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Regulation of ABC Transporters in Colorectal Cancer

Features and Uniqueness
  • Colorectal cancer (CRC) is one of the most common types of cancer worldwide. Surgical resection is the only curative treatment available for primary CRC. We determined the gene expression profiles for ATP binding cassette (ABC) transporters by RNA sequencing in matched colon cancer and normal colon tissue specimens in order to provide insight into the regulatory mechanisms underlying expression of transporters related to colon carcinogenesis. The expression of ABCC3 was repressed by Wnt signaling pathway, suggesting downregulation of ABCC3 might contribute oncogenesis.
Practical Application

Recently, we easily obtain comprehensive data including transcriptome and other omics data. These data are expected to help find a target for drug development, expecting that pharmaceutical industry interpret and extract new knowledge from them.



Graduate School of Medicine

Keiko Nakayama, Professor
Medical Doctor