Research Profile #146 Regulation of TSLP Production in Keratinocytes

Regulation of TSLP Production in Keratinocytes

update：2020-06-16

Features

Thymic stromal lymphopoietin(TSLP)has been focused as a master switch for allergy. We established a mouse keratinocyte cell line which constitutively and highly produces TSLP. This cell line will be useful to find the inhibitor of TSLP production and to study biochemical features of production and action of TSLP. The inhibitor of TSLP production might be used as an external or an inhalation drug, indicating low probability of causing a decrease in immune competence.

Targeted Application(s)/Industry

By using this cell line, we expect we can conduct effective collaborative research in medical fields. For examples, the cell line is useful for analysis of TSLP production and functions, development of inhibitors of TSLP production, and detection of immunotoxic compounds.

Researchers

Graduate School of Pharmaceutical Sciences

HIRASAWA Noriyasu , Professor
PhD

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Keywords

Related Information

1) Identification of a cell line producing high levels of TSLP: Advantages for screening of anti-allergic drugs.
R. Segawa, S. Yamashita, N. Mizuno, M. Shiraki, T. Hatayama, N. Satou, M. Hiratsuka, M. Hide, N. Hirasawa
J. Immunol. Methods 402: 9-14 (2014)