Tohoku University. Research Profiles

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"I" Theme - 17 Result(s)

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ICT Use by Teachers and Students in the Classrooms of Elementary and Secondary Schools

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My research focuses on ICT use in the classrooms of elementary and secondary schools in Japan.
When we consider introducing technologies to the classrooms, particularly for the compulsory education in public schools, there are "inevitable issues" around consistency with the educational mission of academic development of school students, practicability and sustainability of the use of technologies for busy teachers, cost economy, and equity in the public education.
My research is characterized by its direction toward empirical approach to the ICT use in consideration of these issues.
In the past, I have been engaged in (1) a research that found the most accepted ICT among teachers was a document camera and the way teachers use it was dependent on each teacher's teaching style, (2) a research on the technology that takes fewer man-hours to develop digital textbooks and other contents, and (3) a development of e-learning materials with which elementary school students can learn key board typing.

Targeted Application(s)/Industry

My research can be applied to a development of teaching support tools for elementary and secondary school teachers which can be used in the classroom and a consulting service to assist development of digital teaching materials for school students.

Graduate School of Information Sciences
HORITA, Tatsuya, Professor

Identification of Ignition and Combustion Characteristics by a Micro Flow Rector with a Temperature Gradient

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We have developed a methodology for identifying general ignition and combustion characteristics of gaseous and liquid fuels including bio and synthetic fuels. It enables identification of ignition and combustion characteristics of new fuels prior to application for practical combustion devices. The reactor system consists of a small diameter channel which has a temperature gradient from room temperature to the auto ignition temperature and thus reaction characteristics in different temperature levels can be easily investigated. Such a measurement had required research level skills and special devices such as rapid compression machine or shock tube which is costly in general, however, the micro flow reactor with temperature gradient enables reaction analysis easily.

Targeted Application(s)/Industry

It is expected to contribute to the designing of combustion devices, developments of new fuels, and chemical promoter and inhibitor.

Institute of Fluid Science
MARUTA, Kaoru, Professor Doctor of Engineering

Image Guided Local Drug Delivery for Central Nervous System Disorders

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Effective drug delivery to central nervous system is promising as a new therapeutic strategy against various central nervous system disorders. However, it represents a challenge because systemic delivery is always hindered by blood brain barrier, and local delivery cannot be effective because of the restricted distribution. Recently, local drug delivery system that can achieve robust distribution of the infusates by maintaining a pressure gradient at the tip of the infusion catheter during infusion has developed. Although this method is promising, there still exist several problems as loss of infusates by backflow through catheter tract or inconsistent distribution. We recently developed a method to deliver agents with this method under MRI guidance, and now performing clinical trial to treat recurrent gliomas.

Targeted Application(s)/Industry

Focal central nervous system disorders such as tumor, epilepsy, and parkinson's disease can be the target for application of this technique. Developments of the new catheters and pre-infusional similation systems are on their way. We are searching for effective collaborative research in this field.

Department of Neurosurgery, Graduate School of Medicine
TOMINAGA, Teiji, Professor Doctor of Medicine

Imaging and photoregulation of biological functions

Features

To properly understand the functions of biomolecules, it is essential to observe them under physiological conditions where the interactions with other biomolecules are preserved. Therefore, we are developing new functional molecules using both organic chemistry and protein science approaches, and working on the visualization and optical control of biomolecules and their functions. Especially, we have developed fluorescent probes that quantitate the concentration of biomolecules or ions in subcellular regions such as organelles and caged compounds and photoswitches that optically manipulate the biomolecular functions.

Institute of Multidisciplinary Research for Advanced Materials
MIZUKAMI, Shin, Professor Ph.D.

Improvement of Seed Production by Using Reproductive Trait in Crops, Especially, Rice and Cruciferous Crops

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Crops are important for food, environment recovery, energy production, and amenity activity for human being. For improvement of crop seed production, the breeding of crops having environmental stress, is important. Especially the developmental stage from pollination to fertilization is quite weak for these environmental stresses. Thus, by breeding of reproductive trait, we will establish the high productivity and quality of crop seeds. From our research, we found several stress-tolerant genes. We already started the research by both basic and applied level.

Targeted Application(s)/Industry

For application, we evaluated by taking prize for application in 2001. And our basic data has been published in international Journal, "Nature" and "Science". If anyone is interested in these genes, we hope to conduct to collaborative research for establishing the useful breeding lines.

Graduate School of Life Sciences
WATANABE, Masao, Professor PhD.

Induction of Neural Cells from Human Mesenchymal Stem Cells and their Application to Neurodegenerations

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Bone marrow stromal cells have great advantages since they are already applied to patients either by auto- or allo-transplantations, can be harvested in large numbers (10 million cells within several weeks) as adherent cells from bone marrow aspirates, and are with low risk of tumorigenesis. We have established a system to induce neural precursor cells from human bone marrow stromal cells by introducing cells with Notch intracellular domain gene plasmid followed by culturing in neurosphere method. This induction system successfully generates neural precursors which were effective for stroke (J. Neuropathol. Exp. Neurol. , 2005; J Cereb Blood Flow Metab, 2009). They could be further developed into dopamine producing neurons by treating them with cytokines including GDNF (J. Clin. Invest, 2004). The efficiency and safety of induced dopamine neurons were confirmed by rat and monkey model of Parkinson's disease. Importantly, long-term survival of auto-transplanted induced dopamine neurons were verified by 11C-CFT PET scan (J. Clin. Invest, 2013).

Targeted Application(s)/Industry

We hope to collaborate with companies and research groups who are willing to utilize our system.

Graduate School of Medicine
DEZAWA, Mari, Professor Doctor of Medicine

Induction of Schwann cells from human mesenchymal stem cells and their application to spinal cord injury and demyelinating diseases

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Bone marrow stromal cells have great advantages since they are already applied to patients either by auto- or allo-transplantations, can be harvested in large numbers (10 million cells within several weeks) as adherent cells from bone marrow aspirates, and are with low risk of tumorigenesis. Furthermore, marrow bank is available. Likewise, mesenchymal cells harvested from umbilical cord are also easily accessible from cord bank and are a good source of mesenchymal stem cells. We have established a system to induce functional Schwann cells (peripheral glia) from human bone marrow stromal cells and umbilical cord mesenchymal cells by treating cells with a series of reagents and cytokines. This induction system successfully generates Schwann cells with very high efficiency (~97%). They were confirmed to elicit neural regeneration in peripheral nerve damages and spinal cord injury (Eur, J. Neurosci, 2001; J. Neurosurg, 2004, J. Neuropathol. Exp. Neurol, 2005, Biochem Biophys Res Commun, 2007; Tissue Eng., 2011). The efficiency and safety of induced Schwann cells were demonstrated in monkey by 1 year follow up (Exp. Neurol., 2010). Importantly, induced cells not only elicited neural regeneration in both peripheral and central nervous system, but also contributed to functional recovery by restoring myelin and saltatory conduction. Therefore, these cells are expected to be effective to demyelinating diseases as well. We hope to collaborate with companies and research groups who are willing to utilize our system.

Targeted Application(s)/Industry

Graduate School of Medicine
DEZAWA, Mari, Professor Doctor of Medicine

Induction of skeletal muscle cells from human mesenchymal stem cells and their application to muscle degeneration

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Bone marrow stromal cells have great advantages since they are already applied to patients either by auto- or allo-transplantations, can be harvested in large numbers (10 million cells within several weeks) as adherent cells from bone marrow aspirates, and are with low risk of tumorigenesis. We have established a system to induce skeletal muscle cells from human bone marrow stromal cells by treating cells with cytokines followed by Notch intracellular domain gene plasmid introduction. This induction system successfully generates skeletal muscle lineage cells comprised of muscle stem cells, namely, satellite cells, as well as myoblasts and myotubes. Transplantation of satellite cells and myoblasts were effective for muscle regeneration (Science, 2005). Importantly, induced satellite cells integrated into satellite cell location and continuously contributed to muscle regeneration. Our research team is now pursuing the safety and efficiency of these induced cells by using canine muscle degeneration models. We hope to collaborate with companies and research groups who are willing to utilize our system.

Targeted Application(s)/Industry

Graduate School of Medicine
DEZAWA, Mari, Professor Doctor of Medicine

Innovative anemia therapy: Development of new anemia drugs targeting the novel mechanism of erythropoiesis

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Strong points
Anemia is a very prevalent disease. Nevertheless, an effective therapy is yet to be discovered. Erythropoietin is effective only for those with renal dysfunction. We have found that inhibition of an enzyme for epigenetic regulation results in a prominent increase of erythropoiesis, pointing to a new target for anemia therapy. We have also generated a new, cell-based assay system for the enzymatic activity and carried out small molecule screening.

Collaboration with industry partners
We are seeking a collaboration to accelerate the development of new anemia drugs based on these findings. Together we will advance the development of the candidate molecules currently identified as well as conduct further screening of larger chemical space for better candidates and/or for drug repositioning.

Targeted Application(s)/Industry

Department of Biochemistry, Tohoku University Graduate School of Medicine
IGARASHI, Kazuhiko, Professor Doctor of Medicine

Innovative Preparing and Thick Coating Technique without Heat Affected Zone and Phase Transformation

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The cold spray (CS) technique is known as a new technique not only for coating but also for thick depositions. It has many advantages, i.e. dense coating, high deposition rate, low oxidation, and no phase transformation. We have been carrying out establishment of innovative preparing and coating techniques using the CS, and maintenance of reliability and safety of the cold sprayed repairing parts and coatings. Moreover, in order to evaluate the compatibility between a substrate material and particles based on an adhesion mechanism and scientific basis, various adhesion conditions are examined a micro / nano-structure observation and a molecular simulation.

Targeted Application(s)/Industry

Our targets were mainly hot section parts of thermal power plants and reactor piping and tubes etc. Recently, it is possible to make a ceramic coating. Therefore, we accelerate the evolution of the other fields including the creation of the functionality materials in near future.

Fracture and Reliability Research Institute, Graduate School of Engineering
OGAWA, Kazuhiro, Professor Doctor of Engineering

INSTRUMENT AND METHOD FOR ANALYZING METABOLIC CONDITION OF LIVING BODY AND RECORDING MEDIUM

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AIMS: The invention is to analyze metabolic condition, especially in oxygen consumption and energy production in the adipose tissues of human (Patent: JP 3848818).
PROBLEM TO BE SOLVED: To provide an instrument and method for analyzing the metabolism condition of a living body which is constructed in such a manner that it can measure the metabolism condition of a living body correctly and easily, and a recording medium.
SOLUTION: A metabolism condition analyzer is provided with an input means for inputting information about the body of a subject, a control means for processing this information and an output means for outputting results of the processing. The information consists of name, age, sex, race, height, weight, bioelectric resistance value and the date and time of measurement. A data file consisting the control means stores evaluation data of a metabolic condition which is previously determined by medical judgment based on a combination of an internal respiration index and oxygen consumption and energy production in adipose tissues. These are computed by calculating the value obtained by subtracting one from a body density calculated from the height, weight of the subject and the bioelectric resistance value and then multiplying the value. Welcome to your investment or co-operation.

Department of Diabetes Technology, Graduate School of Biomedical Engineering
NONOGAKI, Katsunori, Professor MD, PhD

Integrated Design for Sustainable Energy Systems

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The concept of LCS (low carbon society) is a unique approach having multi-dimensional considerations such as social, economic and environmental dimensions. The LCS aims at an extensive restructuring of worldwide energy supply/demand network system by not only replacing the conventional parts with the new ones, but also integrating all the necessary components and designing absolutely different energy networks. An energy-economic model is a tool for decision making for a variety of purposes, such as energy security planning, climate policy analysis, and technology innovation assessment.

Targeted Application(s)/Industry

Applying this model derives political measures, such as investment in R&D. It is also useful for guiding development policies under the concept of sustainability. In finding suitable energy-economic models for specific purposes, it is important to apply an adequate tool to consider geographical regions in focus, time horizon, energy classification, and economic parameters.

Department of Management Science and Technology , Graduate School of Engineering
NAKATA, Toshihiko, Professor Doctor of Engineering

Integrative Health and Human Subtle Energy

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“Qi” is a fundamental concept in Chinese medicine. “Reiki” is a Japanese concept of Qi energy. Reiki is well known in Europe and America. For example, Brigham and Women’s Hospital (Harvard Medical School) has a certification system of Hospital Reiki Practitioner. We are thinking to use these subtle energies in the field of Integrative Health.

Targeted Application(s)/Industry

At first, technique to detect subtle energy through skin sensor can be offered. Then, cooperative work will start to develop detector of subtle energy. Our final purpose is to use subtle energy in daily life.

Music and Acoustical Medicine, Graduate School of Medicine
ICHIE, Masayoshi, Professor M.D., Ph.D.

Interactive Content to Enrich Our Lives

Features

(1) Displays and Interactive Techniques
Designing original display systems to show visual information accurately and effectively, and interaction techniques to make better use of these display systems.

(2) Interactive Video Content
Creating new interactive content from real video taken by cameras and computer-generated animations.

(3) Modeling and Controlling the “Atmosphere” in a Conversation Space
Aiming to stimulate the “atmosphere” in a conversation space by supplying real-time feedback to the users, we are exploring means of sensing and analyzing change in the space.

(4) Designing and Evaluating Novel Interaction Techniques
Designing and evaluating novel interaction techniques on target selection for variety types of displays including large and touch displays.

Targeted Application(s)/Industry

Research Institute of Electrical Communication
KITAMURA, Yoshifumi, Professor Doctor of Engineering

International industry-academic consortium (CIES consortium) enhances creation of innovative integrated electronic technologies from material/process/LSI to software/tool/system (Center for Innovative Integrated Electronic Systems: CIES)

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Integrated electronic systems are a fundamental technology that makes possible the lifestyles of ease and abundance we enjoy in the modern world. By leveraging innovative core technologies and longstanding accomplishments of industry-academic cooperation in Tohoku University as centripetal forces, we have promoted the CIES Consortium consisting of industry–academic collaborations, major national projects and community-based cooperation projects in the fields of Spintronics, AI hardware and Power Electronics through our cooperation with a diverse range of Japanese and foreign companies from fields such as materials, equipment, devices, circuits and systems. CIES has promoted world level Academic-Industrial Collaboration under establishment of world-first 300mm wafer process line and facilities for prototype manufacturing and characterizing spintronics integrated circuits compatible with world-class companies in university campus.

Targeted Application(s)/Industry

CIES has conducted international industry-academic collaboration in the fields of integrated electronic technologies ranging from materials/equipment to devices/systems. In addition, we have promoted to cooperate with regional and local companies with support of local government (Miyagi Prefecture, Sendai City, Iwate Prefecture, etc) for contributing to Tohoku reconstruction and regional development. We welcome your participation in CIES consortium.

Center for Innovative Integrated Electronic Systems
ENDOH, Tetsuo, Professor Doctor of Engineering

Internet video streams have identities like fingerprints

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According to recent studies, each video that is streamed online has its own unique characteristic. The pattern of data that are sent through the network can vary from one encoding method to another and the change from scene to scene, which is a unique characteristic of each video. This research aims to identify video content in the network without looking at the data itself.

Targeted Application(s)/Industry

This research would be especially useful in preventing illegal distribution of television program such as illegal channel without violating user privacy. Another application would be to prevent confidential online meeting from leaking outside local enterprise network. In addition, it is also possible to investigate the circulation of a video content using method introduced by this work.

Graduate School of Information Sciences
KATO, Nei, Professor Doctor of Engineering

IVR (Interventional Radiology) Treatment of Hypertention: Minimally Invasive Treatment of Primary Aldosteronism Based on the Adrenal Vein Sampling Technology

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Primary aldosteronism is a leading cause of secondary hypertension accounting for approximately 10 % of hypertensive patients; 4 million patients potentially exist in Japan. We aim to optimize the method of ablating aldosterone producing adenoma using newly developed bipolar radiofrequency ablation system with 300-400kHz high-frequency current and electric power of 40W (Celon Prosurge Applicator), and establish a less invasive interventional radiological treatment of primary aldosteronism.

Targeted Application(s)/Industry

Collaboration with medical equipment manufacture and universities are expected to develop new devices enabling ablation of aldosterone producing adenoma. Flexible guide-wire-type ablation system and rapid aldosterone assay system should be co-developed to tread aldosterone producing microadenoma which is difficult to detect due to its small diameter of less than 5mm.

Graduate School of Medicine
TAKASE, Kei, Professor MD, PhD