Development of McH-lpr/lpr-RA1 mouse, a study model that spontaneously develops severe autoimmune arthritis, vasculitis, and sialadenitis
update：2021-07-13
Features
McH/lpr-RA1 mice are recombinant congenic mice descended from MRL/lpr and C3H/lpr mice and develop arthritis, vasculitis, and sialadenitis with high frequency and severity, with severe pannus formation similar to rheumatoid arthritis, polyarteritis nodosa, and Sjogren's syndrome. On the other hand, McH/lpr-RA1 mice do not develop systemic lymphadenopathy and severe nephritis as seen in MRL/lpr mice, so they are easy to breed and maintain and can be used for long-term drug administration experiments.Targeted Application(s)/Industry
Development of diagnostic and therapeutic agents for collagen diseases. It can be applied to the elucidation of the mechanism of onset of immunological adverse events caused by immune checkpoint inhibitors and the development of drugs to prevent the onset of such events, etc. Industry-academia collaboration with pharmaceutical companies, test reagent companies, etc. is possible.Researchers
Graduate School of Biomedical Engineering
KODAMA Tetsuya
, Professor
PhD (Engineering), PhD (Medicine)
Keywords
Related Information
2. Izumiyama T, Mori Y, Mori S, Mori N, Kodama T, Itoi E. The effect of anti-IL-6 receptor antibody for the treatment of McH-lpr/lpr-RA1 mice that spontaneously developed destructive arthritis and enthesitis. BMC Musculoskelet Disord. 2019 Jun 15;20(1):286. doi: 10.1186/s12891-019-2664-3.
3. Mori S, Tanda N, Ito MR, Oishi H, Tsubaki T, Komori H, Zhang MC, Ono M, Nishimura M, Nose M. Novel recombinant congenic mouse strain developing arthritis with enthesopathy. Pathol Int. 2008 Jul;58(7):407-14. doi: 10.1111/j.1440-1827.2008.02245.x.
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