Medical
Information Communication
Environment
Nanotechnology / Materials
Energy
Manufacturing Technology
Social Infrastructure
Frontier
Human and social sciences
Bioimplants that are as close to natural teeth as possible
- Overview of Technology
By applying nanoscale surface modification to individually designed 3D-printed titanium implants based on CT data, a biomimetic microenvironment is recreated, enabling regeneration of periodontal ligament-like tissue through host stem cell induction. This provides a novel treatment approach without cell transplantation for cases where existing implants are difficult to adapt.
- Comparison with Conventional Technology
Conventional implant treatment assumes direct bonding with bone, thus disregarding the regeneration of periodontal tissues such as the periodontal ligament. Furthermore, some patients avoid treatment due to concerns about bone-cutting surgery and multiple invasive procedures. This technology utilizes a nano-surface to induce stem cells, forming periodontal tissues similar to natural teeth. This enables the restoration of natural occlusal sensation through a single minimally invasive procedure.
- Features and Uniqueness
-
Custom-designed for each patient's root morphology, it reproduces natural force transmission and chewing sensation. Furthermore, by utilizing nanostructures to control cell adhesion and differentiation, it enables periodontal tissue reconstruction without the need for cell transplantation or regenerative factor administration.
- Practical Application
-
In the future, we aim to collaborate with implant manufacturers to advance mass-production prototyping and quality evaluation, targeting practical application as a medical device. We also seek partnerships with companies and management talent who can jointly undertake strategic planning and clinical deployment for commercialization.
- Keywords
-
- Custom Implants
- 3D Printing
- Dental Implants
- Nano Surface Modification
- Biomimetic Materials
- Biomaterials
- Periodontal Tissue Regeneration
- Periodontal Ligament Regeneration
- Cell-Directed Implants
- Stem Cell Response
- Immediate Implant Placement in Extraction Sockets
- Custom-Made Medical Devices
- Regenerative Medicine, Minimally Invasive Treatment
- Non-Cell-Based Regenerative Therapy
- Medical Device Development
- Implant Manufacturing Technology
- Biocompatibility Evaluation
- Bone and Periodontal Reconstruction
- Medical-Dental-Engineering Collaboration
Researchers
Graduate School of Biomedical Engineering
Masahiro Yamada, Professor
DDS, PhD.
Custom-made biomimetic nano-surfaced implants induce stem cells to regenerate periodontal tissue. We target patients unsuitable for existing implants, addressing unmet needs without transplantation.
