production specifically. We hope to conduct collaboration research with a willing company for a practical application of this technology in industry.

Graduate school of Agricultural Science
FUTAI, Eugene, Associate Professor Doctor of Agriculture

[gamma-secretase modulator]

Yeast models of familial Alzheimer disease to screen for gamma-secretase inhibitors and modulators

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Features
Using the yeast transcriptional activator Gal4 system, we reconstituted the production of amyloid beta (Aβ), responsible for Alzheimer disease. Aβ production could be monitored by the positive growth in the selection media or by the reporter enzyme (β-Gal). Utilizing familial Alzheimer disease mutants, we established a system to screen for mutations and chemicals that modulate gamma secretase activity and reduce toxic Aβ42.

Targeted Application(s)/Industry
Our yeast system can be used to screen for chemicals, natural products, food ingredients, genes, and mutations that modulate γ-secretase activity and block Aβ42 production specifically. We hope to conduct collaboration research with a willing company for a practical application of this technology in industry.

Graduate school of Agricultural Science
FUTAI, Eugene, Associate Professor Doctor of Agriculture

[genome data analysis]

Development of medical infrastructure with thousands whole-genome Japanese reference panel and its biomedical informatics

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Features
The drastic progress of human genome sequencing technology allows us to obtain the individual’s high quality whole-genome information. Towards the personalized medicine and preventive medicine, each individual genome information will be absolutely necessary. Our organization, Tohoku Medical Megabank Organization, recruits the 150K individuals as a large-scale prospective genome cohort project in Japan. While this project, we are constructing the population scale infrastructure of Japanese genome information towards the personalized medicine and preventive medicine, e.g. thousands whole-genome Japanese reference panel, optimized SNP array for Japanese (Japonica array) and several tens of thousands pseudo whole-genome Japanese reference panel with imputation technology.

Targeted Application(s)/Industry
In parallel, many bioinformatics algorithms and tools related to genome information are developing, e.g. HLA inference software (HLA-VBSeq), ASE-Tigar and others (for more detail refer to our website).

Tohoku Medical Megabank Organization
NAGASAKI, Masao, Professor Doctor of Science

[gfp]

Development of Fish iPS Cell Technology

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Features
In order to utilize for the development of fish iPS cells, we established experimental systems to monitor cellular multipotency using zebrafish and medaka transgenic lines which express GFP fluorescence under the regulation of oct4 promoter. Because fish has strong fin regenerative activity after amputation, and GFP positive cells appear during fin regeneration, fin is expected to be suitable for iPS cell preparation. In addition, we ascertained that MC-LGNSO, a commercially available minicircle DNA developed for human iPS cell preparation, works well in fish cells. By using transgenic lines and the minicircle DNA, we are now trying to establish iPS cells from regenerating fin cells.

Targeted Application(s)/Industry
We expect that in fish, iPS cell technology is applicable to innovative new technologies in aquaculture: i.e. generation of iPS cells from selected fish strains and production of clone individuals of the selected lines, and cryopreservation of important fish strains as cell lines.

Graduate School of Agricultural Science
SUZUKI, Tohru, Professor PhD

 G

[GaN ]

Development in Semiconductor Materials and Research of their Properties Considering Device Applications Bringing System Evolutions

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Features
1. Development of Distributed Feedback (DFB) Laser Diodes (LD) widely used in optical communications systems realizing a highly information-based society.
2. Nitride semiconductors famous for blue light emitting diodes
(a) Proposal of InGaAlN system considering device applications in 1989
(b) Success in growth of single crystalline InGaN by metalorganic vapor phase epitaxy (MOVPE) in 1989
(c) Prediction of band-gap energy (Eg) of InN much smaller than the reported values in 1989 and its experimental confirmation in 2002
(d) Observation of photoluminescense from InGaN in 1991
(e) Prediction of phase separation in InGaAlN in 1997
We promoted the JST-CREST project "Research on InN Semiconductor Laser Diodes with High Temperature-Stability for Optical Communications Systems".

Targeted Application(s)/Industry
DFB-LD: Fabrication of periodic structure with submicron scale, Epitaxial growth of semiconductor films on the substrate with fine structures, LD fabrication process, device evaluation, and device simulation
Nitride Semiconductors: MOVPE growth, N-polar growth, evaluation of materials, fabrication of light-emitting devices, solar cells, high-power transistors, and high-power transistors

Institute for Materials Research
MATSUOKA, Takashi, Professor Doctor of Engineering

[GaN on Si power electronics]

International industry-academic consortium (CIES consortium) enhances creation of innovative integrated electronic technologies from material/process/LSI to software/tool/system (Center for Innovative Integrated Electronic Systems: CIES)

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Features
Integrated electronic systems are a fundamental technology that makes possible the lifestyles of ease and abundance we enjoy in the modern world. By leveraging innovative core technologies and longstanding accomplishments of industry-academic cooperation in Tohoku University as centripetal forces, we have promoted the CIES Consortium consisting of seven industry–academic collaborations, major national projects and community-based cooperation projects through our cooperation with a diverse range of Japanese and foreign companies from fields such as materials, equipment, devices, circuits and systems.  CIES has promoted world level Academic-Industrial Collaboration under establishment of world-first 300mm wafer process line and facilities for prototype manufacturing and characterizing spintronics integrated circuits compatible with world-class companies in university campus.


Targeted Application(s)/Industry
CIES has conducted international industry-academic collaboration in the fields of integrated electronic technologies ranging from materials/equipment to devices/systems. In addition, we have promoted to cooperate with regional and local companies with support of local government (Miyagi Prefecture, Sendai City etc) for contributing to Tohoku reconstruction and regional development. We welcome your participation in CIES consortium.

Center for Innovative Integrated Electronic Systems
ENDOH, Tetsuo, Professor Doctor of Engineering

[GaN/Si hybrid power integrated circuits]

International industry-academic consortium (CIES consortium) enhances creation of innovative integrated electronic technologies from material/process/LSI to software/tool/system (Center for Innovative Integrated Electronic Systems: CIES)

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Features
Integrated electronic systems are a fundamental technology that makes possible the lifestyles of ease and abundance we enjoy in the modern world. By leveraging innovative core technologies and longstanding accomplishments of industry-academic cooperation in Tohoku University as centripetal forces, we have promoted the CIES Consortium consisting of seven industry–academic collaborations, major national projects and community-based cooperation projects through our cooperation with a diverse range of Japanese and foreign companies from fields such as materials, equipment, devices, circuits and systems.  CIES has promoted world level Academic-Industrial Collaboration under establishment of world-first 300mm wafer process line and facilities for prototype manufacturing and characterizing spintronics integrated circuits compatible with world-class companies in university campus.


Targeted Application(s)/Industry
CIES has conducted international industry-academic collaboration in the fields of integrated electronic technologies ranging from materials/equipment to devices/systems. In addition, we have promoted to cooperate with regional and local companies with support of local government (Miyagi Prefecture, Sendai City etc) for contributing to Tohoku reconstruction and regional development. We welcome your participation in CIES consortium.

Center for Innovative Integrated Electronic Systems
ENDOH, Tetsuo, Professor Doctor of Engineering

[GaP]

Development of Frequency Tunable Coherent TERAHERTZ Light Sources and their Potential Applications

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Features
Terahertz wave (THz) is quite new electromagnetic wave. THz wave is expected to show wide variety of important practical applications. In view of the scientific fields, THz spectroscopy can reveal quite new inter-molecular vibration. We successfully realized the THz wave emission via both non-linear optical effects of NIR laser light and the high frequency semiconductor device operations. The frequency region realized is ranging between 0.03THz and a few 10 THz. It is also noted that the device assembly of THz semiconductor devices and the crystal growth of non-linear optical crystal have been performed in our laboratory.

Targeted Application(s)/Industry
Applications
Non-destructive and non-contact defect recognition of building blocks and water diffusion recognition in polymers, paints, woods and concrete, adhesion failure of ceramics tiles on concrete walls, chirality discrimination of medicines, hydro-oxide formation of medicines, recognition of polytypes of organic and nonorganic crystalline compounds, THz spectroscopic imaging using specific molecular vibrations

Industry
Civil and architecture engineering, Metal construction like bridge, tunnel construction, automobile and train, semiconductor fabrication, electronic device fabrication, medicine, chemical engineering.

Department of Materials Science and Engineering, Graduate School of Engineering
OYAMA, Yutaka, Professor Doctor of Engineering

[Gas turbine]

Combustion and Atomization Technology in High-Pressure Gas Turbine Conditions

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Features
Combustion is a complex phenomenon composed of multi-dimensional dynamics of temperature, concentration, velocity, and chemical reactions. Advanced combustion technologies are essential for solving the environmental and energy issues. Our laboratory has a high-pressure combustion test facility which is a unique experimental facility in the world. Research projects have originality, especially in the field of high-pressure combustion and laser diagnostics, and focus on not only aerospace engineering and energy engineering including new fuel technology but also atomization technology and safety operations of chemical plants mostly operated at high pressure.

Targeted Application(s)/Industry
Potential collaborations are in the research fields of aerospace propulsions, automobile engines, power generations and chemical plants, in terms of development of gas turbine combustors for various fuels, generation and control of fuel atomizers, laser diagnostics of combustion and safety design of chemical reactors.

High Speed Reacting Flow Laboratory, Institute of Fluid Science
KOBAYASHI, Hideaki, Professor Doctor of Engineering

[GaSe]

Development of Frequency Tunable Coherent TERAHERTZ Light Sources and their Potential Applications

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Features
Terahertz wave (THz) is quite new electromagnetic wave. THz wave is expected to show wide variety of important practical applications. In view of the scientific fields, THz spectroscopy can reveal quite new inter-molecular vibration. We successfully realized the THz wave emission via both non-linear optical effects of NIR laser light and the high frequency semiconductor device operations. The frequency region realized is ranging between 0.03THz and a few 10 THz. It is also noted that the device assembly of THz semiconductor devices and the crystal growth of non-linear optical crystal have been performed in our laboratory.

Targeted Application(s)/Industry
Applications
Non-destructive and non-contact defect recognition of building blocks and water diffusion recognition in polymers, paints, woods and concrete, adhesion failure of ceramics tiles on concrete walls, chirality discrimination of medicines, hydro-oxide formation of medicines, recognition of polytypes of organic and nonorganic crystalline compounds, THz spectroscopic imaging using specific molecular vibrations

Industry
Civil and architecture engineering, Metal construction like bridge, tunnel construction, automobile and train, semiconductor fabrication, electronic device fabrication, medicine, chemical engineering.

Department of Materials Science and Engineering, Graduate School of Engineering
OYAMA, Yutaka, Professor Doctor of Engineering

[Gel-sol method]

Functional Uniform Nanoparticles Production and Their Industrial Use

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Features
Nanoparticles and/or fine particles to be used for functional materials, such as semiconductor, photocatalysts, dielectric and/or piezoelectric materials, cosmetics, catalysts, etc., has been synthesized in liquid-phase. Their size, shape, composition, and structure have been <strong>precisely controlled</strong> along an expected usage. <strong>Tailor-made synthesis method</strong> has been provided for nanoparticles and/or fine particles the companies wish to use.

Targeted Application(s)/Industry
Until now, we have been supplying nanoparticles and/or fine particles of ITO (Indium Tin Oxides) as TCO, Bi based or Nb based particles for lead-free piezoelectric ceramics, perovskite-based oxides for dielectric materials etc. The gel-sol method as the main synthesis method for uniform particles makes the production cost reduced.

Institute of Multidisciplinary Research for Advanced Materials
MURAMATSU, Atsushi, Professor Doctor of Engineering

[Gene Transfection]

Development of Nano-Medical-Agricultural Applied Technology Using Ion-Controlled Plasma

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Features
Since we have developed the techniques (ion control plasma) to generate and control ions, electrons, reactive species (radicals) in the low temperature non-equilibrium plasmas which I can touch by hand, the composite materials using nanoparticles, nanocarbons, biological molecules are synthesized in the nano-electronics field, the minimally-invasive and highly-efficient drug/gene transfection systems are developed in the medical field, and bacteria and insects are killed by the plasma in place of pesticide in the agricultural field.

Targeted Application(s)/Industry
The ion-controlled plasmas are applied for the minimally-invasive gene transfection system, next-generation agricultural system, the electrode material of highly-efficient battery, and so on. We hope to conduct the collaborative research with a willing company for a practical application of the novel plasma nano-medical-agricultural applied technology in industry.

Department of Electronic Engineering, Graduate School of Engineering
KANEKO, Toshiro, Professor PhD

[Generic medicine]

MEDICINE DETERMINATION SUPPORT SYSTEM AND MEDICINE DETERMINATION SUPPORT PROGRAM

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AIMS: This invention is to support the doctor’s prescription for diabetes and metabolic syndrome, especially in Japanese Clinic (Patent: JP 4176438).
PROBLEM TO BE SOLVED: To perform a further efficient preparation by providing information for original medicine and generic medicine in the preparation.
SOLUTION: The medicine price, pharmacologic effect and the like of each of original medicine and generic medicine are preliminarily recorded in a medicine database, and a generic medicine corresponding to the original medicine inputted by a doctor is automatically retrieved and displayed on a display. When the total number of the inputted medicine exceeds a number determined by insurance medical care, the generic medicine is retrieved so that the drug price of the group of the same usage is a prescribed amount or less. Welcome to your investment or co-operation.

Department of Diabetes Technology, Graduate School of Biomedical Engineering
NONOGAKI, Katsunori, Professor MD, PhD

[Genetic Diversity]

Construction of Monitoring Systems for Genetic Diversity in Aquatic Organisms

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Features
Maintaining genetic diversity within a species is a major issue to conserve biodiversity and sustainable use. To monitor genetic diversity in natural and captive populations using adequate genetic markers is the most important step. We have focused aquatic organisms and studied the genetic diversity using an array of DNA analyses. Our research interest includes 1) genetic structure and phylogeography of natural populations in marine and freshwater organisms and 2) genetic management of commercially important species to contribute the stock enhancement programs.

Targeted Application(s)/Industry
Our skill can be applied to environmental assessment and fish resource management. We are collaborating with national institutes and giving advice to private environmental assessment companies.

Graduate School of Agricultural Science
IKEDA, Minoru, Associate Professor Doctor of Agricultural Sicence

[Genomic imprinting]

New High-Throughput, High Resolution DNA Methylation Analysis Method, PCR-Luminex for the Diagnosis of Genomic Imprinting Disorders in ART Babies

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Features
The parent-of–origin specific expression of the imprinted genes relies on DNA methylation acquired during gametogenesis. Recent studies indicate the possibility of excess imprinting disease occurrence in babies conceived by assisted reproductive technologies (ART). PCR-Luminex method is powerful tool for the methylation analyses, suitable for the use at the clinical diagnosis level because of taking much time and multistep procedures.

Targeted Application(s)/Industry
We have developed a new high-throughput, high resolution DNA methylation analysis method. PCT international patent was performed.

Environment and Genome Research Center, Graduate School of Medicine
ARIMA, Takahiro, Professor Medical Doctor

[Genomics]

Oral Biofilm Functional Analysis: from “What Are They?" to “What Are They Doing?"

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Features
A large number of microorganisms inhabit the oral cavity, such as the teeth, gingiva and tongue, in the form of oral biofilm. The oral cavity forms an ecosystem where the host (humans) and parasites (microorganisms) coexist. Disruption of the balance of this oral ecosystem leads to dental caries, periodontal diseases and oral malodor, and even deterioration of dental materials.

Using leading-edge techniques of anaerobic experimental systems including original and unique devices, as well as the notion of "omics" such as metagenomics and metabolomics, we conduct research on oral biofilm functions. Knowledge of oral biofilms, from "what are they?" to "what are they doing?", enables us to address their control, that is, prevention of and therapy for oral biofilm-associated diseases.

Targeted Application(s)/Industry
Risk assessment of oral biofilm-associated diseases, such as dental caries, periodontal disease, oral malodor and aspiration pneumonia
Effects of medicine and food ingredients on oral biofilm function
Evaluation of biofilm-mediated material deterioration

Division of Oral Ecology and Biochemistry, Graduate School of Dentistry
TAKAHASHI, Nobuhiro, Professor DDS, PhD

[Geosphere Informatics]

Development of Geothermal Energy and Geosphere Environmental Informatics

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Features
My research field is Geothermal Geology, Resource Geology and Environmental Geology. I am conducting exploration of heat source, hydrothermal alteration and characterization of geothermal reservoir by geological techniques. I study water-rock interaction and fluid dynamics in reservoirs on the basis of hydrothermal experiments under sub- to supercritical conditions and numerical simulation. Additionally, risk assessment of soil, river water in terms of heavy metal pollution.

Targeted Application(s)/Industry
I am conducting international collaboration with respect to geothermal geology, mining geology, and geoengineering related to risk assessment of geosphere environment.

Graduate School of Environmental Studies
TSUCHIYA, Noriyoshi, Professor Doctor of Engineering

[Geothermal Energy]

Development of Geothermal Energy and Geosphere Environmental Informatics

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Features
My research field is Geothermal Geology, Resource Geology and Environmental Geology. I am conducting exploration of heat source, hydrothermal alteration and characterization of geothermal reservoir by geological techniques. I study water-rock interaction and fluid dynamics in reservoirs on the basis of hydrothermal experiments under sub- to supercritical conditions and numerical simulation. Additionally, risk assessment of soil, river water in terms of heavy metal pollution.

Targeted Application(s)/Industry
I am conducting international collaboration with respect to geothermal geology, mining geology, and geoengineering related to risk assessment of geosphere environment.

Graduate School of Environmental Studies
TSUCHIYA, Noriyoshi, Professor Doctor of Engineering

[Geothermal Geology]

Development of Geothermal Energy and Geosphere Environmental Informatics

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Features
My research field is Geothermal Geology, Resource Geology and Environmental Geology. I am conducting exploration of heat source, hydrothermal alteration and characterization of geothermal reservoir by geological techniques. I study water-rock interaction and fluid dynamics in reservoirs on the basis of hydrothermal experiments under sub- to supercritical conditions and numerical simulation. Additionally, risk assessment of soil, river water in terms of heavy metal pollution.

Targeted Application(s)/Industry
I am conducting international collaboration with respect to geothermal geology, mining geology, and geoengineering related to risk assessment of geosphere environment.

Graduate School of Environmental Studies
TSUCHIYA, Noriyoshi, Professor Doctor of Engineering