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  • Induction of Neural Cells from Human Mesenchymal Stem Cells and their Application to Neurodegenerations

Induction of Neural Cells from Human Mesenchymal Stem Cells and their Application to Neurodegenerations

update:2018-12-17
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Features
Bone marrow stromal cells have great advantages since they are already applied to patients either by auto- or allo-transplantations, can be harvested in large numbers (10 million cells within several weeks) as adherent cells from bone marrow aspirates, and are with low risk of tumorigenesis. We have established a system to induce neural precursor cells from human bone marrow stromal cells by introducing cells with Notch intracellular domain gene plasmid followed by culturing in neurosphere method. This induction system successfully generates neural precursors which were effective for stroke (J. Neuropathol. Exp. Neurol. , 2005; J Cereb Blood Flow Metab, 2009). They could be further developed into dopamine producing neurons by treating them with cytokines including GDNF (J. Clin. Invest, 2004). The efficiency and safety of induced dopamine neurons were confirmed by rat and monkey model of Parkinson's disease. Importantly, long-term survival of auto-transplanted induced dopamine neurons were verified by 11C-CFT PET scan (J. Clin. Invest, 2013).

Targeted Application(s)/Industry
We hope to collaborate with companies and research groups who are willing to utilize our system.

Researchers

Graduate School of Medicine

DEZAWA, Mari , Professor
Doctor of Medicine

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