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Researchers 287 Result(s), Themes 250 Result(s)

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Elucidation of oncogenesis by Fbxw7

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特徴・独自性
  • In life science research field, it is noteworthy issue how information in genome is interpreted and is transferred to functional molecules. However, during these 10 years, we convinced that the amount of proteins, final functional molecules was regulated by not only by production but also by degradation. For examples, the amount of c-Myc, which promotes cell cycle and inhibits cell death, increase in many types of cancer by failure of protein degradation.
  • We have generated model mice in which function of Fbxw7, inducer of c-Myc degradation is suppressed. We observed promotion of oncogenesis in these mice, suggesting that Fbxw7 is oncosuppressor gene. In other words, Fbxw7 has a great potential to regulate oncogenesis or progress of cancer. These molecules specified the target proteins for proteolysis suggesting that modification of these molecules leads to develop oncosuppressive therapy. We hope to conduct collaborative research with a willing company for a practical application of this knowledge in industry.
実用化イメージ

Researchers

Graduate School of Medicine

Keiko Nakayama

Nonlinear Aeroelastic and Multibody Dynamic Analysis for Floating Wind Turbine and Next-Generation Aircraft

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概要

Floating wind turbine and next-generation aircraft have high-aspect-ratio blade and wing that undergo nonlinear aeroelastic deformation. We have developed a nonlinear aeroelastic analysis framework with absolute nodal coordinate formulation (ANCF). This nonlinear aeroelastic deformation is coupled with multibody dynamics. We are also developing a novel analysis framework for this coupling dynamics.

従来技術との比較

By using the nonlinear analysis method proposed in this study, it is possible to handle the reduction in flutter speed due to large deformations and the coupled phenomenon of deformation and flight behavior that cannot be captured using conventional linear analysis methods.

特徴・独自性
  • Straightforward nonlinear structural analysis method that does not use any rotational coordinates
  • Highly efficient unsteady fluid calculation method for large deformations
  • Multibody dynamics that captures the relative motion between bodies, such as rotating blades and control surfaces
実用化イメージ

Dynamic, aeroelastic, structural, vibration, aerodynamic analyses for Aeroelastic Multibody Systems:
1. Floating wind turbine
2. High altitude platform station (HAPS), high-aspect-ratio-wing commercial jet
3. Helicopter, drone
4. Robot, crane

Researchers

Graduate School of Engineering

Keisuke Otsuka

Development of Compound Semiconductor Radiation Detectors

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特徴・独自性
  • The main research subject of our group is developing material purification methods, crystal growth methods and detector fabrication technologies for compound semiconductor radiation detectors. Our group intensely studies a compound semiconductor, thallium bromide (TlBr), for fabrication of gamma-ray detectors for the advanced radiation applications. The attractive physical properties of TlBr lie in its high atomic number (Tl: 81, Br: 35), high density (7.56 g/cm3) and wide bandgap (2.68 eV). Due to the high atomic number and high density, TlBr exhibits high photon stopping power. The wide bandgap of TlBr permits the device low-noise operation at and above room temperatures.
実用化イメージ

Our group focuses on development of compound semiconductor radiation detectors for advanced radiation applications including ultra-high resolution PET systems, ultra-high resolution SPECT systems, photon counting CT systems and Compton cameras. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Researchers

Graduate School of Engineering

Keitaro Hitomi

Quantitative analysis of microstructure in nuclear materials by week-beam scanning transmission electron microscopy

概要

We have developed a technique for quantitative analysis of microstructures (e.g., dislocations and irradiation defect aggregates) of activated and nuclear-burned specimens in the context of the Week Beam Scanning Transmission Electron Microscope (WB-STEM) method, which boasts extremely high measurement accuracy as a quantitative analysis method for lattice defects.
In combination with a dedicated heated sample holder with fully automated temperature measurement and current control in a cartridge-type heating furnace, changes in dislocation microstructure can be dynamically measured in-situ along with a highly reliable temperature history.

従来技術との比較

Conventional TEM methods require expertise in reciprocal space and dislocation theory, but our WB-STEM method is equipped with automatic analysis software for film thickness measurement and dislocation loop feature extraction, making it possible to analyze irradiation defects easily and precisely.

特徴・独自性
  • Since its design, the WB-STEM method has been developed for implementation and on-site repair in radiation controlled areas where nuclear materials are handled, with special aperture and diffraction disc selection equipment, control and analysis software.
  • WB-STEM accepts irradiation defect analysis of activated specimens from all over the world, including RPV monitoring specimens from European reactors and neutron-irradiated materials from US research reactors.
  • It is also used to analyze the properties of iron-containing nuclear fuel simulated debris in decommissioning projects.
実用化イメージ

We support research organizations that currently use transmission electron microscopy to observe microstructures to introduce the WB-STEM method by special modification. We will instruct researchers who have no experience using transmission electron microscopy in the procedure for dislocation analysis.

Researchers

Institute for Materials Research

Kenta Yoshida

Natural Language Processing for Semantic Analysis of Big Data

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特徴・独自性
  • This lab conducts fundamental research for deep natural language processing (NLP) and NLP-oriented information organization such as classification, extraction, and summarization of language information. Our activities also cover a broad range of applied research including NLP-based information and knowledge mining, information credibility analysis, and resilient ICT through the maximal use of Big Data.
実用化イメージ

(i) Analysis of market trend or research trend through intelligent text mining, (ii) Discovery of potential needs and risks from opinions in social media, (iii) Management of knowledge in a company by analyzing internal documents, etc.

Researchers

Center for Language AI Research

Kentaro Inui

Hands-On Access Fabrication Facility –Open Facility for MEMS and Semiconductor Prototyping–

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概要

We offer shared facility for the development of semiconductor prototypes equipped with 4-inch, 6-inch and some 8-inch wafer fabrication tools available on an hourly basis. Know-how accumulated at Tohoku University is available, and staff provide maximum support for prototyping. The service is performed at the 1,200 m2 Super Clean Room on the second floor of the Junichi Nishizawa Memorial Research Centre at Tohoku University. For information on equipment and fees, see our website.

従来技術との比較

More than 10 experienced technical staff assist customer's usages. Standard process conditions for each process, such as etching and deposition, are provided. allowing customers to start prototyping immediately. Various materials other than silicon can also be supported.

特徴・独自性
  • We support the development of devices and semiconductor materials such as MEMS, optical elements and RF components.
  • Technical consultation on devices and processes before and during prototyping is also available.
  • A
  • 'Prototype lab' for device packaging is also available.
  • The museums where you can learn about the history of semiconductors, measuring instruments and sensors are open.
  • As part of Technology Co-creation for Semiconductor of Tohoku University, we promote R&D of semiconductors and the development of human resources.
  • On-demand semiconductor human resource development programs for students and engineers are available.
  • As a member of the MEXT's Advanced Research Infrastructure for Materials (ARIM) program, we are involved in sharing facility and data.
実用化イメージ

More than 310 companies have used our shared facility since its launch in 2010, not only from device manufacturers such as MEMS, but also from manufacturers of materials, mechanical components and equipment. To date, we have successfully supported the commercialization of about 10 devices.

Researchers

Micro System Integration Center

Kentaro Totsu

Molecular studies on new resources for hybrid rice breeding

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特徴・独自性
  • F1 hybrid breeding is one of the most advanced techniques for production of cultivars with higher yield and desirable traits of both parents. Most of hybrid rice utilize cytoplasmic male sterility (CMS) and fertility restoration system. We develop a Tohoku University-original CW-type CMS and fertility restorer line and study their molecular mechanism. The CW-type cytoplasm enables indica rice cultivars to be CMS, which could not be achieved by other known cytoplasm.
実用化イメージ

Hybrid rice has an average 30% yield advantage over inbred lines, and is cultivated on 13% of the world rice fields. Our study provides a new and original resource for hybrid rice breeding for globalization of rice industry.

Researchers

Graduate School of Agricultural Science

Kinya Toriyama

Philosophy of Science and Technology, Science and Technology Studies (STS)

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特徴・独自性
  • My research area is mainly phenomenology, philosophy of technology, and applied ethics (engineering ethics etc.). Technological Artifacts mediate human activities. So designing artifacts is in itself an ethical behavior. Analysing the ontological structure of the artifacts, describing the epistemological propcess of desingning activities, evaluating the social and ethical influence of artifacts are main issues in philosophy of technology. On the basis of such philosophical investigations, we can develope ethical studies concerining how engineerss, companies can recognize ethical issues in a networks of meanings , how they can make ethical decision among engineers and users.
実用化イメージ

I hope to conduct cooperative research on ethical education of engineers, as well as on human-machine interaction.

Researchers

Graduate School of Arts and Letters

Kiyotaka Naoe

Advanced Vision System with Less Calibration

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特徴・独自性
  • The difficulties of introducing robot systems in production line are maintenance of environment and teaching of robot motion. Environ recognition and motion teaching using vision system will greatly improve the difficulties. However, calibration of vision-robot system is tedious and troublesome. Feedback control using vision sensor information will allow robustness against environment and teach by showing. This technique is called visual servo.
実用化イメージ

Visual servo will allow flexible camera setting, calibration-less system setting, and easy teaching.

Researchers

Graduate School of Information Sciences

Koichi Hashimoto

High Sensitivity Radioactivity Measurement at Ultra-Low Radioactivity Environment

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特徴・独自性
  • Research Center for Neutrino Science established ultra-low radioactivity environment (trillion times lower than natural environment) with 1200 cubic-meter organic scintillator detector at 1000m underground where very stable temperature/humidity and low vibration are maintained. We are pursuing high sensitivity measurements, especially neutrino observation, and are also developing purification system for ultra-low radioactivity and high performance radioactivity detectors.
実用化イメージ

The established ultra-low radioactivity environment is suitable for rare phenomena study and is also applicable for high sensitivity radio-impurity measurement. It may also apply to investigation of biological influence of low radioactivity irradiation. The other applications such as neutrino detection technique for monitoring nuclear reactors and medical use of high sensitivity radioactivity detectors may also be considered.

Researchers

Research Center for Neutrino Science

Kunio Inoue

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Exercising "Cultured" Myotubes!

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特徴・独自性
  • We succeeded in generating highly developed cultured C2C12 myotubes by manipulating intracellular Ca2+ transients with electric pulse stimulation (EPS), that are endowed with similar properties to in vivo skeletal muscle in terms of (1) excitation-induced contractile activity as a result of de novo sarcomere formation, (2) higher energy expenditure (as assessed by AMPK activation), and (3) improved insulin responsiveness (as assessed by exofacial myc-GLUT4 translocation assay).
実用化イメージ

Taking advantage of our “in vitro Exercise Model", our innovation will be an excellent alternative for the animal experimentation that can be applicable for a wide array of skeletal muscle research including drug screen.

Researchers

Graduate School of Biomedical Engineering

Makoto Kanzaki

Electrical Spin Generation and Manipulation in Semiconductors

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特徴・独自性
  • Since spin orbit interactions caused by the structural inversion asymmetry and the bulk inversion asymmetry induce an effective magnetic field in III-Vsemiconductor heterostructures, it is possible to realize the new functional devices based on the electrical control of the spin precession. We study the electrical spin generation by using spatial modulation of spin orbit interaction, which demonstrates Stern-Gerlach spin filter in semiconductors, and research ultra-fast spin dynamics by using time resolved Kerr rotation microscopy. We also investigate a spin MOSFET based on the perpendicular magnetic materials and electric-field induced magnetization control. We can reduce the leak current and the signal delay in the logic circuit. With the non-volatility of the ferromagnetic source and drain electrodes, random access memory is also enabled by using the spin MOSFET structure.
実用化イメージ

Target application will be low power logic devices and non-volatile memory based on electron spins and also future metal-based spintronic devices.

Researchers

Graduate School of Engineering

Makoto Koda

Biomodel for Development of Endovascular Treatment

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特徴・独自性
  • We perform in-vitro or computational researches for development of medical devices. We develop a model of artery or bone to evaluate medical devices. And we apply optimization way for development of medical devices. Our main target is, currently, stent, or catheter.
実用化イメージ

Our collaboration company can be; medical equipment, device, medical image, MEMS, standardization, medical training, or polymer.

Researchers

Institute of Fluid Science

Makoto Ohta

Advanced Analysis of Socio-Economical Data for Capturing Social Needs

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特徴・独自性
  • We have proposed advanced methods of behavior analysis for public transport service.
  • They include a demand composition based on the automatically mesured traffic data, estimation of true demand partly unrealized by the congestion, and intense usage of geographical data. These methods may be applicable for behavior analysis besides transport service.
実用化イメージ

We welcome cooperative research on demand analysis of public services, as well as needs analysis for new goods and services.

Researchers

International Research Institute of Disaster Science

Makoto Okumura

Application of Nuroimaging Technique to Interface Evaluation

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特徴・独自性
  • Nuclear power plants, chemical plants, ironworks and smelters, aircrafts and others that involve large-scale and complex systems yield many benefits to society and daily life, but a serious accident in such systems may result in dire consequences and significant damage. As long as there is human intervention of any kind, it is difficult to completely avoid human error. In light of this, it is crucial to have the mindset of "to err is human, (to forgive divine)." Takahashi Laboratory advocates the improvement of safety based on the harmonization of humans, machines and the environment. The object of our research is the human. Incorporating neuroscience approach and knowledge, we probe into human cognitive and behavioral traits and reflect our findings back into our research with the cooperation of this university's Institute of Development, Aging and Cancer as well as practicing specialists and technical experts. Through our broad vision, flexible mindset and creativity, we pioneer interfaces between humans and systems where safety is ingrained.
実用化イメージ

The core of our research is the examination and understanding of the human factor to be taken into account for the safe and efficient operation of large scale, complex systems, and we are involved in the research of a wide array of subjects not limited to nuclear energy systems but air traffic control operations, man-machine interfaces, cyber security, standardization of rules among others.

Researchers

Graduate School of Engineering

Makoto Takahashi

Study on Tactile/Touch Feeling Sensor

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特徴・独自性
  • Tactile sense and the sense of touch are multiple combinations of fundamental sensations, such as smooth and rough, soft and hard, dry and wet, and hot and cold sensations. These sensations are described with the information on force, distortion, temperature, stickiness and oscillation.
  • A tactile sensor corresponding to several types of human skin sensory receptors and an active tactile sensor system that is an integrated sensor structure imitating human haptic motions have been developed. These sensor systems allowed measurement of "Kansei" words that are extremely vague tactile feelings, and roughness, softness and temperature sensations. However, tactile sense or the sense of touch also includes other sensations and combinations of them. Therefore, to develop a sensor, it is important to define how the sensations and physical information relating to the sensations are obtained and what relationships exist between them.
  • In this research, the relationships between sensations, including fundamental sensations that have already been obtained and other sensations, and the relevant physical information are being investigated. Additionally, on the basis of the knowledge through the investigation, an advanced sensor system that allows obtaining haptic information is being developed.
実用化イメージ

The research is beneficial not only to life science but also to manufacturing fields.

Researchers

Graduate School of Biomedical Engineering

Mami Tanaka

Functional and Molecular Imaging with Positron Emission Tomography (PET)

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特徴・独自性
  • Using positron emission tomography (PET), we can measure the regional metabolism, perfusion and signal transmission between neurotransmitters and receptors in various organ systems of living humans and animals, such as the brain and heart. Recent technical developments have shown that the mind, or at least some parts of it, can be demonstrated by "imaging".
実用化イメージ

Our group has had considerable achievements in clinical research on drug effects and side effects, elucidation of underlying mechanism of alternative and complementary therapies, as well as exercise physiology.

Researchers

Cyclotron and Radioisotope Center

Manabu Tashiro

Induction of Schwann cells from human mesenchymal stem cells and their application to spinal cord injury and demyelinating diseases

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特徴・独自性
  • Bone marrow stromal cells have great advantages since they are already applied to patients either by auto- or allo-transplantations, can be harvested in large numbers (10 million cells within several weeks) as adherent cells from bone marrow aspirates, and are with low risk of tumorigenesis. Furthermore, marrow bank is available. Likewise, mesenchymal cells harvested from umbilical cord are also easily accessible from cord bank and are a good source of mesenchymal stem cells. We have established a system to induce functional Schwann cells (peripheral glia) from human bone marrow stromal cells and umbilical cord mesenchymal cells by treating cells with a series of reagents and cytokines. This induction system successfully generates Schwann cells with very high efficiency (~97%). They were confirmed to elicit neural regeneration in peripheral nerve damages and spinal cord injury (Eur, J. Neurosci, 2001; J. Neurosurg, 2004, J. Neuropathol. Exp. Neurol, 2005, Biochem Biophys Res Commun, 2007; Tissue Eng., 2011). The efficiency and safety of induced Schwann cells were demonstrated in monkey by 1 year follow up (Exp. Neurol., 2010). Importantly, induced cells not only elicited neural regeneration in both peripheral and central nervous system, but also contributed to functional recovery by restoring myelin and saltatory conduction. Therefore, these cells are expected to be effective to demyelinating diseases as well. We hope to collaborate with companies and research groups who are willing to utilize our system.
実用化イメージ

Researchers

Graduate School of Medicine

Mari Dezawa

Induction of skeletal muscle cells from human mesenchymal stem cells and their application to muscle degeneration

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特徴・独自性
  • Bone marrow stromal cells have great advantages since they are already applied to patients either by auto- or allo-transplantations, can be harvested in large numbers (10 million cells within several weeks) as adherent cells from bone marrow aspirates, and are with low risk of tumorigenesis. We have established a system to induce skeletal muscle cells from human bone marrow stromal cells by treating cells with cytokines followed by Notch intracellular domain gene plasmid introduction. This induction system successfully generates skeletal muscle lineage cells comprised of muscle stem cells, namely, satellite cells, as well as myoblasts and myotubes. Transplantation of satellite cells and myoblasts were effective for muscle regeneration (Science, 2005). Importantly, induced satellite cells integrated into satellite cell location and continuously contributed to muscle regeneration. Our research team is now pursuing the safety and efficiency of these induced cells by using canine muscle degeneration models. We hope to collaborate with companies and research groups who are willing to utilize our system.
実用化イメージ

Researchers

Graduate School of Medicine

Mari Dezawa