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Induction of skeletal muscle cells from human mesenchymal stem cells and their application to muscle degeneration

update：2020-06-16
 
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Bone marrow stromal cells have great advantages since they are already applied to patients either by auto- or allo-transplantations, can be harvested in large numbers (10 million cells within several weeks) as adherent cells from bone marrow aspirates, and are with low risk of tumorigenesis. We have established a system to induce skeletal muscle cells from human bone marrow stromal cells by treating cells with cytokines followed by Notch intracellular domain gene plasmid introduction. This induction system successfully generates skeletal muscle lineage cells comprised of muscle stem cells, namely, satellite cells, as well as myoblasts and myotubes. Transplantation of satellite cells and myoblasts were effective for muscle regeneration (Science, 2005). Importantly, induced satellite cells integrated into satellite cell location and continuously contributed to muscle regeneration. Our research team is now pursuing the safety and efficiency of these induced cells by using canine muscle degeneration models. We hope to collaborate with companies and research groups who are willing to utilize our system.

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Graduate School of Medicine

DEZAWA Mari , Professor
Doctor of Medicine

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