"R" Theme - 12 Result(s)
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R&D in Semiconductor Materials and their Device Applications Bringing System EvolutionsFeatures1. Development of Distributed Feedback (DFB) Laser Diodes (LD) widely used in optical communications systems realizing a highly information-based society. This LD increases the transmission capacity by 25,000 times per fiber which means the bit rate of 10Tb/s. Targeted Application(s)/IndustryDFB-LD: Fabrication of periodic structure with submicron scale, Epitaxial growth of semiconductor films on the substrate with fine structures, LD fabrication process, device evaluation, and device simulation New Industry Creation Hatchery Center
MATSUOKA Takashi, Professor
Doctor of Engineering
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Radar Remote SensingFeaturesWe are developing new electromagnetic methodologies including radar and electromagnetic induction techniques, applying to natural resources survey and environmental monitoring. Currently, we are working for topics such as space borne and air borne microwave remote sensing sensors (SAR), Ground Penetrating Radar (GPR), Electromagnetic Induction methods (Metal detector) and their applications to subsurface sensing and humanitarian demining, and borehole radar for hydro geology. One of our sensors, ALIS which is a GPR system for land mine detection has been successfully operated in real mine field in Cambodia. These technologies using applied electromagnetics can be applied to other fields. We are seeking for industries which have interests in subsurface sensing and detection. Targeted Application(s)/Industry•Development and Application of Ground Penetrating Radar (GPR ) , EMI methods |
Radiological Medical InfomaticsFeaturesPET and SPECT have very high sensitivity to detect molecule by means of radiation detection, and are considered to be excellent tools for molecular imaging. We are studying and developing data analysis techniques for PET and SPECT data. Using our approaches, we can analyze data in quantitative manner, and obtain physiological functions in living organism. Targeted Application(s)/IndustryPharmaceutical companies who are interested in using PET to evaluate efficacy of new drug. Companies which are related to medical informatics, medical equipments. |
Real World RoboticsFeaturesReal world robotics is a new field of robotics dealing with robot-related issues in real environments. Several prototypes of real world robots have been designed and developed based on new robot technologies. Real world robots will have great impacts on our daily life, as current industrial robots have had done a lot on industries. We have proposed several fundamental robot technologies such as multiple robots coordination, manipulation, wearable support system, walking support system, human assistive systems and dance partner robot system. We also extend these technologies for developing the real world robot applications such as engine assembly robot, dish washing robot, car transportation system and so on. Targeted Application(s)/IndustryBased on these technologies, we expect we can conduct effective collaboration research in many fields. |
Regulation of ABC Transporters in Colorectal CancerFeaturesColorectal cancer (CRC) is one of the most common types of cancer worldwide. Surgical resection is the only curative treatment available for primary CRC. We determined the gene expression profiles for ATP binding cassette (ABC) transporters by RNA sequencing in matched colon cancer and normal colon tissue specimens in order to provide insight into the regulatory mechanisms underlying expression of transporters related to colon carcinogenesis. The expression of ABCC3 was repressed by Wnt signaling pathway, suggesting downregulation of ABCC3 might contribute oncogenesis. Targeted Application(s)/IndustryRecently, we easily obtain comprehensive data including transcriptome and other omics data. These data are expected to help find a target for drug development, expecting that pharmaceutical industry interpret and extract new knowledge from them. |
Regulation of AngiogenesisFeaturesAngiogenesis, i.e., the formation of new capillaries, takes place under pathophysiological conditions including cancers, ocular neovascular diseases and atherosclerosis. Anti-angiogenic drugs have been developed, and are now in clinical use. However, because of side effects due to the damage to vascular endothelial cells, the development of anti-angiogenic drugs with different modalities is anticipated. We have isolated vasohibin-1 (VASH1) as a novel angiogenesis inhibitor expressed by endothelial cells (ECs), and vasohibin-2 (VASH2) as its homologue having pro-angiogenic activity. Targeted Application(s)/IndustryWe are planning to develop strategies of VASH1 potentiation and VASH2 inhibition. For VASH1 potentiation, we are planning to use recombinant VASH1 protein or search low molecular weight substances having VASH1 like activity. For VASH2 inhibition, we are succeeded in the development of neutralizing anti-human VASH2 monoclonal antibody. |
Regulation of TSLP Production in KeratinocytesFeaturesThymic stromal lymphopoietin(TSLP)has been focused as a master switch for allergy. We established a mouse keratinocyte cell line which constitutively and highly produces TSLP. This cell line will be useful to find the inhibitor of TSLP production and to study biochemical features of production and action of TSLP. The inhibitor of TSLP production might be used as an external or an inhalation drug, indicating low probability of causing a decrease in immune competence. Targeted Application(s)/IndustryBy using this cell line, we expect we can conduct effective collaborative research in medical fields. For examples, the cell line is useful for analysis of TSLP production and functions, development of inhibitors of TSLP production, and detection of immunotoxic compounds. |
Religion, language, society, and life in ancient IndiaFeaturesTargeted Application(s)/Industry |
Resarch and development for maintaining and improving brain and mental healthFeaturesThe Smart Aging International Research Center (SAIRC) was founded on 1 October 2009. This Center proposes the creation of a new field to produce well-rounded personnel who have gained “totally comprehensive intelligence” from their experience, in order to cope with various problems associated with the diverse and complex super-aging society. To this end, the Center will promote interdisciplinary cooperative research, international collaborative research projects, and research collaborations with industry, as well as disseminate and exchange information by holding international conferences and symposia. The SAIRC is designed to develop an approach for maintaining and improving brain and mental health in a diverse and complex society from the standpoints of brain science, with the aim of maintaining and improving brain functions; cognitive neuroscience and psychology, with the aim of maintaining a healthy and tranquil state of mind at each aging stage; and philosophy, phenomenology and ethics that provide a radical reconsideration of the concept of the “mind.” We welcome collaborative researches with companies, and academic consultations. Institute of Development, Aging and Cancer
KAWASHIMA Ryuta, Professor
Doctor of Medicine
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Research and Development of Space Exploration RobotsFeaturesWe study and develop mobile robotics technology for lunar and planetary exploration. Our technology is featured by rich experience in locomotion mechanisms for highly rough terrain and advanced slippage control in loose soil environment. Also by 3D map building technology using a laser scanner for autonomous collision avoidance and for operator assistance in remote control/tele-operation. We also contributed to the design and development of Hayabusa and Hayabusa-2, which are sample-return probes developed and operated by Japanese space agency JAXA. Targeted Application(s)/IndustryThese technologies are also applied to terrestrial robots for such as surveillance or disaster response. Department of Aerospace Engineering, Graduate School of Engineering
YOSHIDA Kazuya, Professor
Doctor of Engineering
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Robot Technology for Achieving Secure SocietyFeaturesTadokoro Laboratory developed ‘Active Scope Camera,' a world-unique rescue robot that can search deep in rubble piles of collapsed structures through a gap of a few cm wide. It also developed ‘Quince,' a world-unique unmanned ground vehicle that could survey the second to fifth floors of Nuclear Reactor Buildings of Fukushima-Daiichi Nuclear Power Plant. Its technologies was applied industries, including unmanned transfer vehicle for outdoors under ice and snow environment being actually used in a factory of Toyota Motor East Japan, and ‘Robo-Scope' for debris inspection in collaboration with Shimizu Corporation. Targeted Application(s)/IndustryWe have a policy of education through and research for solution to actual problems. Current nearly ten collaborative researches focuses on outdoor investigation, infrastructure/plant inspection, and remote/autonomous task execution by robots. Graduate School of Information Sciences
TADOKORO Satoshi, Professor
Doctor of Engineering
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Room temperature bonding using thin metal films (Atomic Diffusion Bonding)FeaturesAtomic diffusion bonding of two flat wafers with thin metal films is a promising process to achieve wafer bonding at room temperature. High surface energies of metal films and a large atomic diffusion coefficient at the grain boundaries and film surfaces enable bonding at room temperature without unusually high loading pressure. This technique, which enables bonding of any mirror-polished wafer, is gaining wider use for fabricating optical and electrical devices. Moreover, bonding of mirror polished metals and polymer sheets can be achieved, which further extends the application of this bonding technique. Targeted Application(s)/IndustryOptical, power and electrical devices, MEMS, bonding of polymer sheets, metals, and ceramics for precision mechanical equipments. Frontier Research Institute for Interdisciplinary Sciences
SHIMATSU Takehito, Professor
Doctor of Engineering
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