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Prevention and amelioration of late-onset hypogonadism by food ingredients

Late-onset hypogonadism (LOH) is induced by age-related decline of testosterone synthesis, which leads to decrease muscle and sexual nature as well as mental symptoms such as depression. Now great attention is focused on prevention and amelioration of LOH via ingestion of foods and supplements.

We developed screening system of functional ingredients from food extracts for anti-LOH using testis-derived cells, and clarified that vitamins, nutraceuticals, and edible plant extracts have potentiating activities for the production of testosterone.


Graduate School of Agricultural Science

SHIRAKAWA Hitoshi , Professor
Doctor of Agricultural Science


Related Information


Horigome S, Maeda M, Ho H.-J, Shirakawa H, Komai M. Effect of Kaempferia parviflora extract and its polymethoxyflavonoid components on testosterone production in mouse testis-derived tumour cells. J. Funct. Food., 2016, 26, 529-538.

Ho H-J, Shirakawa H, Yoshida R, Ito A, Maeda M, Goto T, Komai M. Geranylgeraniol enhances testosterone production via cAMP/protein kinase A pathway in testis-derived tumor I-10 cells. Biosci. Biotechnol. Biochem., 2016, 80, 791-797.

Ito A, Shirakawa H, Takumi N, Minegishi Y, Ohashi A, Howlader ZH, Ohsaki Y, Sato T, Goto T, Komai M. Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells. Lipids Health Dis., 2011, 10, 158.