Advanced Molecular Transformations by Organocatalysts
update：2020-06-16
Features
The development of organic molecules which function as a catalyst has been extensively investigated to achieve selective and efficient transformation of organic molecules. Brønsted acids and bases are commonly employed as the catalyst in synthetic organic chemistry. To aim at their functionalization, axially chiral phosphoric acids and axially chiral guanidine bases have been developed as chiral Brønsted acid and base catalysts, respectively. A variety of optically active compounds has been synthesized through the development of highly stereoselective reactions using these catalysts.Targeted Application(s)/Industry
The development of chiral Brønsted acid and base catalysts has been accomplished as recoverable and reusable organocatalysts and highly stereoselective molecular transformations have been established using these catalysts. The present methodology is applicable to process chemistry in preparing medicines and relevant compounds on the basis of the selective and efficient molecular transformations thus developed with reduction of the waste material.Researchers
Keywords
Related Information
Title of Invention: Process for production of optically active amines by stereoselective nucleophilic addition reaction of imines with C nucleophiles using chiral phosphoric acid derivative.
Priority Application: JP 2004-17725, Application Date: 2004-01-26
Application Number: WO 2005-JP962, Applicant Date: 2005-01-26
Patent Number: WO 2005070875 A1, Publication Date: 2005-08-04
Application Number: US 2006-587279, Application Date: 2006-10-12
Patent Number: US 20070142639 A1, Publication Date: 2007-06-21
2) Literatures:
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