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Researchers 287 Result(s), Themes 265 Result(s)

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Additive Manufacturing of Metallic Parts with Electron Beam Melting (EBM)

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特徴・独自性
  • Electron beam melting (EBM) is a type of additive manufacturing technologies. EBM uses electron beam as an energy source to melt metal powder and produce metal thin layers. This sequence is repeated in a layer-by-layer manner to fabricate three-dimensional (3D) components.
  • This technology can produce any kinds of structures based on 3D CAD models and is suitable for custom-made manufacturing.
  • In addition, our recent studies revealed that the unique microstructure, such as directional solidification and uniform dispersions of fine precipitates, are obtained by EBM; this technology is useful to realize advanced materials that cannot be obtained conventional manufacturing.
実用化イメージ

The EBM technology has received much attention for producing metal parts used in biomedical, aerospace and automotive industries.
Rapid prototyping / rapid tooling is one of the applications of this technology.

Researchers

New Industry Creation Hatchery Center

Akihiko Chiba

Understanding Biological Control Systems and its Application to Development of Life-Like Resilient Systems

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特徴・独自性
  • In contrast to artificial systems, living organisms exhibit astoundingly adaptive and resilient properties. One of the central research goals in our laboratory is to endow artificial systems with similar properties. To this end, we are particularly focusing on the concept of autonomous decentralized control. We have so far successfully developed various types of robots on the basis of decentralized control, including amoeboid robots, snake-like robots, legged robots etc., in collaboration with mathematicians and biologists.
実用化イメージ

Development of adaptive autonomous robotic system, Control of Large D.O.F. system

Researchers

Research Institute of Electrical Communication

Akio Ishiguro

Development of Novel Scintillator and Piezoelectric Crystals

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特徴・独自性
  • Our research target is mainly focused on the topic of development of novel scintillator crystals, piezoelectric crystals, growth technology, characterization and its device application.
  • We design and synthesize new materials from a view point of Crystal Chemistry, and investigate their structure and physical properties. We also study on photo-detector, as suitable photo-detector fully contribute to get maximum signal from scintillator. This activity is very important to realize practical application of our developed materials. Recently, piezoelectric material and high melting temperature alloy project is also started.
実用化イメージ

For the purpose of "real" contribution to human culture, we are always carrying out our research activity considering the industrial application. This point is unique feature of our attitude toward science.

Researchers

Institute for Materials Research

Akira Yoshikawa

Skeletal Regulation of Energy Metabolism

特徴・独自性
  • This project studies the influence of bone on energy metabolism in the body through health and disease.
実用化イメージ

This project may come up with new tools for metabolic syndrome prediction, therapy and diagnosis .

Researchers

Frontier Research Institute for Interdisciplinary Sciences

Aseel Mahmoud Suleiman Marahleh

Methods to Restore Strelity of Gramineous Plants under High- and Low-Temperature Stress Conditions

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特徴・独自性
  • Plant reproductive development is more sensitive than vegetative growth to many environmental stresses. High-temperature injury is becoming an increasingly serious problem due to recent global warming. In wheat, barley, and other crops, the early phase of anther development is most susceptible to high temperature. Oppositely, grain yields in rice plants are often reduced by exposure to low temperature. Unexpected climate change, such as abnormally hot or cool summer temperatures, have occurred repeatedly during recent years. This method indicates that an appropriate use of specific phytohormones, such as auxin and GA, may promote stress tolerance and adaptation to abiotic stresses.
実用化イメージ

These potentially novel functions of the classical phytohormones will be important sustainable agriculture in the face of global climate change.

Researchers

Graduate School of Life Sciences

Atsushi Higashitani

X-Ray Phase Imaging for High-Sensitive Non-Destructive Testing

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特徴・独自性
  • Conventional X-ray imaging methods that rely on X-ray attenuation cannot generate clear contrast in the observation of low-density materials such as polymers consisting of low-Z elements. However, the sensitivity to the materials can be improved drastically by X-ray phase imaging that detects X-ray refraction caused by the materials. X-ray Talbot or Talbot-Lau interferometry consisting of X-ray transmission gratings is now constructed in laboratories for X-ray phase imaging. X-ray phase tomography is also realized, enabling high-sensitive three-dimensional observation.
  • X-ray phase imaging can be utilized for X-ray non-destructive testing of industrial products and baggage that cannot be checked conventionally.
実用化イメージ

We aim at appending a phase-contrast mode to micro-CT apparatuses and developing screening apparatuses in production lines.

Researchers

Institute of Multidisciplinary Research for Advanced Materials

Atsushi Momose

Functional Uniform Nanoparticles Production and Their Industrial Use

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特徴・独自性
  • Nanoparticles and/or fine particles to be used for functional materials, such as semiconductor, photocatalysts, dielectric and/or piezoelectric materials, cosmetics, catalysts, etc., has been synthesized in liquid-phase. Their size, shape, composition, and structure have been <strong>precisely controlled</strong> along an expected usage. <strong>Tailor-made synthesis method</strong> has been provided for nanoparticles and/or fine particles the companies wish to use.
実用化イメージ

Until now, we have been supplying nanoparticles and/or fine particles of ITO (Indium Tin Oxides) as TCO, Bi based or Nb based particles for lead-free piezoelectric ceramics, perovskite-based oxides for dielectric materials etc. The gel-sol method as the main synthesis method for uniform particles makes the production cost reduced.

Researchers

International Center for Synchrotron Radiation Innovation Smart

Atsushi Muramatsu

Creation of Organic-Inorganic Hybrid Materials and their Application

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特徴・独自性
  • Organicl compounds, such as liquid-crsytals, polymers, etc., can be hybridized with inorganic materials in atomic level, in particuar, with nanoparticles. Both of high effeciency of processing ease for the former and high possibilities of physical properties for the latter can be attained through the complete solution of trade-off characteristics. For example, this atomic-level hybridization technique makes inorganic nanoparticles active for the response like a liquid crystal. By using this method, we expect we can conduct effective collaborative research in medical fields.
実用化イメージ

Researchers

International Center for Synchrotron Radiation Innovation Smart

Atsushi Muramatsu

 C

The Construction of a Decentralized Energy Production System Using Small Methane Fermentation Systems That Utilize Exhaust Heat or Hot Springs and a Local Circulation System

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特徴・独自性
  • In this project, we reduce the costs of energy production via anaerobic digestion by utilizing exhaust heat from a factory, which resulted in a positive energy balance, although the methane fermentation system tested was on a small scale.
  • Using small-scale methane fermentation with a positive energy balance, the initial investment is small, enabling a company to invest in, and install, such a system. This would decentralize energy production within an area. Moreover, this system not only produces energy, but is a basis for resource recycling.
実用化イメージ

Food factory, hotel, restaurant, where food garbage or organic waste was produced much.

Researchers

Graduate School of Agricultural Science

Chika Tada

 D

Gastroenteritis virus-binding enteric bacteria for probiotics

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特徴・独自性
  • We have found enteric bacteria that can capture gastroenteritis viruses, such as norovirus and rotavirus, through histo-blood group antigen (HBGA)-like substances. These HBGA-positive bacteria give a significant impant on the ecology of gastroenteritis viruses in human body and in environments.
実用化イメージ

Since gastroenteritis virus-binding bacteria can affect the viral infection capability to host cells, these bacteria and produced HBGA-like substances are available in probiotics application.

Researchers

Graduate School of Engineering

Daisuke Sano

 E

Development of the next generation anti-HIV agents

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特徴・独自性
  • HIV infection is one of most serious concern in infectious diseases. We will perform anti-HIV assays for unmet medical needs in control of HIV infections with established novel assays. We have developed reverse transcriptase inhibitor that has novel mechanism of inhibition, translocation-inhibition (J Biol Chem, 2009). Dr Kodama participated in the primary screening and development of a new HIV integrase inhibitor, elvitegravir (J Virol 2009), and a unique reverse transcriptase inhibitor, islatravir, which phase III clinical trials by the Merck & Co., Inc. will complete, soon. We have a representative resistant HIV strain-library for anti-HIV screening and several target oriented high through-put screening systems.
実用化イメージ

We can establish high through-put screening for new targets, so please consult with us individually. We are open to joint development requiring BSL3/P3 experimental facilities and academic guidance including other microorganisms.

Researchers

International Research Institute of Disaster Science

Eiichi Kodama

Development and evaluation of various inhibitors and disinfectants for SARS-CoV-2

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特徴・独自性
  • Using the infectious SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2), we are evaluating and developing new therapeutic drug candidates as well as evaluating disinfectants. Further analyses such as mechanism of action and resistance may be applicable. Other pathogens, including influenza virus and drug-resistant bacteria, will be examined upon request and discussion. Through joint and collaborative research with domestic and overseas pharmaceutical companies and related companies, we have experience of their clinical application including basic research.
実用化イメージ

We support development and evaluation of various inhibitors and disinfectants for variants of SARS-CoV-2 as well as wild type.

Researchers

International Research Institute of Disaster Science

Eiichi Kodama

Hydrogen embrittlement of high strength steels

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特徴・独自性
  • We are studying hydrogen embrittlement property of high strength steels from the aspects of both the effect of hydrogen on mechanical properties of high strength steels and hydrogen uptake behavior in corrosive environments. The topics of our study includes clarification of mechanism of hydrogen embrittlement of various steels, investigation of hydrogen entry caused by corrosion using electrochemical techniques, hydrogen visualization, proposing evaluation methods for hydrogen embrittlement property and so forth.
実用化イメージ

Collaborative research in the field of hydrogen embrittlement, for example, hydrogen embrittlement properties of high strength steels and the effects of metallographic structure and hydrogen traps, proposal of evaluation methods for hydrogen embrittlement property for some specific steel and for parts with specific shape, development of novel hydrogen visualization techniques.

Researchers

Institute for Materials Research

Eiji Akiyama

Programming Language Theory and Computation Models

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特徴・独自性
  • Our laboratory conducts leading research on programming language theory and high-level computation models. In particular, we focus on research and application of (general proof methods for) program equivalence, functional programing, and type systems (also known as lightweight formal methods), which are attracting revived interests in recent years. Our Japanese translation of "Types and Programming Languages" (Benjamin C. Pierce, University of Pennsylvania)---compiled in cooperation with engineers from top-level electronics and software companies in Japan---has become the 42nd bestseller (rather exceptional as an academic Publications) among new books in Amazon.co.jp. For more information, please see the Web page: http://www.kb.ecei.tohoku.ac.jp/~sumii
実用化イメージ

Our technology can be used for design and development of software artifacts, especially programming languages and tools including DSL (domain specific languages), as well as application of functional programming, type systems, or formal methods.

Researchers

Graduate School of Information Sciences

Eijiro Sumii

Yeast models of familial Alzheimer disease to screen for gamma-secretase inhibitors and modulators

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特徴・独自性
  • Using the yeast transcriptional activator Gal4 system, we reconstituted the production of amyloid beta (Aβ), responsible for Alzheimer disease. Aβ production could be monitored by the positive growth in the selection media or by the reporter enzyme (β-Gal). Utilizing familial Alzheimer disease mutants, we established a system to screen for mutations and chemicals that modulate gamma secretase activity and reduce toxic Aβ42.
実用化イメージ

Our yeast system can be used to screen for chemicals, natural products, food ingredients, genes, and mutations that modulate γ-secretase activity and block Aβ42 production specifically. We hope to conduct collaboration research with a willing company for a practical application of this technology in industry.

Researchers

Graduate School of Agricultural Science

Eugene Futai

 F

Design, fabrication and test of high performance miniaturized sensor and actuator systems

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特徴・独自性
  • Micro and nano electro-mechanical systems (MEMS/NEMS) have completely changed human society in the past decades. Many devices that are taken for granted these days like smart phone, future car and drone would be unthinkable without them.
  • The integration of various new kinds of materials, such as metallic glass and nanostructures into micro technologies allows us to create devices with novel performance and characteristics; examples include acoustic sensors and actuators, thermoelectric generators and wafer level packages.
  • In collaboration with partners inside and outside Tohoku University, technologies are being developed that can be transferred to industry ranging from material integration and processes to packaging and reliability.
実用化イメージ

Wide collaboration in Microsystem technology is possible. We develop, implement and optimize processes, devices and systems until they are ready for use, keeping in mind reliability, yield and other important features for commercialization. We work with also with partners, such as Fraunhofer. Flexible interlinking of expertise and capacities with other research groups enables us to meet broad project requirements and create complex system solutions.

Researchers

Micro System Integration Center

Froemel Joerg Eckhardt

Development of Intelligent Molecules for the Regulation of Gene Expression in Cells

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特徴・独自性
  • The artificial control of gene expression by synthetic oligodeoxynucleotides (ODNs) has been the subject of considerable interest. In particular, ODNs conjugated with a cross-linking agent have been expected to enhance the inhibitory effect. Recently, microRNAs (miRNA) endogenously expressed small regulatory non-coding RNAs, are recognized as playing a critical role in regulating gene expression and the great concerns have been raised about efficient antisense oligonucleotides against miRNAs. We have already demonstrated that ODNs bearing a 2-amino-6-vinylpurine (2-AVP) derivative exhibited efficient interstrand cross-linking to cytosine selectively. The unique structural features of AVP are to possess both the hydrogen bond donor-acceptor sites as recognition sites and the vinyl group as a reactive moiety in a single molecule. Recently, we have developed of the novel cross-linking agents, which are designed based on the unique structure of AVP. These derivatives can react to thymine at the complementary site with highly selective and efficient under neutral conditions. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.
実用化イメージ

Researchers

Institute of Multidisciplinary Research for Advanced Materials

Fumi Nagatsugi

Performance enhancement and application development of energy harvesting materials by microstructure design

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特徴・独自性
  • To realize IoT society, it is required the sensors, which function without battery charge. We study on energy harvesting materials using our knowledge about materials mechanics and numerical simulation such as finite element method. We recently address to develop energy harvesting devices, which can recovery the unharnessed energy around us as electrical energy.
実用化イメージ

Researchers

Graduate School of Environmental Studies

Fumio Narita

 H

Development of Immunobiotic Evaluation System for Functional Feeds as a Livestock Animal Model

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特徴・独自性
  • Pattern recognition receptor (PRR) family plays an important role in the defense through recognition of pathogen-associated molecular patterns or microorganisms-associated molecular patterns (PAMPs/MAMPs).
  • Some functional feed materials are thought to regulate intestinal immunity by contact and stimulation of epithelial cells and immunocompetent cells via PRRs in the gastrointestinal tract and induction of cytokine production. In this "new world" of feed immunology, however, much remains unknown about the underlying mechanisms of intestinal immunity because of lack of appropriate intestinal immunoassay system for livestock animals.
  • We have advanced application of originally established porcine and bovine intestinal epitheliocytes (PIE, BIE) cell lines (see photo) for evaluation of immunobiotics and immunogenics exerting anti-inflammatory responses both in PIE cell monolayer and co-culture system with porcine peyer's patch immune cells as a peyer's patch culture model (see illustration).
実用化イメージ

This evaluation system may also contribute to elucidate immunoregulatory mechanism of immunobiotics and immunogenics mediated by pattern recognition receptors essential to future development of not only immunobiotic feeds but also vaccines using immunobiotics to prevent specific diseases. This can benefit mankind by offering immunobiotic feeds as a safer alternative to conventional antibiotic drug therapy.

Researchers

Graduate School of Agricultural Science

Haruki Kitazawa