Tohoku University. Research Profiles

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Sorted by Keyword - 1714 word(s), 315 profile(s)

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[ABC transporter]

Regulation of ABC Transporters in Colorectal Cancer

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Features
Colorectal cancer (CRC) is one of the most common types of cancer worldwide. Surgical resection is the only curative treatment available for primary CRC. We determined the gene expression profiles for ATP binding cassette (ABC) transporters by RNA sequencing in matched colon cancer and normal colon tissue specimens in order to provide insight into the regulatory mechanisms underlying expression of transporters related to colon carcinogenesis. The expression of ABCC3 was repressed by Wnt signaling pathway, suggesting downregulation of ABCC3 might contribute oncogenesis.

Targeted Application(s)/Industry
Recently, we easily obtain comprehensive data including transcriptome and other omics data. These data are expected to help find a target for drug development, expecting that pharmaceutical industry interpret and extract new knowledge from them.

Graduate School of Medicine
NAKAYAMA, Keiko, Professor Medical Doctor

[Acoustic reconance]

Dry-Contact Ultrasonic Technique

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A new dry-contact technique for transduction of broadband, high-frequency ultrasound via a solid layer inserted between water and the sample, whereat the pressure of about 0.1 MPa is applied at the layer/sample interface by evacuating air between them, has been developed (JP patent No. 3709559). Based on the technique, acoustic imaging of an electronic package is realized under the dry environment (Fig. 1). Typically, the polymer films are used as the intermediate layer for water protection of the sample, and by utilizing the acoustic resonance phenomenon among water, film and the sample, higher quality acoustic image of the testing sample than that for the water immersion case can be recorded without getting the sample wet (Fig. 2). Moreover, thin materials, e.g., polymer film (Fig. 3), etc. can be characterized by analyzing the acoustic resonance phenomenon among the three media (JP Patent No. 4403280). We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Graduate School of Engineering
TOHMYOH, Hironori, Associate Professor Doctor of Engineering

[Acoustic resonator]

MEMS/Micromachines and Microfabrication Technology

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Features
We are studying MEMS (Micro Electro Mechanical Systems) and related technologies, which are typically used for the input/output of information/communication devices, the safety of automobiles etc. Our representative topics include integrated sensors, piezoelectric devices, RF MEMS, micro energy devices and wafer-level packages. Our facilities are open-accessible and well equipped with a lot of tools for lithography, dry/wet etching, thin film deposition, wafer bonding, device mounting and evaluations, which can be operated by each researcher. Using these tools, a variety of MEMS are being prototyped. Also, new microfabrication tools are being developed by ourselves.

Targeted Application(s)/Industry
We are collaborating with many companies, from which visiting researchers are dispatched to our laboratory. We also accept companies which want to just use specific tools in our facilities. Consultation is always welcome.

Department of Bioengineering and Robotics, Graduate School of Engineering
TANAKA, Shuji, Professor Doctor of Engineering

[Actuator]

MEMS/Micromachines and Microfabrication Technology

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Features
We are studying MEMS (Micro Electro Mechanical Systems) and related technologies, which are typically used for the input/output of information/communication devices, the safety of automobiles etc. Our representative topics include integrated sensors, piezoelectric devices, RF MEMS, micro energy devices and wafer-level packages. Our facilities are open-accessible and well equipped with a lot of tools for lithography, dry/wet etching, thin film deposition, wafer bonding, device mounting and evaluations, which can be operated by each researcher. Using these tools, a variety of MEMS are being prototyped. Also, new microfabrication tools are being developed by ourselves.

Targeted Application(s)/Industry
We are collaborating with many companies, from which visiting researchers are dispatched to our laboratory. We also accept companies which want to just use specific tools in our facilities. Consultation is always welcome.

Department of Bioengineering and Robotics, Graduate School of Engineering
TANAKA, Shuji, Professor Doctor of Engineering

Design, fabrication and test of high performance miniaturized sensor and actuator systems

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Features
Micro and nano electro-mechanical systems (MEMS/NEMS) have completely changed human society in the past decades. Many devices that are taken for granted these days like smart phone, future car and drone would be unthinkable without them.
The integration of various new kinds of materials, such as metallic glass and nanostructures into micro technologies allows us to create devices with novel performance and characteristics; examples include acoustic sensors and actuators, thermoelectric generators and wafer level packages.
In collaboration with partners inside and outside Tohoku University, technologies are being developed that can be transferred to industry ranging from material integration and processes to packaging and reliability.

Targeted Application(s)/Industry
Wide collaboration in Microsystem technology is possible. We develop, implement and optimize processes, devices and systems until they are ready for use, keeping in mind reliability, yield and other important features for commercialization. We work with also with partners, such as Fraunhofer. Flexible interlinking of expertise and capacities with other research groups enables us to meet broad project requirements and create complex system solutions.


Advanced Institute for Materials Research
FROEMEL, Joerg, Associate Professor Doctor of Engineering

[Additive manufacturing]

Additive Manufacturing of Metallic Parts with Electron Beam Melting (EBM)

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Features
Electron beam melting (EBM) is a type of additive manufacturing technologies. EBM uses electron beam as an energy source to melt metal powder and produce metal thin layers. This sequence is repeated in a layer-by-layer manner to fabricate three-dimensional (3D) components.
This technology can produce any kinds of structures based on 3D CAD models and is suitable for custom-made manufacturing.
In addition, our recent studies revealed that the unique microstructure, such as directional solidification and uniform dispersions of fine precipitates, are obtained by EBM; this technology is useful to realize advanced materials that cannot be obtained conventional manufacturing.

Targeted Application(s)/Industry
The EBM technology has received much attention for producing metal parts used in biomedical, aerospace and automotive industries.
Rapid prototyping / rapid tooling is one of the applications of this technology.

Institute for Materials Reserach
CHIBA, Akihiko, Professor PhD

[Advanced Brain Science]

Resarch and development for maintaining and improving brain and mental health

The Smart Aging International Research Center (SAIRC) was founded on 1 October 2009. This Center proposes the creation of a new field to produce well-rounded personnel who have gained “totally comprehensive intelligence” from their experience, in order to cope with various problems associated with the diverse and complex super-aging society. To this end, the Center will promote interdisciplinary cooperative research, international collaborative research projects, and research collaborations with industry, as well as disseminate and exchange information by holding international conferences and symposia.  The SAIRC is designed to develop an approach for maintaining and improving brain and mental health in a diverse and complex society from the standpoints of brain science, with the aim of maintaining and improving brain functions; cognitive neuroscience and psychology, with the aim of maintaining a healthy and tranquil state of mind at each aging stage; and philosophy, phenomenology and ethics that provide a radical reconsideration of the concept of the “mind.” We welcome collaborative researches with companies, and academic consultations.

Institute of Development, Aging and Cancer
KAWASHIMA, Ryuta, Professor Doctor of Medicine

[Advanced Functional Electronic Devices]

IVR (Interventional Radiology) Treatment of Hypertention: Minimally Invasive Treatment of Primary Aldosteronism Based on the Adrenal Vein Sampling Technology

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Features
Primary aldosteronism is a leading cause of secondary hypertension accounting for approximately 10 % of hypertensive patients; 4 million patients potentially exist in Japan. We aim to optimize the method of ablating aldosterone producing adenoma using newly developed bipolar radiofrequency ablation system with 300-400kHz high-frequency current and electric power of 40W (Celon Prosurge Applicator), and establish a less invasive interventional radiological treatment of primary aldosteronism.

Targeted Application(s)/Industry
Collaboration with medical equipment manufacture and universities are expected to develop new devices enabling ablation of aldosterone producing adenoma. Flexible guide-wire-type ablation system and rapid aldosterone assay system should be co-developed to tread aldosterone producing microadenoma which is difficult to detect due to its small diameter of less than 5mm.

Graduate School of Medicine
TAKASE, Kei, Professor MD, PhD

[Affective processing]

Multimodal Affective Processing

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Features
We have investigated main three dimensions underlying human affective processing. Our neuro-imaging studies have found that the Evaluation dimension is related to the orbitofrontal cortex, the Activity to the auditory association areas, and the Potency to the somatosensory and motor areas.
We have also developed a new method, Modality Differential Method, useful for analyzing human affective processing in relation to the multimodal sensory processing.

Targeted Application(s)/Industry
Our study can be applicable to assess various problems and disorders in emotion, affection, and cognition by profiling the individual characteristics on the three main dimensions. The findings revealed by our method can be useful and supportive for promoting mental well-being.

Graduate School of Arts and Letters
GYOBA, Jiro, Professor PhD

 a

[acceleration sensor]

Assessment of Physical Activities Using Wearable Sensors

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Features
Maintaining appropriate amount of physical activity is essential for health and disease prevention. Gait is the most common type of physical activity in everyday life. Monitoring the amount of physical activity in everyday lives may benefit mainly those who are at threat of metabolic syndrome and overweight. Towards better estimation of the amount of physical activity utilizing wearable sensors, we focused on taking running and walking economy into account. The relationship between step length and oxygen uptake was first determined. Step length estimation with moderate accuracy was accomplished using acceleration signals during walking. Step length was then taken into energy expenditure calculation as one of the variables.

Targeted Application(s)/Industry
Together with the basic version of the current locomotion monitoring system capable of counting staircase climbing up & down, we managed to upgrade our locomotion monitoring system into 3 dimensional.

Graduate School of Biomedical Engineering
NAGATOMI, Ryoichi, Professor

[access control]

Network Roaming System with Flexible Access Control

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Features

The laboratory works on development of authentication wireless LAN systems which refer user attribute to realize flexible access control capability.Improvement and evaluation of new access control is devised based on experience of operation of an international wireless lan roaming service ‘eduroam' which is based on 802.1x authorization protocol.


Targeted Application(s)/Industry

The development contains application of OpenFlow technology to select a connecting network depending on user affiliation, as well as access control based on pre-defined attribute information.

Cyberscience Center
SONE, Hideaki, Professor PhD

[acoustic power]

Understanding and application of thermoacoustic phenomena

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Features
Acoustic oscillations of a gas column in narrow flow channels can lead to various thermal phenomena such as production and amplification of acoustic power from heat and generation of low temperatures. We aim at understanding these thermoacoustic phenomena from experimental point of view, and developing heat engines that can operate without any moving parts like solid pistons.

Targeted Application(s)/Industry
Acoustic prime mover can use various heat sources like industrial waste heat and sunlight. Acoustic cooler is a Helium-gas based heat pump that needs no Freon gases as a coolant.

Graduate School of Engineering
BIWA, Tetsushi, Professor Doctor of Engineering

[acoustics]

Three Dimensional (3D) Sound Sensing and Synthesis Technologies

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Features

We are developing high-definition 3D sound-filed acquisition sensing systems as well as 3D auditory displays based on our scientific knowledge of humans' 3D spatial hearing processes.
Sensing systems: (1) Sensing systems with two-microphone inputs which can enhance a target sound of a specified direction while preserving perceptual cues for binaural hearing, (2) Sensing system with a lot of microphones which can realize the precise and comprehensive acquisition of 3D sound field information.


Targeted Application(s)/Industry

Our technologies can be directly applied to high-definition communications, broadcasting, and comprehensive recording of sound spaces such as music performances in music halls as well as to sound-space surveillances, hearing-aid systems. Moreover, they may be applied in various applications in Kansei engineering, tele-existence, tele-works, and tele-medicine fields.

Research Institute of Electrical Communication
SUZUKI, Yoiti, Professor Doctor of Engineering

[adhesion to human colon]

Reserach on Cell Surface Lectin of Lactic Acid Bacteria and their Interaction with Human Colon Mucin

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Features
We first proposed the selection method (screening method) for probiotics such as lactic acid bacteria (LAB) and/or Bifidobacteria to human colon mucin by using a biosensor Biacore. We first discovered LAB with high adhesion to human ABO blood type antigen. We also discovered several adhesin such as surface layer protein, GAPDH, transporter protein, etc.

Targeted Application(s)/Industry
We are expecting the exclusion of harmful bacteria which may be the cause of UC and CD of IBD by using such LAB in the near future.

Graduate School of Agricultural Science
SAITO, Tadao, Professor Ph.D.

[adipose tissue]

INSTRUMENT AND METHOD FOR ANALYZING METABOLIC CONDITION OF LIVING BODY AND RECORDING MEDIUM

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AIMS: The invention is to analyze metabolic condition, especially in oxygen consumption and energy production in the adipose tissues of human (Patent: JP 3848818).
PROBLEM TO BE SOLVED: To provide an instrument and method for analyzing the metabolism condition of a living body which is constructed in such a manner that it can measure the metabolism condition of a living body correctly and easily, and a recording medium.
SOLUTION: A metabolism condition analyzer is provided with an input means for inputting information about the body of a subject, a control means for processing this information and an output means for outputting results of the processing. The information consists of name, age, sex, race, height, weight, bioelectric resistance value and the date and time of measurement. A data file consisting the control means stores evaluation data of a metabolic condition which is previously determined by medical judgment based on a combination of an internal respiration index and oxygen consumption and energy production in adipose tissues. These are computed by calculating the value obtained by subtracting one from a body density calculated from the height, weight of the subject and the bioelectric resistance value and then multiplying the value. Welcome to your investment or co-operation.

Department of Diabetes Technology, Graduate School of Biomedical Engineering
NONOGAKI, Katsunori, Professor MD, PhD

[adsorption/desorption]

Selective recovery of tocotrienol from vegetable oils using ion-exchange resins

Features
Tocotrienol, one of vitamin E, has recovered by the conventional method with molecular distillation from deodrizer distillate discharged from the oil refining processes. However, tocotrienol easily loses its activity due to its low thermal stability, so that its recovery ratio and purity were extremely low. We proposed a novel method to selectively recover tocotrienol by adsorption/desorption using anion-exchange resin at 50 degree C. Tocotrienol is retained on the resin by ion-exchange reaction, and then released and recoverd from the resin by other ion-exchange reaction. Prior to the adsorption/desorption, free fatty acid, a major component of the feed, should be removed by esterification using cation-exchange resin at 50 degree C.

Targeted Application(s) / Industry
This innovative technology succeeds in solving the serious problems in the current tocotrienol production, the large weight loss due to the thermal decomposition and large amount of remaining impurities. This technology applies to the production of not only tocotrienol but also tocopherol as bioactive compounds s in food chemicals.

Graduate School of Engineering
SHIBASAKI-KITAKAWA, Naomi, Professor Doctor of Engineering

[aging]

Visualization of Biological Microstructure with High Frequency Ultrasound and Photoacoustic Imaging

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"Features"
High-resolution imaging of biological tissue is non-invasively obtained with high frequency ultrasound. We have developed some ultrasound microscope systems which realized the resolution of 15-micron with 100 MHz and resolution to visualize a single cell with GHz range ultrasound. Ultrasonic imaging provides not only tissue morphology but also information on tissue elasticity. Recently, we have developed a real-time three-dimensional photoacoustic imaging system for visualization of subcutaneous micro vasculature and oxygen saturation.
"Targeted Application(s)/Industry"
High frequency ultrasound and photoacoustic imaging is repeatedly and non-invasively applied for early diagnosis of atherosclerosis, skin aging and tissue metabolism. They are useful for efficacy assessment of cosmetics and pharmaceuticals. High frequency ultrasound is also applied in the industrial areas where thickness measurement of opaque film or bilayer thin coating with the precision of 0.1 micron is required.

Biomedical Imaging Laboratory, Graduate School of Biomedical Engineering
SAIJO, Yoshifumi, Professor PhD (Medicine)

Brain Development and Aging Using Large Brain MRI Database

Features
We have revealed relationships among brain structure, brain function, lifestyle, genetic factor, and cognitive function using brain magnetic resonance imaging (MRI) database. The goal of our project is to prevent several diseases and disorders such as dementia by performing personalized medicine using the large brain MRI database.

Targeted Application(s)/Industry
Our research is related with several industrial fields such as food, sleep, and other lifestyle industries. In addition, our research is also related with medical field such as preventing medicine and brain check-up.

Institute of Development, Aging and Cancer
TAKI Yasuyuki, Professor Ph.D.

Economics of Aging

Features
I investigate on the economics of aging, the optimal social welfare policy, low fertility and so on not based on the historical and systematic approach but based on the neo-classical economic theory. I also use econometric method and statistical approach. I often estimate the future projections of the population, public finance, magnitude of private markets, the results of public policies.
I also research on the comparative studies on East Asia (Japan, China, Korea, Taiwan) and European (especially Scandinavian countries). I provide statistic data and information on the economic and political systems on the aging in Japan.

Targeted Application(s)/Industry
The future estimation on the financial status , market caused by low fertility and aging. The effective management of the medical institutions, social welfare systems, gender equality societies for the central and local government, research institutions, public enterprises, and financial Institutions.

Graduate School of Economics and Managemant
YOSHIDA, Hiroshi, Professor

[aging care]

The Novel Ultrasound Irradiation Device

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Features
Dr. Katsunori Nonogaki has developed the novel ultrasound irradiation device, which can improve the autonomic nervous system activity and peripheral circulation. In addition, the ultrasoud device can improve hypertension and hyperglycemia within 20 min in subjects with drug-resistant hypertension and diabetes. Our initial device was approved in Japan (226AIBZX00028000). This device will be avaliable for the treatment of 1) muscle pain, 2) the autonomic neural dysfunction and stress-related disorders, 3) hypertention, and 4) diabetes. Moreover, the device will be usefull for your healthy life and aging care.

Targeted Application(s)/Industry
Our aims are to export the device internationally. We seek the investment and international business partners.

Department of Diabetes Technology, Graduate School of Biomedical Engineering
NONOGAKI, Katsunori, Professor MD, PhD