"Y" Researcher - 27 Result(s)

Y

 Y

Regulation of Angiogenesis

NEXT
PREV
特徴・独自性
  • Angiogenesis, i.e., the formation of new capillaries, takes place under pathophysiological conditions including cancers, ocular neovascular diseases and atherosclerosis. Anti-angiogenic drugs have been developed, and are now in clinical use. However, because of side effects due to the damage to vascular endothelial cells, the development of anti-angiogenic drugs with different modalities is anticipated. We have isolated vasohibin-1 (VASH1) as a novel angiogenesis inhibitor expressed by endothelial cells (ECs), and vasohibin-2 (VASH2) as its homologue having pro-angiogenic activity.
実用化イメージ

We are planning to develop strategies of VASH1 potentiation and VASH2 inhibition. For VASH1 potentiation, we are planning to use recombinant VASH1 protein or search low molecular weight substances having VASH1 like activity. For VASH2 inhibition, we are succeeded in the development of neutralizing anti-human VASH2 monoclonal antibody.

Researchers

New Industry Creation Hatchery Center

Yasufumi Sato

Business Administration and Corporate Social Responsibility

NEXT
PREV
特徴・独自性
  • My research areas are primarily business ethics, nonprofit organization (NPO) and business and society. I have explored these fields in epistemological, ethical, or managerial approaches from various theoretical points of view. Some of themes that I study now are on how companies should recognize ethical issues on a cognitive formed framework or how companies should create a dialogue between the company and stakeholders (consumers and employees, etc.) through PL (product liability) or labor litigation process.
実用化イメージ

I have also experiences in engaging with a domestic manufacturer in developing their PL cases and training programs as well as stating third-party opinions in CSR reports issued by a local power company. I am willing to give you any knowledge of these areas.

Researchers

Graduate School of Economics and Management

Yasunari Takaura

Development of High Sensitive Magnetic Sensor Operating at Room Temperature with Tunnel Magnetoresistance Devices

NEXT
PREV
特徴・独自性
  • Recently, many tunnel magnetoresistance devices with high magnetoresistance effect are reported. These are expected to be applied to high sensitive magnetic sensors. There are many magnetic sensors with variety of the mechanism, in order to meet the demand of the very wide range of sensing magnetic field. However, there is no magnetic sensor which has high sensitivity, easy to use, operation at room temperature and low cost. Only a magnetic sensor with tunnel magnetoresistance devices can satisfy all the demand in principle. As the device has very wide range of the sensing magnetic field, it can be designed for any demand to the sensors.
実用化イメージ

For example, this device can sense a bio-magnetic field easily at room temperature, so that it could be replaced SQUID device, which is popular now but is very expensive and not easy to use personally. Therefore, by using this device, we expect we can conduct effective collaborative research in medical field.

Researchers

Graduate School of Engineering

Yasuo Ando

Analysis and Function Elucidation of Fine Clusters and Defects in Materials Invisible by Electron Microscopy

NEXT
PREV
特徴・独自性
  • It is well known that nano-scale impurity/solute clusters, defects, defect clusters and their complexes affect the mechanical and electrical properties in materials. However, it is very difficult to observe these objects even by state-of-the-art electron microscopes. We overcome the difficulty by employing noble two techniques: laser three-dimensional atom probe (3D-AP) technique and positron annihilation spectroscopy (PAS). Laser 3D-AP can map out each atom in various materials (metals, semiconductors, insulators) in three-dimensional real space with nearly atomic scale resolution. PAS can detect vacancy-type defects and defect-impurity complexes very sensitively.
実用化イメージ

By combining these methods, we are going to reveal the functions of the fine impurity clusters and defects to the materials: developments of new nano-structured materials, the mechanism of degradation of aged structural materials, the fall in the yield of semiconductor device production, and developments of quantum devices etc.

Researchers

Institute for Materials Research

Yasuyoshi Nagai

Prediction and evaluation of future thermal and wind environments based on CFD, and planning of urban environments adaptable to future climate

NEXT
PREV
特徴・独自性
  • Numerical simulations of the physical environment of urban outdoor spaces are conducted to predict the physical environment, such as temperature, humidity, wind, and pollutant concentration, and field measurements are conducted to understand the actual physical environment. In addition, the future outdoor environments and heat stroke risks due to global warming are predicted and evaluated.
    Furthermore, the impacts of urban morphology (building shape and layout, street trees, etc.) on the adaptation to severe heat in summer and rare typhoons and floods are evaluated quantitatively.
実用化イメージ

Numerical analysis is used to quantitatively evaluate the "merits and demerits" of designing buildings, planning city blocks and urban areas, and introducing various heat control technologies on the wider thermal environment and the formation of wind ventilation paths, as well as the adverse effects of typhoons and other disasters. The materials for making decisions on whether or not to introduce these technologies are provided.

Researchers

Graduate School of Engineering

Yasuyuki Ishida

Brain Development and Aging Using Large Brain MRI Database

NEXT
PREV
特徴・独自性
  • We have revealed relationships among brain structure, brain function, lifestyle, genetic factor, and cognitive function using brain magnetic resonance imaging (MRI) database. The goal of our project is to prevent several diseases and disorders such as dementia by performing personalized medicine using the large brain MRI database.
実用化イメージ

Our research is related with several industrial fields such as food, sleep, and other lifestyle industries. In addition, our research is also related with medical field such as preventing medicine and brain check-up.

Researchers

Smart-Aging Research Center

Yasuyuki Taki

Colorful titanium oxide pigments without transition metals

概要

Colorful TiO2 Particle
https://www.t-technoarch.co.jp/data/anken_en/T19-849.pdf

従来技術との比較

Transition metal compounds are known to exhibit a wide variety of colors. Until now, it has been possible to color white titanium oxide by doping with transition metal ions, but it is difficult to avoid biotoxicity derived from transition metals.

特徴・独自性
  • In the present invention, titanium oxide inorganic pigments that do not contain transition metals and have various colors such as white, yellow, red, gray, green, purple, black, and skin color have been realized.
実用化イメージ

New applications of titanium oxide pigments are expected in the cosmetics field, where biotoxicity is an issue.

Researchers

Institute of Multidisciplinary Research for Advanced Materials

Yin Shu

Minimally Invasive Medical Devices and Healthcare Devices Using Micro/Nano Machining Technology

NEXT
PREV
特徴・独自性
  • Medical devices and healthcare devices which have several functions with small size have been developed using precise micromachining technology and MEMS (Microelectromechanical systems) technology. More precise and safe diagnostics and therapy, as well as novel diagnostics and treatment can be realized by developing high-functionalized endoscopes and catheters and developing novel medical devices. Healthcare without restriction of location and time is aimed by developing thin, light and high-functionalized new healthcare devices.
実用化イメージ

Besides of basic research, we are working in cooperation with clinicians and medical device companies for practical use. We founded a university-launched venture company for bridge-building between university and company and collaborative researches have been performed.

Researchers

Graduate School of Biomedical Engineering

Yoichi Haga

Development of Miniature and Highly-Functional Photonic Devices Using Ultrafine Microstructures

NEXT
PREV
特徴・独自性
  • In our laboratory, miniature and highly-functional photonic devices based on new optical phenomena caused by the interaction of ultrafine microstructures with light have been studied. In addition, development of new production technology to overcome the problems that have been obvious from the practical application viewpoint of nanophotonic devices has been performed.
    • -Main research topics--
    MEMS tunable metamaterials for optical control.
  • Structural color filters using subwavelength gratings for the applications of display and spectroscopic analyzers.
  • Surface-smoothing technology using surface self-diffusion.
  • Study of low loss silicon nanophotonic devices.
実用化イメージ

We aim to realize optical filters, optical resonators, and color filters, by using above technologies. Also, development of nano-photonic elements fabricated by a nanoimprint technology has been progressed.
We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Researchers

Graduate School of Engineering

Yoshiaki Kanamori

Interactive Content to Enrich Our Lives

NEXT
PREV
特徴・独自性
  • (1) Displays and Interactive Techniques
  • Designing original display systems to show visual information accurately and effectively, and interaction techniques to make better use of these display systems.
  • (2) Interactive Video Content
  • Creating new interactive content from real video taken by cameras and computer-generated animations.
  • (3) Modeling and Controlling the “Atmosphere” in a Conversation Space
  • Aiming to stimulate the “atmosphere” in a conversation space by supplying real-time feedback to the users, we are exploring means of sensing and analyzing change in the space.
  • (4) Designing and Evaluating Novel Interaction Techniques
  • Designing and evaluating novel interaction techniques on target selection for variety types of displays including large and touch displays.
実用化イメージ

Researchers

Research Institute of Electrical Communication

Yoshifumi Kitamura

Visualization of Biological Microstructure with High Frequency Ultrasound and Photoacoustic Imaging

NEXT
PREV
特徴・独自性
  • "Features"
  • High-resolution imaging of biological tissue is non-invasively obtained with high frequency ultrasound. We have developed some ultrasound microscope systems which realized the resolution of 15-micron with 100 MHz and resolution to visualize a single cell with GHz range ultrasound. Ultrasonic imaging provides not only tissue morphology but also information on tissue elasticity. Recently, we have developed a real-time three-dimensional photoacoustic imaging system for visualization of subcutaneous micro vasculature and oxygen saturation.
  • "Targeted Application(s)/Industry"
  • High frequency ultrasound and photoacoustic imaging is repeatedly and non-invasively applied for early diagnosis of atherosclerosis, skin aging and tissue metabolism. They are useful for efficacy assessment of cosmetics and pharmaceuticals. High frequency ultrasound is also applied in the industrial areas where thickness measurement of opaque film or bilayer thin coating with the precision of 0.1 micron is required.
実用化イメージ

Researchers

Graduate School of Biomedical Engineering

Yoshifumi Saijo

Brainmorphic Computing Hardware

NEXT
PREV
特徴・独自性
  • We will develop a brainmorphic computing hardware, which realizes the brain-specific functions such as conscious/sub-conscious process, self, selective attention, and so on, by directly using inherent physics and dynamics of constituent devices. The resulting hardware would be small, efficient, high-performance. Some examples include the chaotic neural network reservoir, optimization through high-dimensional complex dynamics, and neural network composed of spin-orbit torque nano-devices.
  • The resulting hardware is suitable for the edge AI which learns users’ personal behavior. Examples include watching service devices embedded in hearing aids or dental implants, which monitor and learn personal cardiac and brain-wave signals or saliva ingredients, to detect abnormal situations.
実用化イメージ

Edge AI devices, especially for peri-personal space), Time-series processing (prediction, recognition, and categorization), Online real-time learning.

Researchers

Research Institute of Electrical Communication

Yoshihiko Horio

High-Precision Capturing of 3-D Dental-Arch Shapes and Their Occlusal Relation and its Potential Implementation into CAD/CAM Dentistry

NEXT
PREV
特徴・独自性
  • In spite of the long history of digital dentistry, the accuracy of the prosthetics fabricated with CAD/CAM systems is far from satisfactory. Jaw opening during taking impression elicits deformation of the mandible and the lower dental arch, and consequently causes the inaccuracy of occlusal relationship of the upper and lower dental arches on the CAD data. The method presented here utilizes the check-bite record at the maximum intercuspation to correct the relative positions among the teeth in the dental arches as well as between the arches. After this correction, the accuracy of the CAD data is satisfactory enough for the fabrication of the dental prosthetics which need no adjustment during their setting.
実用化イメージ

This method uses the newly-developed check-bite recording technique together with the conventional precious impression or optical impression techniques. It can easily be applied to the commercial CAD/CAM systems in the market. We hope to collaborate to the manufacturers of dental CAD/CAM systems to increase the accuracy of the systems.

Researchers

Graduate School of Dentistry

Yoshinori Hattori

Transport Control of Semiconductor Quantum Structures and Highly Sensitive NMR

NEXT
PREV
特徴・独自性
  • Highly-sensitive NMR technique has been developed by manipulation polarization of nuclear spins via control of transport characteristics in GaAs and InSb quantum structures. This highly-sensitive NMR can be applied to two-dimensional and nanostructures. Furthermore, ideal gate controllability has been demonstrated in InSb quantum structures with Al2 O3 dielectrics. More importantly, the concept of generalized coherence time was introduced, where noise characteristics felt by nuclear spins can be measured including their frequency dependence. This concept will bring about a change in all nuclear-spin related measurements.
実用化イメージ

Next generation InSb devices based on good gate controllability. Various nuclear-spin based measurements and NMR utilizing the concept of generalized coherence time. Highly-sensitive NMR is now important for fundamental physics studies. In the future, it will contribute to quantum information processing.

Researchers

Center for Science and Innovation in Spintronics

Yoshiro Hirayama

Vacuum Engineering of Solid-Liquid Interfaces and its Process Applications

NEXT
PREV
特徴・独自性
  • We challenge to fabricate in vacuum-stabilized micro/nano-scale liquid materials, explore their novel chemicophysical properties and develop their vacuum processing applications. The representative examples include ultra thin film ionic liquid on the nanometer scale and advanced vapor-liquid-solid growth (VLS) of inorganic/organic materials, such as 4H- and 3C-SiC films, single crystal pentacene and a porous polymer film of plolythiophene.
実用化イメージ

Our research outcomes will contribute to the following research and development:
1) a next-generation semiconductor process with the merits of the wet process
2) a new purification process of organic semiconductors, by which some part of inorganic semiconductor materials would be replaced in response to the present world-wide shortage of semiconductors.

In addition, the consultation of how to use our ionic liquid-assisted vapor growth method in attempt to obtain organic single crystals is welcome.

Researchers

Graduate School of Engineering

Yuji Matsumoto

Development of Optical Sysytems for Noninvasive Treatment and Diagnosis

NEXT
PREV
特徴・独自性
  • Optical fiber-based endoscopic systems for non-invasive treatment and diagnosis are developed. The fiber transmits high-powered laser light for treatment and low-powered light for diagnosis. We develop treatment and diagnosis systems utilizing not only common glass-based optical fibers but hollow-optical fibers. Hollow optical fibers deliver high-powered infrared lasers and light with wide range of wavelength from ultraviolet and far infrared.
実用化イメージ

Our potential collaborators will be medical device manufactures, as well as any electronic device, communication device, and measurement instrument manufactures considering new entry to the field.

Researchers

Graduate School of Biomedical Engineering

Yuji Matsuura

Study on Phase Change Materials for PCRAM Application

NEXT
PREV
特徴・独自性
  • Phase change random access memory (PCRAM) has attracted attention as next-generation non-volatile memories. A conventional PCM is Ge-Sb-Te which shows a fast crystallization speed and an excellent reversibility of phase transition. However, Ge-Sb-Te has a low crystallization temperature of about 150 ºC and a high melting temperature of over 600 ºC , which limits data retention and causes high power consumption, respectively.
  • We have developed a new phase change materials with high crystallization temperature and low melting point such as Ge-Cu-Te etc, which have high potential as PCRAM materials with high thermal stability and low power consumption (Fig.1,2).
実用化イメージ

Our materials are developed for PCRAM, DVD recording materials etc. We hope the collaboration research with companies which are interested in our developed phase change materials.

Researchers

Graduate School of Engineering

Yuji Suto

Development of New Reactions Using Organocatalyst

NEXT
PREV
特徴・独自性
  • Organocatalyst is a synthetically useful catalyst in synthetic organic chemistry, because of the several merits. We have been investigating the development of new and efficient organocatalysts derived from proline. We have already reported the diphenylprolinol silyl ether, which is called as a Jorgensen-Hayashi catalyst, and siloxyproline, which is effective in the presence of water. We have also developed several practical asymmetric catalytic reactions based on the organocatalysts. We also applied these reactions to the total synthesis of natural products and drugs. We have already synthesized Tamiflu in one-pot reaction, and prostaglandin E1 methyl ester via three one-pot procedure.
実用化イメージ

Our newly developed reactions using organocatalysis can be widely used for synthesis of medicines, agrichemicals, and chemical products.

Researchers

Graduate School of Science

Yujiro Hayashi

Generation of Rice Plants Suitable for Biofuel Production

NEXT
PREV
特徴・独自性
  • To generate a rice plant suitable for efficient biofuel production from its straw, we examined effects of overexpression of cellulase on saccharification of straw. The transgenic plant constitutively overexpressing cellulase showed enhanced saccharification, but various physiological and morphological abnormalities were also observed. To overcome this problem, a senescence-inducible promoter was used to express the cellulase. The plants successfully avoided the problem and showed enhanced saccharification after senescence.
実用化イメージ

Rice straw will be an efficient material for biofuel production. This method can be applied to other plants. In combination with highly engineered microorganisms for saccharification and fermentation, this method will contribute to efficient production of biofuels.

Researchers

Graduate School of Agricultural Science

Yukihiro Ito

  • 1
  • 2