"H" Researcher - 38 Result(s)

H

 H

Development of Immunobiotic Evaluation System for Functional Feeds as a Livestock Animal Model

NEXT
PREV
特徴・独自性
  • Pattern recognition receptor (PRR) family plays an important role in the defense through recognition of pathogen-associated molecular patterns or microorganisms-associated molecular patterns (PAMPs/MAMPs).
  • Some functional feed materials are thought to regulate intestinal immunity by contact and stimulation of epithelial cells and immunocompetent cells via PRRs in the gastrointestinal tract and induction of cytokine production. In this "new world" of feed immunology, however, much remains unknown about the underlying mechanisms of intestinal immunity because of lack of appropriate intestinal immunoassay system for livestock animals.
  • We have advanced application of originally established porcine and bovine intestinal epitheliocytes (PIE, BIE) cell lines (see photo) for evaluation of immunobiotics and immunogenics exerting anti-inflammatory responses both in PIE cell monolayer and co-culture system with porcine peyer's patch immune cells as a peyer's patch culture model (see illustration).
実用化イメージ

This evaluation system may also contribute to elucidate immunoregulatory mechanism of immunobiotics and immunogenics mediated by pattern recognition receptors essential to future development of not only immunobiotic feeds but also vaccines using immunobiotics to prevent specific diseases. This can benefit mankind by offering immunobiotic feeds as a safer alternative to conventional antibiotic drug therapy.

Researchers

Graduate School of Agricultural Science

Haruki Kitazawa

Combustion and Atomization Technology in High-Pressure Gas Turbine Conditions

NEXT
PREV
特徴・独自性
  • Combustion is a complex phenomenon composed of multi-dimensional dynamics of temperature, concentration, velocity, and chemical reactions. Advanced combustion technologies are essential for solving the environmental and energy issues. Our laboratory has a high-pressure combustion test facility which is a unique experimental facility in the world. Research projects have originality, especially in the field of high-pressure combustion and laser diagnostics, and focus on not only aerospace engineering and energy engineering including new fuel technology but also atomization technology and safety operations of chemical plants mostly operated at high pressure.
実用化イメージ

Potential collaborations are in the research fields of aerospace propulsions, automobile engines, power generations and chemical plants, in terms of development of gas turbine combustors for various fuels, generation and control of fuel atomizers, laser diagnostics of combustion and safety design of chemical reactors.

Researchers

Institute of Fluid Science

Hideaki Kobayashi

Network Roaming System with Flexible Access Control

NEXT
PREV
特徴・独自性
  • The laboratory works on development of authentication wireless LAN systems which refer user attribute to realize flexible access control capability.Improvement and evaluation of new access control is devised based on experience of operation of an international wireless lan roaming service ‘eduroam' which is based on 802.1x authorization protocol.
実用化イメージ

The development contains application of OpenFlow technology to select a connecting network depending on user affiliation, as well as access control based on pre-defined attribute information.

Researchers

Organization for Innovations in Data Synergy

Hideaki Sone

Development of devices regulating inter-organ neural network for diabetes therapy

NEXT
PREV
特徴・独自性
  • Diabetes induces several complications, including retinopathy and nephropathy. In patients with type 1 diabetes as well as those with type 2 diabetes, pancreatic beta cells have reportedly decreased. Therefore, regeneration therapy of pancreatic beta cells may be very effective for major populations of diabetic patients. We discovered a neuronal network, from the liver, which selectively elicits pancreatic beta cell proliferation (Science 2008, Fig.). In a murine model with insulin-deficient diabetes, stimulation of this network improved diabetes. Thus, building devices which regulate the inter-organ neuronal network may lead to “regenerative therapy” for diabetes which regenerates pancreatic beta cells in the pancreas using patients’ own cells and patients’ own systems. We hope to conduct collaborative research with a willing company for a practical application of this technology.
実用化イメージ

Researchers

Graduate School of Medicine

Hideki Katagiri

Development of New Drugs and Devices Regulating Inter-Organ Neural Network for Obesity Therapy

NEXT
PREV
特徴・独自性
  • Obesity induced the metabolic syndrome, which causes cardiovascular diseases. Obesity has now become a major health concern not only in developed countries but developing countries. However, diet and exercise are still major therapies. We discovered endogenous systems maintaining homeostasis of energy metabolism and revealed several neuronal networks among organs to be responsible for the regulation systems.
  • 1) Afferent neuronal signals from adipose tissue regulate appetite and prevent over-eating during obesity development (Cell Metab 2006)
  • 2) Neuronal network from the liver enhances basal metabolic rates to prevent obesity development when energy store is increasing (Science 2006) 3) Neuronal network from the liver suppresses adaptive thermogenesis in brown adipose tissue (Cell Metab 2012).
実用化イメージ

On the basis of these original discoveries, we are aiming at developing new drugs and/or building devices which regulate the inter-organ neuronal networks and hope to conduct collaborative research with a willing company for a practical application to obesity therapy.

Researchers

Graduate School of Medicine

Hideki Katagiri

Study on Molecular Mechanism for Plant Immune System

NEXT
PREV
特徴・独自性
  • Plants have immune system against pathogen infection. In our research group, isolation of disease resistance genes, analysis of signal transduction pathways for disease resistance and characterization of defense-related proteins have been performed so far. In addition, we produced transgenic plants expressing green fluorescent protein under the control of defense-inducible promoter, which will be useful to visualize the induction of defense system.
実用化イメージ

Our knowledge obtained from the study on the mechanism(s) for plant immune system and the reporter transgenic plants will be available for screening chemical compounds activating plant immune system (so-called "plant activator").

Researchers

Graduate School of Agricultural Science

Hideki Takahashi

Development of Open Nanoporous Base and Half Metals, Metalloids and their Alloys

NEXT
PREV
特徴・独自性
  • Nanoporous metals have drawn considerable attention due to their highly functional properties. They are generally produced by selective dissolution of elements from a multicomponent alloy (known as the dealloying method). As this method is based on differences in the electrode potential of each element present in the alloy, and this potential is high for noble metals, porous structure can be obtained only for noble metals. Recently we have found a new, simple and easy dealloying method without using aqueous solution, which enable us to develop an open nanoporous non-oxidized metallic material even with base metals (such as Ti, Ni, Cr, Fe, Mo, etc), metalloids and their alloys.
実用化イメージ

This technique is very powerful for developing new functional electrodes, catalysts, filters as well for removing toxic metallic element from the surface of biomaterials containing the toxic element.

Researchers

Institute for Materials Research

Hidemi Kato

Advanced Technology on Flexible Liquid Crystal Displays

NEXT
PREV
特徴・独自性
  • Flexible liquid crystal displays using thin plastic film substrates instead of glass substrates contained in current liquid crystal displays, are bendable, thin, lightweight, and do not crack, and generate new usage styles and human interfaces due to their excellent storability and portability. We have been researching the basic technologies for large-screen and high-quality flexible displays using functional organic materials including liquid crystal and polymer, so that anyone can enjoy fertile information services.
実用化イメージ

We hope to conduct collaborative research with a willing company in industry, for development and practical application of the advanced flexible display technologies.

Researchers

Graduate School of Engineering

Hideo Fujikake

A Microwave-Based Non-Destructive Testing Method for the Long Range Inspection of Metallic Pipe

NEXT
PREV
特徴・独自性
  • We are developing a non-destructive testing method for the long range rapid inspection of metallic pipe using microwaves. The method propagates a microwave inside a pipe, and evaluates flaws appearing at the inner surface of the pipe on the basis of the reflection and transmission of the microwave. The method does not require scanning probes unlike conventional non-destructive methods, which enables one to inspect a pipe quite quickly. Our experimental validations have demonstrated the effectiveness of the method using a pipe as long as 30 m.
実用化イメージ

The NDT method proposed here is applicable when many pipes are inspected or conventional methods are not available due to pipe length and its configuration.

Researchers

Graduate School of Engineering

Hidetoshi Hashizume

Development of an Industrial Instrument / the Medical Equipment Using the Contactless Power Transmission System

NEXT
PREV
特徴・独自性
  • Using a non-contact power transmission technique, we develop an industrial instrument and the medical equipment. In the industrial instrument, we deal with the wide non-contact electricity transmission of the dozens of kW class from mW class from a small size electric apparatus represented by a cell-phone to the factory carrier device. In addition, we develop the contactless electricity transmission to an artificial heart (TETS) and a functional electrical stimulator (FES) aiming at the exercise of limbs inconvenience person function rebuilding mainly in the medical equipment.
実用化イメージ

We develop soft-heating hyperthermia using the small implantation element which does not need an internal temperature measurement as cancer treatment.

Researchers

International Research Institute of Disaster Science

Hidetoshi Matsuki

Morphology Control of Alloy Nanoparticles by Restrict Controlling of Metal Complex

NEXT
PREV
特徴・独自性
  • To apply the specific properties of nano materials for the industrial products, various technologies, such as synthesis method for single phase alloy nanoparticles which shows the effective activity for aimed reaction, that for well crystallized alloy nanoparticles which shows the resistively against for undesirable reaction, and that for single layered surface control method, etc, is developed by precise control of metal complexes in the solution by using the calculation and various research equipment including the photon factory.
実用化イメージ

Our technology can be useful for various industry which need the restrict control of surface properties, such as catalysts and electronics.

Researchers

Graduate School of Environmental Studies

Hideyuki Takahashi

High Performance Computer Architectures and their Applications

NEXT
PREV
特徴・独自性
  • My research interests include the design and development of high-performance supercomputing systems and their applications. Targeted areas range from the key components of supercomputing systems, which include processor architectures, memory subsystems, network systems, task schedulers, and compilers, to high-performance multimedia processing algorithms such as photo-realistic computer graphics.
実用化イメージ

Currently I am conducting joint-research projects with several companies in the fields of high-performance computer architecture design and advanced simulation technologies for industrial design such as next-generation supercomputers and highly efficient and comfortable regional jets.

Researchers

Graduate School of Information Sciences

Hiroaki Kobayashi

Business Continuity Management (BCM)

NEXT
PREV
特徴・独自性
  • Business continuity management (BCM) is a strategy of a company or a public organization to continue critical operations or recover them early even when they suffer serious damage from disasters, major accidents, terrorism, infectious diseases and so on. The plans for BCM is called BCPs. Japanese government and industry organizations actively promote introduction and improvement of BCM. My laboratory have studied how to spread and improve BCM. I participate in development of governmental guidelines for BCM. I also operate a BCM study group consist of companies, governmental organizations and research institutes in Sendai City.
実用化イメージ

I would be able to give an advice to companies or organizations which are going to introduce or improve their BCM and BCP at the request of them. In addition, collaboration with corporate groups can be assumed to promote or improve BCM practically.

Researchers

International Research Institute of Disaster Science

Hiroaki Maruya

Multi-functionalization of composite materials by microstructure design

NEXT
PREV
特徴・独自性
  • For further social development, it is required the miniaturization, weight saving, high performance of various devices. We study on fiber, particle reinforced polymer, metal, ceramic matrices composite materials using our knowledge about materials mechanics and numerical simulation such as finite element method. We recently address to develop multi-functionalized composite materials, which have high strength, super lightweight, energy harvesting function, damage monitoring function, biodegradable at the same time.
実用化イメージ

Researchers

Graduate School of Environmental Studies

Hiroki Kurita

Mathematical Biology

NEXT
PREV
特徴・独自性
  • Principal subject of our study is the mathematical model analysis to make clear or present the point at issue for scientific discussion about real biological/social phenomena, or to promote the advanced theoretical research: what theoretical problem about target phenomenon is treated, how the problem is mathematically modeled, what mathematical analysis is applied for the model, and how the mathematical result is lead to the discussion in biological/social science.
実用化イメージ

Researchers

Graduate School of Information Sciences

Hiromi Seno

Dry-Contact Ultrasonic Technique

NEXT
PREV
特徴・独自性
  • A new dry-contact technique for transduction of broadband, high-frequency ultrasound via a solid layer inserted between water and the sample, whereat the pressure of about 0.1 MPa is applied at the layer/sample interface by evacuating air between them, has been developed. Based on the technique, acoustic imaging of an electronic package is realized under the dry environment (Fig. 1). Typically, the polymer films are used as the intermediate layer for water protection of the sample, and by utilizing the acoustic resonance phenomenon among water, film and the sample, higher quality acoustic image of the testing sample than that for the water immersion case can be recorded without getting the sample wet (Fig. 2). Moreover, thin materials, e.g., polymer film (Fig. 3), etc. can be characterized by analyzing the acoustic resonance phenomenon among the three media. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.
実用化イメージ

Researchers

Graduate School of Engineering

Hironori Tohmyoh

Joule Heat Welding of Ultrathin Metallic Wires and its Application for Producing Functionality

NEXT
PREV
特徴・独自性
  • For producing a new functionality from metallic micro and nano matarials, the welding and cutting technologies for small scale materials utilizing Joule heat has been developed (Fig. 1). A constant direct current is supplied to the system, where the free ends of two metallic wires are contacted, and the ends are successfully welded together in self-completed manner. This technology is also useful for manipulating a small scale materials.
実用化イメージ

Joule heat welding technology enables us to produce the functional elements on the electrode chips, e.g., a free-standing micro-ring and very-thin thermoelectric element (Fig. 2). Moreover, we have developed the technique for characterizing the physical properties of small scale materials (Fig. 3). We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Researchers

Graduate School of Engineering

Hironori Tohmyoh

Development of Renewable Energy Systems for Sustainable Development Society

NEXT
PREV
特徴・独自性
  • Development of renewable energy systems as well as research on high efficient energy conversion systems is a key technology to solve the global-scale environmental destruction and energy problems. We are working on the research on the advanced technology of renewable energy such as solar energy and hydrogen. Topics of research are two of the following roughly separately. 
(1) Development of highly effective thermal energy systems and energy saving systems by using spectral control of thermal radiation. 
(2) Aiming at the achievement of the hydrogen energy society, we develop new energy conversion devices based on solid state ionics, and perform feasible studies for solid oxide fuel cells (SOFCs) based on mechanics of materials.
実用化イメージ

High temperature solar absorption materials
High effieciency solar-termophotovoltaic (STPV) system
Small power source for mobile electric devices based on micro-SOFC
New energy harvesting devices in harsh environment

Researchers

Graduate School of Engineering

Hiroo Yugami

DIFFERENTIATION INDUCING METHOD ENABLING TUMORIGENESIS OF IPS CELLS TO BE SUPPRESSED

特徴・独自性
  • The present invention relates to a technique for differentiating iPS cells into target differentiated cells while suppressing tumorigenesis in the iPS cells. In use of a statin and a differentiation inducer, iPS cells are differentiated into target differentiated cells, whereby iPS cells can be differentiated into differentiated cells in which tumorigenesis is suppressed.
実用化イメージ

Researchers

Graduate School of Dentistry

Hiroshi Egusa

Method for efficient production of induced pluripotent stem cells utilizing cells derived from oral mucosa

特徴・独自性
  • We provide a technique which can produce induced pluripotent stem (iPS) cells with high establishment efficiency and imposes lower burden on patients. iPS cells can be produced efficiently with significantly increased establishment efficiency by selecting cells derived from the oral mucosa and introducing a reprogramming factor, which can induce the reprogramming of the cells into pluripotent stem cells, into the cells.
実用化イメージ

Researchers

Graduate School of Dentistry

Hiroshi Egusa

  • 1
  • 2