"K" Researcher - 32 Result(s)

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Regulation of ABC Transporters in Colorectal Cancer

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特徴・独自性
  • Colorectal cancer (CRC) is one of the most common types of cancer worldwide. Surgical resection is the only curative treatment available for primary CRC. We determined the gene expression profiles for ATP binding cassette (ABC) transporters by RNA sequencing in matched colon cancer and normal colon tissue specimens in order to provide insight into the regulatory mechanisms underlying expression of transporters related to colon carcinogenesis. The expression of ABCC3 was repressed by Wnt signaling pathway, suggesting downregulation of ABCC3 might contribute oncogenesis.
実用化イメージ

Recently, we easily obtain comprehensive data including transcriptome and other omics data. These data are expected to help find a target for drug development, expecting that pharmaceutical industry interpret and extract new knowledge from them.

Researchers

Graduate School of Medicine

Keiko Nakayama

Elucidation of oncogenesis by Fbxw7

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特徴・独自性
  • In life science research field, it is noteworthy issue how information in genome is interpreted and is transferred to functional molecules. However, during these 10 years, we convinced that the amount of proteins, final functional molecules was regulated by not only by production but also by degradation. For examples, the amount of c-Myc, which promotes cell cycle and inhibits cell death, increase in many types of cancer by failure of protein degradation.
  • We have generated model mice in which function of Fbxw7, inducer of c-Myc degradation is suppressed. We observed promotion of oncogenesis in these mice, suggesting that Fbxw7 is oncosuppressor gene. In other words, Fbxw7 has a great potential to regulate oncogenesis or progress of cancer. These molecules specified the target proteins for proteolysis suggesting that modification of these molecules leads to develop oncosuppressive therapy. We hope to conduct collaborative research with a willing company for a practical application of this knowledge in industry.
実用化イメージ

Researchers

Graduate School of Medicine

Keiko Nakayama

Nonlinear Aeroelastic and Multibody Dynamic Analysis for Floating Wind Turbine and Next-Generation Aircraft

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概要

Floating wind turbine and next-generation aircraft have high-aspect-ratio blade and wing that undergo nonlinear aeroelastic deformation. We have developed a nonlinear aeroelastic analysis framework with absolute nodal coordinate formulation (ANCF). This nonlinear aeroelastic deformation is coupled with multibody dynamics. We are also developing a novel analysis framework for this coupling dynamics.

従来技術との比較

By using the nonlinear analysis method proposed in this study, it is possible to handle the reduction in flutter speed due to large deformations and the coupled phenomenon of deformation and flight behavior that cannot be captured using conventional linear analysis methods.

特徴・独自性
  • Straightforward nonlinear structural analysis method that does not use any rotational coordinates
  • Highly efficient unsteady fluid calculation method for large deformations
  • Multibody dynamics that captures the relative motion between bodies, such as rotating blades and control surfaces
実用化イメージ

Dynamic, aeroelastic, structural, vibration, aerodynamic analyses for Aeroelastic Multibody Systems:
1. Floating wind turbine
2. High altitude platform station (HAPS), high-aspect-ratio-wing commercial jet
3. Helicopter, drone
4. Robot, crane

Researchers

Graduate School of Engineering

Keisuke Otsuka

Development of Compound Semiconductor Radiation Detectors

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特徴・独自性
  • The main research subject of our group is developing material purification methods, crystal growth methods and detector fabrication technologies for compound semiconductor radiation detectors. Our group intensely studies a compound semiconductor, thallium bromide (TlBr), for fabrication of gamma-ray detectors for the advanced radiation applications. The attractive physical properties of TlBr lie in its high atomic number (Tl: 81, Br: 35), high density (7.56 g/cm3) and wide bandgap (2.68 eV). Due to the high atomic number and high density, TlBr exhibits high photon stopping power. The wide bandgap of TlBr permits the device low-noise operation at and above room temperatures.
実用化イメージ

Our group focuses on development of compound semiconductor radiation detectors for advanced radiation applications including ultra-high resolution PET systems, ultra-high resolution SPECT systems, photon counting CT systems and Compton cameras. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Researchers

Graduate School of Engineering

Keitaro Hitomi

newQuantitative analysis of microstructure in nuclear materials by week-beam scanning transmission electron microscopy

概要

We have developed a technique for quantitative analysis of microstructures (e.g., dislocations and irradiation defect aggregates) of activated and nuclear-burned specimens in the context of the Week Beam Scanning Transmission Electron Microscope (WB-STEM) method, which boasts extremely high measurement accuracy as a quantitative analysis method for lattice defects.
In combination with a dedicated heated sample holder with fully automated temperature measurement and current control in a cartridge-type heating furnace, changes in dislocation microstructure can be dynamically measured in-situ along with a highly reliable temperature history.

従来技術との比較

Conventional TEM methods require expertise in reciprocal space and dislocation theory, but our WB-STEM method is equipped with automatic analysis software for film thickness measurement and dislocation loop feature extraction, making it possible to analyze irradiation defects easily and precisely.

特徴・独自性
  • Since its design, the WB-STEM method has been developed for implementation and on-site repair in radiation controlled areas where nuclear materials are handled, with special aperture and diffraction disc selection equipment, control and analysis software.
  • WB-STEM accepts irradiation defect analysis of activated specimens from all over the world, including RPV monitoring specimens from European reactors and neutron-irradiated materials from US research reactors.
  • It is also used to analyze the properties of iron-containing nuclear fuel simulated debris in decommissioning projects.
実用化イメージ

We support research organizations that currently use transmission electron microscopy to observe microstructures to introduce the WB-STEM method by special modification. We will instruct researchers who have no experience using transmission electron microscopy in the procedure for dislocation analysis.

Researchers

Institute for Materials Research

Kenta Yoshida

Natural Language Processing for Semantic Analysis of Big Data

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特徴・独自性
  • This lab conducts fundamental research for deep natural language processing (NLP) and NLP-oriented information organization such as classification, extraction, and summarization of language information. Our activities also cover a broad range of applied research including NLP-based information and knowledge mining, information credibility analysis, and resilient ICT through the maximal use of Big Data.
実用化イメージ

(i) Analysis of market trend or research trend through intelligent text mining, (ii) Discovery of potential needs and risks from opinions in social media, (iii) Management of knowledge in a company by analyzing internal documents, etc.

Researchers

Center for Language AI Research

Kentaro Inui

Hands-On Access Fabrication Facility –Open Facility for MEMS and Semiconductor Prototyping–

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概要

We offer shared facility for the development of semiconductor prototypes equipped with 4-inch, 6-inch and some 8-inch wafer fabrication tools available on an hourly basis. Know-how accumulated at Tohoku University is available, and staff provide maximum support for prototyping. The service is performed at the 1,200 m2 Super Clean Room on the second floor of the Junichi Nishizawa Memorial Research Centre at Tohoku University. For information on equipment and fees, see our website.

従来技術との比較

More than 10 experienced technical staff assist customer's usages. Standard process conditions for each process, such as etching and deposition, are provided. allowing customers to start prototyping immediately. Various materials other than silicon can also be supported.

特徴・独自性
  • We support the development of devices and semiconductor materials such as MEMS, optical elements and RF components.
  • Technical consultation on devices and processes before and during prototyping is also available.
  • A
  • 'Prototype lab' for device packaging is also available.
  • The museums where you can learn about the history of semiconductors, measuring instruments and sensors are open.
  • As part of Technology Co-creation for Semiconductor of Tohoku University, we promote R&D of semiconductors and the development of human resources.
  • On-demand semiconductor human resource development programs for students and engineers are available.
  • As a member of the MEXT's Advanced Research Infrastructure for Materials (ARIM) program, we are involved in sharing facility and data.
実用化イメージ

More than 310 companies have used our shared facility since its launch in 2010, not only from device manufacturers such as MEMS, but also from manufacturers of materials, mechanical components and equipment. To date, we have successfully supported the commercialization of about 10 devices.

Researchers

Micro System Integration Center

Kentaro Totsu

Molecular studies on new resources for hybrid rice breeding

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特徴・独自性
  • F1 hybrid breeding is one of the most advanced techniques for production of cultivars with higher yield and desirable traits of both parents. Most of hybrid rice utilize cytoplasmic male sterility (CMS) and fertility restoration system. We develop a Tohoku University-original CW-type CMS and fertility restorer line and study their molecular mechanism. The CW-type cytoplasm enables indica rice cultivars to be CMS, which could not be achieved by other known cytoplasm.
実用化イメージ

Hybrid rice has an average 30% yield advantage over inbred lines, and is cultivated on 13% of the world rice fields. Our study provides a new and original resource for hybrid rice breeding for globalization of rice industry.

Researchers

Graduate School of Agricultural Science

Kinya Toriyama

Philosophy of Science and Technology, Science and Technology Studies (STS)

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特徴・独自性
  • My research area is mainly phenomenology, philosophy of technology, and applied ethics (engineering ethics etc.). Technological Artifacts mediate human activities. So designing artifacts is in itself an ethical behavior. Analysing the ontological structure of the artifacts, describing the epistemological propcess of desingning activities, evaluating the social and ethical influence of artifacts are main issues in philosophy of technology. On the basis of such philosophical investigations, we can develope ethical studies concerining how engineerss, companies can recognize ethical issues in a networks of meanings , how they can make ethical decision among engineers and users.
実用化イメージ

I hope to conduct cooperative research on ethical education of engineers, as well as on human-machine interaction.

Researchers

Graduate School of Arts and Letters

Kiyotaka Naoe

Advanced Vision System with Less Calibration

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特徴・独自性
  • The difficulties of introducing robot systems in production line are maintenance of environment and teaching of robot motion. Environ recognition and motion teaching using vision system will greatly improve the difficulties. However, calibration of vision-robot system is tedious and troublesome. Feedback control using vision sensor information will allow robustness against environment and teach by showing. This technique is called visual servo.
実用化イメージ

Visual servo will allow flexible camera setting, calibration-less system setting, and easy teaching.

Researchers

Graduate School of Information Sciences

Koichi Hashimoto

High Sensitivity Radioactivity Measurement at Ultra-Low Radioactivity Environment

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特徴・独自性
  • Research Center for Neutrino Science established ultra-low radioactivity environment (trillion times lower than natural environment) with 1200 cubic-meter organic scintillator detector at 1000m underground where very stable temperature/humidity and low vibration are maintained. We are pursuing high sensitivity measurements, especially neutrino observation, and are also developing purification system for ultra-low radioactivity and high performance radioactivity detectors.
実用化イメージ

The established ultra-low radioactivity environment is suitable for rare phenomena study and is also applicable for high sensitivity radio-impurity measurement. It may also apply to investigation of biological influence of low radioactivity irradiation. The other applications such as neutrino detection technique for monitoring nuclear reactors and medical use of high sensitivity radioactivity detectors may also be considered.

Researchers

Research Center for Neutrino Science

Kunio Inoue

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