Tohoku University. Research Profiles

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"G" Researcher - 4 Result(s)

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Development of Sensors and Measuring Systems for Ultra-Precision Manufacturing and Nanomanufacturing

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Features

The research is being focused on measurement of surface forms of precision workpieces and stage motions of precision machines, which are important items for ultra-precision manufacturing and nanomanufacturing. Optical sensors are being developed for measurement of angle and displacement, which are fundamental quantities for manufacturing. Technologies for improvement of the sensor sensitivity and bandwidth, reduction of the sensor size as well as new multi-axis sensing methods are being The research is being focused on measurement of surface forms of precision workpieces and stage motions of precision machines. Optical sensors are being developed for measurement of angle and displacement. A number of scanning-type measuring systems for precision measurement of surface forms and stage motions are also being developed. Error separation algorithms and systems for straightness and roundness, which are the most fundamental geometries treated in ultra-precision manufacturing, are being investigated. Novel systems based on scanning probe microscopy are under development for micro- and nano-structures as well as freeform optics in responding to new and important challenges from ultra-precision manufacturing and nanomanufacturing.

Targeted Application(s)/Industry

The multi-axis optical displacement and angle sensors developed in the laboratory are expected to measure motions of semiconductor/IC manufacturing and inspection equipment, precision machine tools, ultra-precision measuring instrument. The surface profile measurement systems are expected t play an important role in ultra-precision manufacturing and nanomanufacturing industries.

Department of Nanomechanics, Graduate School of Engineering
GAO Wei, Professor PhD

Development of Production System of Valuable Proteins Using a Koji-Mold, Aspergillus Oryzae, as a Host

Features

Because a koji-mold, Aspergillus oryzae, has an ability to secret a higher amount of proteins and is regarded as a safe microorganism, it has been expected as a promising host for production of useful proteins derived from plants and animals. However, Aspergillus oryzae produces various proteolytic enzymes that could degrade heterologous proteins produced, and hence we constructed mutant strains in which a transcription factor gene involved in proteolytic enzyme production was disrupted. In addition, codon optimization of heterologous gene resulted in a significant increase in the stability of heterologous gene transcripts. These attempts would lead to an increase in the amount of valuable proteins produced.

Targeted Application(s)/Industry

The technology could be applied to the high-level production of pharmaceutical proteins and industrially useful enzymes. We look forward to developing the collaborative project with enzyme and pharmaceutical industries.

Graduate School of Agricultural Science
GOMI Katsuya, Professor PhD

Establishment of Minimally Invasive Cell Therapy for Diabetes by Introducing Interdisciplinary Approach

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The islet transplantation is the ideal "minimum invasive" cell transplant therapy for the severe diabetic patients who are suffering with controlling the blood glucose levels. In this project, we try to have a cross organization among the advanced technologies in islet transplantation as one of the typical cases. Our chief objective is to construct the center of medical cell-engineering therapy as successful examples in Tohoku University. We are convinced that technical innovation through this project could contribute much more to the activation of medical industry based upon cell therapy.

Targeted Application(s)/Industry

We have already established effective academic-industrial alliances regarding our several projects including a development of new type of cell-isolation enzyme. However, we are still looking for possible candidates concerning a special device for cell transplantation and medical grade-pathogen free animals.

Graduate School of Medicine
GOTO Masafumi, Professor Doctor of Medicine

Corpus-Based Lexicology of Modern Japanese

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I am doing empirical research in the vocabulary in Modern Japanese, focusing mainly on the senses and usages of nouns and verbs, based on evidence from corpora. I am also interested in the theoretical side of the corpus studies and the use of corpora in other languages, such as English. I am on of the pioneers in this field in Japan.

Targeted Application(s)/Industry

Application is possible in dictionary-making, teaching of Japanese and English.

Graduate School of Arts and Letters
GOTOO Hitosi, Professor M.A.