Development of PHD-Targeted Drug for Ischemic Injury
update：2020-06-16
Features
All the living organisms generate energy from molecular oxygen to maintain their own lives. Once the concentration of oxygen falls down, life activity gets severely hampered and it could sometimes cause death. Typical examples that are related to local hypoxia are ischemic heart disease, stroke and kidney disease.We focus on the function of prolyl hydroxylase (PHD) as a sensor to detect the hypoxia, and we are developing drugs to treat ischemic injury by controlling hypoxia.
Targeted Application(s)/Industry
Currently, we have several compounds that inhibit the PHD. We want to commercialize in conjunction with pharmaceutical companies in Japan and overseas, advancing our non-clinical studies for clinical development.Researchers
Division of Molecular Medicine and Therapy, United Centers for Advanced Research and Translational Medicine (ART), Graduate School of Medicine
MIYATA Toshio
, Professor
M.D., PhD
Keywords
Related Information
１. Neovascularization induced by hypoxia inducible transcription factor is associated with the improvement of cardiac dysfunction in experimental autoimmune myocarditis. Expert Opin Investig Drugs. 2014, 23, p149-62.
２. Diabetic nephropathy: are there new and potentially promising therapies targeting oxygen biology? Kidney Int. 2013, 84, p693-702.
３. New era for drug discovery and development in renal disease, Nat Rev Nephrol 2011, 7, p.469-477.
４. Hypoxia. 1. Intracellular sensors for oxygen and oxidative stress: novel therapeutic targets : Am J Physiol Cell Physiol, 2011, 300, p.226-231.
５. A Novel Class of Prolyl Hydroxylase Inhibitors Induces Angiogenesis and Exerts Organ Protection Against Ischemia, Arterioscler Thromb Vasc Biol, 2007, 27, p.2548-2554.
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