Tohoku University. Research Profiles

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"H" Keywords - 76 Result(s)

H

 h

[hydrogen]

“HYDRIDE" Researches for Energy Applications

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Features
This group is engaged in basic and applied researches of "hydrides" for practical use in hydrogen energy system. The main subject is the exploration of advanced hydrogen storage materials which support hydrogen energy technologies such as fuel cells. Currently, we synthesize a wide variety of novel hydrides composed of lightweight metals with specific nano-structures using advanced techniques for crystal and electronic structure analyses. In addition to the hydrogen storage, we develop the wide research fields related to hydrides, such as fast lithium ionic conductors.

Targeted Application(s)/Industry
Besides the contributions in industrial progress through the material development for future hydrogen energy system and next-generation secondary battery, we positively provide technical assistance to organizations and companies concerned about our findings.

WPI Advanced Institute for Materials Research /Institute for Materials Research
ORIMO, Shin-ichi, Professor

Hydrogen embrittlement of high strength steels

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1) Features
We are studying hydrogen embrittlement property of high strength steels from the aspects of both the effect of hydrogen on mechanical properties of high strength steels and hydrogen uptake behavior in corrosive environments. The topics of our study includes clarification of mechanism of hydrogen embrittlement of various steels, investigation of hydrogen entry caused by corrosion using electrochemical techniques, hydrogen visualization, proposing evaluation methods for hydrogen embrittlement property and so forth.

2) Targeted Applications / Industry
Collaborative research in the field of hydrogen embrittlement, for example, hydrogen embrittlement properties of high strength steels and the effects of metallographic structure and hydrogen traps, proposal of evaluation methods for hydrogen embrittlement property for some specific steel and for parts with specific shape, development of novel hydrogen visualization techniques.

Institute for Materials Research
AKIYAMA, Eiji, Professor Doctor of Science

[hydrophobin]

Monomer-Recycle System of Biodegradable Plastics by Industrial Fungal Fermentation and Application of Fungal Biosurfactant Proteins to Nanoparticles for Medical Use

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Features
In Japan, solid-phase fungal fermentation systems using the industrial fungus Aspergillus oryzae have been extensively used for producing fermented foods such as soy sauce and sake; the annual production volume of the products is over one million tons. The efficient enzymatic hydrolyzing systems are expected to be applicable to biological recycling of biodegradable plastics. We found that A. oryzae can effectively degrade polybutylene succinate-coadipate (PBSA) by the combination with an esterase (cutinase) CutL1 and novel surfactant proteins, RolA and HsbA that are attached to the surface of PBSA and then recruit CutL1. The recruitment of Cutl1 by the surfactants stimulated PBSA degradation.

Targeted Application(s)/Industry
The fungal biosurfactant protein is applicable to industrial recycling of biodegradable plastics and to production of immune-response free nano-particles for medical use.

Graduate School of Agricultural Science
ABE, Keietsu, Professor Doctor of Agriculture

[hyperglycemia]

The Novel Ultrasound Irradiation Device

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Features
Dr. Katsunori Nonogaki has developed the novel ultrasound irradiation device, which can improve the autonomic nervous system activity and peripheral circulation. In addition, the ultrasoud device can improve hypertension and hyperglycemia within 20 min in subjects with drug-resistant hypertension and diabetes. Our initial device was approved in Japan (226AIBZX00028000). This device will be avaliable for the treatment of 1) muscle pain, 2) the autonomic neural dysfunction and stress-related disorders, 3) hypertention, and 4) diabetes. Moreover, the device will be usefull for your healthy life and aging care.

Targeted Application(s)/Industry
Our aims are to export the device internationally. We seek the investment and international business partners.

Department of Diabetes Technology, Graduate School of Biomedical Engineering
NONOGAKI, Katsunori, Professor MD, PhD

[hypernuclei]

Experimental Nuclear Physics

1) Study of strangeness nuclear physics and hypernuclei with high energy electron/photon beams

2)加速器研究施設で収集される大量のデータ解析技術、
  荷電粒子、高エネルギー光子の測定技術、

Department of Physics, Graduate School of Science
NAKAMURA, Satoshi N., Professor Doctor of Science

[hypertension]

The Novel Ultrasound Irradiation Device

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Features
Dr. Katsunori Nonogaki has developed the novel ultrasound irradiation device, which can improve the autonomic nervous system activity and peripheral circulation. In addition, the ultrasoud device can improve hypertension and hyperglycemia within 20 min in subjects with drug-resistant hypertension and diabetes. Our initial device was approved in Japan (226AIBZX00028000). This device will be avaliable for the treatment of 1) muscle pain, 2) the autonomic neural dysfunction and stress-related disorders, 3) hypertention, and 4) diabetes. Moreover, the device will be usefull for your healthy life and aging care.

Targeted Application(s)/Industry
Our aims are to export the device internationally. We seek the investment and international business partners.

Department of Diabetes Technology, Graduate School of Biomedical Engineering
NONOGAKI, Katsunori, Professor MD, PhD

IVR (Interventional Radiology) Treatment of Hypertention: Minimally Invasive Treatment of Primary Aldosteronism Based on the Adrenal Vein Sampling Technology

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Features
Primary aldosteronism is a leading cause of secondary hypertension accounting for approximately 10 % of hypertensive patients; 4 million patients potentially exist in Japan. We aim to optimize the method of ablating aldosterone producing adenoma using newly developed bipolar radiofrequency ablation system with 300-400kHz high-frequency current and electric power of 40W (Celon Prosurge Applicator), and establish a less invasive interventional radiological treatment of primary aldosteronism.

Targeted Application(s)/Industry
Collaboration with medical equipment manufacture and universities are expected to develop new devices enabling ablation of aldosterone producing adenoma. Flexible guide-wire-type ablation system and rapid aldosterone assay system should be co-developed to tread aldosterone producing microadenoma which is difficult to detect due to its small diameter of less than 5mm.

Graduate School of Medicine
TAKASE, Kei, Professor MD, PhD

Quantitative Evaluation of the Baroreflex Sensitivity of the Heart and Artery

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Features
Metabolic syndrome is an important view point, when we consider the preventive medicine. Hypertension is one of the most important points to prevent the cardiovascular events. However, there is no method to measure the baroreflex sensitivity of the artery in the patients with hypertension. Tohoku University had invented the new method to evaluate the baroreflex sensitivity of the heart and artery (JP Patent No.4789203).

Targeted Application(s)/Industry
By the use of this machine, the baroreflex sensitivity of an artery in the patients can easily be measured noninvasively. It enables to predict the occurrence of hypertension and evaluate the therapy of hypertension easily, while allowing prevention of the cardiovascular events.

Institute of Development, Aging and Cancer
YAMBE, Tomoyuki, Professor

 H

[Hydrogen Embrittlement]

Cavitation Peening

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Features
Surface modification method to improve fatigue strength has been developed using cavitation impacts, which are normally causes severe damage in hydraulic machineries. The method was called "cavitation peening". In order to make clear the mechanism, a load controlled plate bending fatigue test machine was developed. It was proved by using the test machine that the threshold level of stress intensity factor was improved about 1.9 times by cavitation peening. The mitigation of hydrogen embrittlement by cavitation peening was also improved.

Targeted Application(s)/Industry
The cavitation peening can apply to component of automobile and forging die. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Graduate School of Engineering
SOYAMA, Hitoshi, Professor Doctor of Engineering

Hydrogen embrittlement of high strength steels

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1) Features
We are studying hydrogen embrittlement property of high strength steels from the aspects of both the effect of hydrogen on mechanical properties of high strength steels and hydrogen uptake behavior in corrosive environments. The topics of our study includes clarification of mechanism of hydrogen embrittlement of various steels, investigation of hydrogen entry caused by corrosion using electrochemical techniques, hydrogen visualization, proposing evaluation methods for hydrogen embrittlement property and so forth.

2) Targeted Applications / Industry
Collaborative research in the field of hydrogen embrittlement, for example, hydrogen embrittlement properties of high strength steels and the effects of metallographic structure and hydrogen traps, proposal of evaluation methods for hydrogen embrittlement property for some specific steel and for parts with specific shape, development of novel hydrogen visualization techniques.

Institute for Materials Research
AKIYAMA, Eiji, Professor Doctor of Science

[Hydrogen energy]

Development of Sustainable Integrated Multiphase Energy System

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Features
Our laboratory is focusing in the development of innovative multiphase fluid dynamic methods based on the multiscale integration of massively parallel supercomputing and advanced measurements, and research related to creation of environmentally conscious energy systems. Furthermore, we promote basic research for the creation of risk management science and associated new multiphase flow system directly linked to sustainable energy represented by a high-density hydrogen storage technology.

Targeted Application(s)/Industry
P2P Hydrogen supply chain, Elastohydrodynamic lubrication, Supercomputing of Laser melting and sputter particle formation, High pressure diecast computing / Automotive industry, Additive manufacturing

Institute of Fluid Science
ISHIMOTO, Jun, Professor Doctor of Engineering

[Hydrogen Production]

Development of Solid-State-Ionics Materials for Energy Conversion, Storage and Utilization

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Features
Our focus is on the development of solid-state-ionics materials to be used for a variety of energy conversion systems. To further improve the performance of fuel cells and lithium batteries, novel ionic conductors and mixed conductors with high ionic conductivity and chemical stability are highly demanded. We have been developing such the materials based on defect chemistry and thermodynamics of ceramics, and trying to apply those materials to actual energy conversion devices.

Targeted Application(s)/Industry
To date, a hydrogen production system utilizing oxygen permeable membranes and an all-solid-state battery have been prepared.

Department of Materials Science, Graduate School of Engineering
TAKAMURA, Hitoshi, Professor Doctor of Engineering

[Hydrogen Storage]

“HYDRIDE" Researches for Energy Applications

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Features
This group is engaged in basic and applied researches of "hydrides" for practical use in hydrogen energy system. The main subject is the exploration of advanced hydrogen storage materials which support hydrogen energy technologies such as fuel cells. Currently, we synthesize a wide variety of novel hydrides composed of lightweight metals with specific nano-structures using advanced techniques for crystal and electronic structure analyses. In addition to the hydrogen storage, we develop the wide research fields related to hydrides, such as fast lithium ionic conductors.

Targeted Application(s)/Industry
Besides the contributions in industrial progress through the material development for future hydrogen energy system and next-generation secondary battery, we positively provide technical assistance to organizations and companies concerned about our findings.

WPI Advanced Institute for Materials Research /Institute for Materials Research
ORIMO, Shin-ichi, Professor

Synthesis of Novel Nano-Carbon Materials Using Nano-Space as a Reaction Field

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Features
We are designing and developing novel nanocarbon materials together with their hybrids by controlling the reaction nano-fields for the syntheses of these materials. One example is fully tailored carbon nanotubes with uniform diameter and length. Another noteworthy material is zeolite-templated carbon which has structure regularity like zeolite and a surprisingly large surface area up to 4000 m2/g. In addition, we have recently developed a method for a complete coating of the entire surface of mesoporous silica with graphene layers.

Targeted Application(s)/Industry
We are trying to apply these unique nanomaterials to electronic device, electrochemical capacitors, lithium-ion batteries, hydrogen storage, biosensors and capsules for drug and gene delivery. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Institute of Multidisciplinary Research for Advanced Materials
KYOTANI, Takashi, Professor Doctor of Engineering

[Hypertrophy]

Development of Grass-field Shorthorn Cattle and it's Innocative Green-Technology for Sustainable and Improving Beef Production

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Grass-field Shorthorn Cattle(trademark registration No. 5270386 Fig.1)that possess a loss of functional myostatin result in the double-muscled phenotype with generalized hyperplasia and hypertrophy of the muscle. The cattle were developed form Japanese Shorthorn Cattle, and have superior carcass characteristics including a larger proportion of muscle (about 50% more muscle mass than normal-muscled cattle), lower proportions of fat and more tender meat (Fig. 2). The increased lean beef production shows that Grass-field Shorthorn Cattle are estimated to be a hopeful breed as meat cattle in days to come. Therefore, we are studying the further development of Grass-field Shorthorn Cattle and it’s whole mechanisms of increased muscle muss (Fig.3) as a new breed to reduce the environmental loading on beef production. The goal of our research is to establish innovative Green-Technology for sustainable and improving beef production of GSC and to utilize them for practical use.

Graduate School of Agricultural Science
ASO, Hisashi, Professor Doctor of Medicine

[Hypoxia-Inducible Factor alpha, HIF-a]

Development of PHD-Targeted Drug for Ischemic Injury

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Features
All the living organisms generate energy from molecular oxygen to maintain their own lives. Once the concentration of oxygen falls down, life activity gets severely hampered and it could sometimes cause death. Typical examples that are related to local hypoxia are ischemic heart disease, stroke and kidney disease.
We focus on the function of prolyl hydroxylase (PHD) as a sensor to detect the hypoxia, and we are developing drugs to treat ischemic injury by controlling hypoxia.

Targeted Application(s)/Industry
Currently, we have several compounds that inhibit the PHD. We want to commercialize in conjunction with pharmaceutical companies in Japan and overseas, advancing our non-clinical studies for clinical development.

Division of Molecular Medicine and Therapy, United Centers for Advanced Research and Translational Medicine (ART), Graduate School of Medicine
MIYATA, Toshio, Professor M.D., PhD