Tohoku University. Research Profiles

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"P" Theme - 16 Result(s)

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Peptide and Protein Designs for Unexplored Fileds

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I am proposing methodologies to design recombinant peptides and proteins with appropriate structures and functions in the medicinal, environmental, material, and nanotechnological fields, with molecular evolutional and domain shuffling engineering. At present, we have constructed the methodologies for efficient renaturation of functional proteins from inclusion bodies expressed in bacteria, generation of peptides and proteins with the function of biomineralization, generation of peptides and proteins with affinity for inorganic materials to spontaneously make linkages between various nanomaterials, and high enhancement of cellulolytic enzyme activity induced by nanoclustering design on nanomaterials.

Targeted Application(s)/Industry

We hope the business partners in the in the medicinal, environmental, material, and nanotechnological fields would be interested in my approaches and we could conduct effective collaboration research with them.

Graduate School of Engineering
UMETSU mitsuo, Professor Doctor of Engineering

Peptide formation under high P and T conditions: new carbon fibers

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Peptides are formed through the enzymatic actions in living organisms, but difficulty exists to form peptide by non-enzymatic actions. Here we report the success of peptide formation under anhydrous, high P and T conditions. We were successful to form 11-mer of glycine and 5-mer of alanine. They are important constituents of spider silk, which is a candidate of next generation of carbon fibers. Therefore, our techniques have potentials to apply making new carbon fibers without biotechnology.

Targeted Application(s)/Industry

Geosciences Department, Graduate School of Science
KAKEGAWA Takshi, Professor Ph.D.

Performance enhancement and application development of energy harvesting materials by microstructure design

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To realize IoT society, it is required the sensors, which function without battery charge. We study on energy harvesting materials using our knowledge about materials mechanics and numerical simulation such as finite element method. We recently address to develop energy harvesting devices, which can recovery the unharnessed energy around us as electrical energy.

Targeted Application(s)/Industry

Department of Materials Processing, Graduate School of Engineering
NARITA Fumio, Professor Doctor of Engineering

Philosophy of Science and Technology, Science and Technology Studies (STS)

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My research area is mainly phenomenology, philosophy of technology, and applied ethics (engineering ethics etc.). Technological Artifacts mediate human activities. So designing artifacts is in itself an ethical behavior. Analysing the ontological structure of the artifacts, describing the epistemological propcess of desingning activities, evaluating the social and ethical influence of artifacts are main issues in philosophy of technology. On the basis of such philosophical investigations, we can develope ethical studies concerining how engineerss, companies can recognize ethical issues in a networks of meanings , how they can make ethical decision among engineers and users.

Targeted Application(s)/Industry

I hope to conduct cooperative research on ethical education of engineers, as well as on human-machine interaction.

Graduate School of Arts and Letters
NAOE Kiyotaka, Professor PhD

Photo-Functional Advanced Materials for Nanofabrication by Nanoimprint Lithography

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Nakagawa group has dedicated to pursue scientific principles for molecular control of interface function occurring at polymer/other material interfaces and to put them into practice in nanoimprint lithography promising as a next generation nanofabrication tool. We are developing advanced photo-functional materials such as sticking molecular layers for "fix by light", UV-curable resins and antisticking molecular layers for "preparation by light", fluorescent resist materials for "inspection by light", and hybrid optical materials "available to light" and new research tools such as mechanical measurement systems to evaluate release property of UV-curable resins.

Targeted Application(s)/Industry

Our research aims at creating new devices to control photon, electron, and magnetism.

Institute of Multidisciplinary Research for Advanced Materials
NAKAGAWA Masaru, Professor Doctor of Engineering

Photo-Induced Characteristics of TiO2 Prepared by Anodic Oxidation

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Ti anodizing technique has been offered for coloring the surface of Ti, and its mechanism is understood by light interference varied with the oxide thickness. A characteristic of this study is to control the crystallinity of the oxide, and its originality is to provide photo-induced characteristics to Ti and its alloys by controlling the electrochemical conditions differed from that of coloration technology. This study is aimed for controlling the surface of Ti by using a simple and easy, inexpensive technique and to fabricate high functional titanium materials.

Targeted Application(s)/Industry

Related to practical applications, it is considered as a use for environmental purification such as deodorization and water purification, biomaterial and antibacterial and structural titanium.

Institute for Materials Research
MASAHASHI Naoya, Professor Doctor of Engineering

Polymer-nanoparticle hybrid materials

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Hybrid materials that show multi-functions of polymer and nanoparticles are expected to be used in future industries, and thus many research and development have been actively conducted. However, since the affinity of polymer and inorganic nanoparticles is very low, in most of the cases, properties of different materials are incompatible in the hybrid materials. To create the hybrid materials with incompatible multi-functions has been considered a difficult task.
However, by using supercritical fluid technology, we have succeeded in making hybrid materials with incompatible multi-functions.

Targeted Application(s)/Industry

Now, variety of hybrid materials are being developed, including
・Transparent, flexible, high reflective index, and high fabricability,
・Flexible, high heat conductivity, low electric resistivity, and high fabricability.

Advanced Institute for Materials Research
ADSCHIRI Tadafumi, Professor Doctor of Engineering

Powder Processing Contributing to the Global Environmental Protection

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Material properties and characteristics of the product as a raw material powder are dependent on the particle packing structure as well as the chemical composition. Sophisticated control of the powder processing such as mixing and grinding is strongly required. In our laboratory, we are creating the simulation method as a tool for controlling the powder processing and optimizing the powder process for achieving a resource-saving and energy-saving by the computer simulation.

Targeted Application(s)/Industry

We are conducting research on analysis/optimization of powder processing such as grinding, mixing, and packing by using simulation, metal recycle from urban mine through active utilization of mechanochemical effect, and generation of energy from biomass.

Institute of Multidisciplinary Research for Advanced Materials
KANO Junya, Professor Doctor of Engineering

Precipitation Hardened Co-based Alloy

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The high-temperature strength in Co-based alloys is inferior to that in Ni-based superalloys due to no available ’ phase for strengthening Co-based alloys. We have found a new intermetallic compound Co3(Al,W) ’ phase, and /’ Co-Al-W-based wrought and cast alloys show excellent high-temperature strength. The /’ Ir-Al-W-based alloys are also available for high-temperature uses at over 1100 °C. The Co-based alloys also have good wear resistance. For example, friction stir welding (FSW) of high-softening-temperature materials such as steels and titanium alloys is possible using a Co-based alloy tool. We hope to conduct collaborative research with willing company for a practical application of the Co- or Ir-based alloys for high-temperature uses including FSW applications.

Department of Metallurgy, Graduate School of Engineering
OMORI Toshihiro, Associate Professor Ph.D.

Prediction and Prevention of Fractures

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We have been developing methods for explicating the dominant factors that determine the physical and chemical properties of materials and stacked structures used in human societies. Since the number of element atoms which consists of advanced materials has been increasing, and the crystallographic structure of the materials has become very complicated, both the various properties and reliability of the materials fluctuate significantly in nano-scale, and thus, deteriorate easily due to the local damages of the materials.

Targeted Application(s)/Industry

To design the optimal structure, composition of materials, and the fabrication process of both materials and stacked structures, we are going to develop a method of analyzing the atomic structure of thin film materials based on quantum mechanics and experimental methods for measuring material properties, atomic scale damage or defects in nano-materials.

Fracture and Reliability Research Institute, Graduate School of Engineering
MIURA Hideo, Professor PhD., Dr. of Engineering

Prevention and amelioration of late-onset hypogonadism by food ingredients

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Late-onset hypogonadism (LOH) is induced by age-related decline of testosterone synthesis, which leads to decrease muscle and sexual nature as well as mental symptoms such as depression. Now great attention is focused on prevention and amelioration of LOH via ingestion of foods and supplements.

We developed screening system of functional ingredients from food extracts for anti-LOH using testis-derived cells, and clarified that vitamins, nutraceuticals, and edible plant extracts have potentiating activities for the production of testosterone.

Targeted Application(s)/Industry

Graduate School of Agricultural Science
SHIRAKAWA Hitoshi, Professor Doctor of Agricultural Science

Production of Tumor-Specific Monoclonal Antibodies

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Podoplanin (PDPN/Aggrus/T1α), a platelet aggregation-inducing mucin-like sialoglycoprotein, is highly expressed in many cancers and normal tissues. A neutralizing monoclonal antibody (mAb; NZ-1) can block the association between podoplanin and C-type lectin-like receptor-2 (CLEC-2) and inhibit podoplanin-induced cancer metastasis, but NZ-1 reacts with podoplanin-expressing normal cells such as lymphatic endothelial cells. Recently, we established a platform to produce cancer-specific mAbs (CasMabs). The newly established LpMab-2 mAb reacted with podoplanin-expressing cancer cells but not with normal cells, as shown by flow cytometry and immunohistochemistry; therefore, LpMab-2 is an anti-podoplanin CasMab that is expected to be useful for molecular targeting therapy against podoplanin-expressing cancers.

Targeted Application(s)/Industry

We can produce cancer-specific mAbs (CasMabs) against all membranous proteins. CasMabs are expected to be useful for molecular targeting therapy without side effects.

Graduate School of Medicine
KATO Yukinari, Professor M.D.,PhD

Programming Language Theory and Computation Models

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Our laboratory conducts leading research on programming language theory and high-level computation models. In particular, we focus on research and application of (general proof methods for) program equivalence, functional programing, and type systems (also known as lightweight formal methods), which are attracting revived interests in recent years. Our Japanese translation of "Types and Programming Languages" (Benjamin C. Pierce, University of Pennsylvania)---compiled in cooperation with engineers from top-level electronics and software companies in Japan---has become the 42nd bestseller (rather exceptional as an academic Publications) among new books in Amazon.co.jp. For more information, please see the Web page: http://www.kb.ecei.tohoku.ac.jp/~sumii

Targeted Application(s)/Industry

Our technology can be used for design and development of software artifacts, especially programming languages and tools including DSL (domain specific languages), as well as application of functional programming, type systems, or formal methods.

Graduate School of Information Sciences
SUMII Eijiro, Professor

Project “The Mirror Magical”: Remote and Non-Contact Extraction of Biological Information

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We engage in development of a cyber-medical system, “The Mirror Magical” for taking a medical check-up anytime and anywhere by use of information and communication technology (ICT). We only have to stand still in front of the mirror to check our autonomic nervous function related to baroreflex on the basis of video signals capable of remote and non-contact measurement. Demonstration experiments have been held to verify the validity of the system in estimation of blood pressure variability and the effects of physical exercise.

Targeted Application(s)/Industry

We can conduct effective collaborative research using the system not only in medical and welfare fields but also for application to smartphones, automobiles, emotion recognition robots, security cameras, sports broadcast and so on.

Center for Promotion of Innovation Strategy
YOSHIZAWA Makoto, Dr Eng

PVT-Variation-Aware VLSI System Based on Nonvolatile-Device/MOS-Hybrid Circuitry

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Nonvolatile devices, which can remain stored data without power supply, are generally used for ROM (Read-Only Memory) to store boot programs (the information to start up the computer and the basic instructions that operate it) in computers. One attractive feature is that it does not consume any static power while it remains stored data. ‘Nonvolatile logic' is a novel logic style that a nonvolatile device is used for not only a nonvolatile storage element such as ROM but also a logic-circuit element which is the basic component of a CPU and an entire system. By using the nonvolatile devices as storage elements of circuit-configuration information, we can realize a process-variation- aware logic circuit with small hardware overhead.

Targeted Application(s)/Industry

The proposed technique is effective for implementing high-performance and highly-reliable LSI fabricated with cutting-edge process technology. We expect we can conduct effective collaborative research in highly reliable VLSI-systems fields.

Research Institute of Electrical Communication
HANYU Takahiro, Professor PhD of Engineering