Tohoku University. Research Profiles


Development of an intranodal administration method



(1) The amount of anticancer drug required to treat one metastatic lymph node is 1/1,000 to 1/10,000 of the systemic dose.
(2) The drug can be administered into the lymph node under ultrasound guidance.
(3) An international patent has been filed for the solvent of the administered drug.

Targeted Application(s)/Industry

1. Treatment and prophylactic therapy of affiliated lymph nodes in head and neck cancer, breast cancer, etc.
2. Pharmaceutical companies aiming to develop drugs by drug repositioning and generics
3. Medical device manufacturers aiming to develop a dosing system


Graduate School of Biomedical Engineering

KODAMA Tetsuya , Professor
PhD (Engineering), PhD (Medicine)


Related Information

1. Concept of intranodal drug injection (lymphatic drug delivery system: LDDS)

2. Lymphatic flow induced by intranodal injection

3. Optimal solvent properties for intranodal drugs
Fukumura R, Sukhbaatar A, Mishra R, Sakamoto M, Mori S, Kodama T
Study of the physicochemical properties of drugs suitable for administration using a lymphatic drug delivery system. Cancer Sci. 2021 May;112(5):1735-1745.