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Development of Recombinant Inbred Mice with a Genetic Predisposition to Collagen Disease



Eleven strains of recombinant inbred (RI) mice derived from MRL/lpr and C3H/lpr mice were established. This RI is the only one in the world that randomly develops lesions such as nephritis, arthritis, sialadenitis, vasculitis, and production of autoantibodies in each strain. The genomes of the two strains of mice are randomly held in homozygous condition, and the phenotypes of each strain and the effects of administered drugs could be compared based on their genotype maps. It is possible to identify the regions of gene loci involved in the phenotype and drug sensitivity.

Targeted Application(s)/Industry

Development of diagnostic and therapeutic agents for autoimmune diseases. It can be applied to the elucidation of the mechanism of onset of immunological adverse events caused by immune checkpoint inhibitors and the development of drugs to prevent the onset of such events, and industry-academia collaboration with pharmaceutical companies, test reagent companies, etc. is possible.


Graduate School of Biomedical Engineering

KODAMA Tetsuya , Professor
PhD (Engineering), PhD (Medicine)


Related Information

1. Nose M, Komori H, Miyazaki T, Mori S. Genomics of vasculitis: lessons from mouse models. Ann Vasc Dis. 2013;6(1):16-21. doi: 10.3400/avd.oa.12.00096.

2. Yuki Tanaka, Hiroaki Komori, Shiro Mori, Yoshiko Soga, Takahito Tsubaki, Miho Terada, Tatsuhiko Miyazaki, Takahiro Fujino, Satoshi Nakamura, Hiroyuki Kanno, Tatsuya Sawasaki, Yaeta Endo, Masato Nose. Evaluating the Role of Rheumatoid Factors for the Development of Rheumatoid Arthritis in a Mouse Model with a Newly Established ELISA System. Tohoku J Exp Med. 2010 Mar;220(3):199-206. doi: 10.1620/tjem.220.199.