Tohoku University. Research Profiles

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"I" Researcher - 19 Result(s)

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Innovative anemia therapy: Development of new anemia drugs targeting the novel mechanism of erythropoiesis

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Features

Strong points
Anemia is a very prevalent disease. Nevertheless, an effective therapy is yet to be discovered. Erythropoietin is effective only for those with renal dysfunction. We have found that inhibition of an enzyme for epigenetic regulation results in a prominent increase of erythropoiesis, pointing to a new target for anemia therapy. We have also generated a new, cell-based assay system for the enzymatic activity and carried out small molecule screening.

Collaboration with industry partners
We are seeking a collaboration to accelerate the development of new anemia drugs based on these findings. Together we will advance the development of the candidate molecules currently identified as well as conduct further screening of larger chemical space for better candidates and/or for drug repositioning.

Targeted Application(s)/Industry

Department of Biochemistry, Tohoku University Graduate School of Medicine
IGARASHI Kazuhiko, Professor Doctor of Medicine

Analysis of Function of Functional Food Components Preventing Atherosclerosis

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Features

We have much experience on basic studies including experimental animal research on improvement of lipid metabolism and prevention of obesity by functional food components. Causes of obesity and abnormality of lipid metabolism are complex, and measurement of enzyme activity and gene expression does not necessarily give us the precise information on mechanisms of improvement of lipid metabolism and prevention of obesity by food components.

Targeted Application(s)/Industry

Based on our experience, we are prepared to provide academic consultations to companies interested in our research. In some situations, we can conduct effective collaborative research in this field.

Food Function and Health, Graduate School of Agricultural Science
IKEDA Ikuo, Professor Doctor of Agriculture

Construction of Monitoring Systems for Genetic Diversity in Aquatic Organisms

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Maintaining genetic diversity within a species is a major issue to conserve biodiversity and sustainable use. To monitor genetic diversity in natural and captive populations using adequate genetic markers is the most important step. We have focused aquatic organisms and studied the genetic diversity using an array of DNA analyses. Our research interest includes 1) genetic structure and phylogeography of natural populations in marine and freshwater organisms and 2) genetic management of commercially important species to contribute the stock enhancement programs.

Targeted Application(s)/Industry

Our skill can be applied to environmental assessment and fish resource management. We are collaborating with national institutes and giving advice to private environmental assessment companies.

Graduate School of Agricultural Science
IKEDA Minoru, Professor Doctor of Agricultural Sicence

Supercritical Fluid Technology Based on its Unique Properties

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We have investigated various physical properties of supercritical fluids and their mixture. The properties studied are density, viscosity, phase equilibria, solubility, etc. under high temperatures and pressures. Using these suprecritical fluid features, we have proposed their application technologies; such as extraction of natural resources, cleaning, drying, catalyst preparation, polymer processing, polymer recycling, biomass conversion and controlled delivery. The methodologies used are experiments, simulation and theretical ones.

Targeted Application(s)/Industry

Cleaning Technology: precision machinery component, optical component, etc.
Extraction of Natural Resources: food, supplements, aroma.
Polymer Processing: functional resin, electronic component, etc.

Graduate School of Engineering
INOMATA Hiroshi, Professor Doctor of Engineering

High Sensitivity Radioactivity Measurement at Ultra-Low Radioactivity Environment

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Features

Research Center for Neutrino Science established ultra-low radioactivity environment (trillion times lower than natural environment) with 1200 cubic-meter organic scintillator detector at 1000m underground where very stable temperature/humidity and low vibration are maintained. We are pursuing high sensitivity measurements, especially neutrino observation, and are also developing purification system for ultra-low radioactivity and high performance radioactivity detectors.

Targeted Application(s)/Industry

The established ultra-low radioactivity environment is suitable for rare phenomena study and is also applicable for high sensitivity radio-impurity measurement. It may also apply to investigation of biological influence of low radioactivity irradiation. The other applications such as neutrino detection technique for monitoring nuclear reactors and medical use of high sensitivity radioactivity detectors may also be considered.

Research Center for Neutrino Science
INOUE Kunio, Professor Doctor of Science

Natural Language Processing for Semantic Analysis of Big Data

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This lab conducts fundamental research for deep natural language processing (NLP) and NLP-oriented information organization such as classification, extraction, and summarization of language information. Our activities also cover a broad range of applied research including NLP-based information and knowledge mining, information credibility analysis, and resilient ICT through the maximal use of Big Data.

Targeted Application(s)/Industry

(i) Analysis of market trend or research trend through intelligent text mining, (ii) Discovery of potential needs and risks from opinions in social media, (iii) Management of knowledge in a company by analyzing internal documents, etc.

Graduate School of Information Sciences
INUI Kentaro, Professor Doctor of Engineering

Prediction and evaluation of future thermal and wind environments based on CFD, and planning of urban environments adaptable to future climate

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Numerical simulations of the physical environment of urban outdoor spaces are conducted to predict the physical environment, such as temperature, humidity, wind, and pollutant concentration, and field measurements are conducted to understand the actual physical environment. In addition, the future outdoor environments and heat stroke risks due to global warming are predicted and evaluated.
Furthermore, the impacts of urban morphology (building shape and layout, street trees, etc.) on the adaptation to severe heat in summer and rare typhoons and floods are evaluated quantitatively.

Targeted Application(s)/Industry

Numerical analysis is used to quantitatively evaluate the "merits and demerits" of designing buildings, planning city blocks and urban areas, and introducing various heat control technologies on the wider thermal environment and the formation of wind ventilation paths, as well as the adverse effects of typhoons and other disasters. The materials for making decisions on whether or not to introduce these technologies are provided.

Dept. of Architecture & Building Science Graduate School of Engineering, Tohoku University
ISHIDA Yasuyuki, Assistant Professor Doctor of Engineering, Ph. D.

Data Analytics for Creation of Social Values

Features

My research field is a data analytics for creation of social values by data science approaches. In modern society, we can observe various data sets about our daily life, business or community. I aim to create new services for it using such data set and methods of Bayesian modeling, data mining or machine learning.

Targeted Application(s)/Industry

Graduate School of Economics and Management
ISHIGAKI Tsukasa, Associate Professor Doctor of Philosophy

Understanding Biological Control Systems and its Application to Development of Life-Like Resilient Systems

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In contrast to artificial systems, living organisms exhibit astoundingly adaptive and resilient properties. One of the central research goals in our laboratory is to endow artificial systems with similar properties. To this end, we are particularly focusing on the concept of autonomous decentralized control. We have so far successfully developed various types of robots on the basis of decentralized control, including amoeboid robots, snake-like robots, legged robots etc., in collaboration with mathematicians and biologists.

Targeted Application(s)/Industry

Development of adaptive autonomous robotic system, Control of Large D.O.F. system

Research Institute of Electrical Communication
ISHIGURO Akio, Professor Doctor of Engineering

Development of Sustainable Integrated Multiphase Energy System

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Our laboratory is focusing in the development of innovative multiphase fluid dynamic methods based on the multiscale integration of massively parallel supercomputing and advanced measurements, and research related to creation of environmentally conscious energy systems. Furthermore, we promote basic research for the creation of risk management science and associated new multiphase flow system directly linked to sustainable energy represented by a high-density hydrogen storage technology.

Targeted Application(s)/Industry

P2P Hydrogen supply chain, Elastohydrodynamic lubrication, Supercomputing of Laser melting and sputter particle formation, High pressure diecast computing / Automotive industry, Additive manufacturing

Institute of Fluid Science
ISHIMOTO Jun, Professor Doctor of Engineering

Development of integrated safety management technology for hydrogen energy systems

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Features

To investigate the diffusion and combustion phenomena of reactive hydrogen gas leakage when a high-pressure hydrogen tank fails due to crack propagation caused by an initial defect, we have developed a coupled analysis method that simultaneously analyzes the material structure and reactive turbulent multiphase flow through an interdisciplinary research approach. Furthermore, we have developed a new numerical prediction method related to the diffusion flow characteristics and combustion limits of hydrogen leaking due to crack propagation failure of high-pressure tank bulkheads.

Targeted Application(s)/Industry

We contribute to the design of hydrogen storage containers for various types of transportation equipment and the development of safety guidelines and risk management for hydrogen station configurations.

Institute of Fluid Science
ISHIMOTO Jun, Professor Ph.D

Advanced die casting process computing with solidification phenomena

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Features

Die casting is a method of mass-producing high-precision castings in a short time by filling the mold with molten metal at high pressure and high speed. Since solidification is completed quickly under high pressure, various defects peculiar to die casting occur. Significantly, the casting cavity has a high incidence in die casting, and it is a factor that hinders the quality. Therefore, a numerical approach to the die casting process is expected to prevent these problems, and the information obtained from the numerical analysis is expected to be reflected in the casting plan to reduce the number of prototypes, the lead time to product development, and the cost. In this study, a multiphase flow analysis with solidification phenomena of molten aluminum inside mold was conducted for a high-pressure die casting process of the throttle body.

Targeted Application(s)/Industry

Automotive industry, Automotive suppliers, Foundry industry

Institute of Fluid Science
ISHIMOTO Jun, Professor Ph.D

Development of the high-quality and low-power display system for ultra-realistic communications

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Recently, with a spread of high definition video streaming services and ubiquitous network, development of high-quality, ultra-realistic and low-power display systems has been demanded. We have been studying physical properties of liquid crystal materials, precise control technique of polarization, high performance liquid crystal display (LCD) devices and its application to the advanced display systems for the realization of new media such as electric paper display and digital signage display, and low-energy society. We established a polarization control technology which realizes a precise control of polarization with liquid crystal materials. By using this world-leading technology, we have been studying the control of the surface alignment of liquid crystal molecules and developed a wide-viewing angle and fast switching liquid crystal display, ultra-high definition field-sequential-color display (Fig. 1), ultra-low power reflective full-color display (Fig. 2) and large-size high-quality display system.
We are also studying the ultra-realistic display systems such as a spatial 3D display and a multiple directional viewing display based on the precise light control technique as a next generation interactive communication technologies (Fig.3). We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Graduate School of Engineering
ISHINABE Takahiro, Associate Professor Doctor of Engineering

Magnetic Applications and Magnetic Materials

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The aim of our research are to obtain the high accuracy sensor system for the signals from the human body or electric devices and to obtain the system for approaching action to the human body by using the nano-scale controlled magnetic materials and by the development of the devices under the functions of the magnetics.
We studied the mechanism of obtaining the magnetic anisotropy of the magnetic thin films for the sensitive magnetic sensors. We obtained a non-metal probe for high frequency magnetic field, and confirmed the probe can measure the high frequency magnetic field with its phase information. In addition, 3D position detecting system using magnetic markers was studied to improve its position accuracy. The study about the magnetic actuator driven by the external magnetic field was carried out for biomimetic robots using the rotational magnetic field, and small wireless pumps were obtained and clarified for their application for an artificial heart-support pump.

Targeted Application(s)/Industry

<Medical Applications>
Motion system for capsule endoscope, Support system for endoscopic surgery, Position detecting system (motion capture), Wireless pump for artificial heart
<Sensors>
Magnetic field sensors, Strain sensors, Wireless sensors
<Materials>
Electrical steels of ultra low loss, Electrochemicaly produced materials (structure controlled in nano-scale)

Research Institute of Electrical Communication
ISHIYAMA Kazushi, Professor Doctor of Engineering

Development of the method of Baby Borehole Hydraulic Fracturing, BABHY

Features

For the effective measurement of the reopening pressure in hydraulic fracturing, it is necessary to use the testing equipment with sufficiently small compliance. This limitation makes it difficult to apply the hydraulic fracturing for the measurement of the maximum stress, because the compliance of conventional equipments is generally so large. Taking account of this situation, we proposed a new concept which allows us to do the in-situ tests of hydraulic fracturing for stress measurement at so deep depths as more than 1 km. We call the concept the Baby Borehole Hydrofracturing, BABHY for short. In order to put the new concept into practice, we developed the BABHY sonde and finally we succeeded to carry out hydraulic fracturing test by using the tools in a vertical borehole of 811 m depth. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Large-Scale Environmental Fluid Dynamics Laboratory, Complex Flow Division, Institute of Fluid Science
ITO Takatoshi, Professor Doctor of Engineering

Generation of Rice Plants Suitable for Biofuel Production

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To generate a rice plant suitable for efficient biofuel production from its straw, we examined effects of overexpression of cellulase on saccharification of straw. The transgenic plant constitutively overexpressing cellulase showed enhanced saccharification, but various physiological and morphological abnormalities were also observed. To overcome this problem, a senescence-inducible promoter was used to express the cellulase. The plants successfully avoided the problem and showed enhanced saccharification after senescence.

Targeted Application(s)/Industry

Rice straw will be an efficient material for biofuel production. This method can be applied to other plants. In combination with highly engineered microorganisms for saccharification and fermentation, this method will contribute to efficient production of biofuels.

Graduate School of Agricultural Science
ITO Yukihiro, Associate Professor PhD

Development of the cyclotron accelerator and its application

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We develop technology of the cyclotron accelerator and its application as follows. 1)Ion source (particularly heavy ion source), 2)design of ion optics, 3)device control system for the cyclotron, 4)RF system, 5)detectors for charged particles, gamma ray, and neutron, 6) radiation test by ion and neutron beam.

Targeted Application(s)/Industry

We have beam lines dedicated to the neutron irradiation and the ion irradiation, respectively. We can provide fast neutron beam (20-70 MeV), and various ion beam such as p, alpha, and heavy ions up to Xe. We also develop a neutron imaging technique using fast neutron.

Cyclotron and Radioisotope Center
ITOH Masatoshi, Professor PhD

Mechanism of Restoration and Rehabilitative Treatment of Movement Disorders

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Our investigation aims to develop rehabilitative treatment for movement disorders due to brain damage using non-invasive brain stimulation (NIBS) such as transcranial magnetic stimulation (TMS), and transcranial direct current stimulation (tDCS). TMS, eddy current stimulation, and tDCS (1-5 mA, 10 minutes) both can modulate excitability of the cerebral cortex, and are applicable for restoration of limb paresis. We focus on modulating body scheme to induce appropriate adaptive changes of the central nervous system using NIBS.

Targeted Application(s)/Industry

Our goal is to develop therapeutic systems for movement disorders in which NIBS devices are combined with robotics or sensors. We would like to collaborate with companies for developing, manufacturing, and selling innovative medical devices.

Department of Physical Medicine and Rehabilitation, Graduate School of Biomedical Engineering
IZUMI Shin-ichi, Professor PhD