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Development of Novel Bone Substitute Biomaterials Showing Highly Osteoconductive Property



Novel bone substitute biomaterials should have a property not only to support cellular attachment on the material surfaces but also activate cellular function of osteoblasts that promote regeneration of bone tissue. Our laboratory successfully developed such materials composed of octacalcium phosphate (OCP) (Suzuki O et al. Dent Mater J 39:187, 2020. doi: 10.4012/dmj.2020-001), obtained by a restricted synthesis condition originally developed, with specific crystal characteristics, and various natural polymers, such as gelatin, collagen, alginate and hyaluronic acid. The materials consist from OCP and these polymers are capable of enhancing new bone formation concomitant with their own biodegradations. The concept to develop such materials is that (1) design of reaction of calcium phosphate ceramics and the synthesis; (2) design of material strength to meet the mechanical stress from living body; (3) selection of natural and synthetic polymer materials for the calcium phosphate ceramics.

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Division of Craniofacial Function Engineering, Graduate School of Dentistry

SUZUKI Osamu , Professor
Doctor in Medical Sciencese


Related Information


1) Hamai R, Suzuki O et al. Octacalcium phosphate crystals including a higher density dislocation improve its materials osteogenecity. App Mater Today 26: 101279, 2022.

2) Hamada S, Suzuki O et al. Octacalcium phosphate/gelatin composite (OCP/Gel) enhances bone repair in a critical-sized transcortical femoral defect rat model. Clin Orthop Relat Res 2022 in press. doi: 10.1097/CORR.0000000000002257