Tohoku University. Research Profiles

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"T" Researcher - 37 Result(s)

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Hierarchy Control in Structure and Creation of Novel Properties in Nano Scale Materials

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Crystals produced from the building blocks using a concept of geometrical materials, from the ubiquitous elements such as B, C, N, O, Si, Ge and 3-d elements show the following characteristics:
(1) Special properties resulting from the bonding nature and geometrical symmery.
(2) New properties expected from confinement and interface.
(3) A variety of phonons as phonon engineering.
(4) Interplay among phonons, itinerant electrons and magnons.
Materials are synthesized using the strategy of natural aboundant ubiquitous elements for safety. Novel properties can be expected for advanced electronic devices. The structure of new materials can accurately be determined by various experimental techniques.

Targeted Application(s)/Industry

New materials produced by employing a new concept beyond the conventional methods can promote a new materials science for future electronics. Our research covers nano materials consisting of organic to innorganic elements. Thermoelectric materials for energy conversion and high mobility materials via Dirac quantum statse will be avialable for future electronic materials.

WPI Advanced Institute for Materials Research
TANIGAKI, Katsumi, Professor Doctor of Engineering

Functional and Molecular Imaging with Positron Emission Tomography (PET)

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Using positron emission tomography (PET), we can measure the regional metabolism, perfusion and signal transmission between neurotransmitters and receptors in various organ systems of living humans and animals, such as the brain and heart. Recent technical developments have shown that the mind, or at least some parts of it, can be demonstrated by "imaging".

Targeted Application(s)/Industry

Our group has had considerable achievements in clinical research on drug effects and side effects, elucidation of underlying mechanism of alternative and complementary therapies, as well as exercise physiology.

Cyclotron and Radioisotope Center
TASHIRO, Manabu, Professor doctor of medical sciences

Advanced Molecular Transformations by Organocatalysts

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The development of organic molecules which function as a catalyst has been extensively investigated to achieve selective and efficient transformation of organic molecules. Brønsted acids and bases are commonly employed as the catalyst in synthetic organic chemistry. To aim at their functionalization, axially chiral phosphoric acids and axially chiral guanidine bases have been developed as chiral Brønsted acid and base catalysts, respectively. A variety of optically active compounds has been synthesized through the development of highly stereoselective reactions using these catalysts.

Targeted Application(s)/Industry

The development of chiral Brønsted acid and base catalysts has been accomplished as recoverable and reusable organocatalysts and highly stereoselective molecular transformations have been established using these catalysts. The present methodology is applicable to process chemistry in preparing medicines and relevant compounds on the basis of the selective and efficient molecular transformations thus developed with reduction of the waste material.

Graduate School of Science
TERADA, Masahiro, Professor PhD

Highly Sensitive and Simultaneous Absolute Protein Quantification by LC-MS/MS

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Quantification of functional proteins in each organ of animals and humans at normal and disease states is fundamental for drug discovery and development. The target proteins were digested in-silico, and target peptides for analysis were chosen on the basis of the selection criteria. Samples tissues were digested with trypsin, and mixed with stable isotope labeled-peptide as a quantitative standard. The amounts of target proteins were simultaneously determined by the HPLC system connected to an ESI–triple quadrupole mass spectrometer. A detection limit would be ~ 1 fmol/assay and 37 different proteins could be quantified simultaneously.

Targeted Application(s)/Industry

This technology will be applicable for the drug discovery and development, diagnosis, personalized chemotherapy. This technology will be widely applicable for any life science relating industries including food and environment science. Fig. 3 summarizes possible applications for Pharmaceutical and Medical fields.

Graduate School of Pharmaceutical Sciences
TERASAKI, Tetsuya, Professor PhD,

Nano-Scale Total-Analysis Based on TEM

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Our lab develops accurate nanometer scale characterization methods of crystal structures by convergent-beam electron diffraction (<strong>CBED</strong>) and electronic structures by electron energy-loss spectroscopy (EELS) and soft-X-ray emission spectroscopy (<strong>SXES</strong>) for evaluating new functional materials. For performing crystal structure studies, we developed a new Ω-filter electron microscope and a refinement soft-ware, which can perform not only atom positions but also electrostatic potential and charge distributions. For electronic structure studies, a high-resolution EELS microscope and SXES instruments were developed.

Targeted Application(s)/Industry

Collaborated research of Local structures (symmetry, polarity, lattice defects) by CBED and electronic structures (bandgap, dielectric property and chemical state) by EELS and SXES on semiconductors, metals and dielectric materials are acceptable. Instructions of those analysis methods are also acceptable.

Institute of Multidisciplinary Research for Advanced Materials
TERAUCHI, Masami, Professor Doctor of Science

Dry-Contact Ultrasonic Technique

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A new dry-contact technique for transduction of broadband, high-frequency ultrasound via a solid layer inserted between water and the sample, whereat the pressure of about 0.1 MPa is applied at the layer/sample interface by evacuating air between them, has been developed. Based on the technique, acoustic imaging of an electronic package is realized under the dry environment (Fig. 1). Typically, the polymer films are used as the intermediate layer for water protection of the sample, and by utilizing the acoustic resonance phenomenon among water, film and the sample, higher quality acoustic image of the testing sample than that for the water immersion case can be recorded without getting the sample wet (Fig. 2). Moreover, thin materials, e.g., polymer film (Fig. 3), etc. can be characterized by analyzing the acoustic resonance phenomenon among the three media. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Graduate School of Engineering
TOHMYOH, Hironori, Professor Doctor of Engineering

Joule Heat Welding of Ultrathin Metallic Wires and its Application for Producing Functionality

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For producing a new functionality from metallic micro and nano matarials, the welding and cutting technologies for small scale materials utilizing Joule heat has been developed (Fig. 1). A constant direct current is supplied to the system, where the free ends of two metallic wires are contacted, and the ends are successfully welded together in self-completed manner. This technology is also useful for manipulating a small scale materials.

Targeted Application(s)/Industry

Joule heat welding technology enables us to produce the functional elements on the electrode chips, e.g., a free-standing micro-ring and very-thin thermoelectric element (Fig. 2). Moreover, we have developed the technique for characterizing the physical properties of small scale materials (Fig. 3). We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Graduate School of Engineering
TOHMYOH, Hironori, Professor Doctor of Engineering

Quantum and Molecular Dynamic Simulations of Transport Phenomena in Fuel Cell

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It is necessary to grasp nanoscale transport phenomena of materials in polymer electrolyte fuel cell to improve its performance. In our laboratory, nanoscale transport phenomena are analyzed by large scale molecular dynamics simulations using a supercomputer system. As the present theme, the dependence of the materials or structures of polymer electrolyte membrane on the ability of proton transfer(Fig. 1), the ability of proton transfer or oxygen permeability of ionomer in catalyst layer(Fig. 2), and the mechanism of transport phenomena of a water droplet in a nano pore in gas diffusion layer or micro porous layer(Fig. 3), are analyzed in detail.

Targeted Application(s)/Industry

These research can be applied to the analysis of flow field in devices which have nanoscale structure, for instance, fabrication process of semiconductor, friction phenomena of such nanoscale devices or next generation batteries, as well as the field of fuel cell.

Quantum Nanoscale Flow Systems Laboratory, Institute of Fluid Science
TOKUMASU, Takashi, Professor Doctor of Engineering

Development of a novel therapeutic drug, TMS-007, for acute cerebral infarction

Features

The currently approved fibrynolytic therapy is only alteplase, but the use of it has been limited to 5% of patients with acute cerebral infarction due to possible side effects including hemorrhagic infarction that may be life-threatening. TMS-007 is a novel drug that has both fibrynolytic activity and brain protective effects. The aim of this project is to perform a clinical trial of this drug and to further achieve a commercial-based clinical use. We believe that this drug would contribute significantly in the treatment of acute cerebral infarction.

Department of Neurosurgery, Graduate School of Medicine
TOMINAGA, Teiji, Professor Doctor of Medicine

Clinical application of pulsed jet device to achieve maximal resection of the lesion and functional preservation

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Maximal resection and functional preservation, are often conflicting, but are both important factors to improve patient’s quality of life. Pulsed jet system is designed to achieve this goal by removing lesions without impairing small diameter vessels (100 μm - ). Standardization and specialization of surgical procedures is expected to achieve more easily compared to conventional surgical device using pulsed jet system. We have already reported significant increase of tumor removal rate, significant reduction of intraoperative blood loss and operation time in difficult lesions in the vicinity of sella turcica and skull base through expanded transsphenoidal approach. The system can eject small amount ( - 2 μl) of high speed liquid (- 50 m/s) for minimally invasive surgery, such as endoscopic, catheter, and microscopic surgery. The system is now under stage to expand clinical application outside the field of neurosurgery, and we are expecting new collaboration who can deal with increasing safety, effectiveness, differentiation from conventional instruments, accessibility.

Department of Neurosurgery, Graduate School of Medicine
TOMINAGA, Teiji, Professor Doctor of Medicine

Image Guided Local Drug Delivery for Central Nervous System Disorders

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Effective drug delivery to central nervous system is promising as a new therapeutic strategy against various central nervous system disorders. However, it represents a challenge because systemic delivery is always hindered by blood brain barrier, and local delivery cannot be effective because of the restricted distribution. Recently, local drug delivery system that can achieve robust distribution of the infusates by maintaining a pressure gradient at the tip of the infusion catheter during infusion has developed. Although this method is promising, there still exist several problems as loss of infusates by backflow through catheter tract or inconsistent distribution. We recently developed a method to deliver agents with this method under MRI guidance, and now performing clinical trial to treat recurrent gliomas.

Targeted Application(s)/Industry

Focal central nervous system disorders such as tumor, epilepsy, and parkinson's disease can be the target for application of this technique. Developments of the new catheters and pre-infusional similation systems are on their way. We are searching for effective collaborative research in this field.

Department of Neurosurgery, Graduate School of Medicine
TOMINAGA, Teiji, Professor Doctor of Medicine

Development of catalytic reaction system for direct synthesis from CO2 and diols

Features

We found an effective catalyst system composed of CeO2 and 2-cyanopyridine for direct and catalytic polycarbonate formation reaction from CO2 and diols. CeO2 acted as an activator for CO2 and diols, and 2-cyanopyridine shifted the equilibrium in favor of the product side by hydration of 2-cyanopyridine, promoting the reaction. Green polycarbonates can be synthesized by combination of the catalyst system with a technique of diol syntheses from biomass.

Targeted Application(s)/Industry

This catalyst system is effective for direct transformation of CO2, contributing to the effective utilization and emission reduction of CO2. Combination of the catalyst system with a concentration technique of CO2 will bring about much advantage.

Graduate School of Engineering / Research Center for Rare Metal and Green Innovation
TOMISHIGE Keiichi, Professor Doctor of Science

Molecular studies on new resources for hybrid rice breeding

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F1 hybrid breeding is one of the most advanced techniques for production of cultivars with higher yield and desirable traits of both parents. Most of hybrid rice utilize cytoplasmic male sterility (CMS) and fertility restoration system. We develop a Tohoku University-original CW-type CMS and fertility restorer line and study their molecular mechanism. The CW-type cytoplasm enables indica rice cultivars to be CMS, which could not be achieved by other known cytoplasm.

Targeted Application(s)/Industry

Hybrid rice has an average 30% yield advantage over inbred lines, and is cultivated on 13% of the world rice fields. Our study provides a new and original resource for hybrid rice breeding for globalization of rice industry.

Graduate School of Agricultural Science
TORIYAMA, Kinya, Professor Doctor of Agriculture

Hands-On Access Fabrication Facility –Open Facility for MEMS and Semiconductor Prototyping–

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We offer a hands-on-access fabrication facility for MEMS and semiconductor research and development. The facility is located at the 1800m2 clean room, Jun-ichi Nishizawa Memorial Research Center, Tohoku University, and started in 2010. The principle is an open access that users can utilize the fab and operate the equipment by themselves. Users also can access a great deal of know-how accumulated at Tohoku University. More than 260 companies have utilized the fab for developing various devices. To accelerate University's R&D and education, product fabrication by a company user is started in July 2013.

Targeted Application(s)/Industry

Our target is MEMS and semiconductor devices including sensors (accelerometer, gyroscope, pressure sensor, force sensor, photo diode, radiation sensor, microphone, bio sensor), solar cell, RF device, optical device, micro actuator. Process technology, such as etching, sputtering, oxidation/diffusion, CVD and bonding is also available.

Micro System Integration Center
TOTSU, Kentaro, Associate Professor Doctor of Engineering

Development of Geothermal Energy and Geosphere Environmental Informatics

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My research field is Geothermal Geology, Resource Geology and Environmental Geology. I am conducting exploration of heat source, hydrothermal alteration and characterization of geothermal reservoir by geological techniques. I study water-rock interaction and fluid dynamics in reservoirs on the basis of hydrothermal experiments under sub- to supercritical conditions and numerical simulation. Additionally, risk assessment of soil, river water in terms of heavy metal pollution.

Targeted Application(s)/Industry

I am conducting international collaboration with respect to geothermal geology, mining geology, and geoengineering related to risk assessment of geosphere environment.

Graduate School of Environmental Studies
TSUCHIYA, Noriyoshi, Professor Doctor of Engineering

Development of healthy longevity meal and health supplement based on the Japanese diet

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We studied the health function of the Japanese diet, and clarified that the Japanese diet from 1975 has the function of reducing stress, obesity, diabetes, fatty liver, dementia, cancer, and aging speed. And, with various evaluation systems, we clarified the characteristics of 1975 Japanese diet (Fig.1). The various findings obtained in this research are a considerable advantage in developing health foods, which helps to develop healthy longevity meals and health supplements.

Targeted Application(s)/Industry

In addition to research on functionality of foods, the identification of functional ingredients by simultaneous analysis of meals and ingredients (Fig.2) and the identification of ingredients that improve the balance of intestinal flora better (Fig.3) are also possible.

Graduate School of Agriculture
TSUDUKI, Tsuyoshi, Associate Professor Doctor of Agriculture