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Development of Novel Bone Substitute Biomaterials Showing Highly Osteoconductive Property



Novel bone substitute biomaterials should have a property not only to support cellular attachment on the material surfaces but also activate cellular function of osteoblasts that promote regeneration of bone tissue. Our laboratory successfully developed such materials composed of octacalcium phosphate (OCP) (Suzuki O et al. Biomaterials 27:2671, 2006), obtained by a restricted synthesis condition originally developed, with specific crystal characteristics, and various natural polymers, such as gelatin, collagen, alginate and hyaluronic acid. The materials consist from OCP and these polymers are capable of enhancing new bone formation concomitant with their own biodegradations. The concept to develop such materials is that (1) design of reaction of calcium phosphate ceramics and the synthesis; (2) design of material strength to meet the mechanical stress from living body; (3) selection of natural and synthetic polymer materials for the calcium phosphate ceramics.

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Division of Craniofacial Function Engineering, Graduate School of Dentistry

SUZUKI, Osamu , Professor
Doctor in Medical Sciencese


Related Information


1) Kurobane T, Suzuki O et al. (2019) Angiogenesis involvement by octacalcium phosphate-gelatin composite-driven bone regeneration in rat calvaria critical-sized defect. Acta Biomater 88: 514-526.

2) Suzuki O. (2019) Evolution of octacalcium phosphate biomaterials. In Chapter 1, Octacalcium Phosphate Biomaterials, pp.1-15. Edits: O Suzuki, G Insley. Woodhead Publishing Series in Biomaterials, Elsevier.