Tohoku University. Research Profiles

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"K" Researcher - 55 Result(s)

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High-Speed Vision for Real-Time Motion Analysis

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We are investigating high-speed vision systems that enable real-time image acquisition and visual processing at frame rates substantially higher than the standard video rate.

Targeted Application(s)/Industry

High-speed vision systems are useful for fast measurement and control of dynamic systems in general. When combined with external facilities such as high-speed projectors or acceleration sensors, they enable further wider applications including fast 3D measurement or object identification.

Graduate School of Information Sciences
KAGAMI, Shingo, Associate Professor Ph.D. (Eng.)

Novel Cu-Based Shape Memory Alloy with High Ductility

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Recently, we have developed a novel Cu-Al-Mn based shape memory alloy with high SM properties and with a ductility twice higher than that in Nitinol . Furthermore, this novel SM alloy needs no die for the shape setting and is fabricated with relatively low cost. Very recently, we have successfully developed a device to cure ingrown toenail by using this SM alloy.

Targeted Application(s)/Industry

Very recently, we established a fabrication process for the Cu-Al-Mn sheet, wire and bar with 0.1 - 20mm in thickness or diameter. We hope to conduct collaborative research with a willing company for a practical application with this new SM alloy.

Department of Materials Science, Graduate School of Engineering
KAINUMA, Ryosuke, Professor Doctor of Engineering

Peptide formation under high P and T conditions: new carbon fibers

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Peptides are formed through the enzymatic actions in living organisms, but difficulty exists to form peptide by non-enzymatic actions. Here we report the success of peptide formation under anhydrous, high P and T conditions. We were successful to form 11-mer of glycine and 5-mer of alanine. They are important constituents of spider silk, which is a candidate of next generation of carbon fibers. Therefore, our techniques have potentials to apply making new carbon fibers without biotechnology.

Targeted Application(s)/Industry

Geosciences Department, Graduate School of Science
KAKEGAWA Takeshi, Professor Ph.D.

High-Performance Photoceramics via Green Processes

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The main objective of our research is to acquire profound understanding of "synthesis-structure-properties" relationship for the modern inorganic materials and to apply this knowledge for development of new materials with improved performance. The special attention is paid to the design of phosphors for white LEDs and photocatalysts with visible light response within oxide, oxynitride, oxynitride, and sulfide systems. The utilization of "green" solution processing towards these photoceramic materials is the paradigm of our group.

Targeted Application(s)/Industry

Through the synthesis of novel compounds in oxide, oxynitride, sulfide systems, development of new high-performance inorganic phosphors with various excitation and emission properties is possible. These high-performance phosphors are expected to be applied for the industrial use such as white light emitting diodes (white LEDs) and tools for sensing temperature.

Institute of Multidisciplinary Research for Advanced Materials
KAKIHANA, Masato, Professor Doctor of Science

Bone Regenerative Therapy by Octacalcium Phosphate (OCP) Collagen Composites

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Octacalcium phosphate (OCP) collagen composite (OCP/Col) is a new bone regenerative material, which is consisted of synthetic OCP and porcine atelocollagen. OCP/Col surpassed bone regenerative properties of existing bone substitutes, and achieved efficient bone regeneration without cell transplantation and exogenous osteogenic cytokines. It has excellent resorbability, moldability, operability, and high cost performance without complicated handling or management system. Preclinical studies and the sponsor-initiated multicenter clinical trial have been completed successful. As a medical device for the bone defect in oral and maxillofacial region, the sales of OCP/Col are planned to commence in fiscal 2018.

Targeted Application(s)/Industry

As a medical devise of bone regenerative material, expansion of application in various bone defect (orthopedic surgery, neurosurgery, etc.) and overseas expansion would be expected. Furthermore, recently developed combination product based on OCP/Col would provide a therapeutic alternative for difficult bone defects or urgent surgery.

Bone Regenerative Engineering Laboratory, Regenerative and Biomedical Engineering Division, Graduate School of Biomedical Engineering
KAMAKURA, Shinji, Professor Doctor of Dental Science

Noninvasive Ultrasonic Measurement of Dynamic Properties of Heart and Arteries

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Complexity of the cardiac contraction sequence is still not fully understood because the dynamic mechanical excitation process, which directly correlates with contraction, cannot be accurately measured by CT, MRI, SPECT, or conventional ultrasound. By developing a noninvasive novel imaging modality with high temporal and spatial resolutions (US patent 5840028), we have detected the minute mechanical response (velocity component) to the propagation of the action potential in the human heart or to detect the propagation of the vibrations along the heart wall caused by the valve closure (Fig. 2).
By applying the same procedure to the human arteries, the regional change in wall thickness caused during one cardiac cycle can be measured with high spatial resolution (Fig. 1). From the measurement, the regional elasticity of tissue surrounding atherosclerotic plaque can be determined. By comparing the pathological findings with the distribution of elasticity, elasticity of lipid and that of fibrous tissue were determined. Thus, each point inside the plaque is classified into lipid or fibrous tissue using transcutaneous ultrasound (Fig. 3).

Targeted Application(s)/Industry

This novel method offers potential as a diagnostic technique for detection of plaque vulnerability with high spatial resolution.
We are prepared to provide academic consultations to companies interested in our research.

Department of Electronic Engineering, Graduate School of Engineering
KANAI, Hiroshi, Professor PhD

Development of Miniature and Highly-Functional Photonic Devices Using Ultrafine Microstructures

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In our laboratory, miniature and highly-functional photonic devices based on new optical phenomena caused by the interaction of ultrafine microstructures with light have been studied. In addition, development of new production technology to overcome the problems that have been obvious from the practical application viewpoint of nanophotonic devices has been performed.

  • -Main research topics--
MEMS tunable metamaterials for optical control.
Structural color filters using subwavelength gratings for the applications of display and spectroscopic analyzers.
Surface-smoothing technology using surface self-diffusion.
Study of low loss silicon nanophotonic devices.

Targeted Application(s)/Industry

We aim to realize optical filters, optical resonators, and color filters, by using above technologies. Also, development of nano-photonic elements fabricated by a nanoimprint technology has been progressed.
We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Graduate School of Engineering
KANAMORI, Yoshiaki, Professor Doctor of Engineering

Development of Nano-Medical-Agricultural Applied Technology Using Ion-Controlled Plasma

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Since we have developed the techniques (ion control plasma) to generate and control ions, electrons, reactive species (radicals) in the low temperature non-equilibrium plasmas which I can touch by hand, the composite materials using nanoparticles, nanocarbons, biological molecules are synthesized in the nano-electronics field, the minimally-invasive and highly-efficient drug/gene transfection systems are developed in the medical field, and bacteria and insects are killed by the plasma in place of pesticide in the agricultural field.

Targeted Application(s)/Industry

The ion-controlled plasmas are applied for the minimally-invasive gene transfection system, next-generation agricultural system, the electrode material of highly-efficient battery, and so on. We hope to conduct the collaborative research with a willing company for a practical application of the novel plasma nano-medical-agricultural applied technology in industry.

Department of Electronic Engineering, Graduate School of Engineering
KANEKO, Toshiro, Professor PhD

Clinical Applications of Motion Capture System for Living Body

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We have developed a wireless motion capture system for living body that could non-invasively measure various biological movements without any contact. By utilizing the LC resonant magnetic marker due to the latest magnetic engineering technology, we have achieved a magnetic wireless system which could be used even in a shielded space such as oral cavity by applying a magnetic field from outside the body. By using the infrared reflective markers of small and light, we have also succeeded in developing an optical system capable of synchronous real-time measurement at up to 50 locations at 250 hertz.

Targeted Application(s)/Industry

This new system can three dimensionally analyze various biological movements and can be applied to such diagnostic and medical equipment that requires a motion analysis non-invasively without any contact. It is possible to specialize this system to suit the required conditions, so I would like to joint research with companies and organizations that want to take advantage of this system.

Liaison Center for Innovative Dentistry, Graduate School of Dentistry
KANETAKA, Hiroyasu, Associate Professor D. D. S., Ph. D

Powder Processing Contributing to the Global Environmental Protection

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Material properties and characteristics of the product as a raw material powder are dependent on the particle packing structure as well as the chemical composition. Sophisticated control of the powder processing such as mixing and grinding is strongly required. In our laboratory, we are creating the simulation method as a tool for controlling the powder processing and optimizing the powder process for achieving a resource-saving and energy-saving by the computer simulation.

Targeted Application(s)/Industry

We are conducting research on analysis/optimization of powder processing such as grinding, mixing, and packing by using simulation, metal recycle from urban mine through active utilization of mechanochemical effect, and generation of energy from biomass.

Institute of Multidisciplinary Research for Advanced Materials
KANO, Junya, Professor Doctor of Engineering

Exercising "Cultured" Myotubes!

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We succeeded in generating highly developed cultured C2C12 myotubes by manipulating intracellular Ca2+ transients with electric pulse stimulation (EPS), that are endowed with similar properties to in vivo skeletal muscle in terms of (1) excitation-induced contractile activity as a result of de novo sarcomere formation, (2) higher energy expenditure (as assessed by AMPK activation), and (3) improved insulin responsiveness (as assessed by exofacial myc-GLUT4 translocation assay).

Targeted Application(s)/Industry

Taking advantage of our “in vitro Exercise Model", our innovation will be an excellent alternative for the animal experimentation that can be applicable for a wide array of skeletal muscle research including drug screen.

Graduate School of Biomedical Engineering
KANZAKI, Makoto, Associate Professor PhD

Development of Electronic Instruments (Radio, Infrared, Optical, and Digital), Extensible Unit, and Embedded Software for Spacecraft

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We have performed the development of the radio wave receivers, radars, infrared & optical cameras / spectrometers, and digital instruments for various space projects. (Ex. KAGUYA [Lunar orbiter], BepiColombo [Mercury orbiter], Exceed [EUV space telescope], Reimei [Small aurora-observatory], ERG [radiation belt], JUICE [Jupiter], the International Space Station [by atmospheric camera IMAP], several sounding rockets and high-altitude balloon experiments.)

Targeted Application(s)/Industry

By historical reasons, the developments of these analog / digital circuits, FPGA, embedded software, extensible mechanics have mainly been with companies and engineers in Kanto and Chubu areas. We hope to find the counter companies / persons in Sendai / Miyagi / Tohoku areas.

Department of Geophysics, Graduate School of Science
KASABA, Yasumasa, Professor PhD (Electronics)

Advanced Recycling Process and Development of Environmental Preservation Technologies

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A large amount of resources are utilized in the base metal production processes such as iron & steel, copper and zinc. Therefore, it is important to improve such process efficiencies for solving the energy and environmental issues. On the other hand, the increasing production in developing countries leads to the depletion of high-grade resources. In this laboratory, basic researches for integrated processes from pretreatment, metal manufacturing, refining and recycling are made for the development of new processes with high efficiency and low environmental load by utilizing "low-grade" resources.

Targeted Application(s)/Industry

Iron & steel making and nonferrous industries, development of efficient utilization processes of biomass and organic waste energies

Graduate School of Environmental Studies
KASAI, Eiki, Professor Doctor of Engineering

Fabrication of The Novel Designed Nanodrugs Composed of Poorly Water-Soluble Compounds

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One of our major research focuses is to design the novel drug nanoparticles, so called “Nano-prodrugs”, and to apply them as anticancer drugs or eye drops with excellent delivery efficiency. Nano-prodrugs are constructed by synthetic prodrugs molecules which contains poorly water-soluble substituent. They could be fabricated to nanoparticles with 100 nm or less in size by our reprecipitation technique, which has been used to create organic nanomaterials. We are aiming at practical application of our Nano-prodrugs in the near future.

Targeted Application(s)/Industry

Our reprecipitation technique for fabricating organic nanomaterials is a versatile technique that can be applied to various organic molecules as well as drug compounds. We hope to conduct collaborative research with a willing company on controlling and evaluating properties of the organic nanoparticles.

Institute of Multidisciplinary Research for Advanced Materials
KASAI, Hitoshi, Professor Doctor of Science

Development of devices regulating inter-organ neural network for diabetes therapy

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Diabetes induces several complications, including retinopathy and nephropathy. In patients with type 1 diabetes as well as those with type 2 diabetes, pancreatic beta cells have reportedly decreased. Therefore, regeneration therapy of pancreatic beta cells may be very effective for major populations of diabetic patients. We discovered a neuronal network, from the liver, which selectively elicits pancreatic beta cell proliferation (Science 2008, Fig.). In a murine model with insulin-deficient diabetes, stimulation of this network improved diabetes. Thus, building devices which regulate the inter-organ neuronal network may lead to “regenerative therapy” for diabetes which regenerates pancreatic beta cells in the pancreas using patients’ own cells and patients’ own systems. We hope to conduct collaborative research with a willing company for a practical application of this technology.

Center for Metabolic Diseases, Graduate School of Medicine
KATAGIRI, Hideki, Professor MD, PhD

Development of New Drugs and Devices Regulating Inter-Organ Neural Network for Obesity Therapy

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Obesity induced the metabolic syndrome, which causes cardiovascular diseases. Obesity has now become a major health concern not only in developed countries but developing countries. However, diet and exercise are still major therapies. We discovered endogenous systems maintaining homeostasis of energy metabolism and revealed several neuronal networks among organs to be responsible for the regulation systems.
1) Afferent neuronal signals from adipose tissue regulate appetite and prevent over-eating during obesity development (Cell Metab 2006)
2) Neuronal network from the liver enhances basal metabolic rates to prevent obesity development when energy store is increasing (Science 2006) 3) Neuronal network from the liver suppresses adaptive thermogenesis in brown adipose tissue (Cell Metab 2012).

Targeted Application(s)/Industry

On the basis of these original discoveries, we are aiming at developing new drugs and/or building devices which regulate the inter-organ neuronal networks and hope to conduct collaborative research with a willing company for a practical application to obesity therapy.

Center for Metabolic Diseases, Graduate School of Medicine
KATAGIRI, Hideki, Professor MD, PhD

Development of Open Nanoporous Base and Half Metals, Metalloids and their Alloys

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Nanoporous metals have drawn considerable attention due to their highly functional properties. They are generally produced by selective dissolution of elements from a multicomponent alloy (known as the dealloying method). As this method is based on differences in the electrode potential of each element present in the alloy, and this potential is high for noble metals, porous structure can be obtained only for noble metals. Recently we have found a new, simple and easy dealloying method without using aqueous solution, which enable us to develop an open nanoporous non-oxidized metallic material even with base metals (such as Ti, Ni, Cr, Fe, Mo, etc), metalloids and their alloys.

Targeted Application(s)/Industry

This technique is very powerful for developing new functional electrodes, catalysts, filters as well for removing toxic metallic element from the surface of biomaterials containing the toxic element.

Institute for Materials Research
KATO, Hidemi, Professor PhD (Engineering)

Message Transmission without Cellular Coverage, “Relay-by-Smartphone"

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Our technology provides the necessary method for sending messages even when the physical infrastructure is not available. The technology utilizes common smartphone WiFi functionality to send message in a multi-hop fashion. Thus it is possible to send message to people further away. Our technology has been designed to be based on Delay-Tolerant Networks (DTN), but the technical key idea is the combination of DTN and Mobile Adhoc Network (MANET), which can improve the message delivery in an area with high population density or where mobility are fixed such as evacuation center.

Targeted Application(s)/Industry

This technology can be used to distribute information during emergency situation such as after disaster. In addition, it is possible to provide additional services such as advertisement within shopping areas, distribution of coupons, exchange of information within small group during public events or uses as transceiver during group hiking. There is also possibility of using this technology to provide communications service in developing nations.

Graduate School of Information Sciences
KATO, Nei, Professor Doctor of Engineering

Internet video streams have identities like fingerprints

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According to recent studies, each video that is streamed online has its own unique characteristic. The pattern of data that are sent through the network can vary from one encoding method to another and the change from scene to scene, which is a unique characteristic of each video. This research aims to identify video content in the network without looking at the data itself.

Targeted Application(s)/Industry

This research would be especially useful in preventing illegal distribution of television program such as illegal channel without violating user privacy. Another application would be to prevent confidential online meeting from leaking outside local enterprise network. In addition, it is also possible to investigate the circulation of a video content using method introduced by this work.

Graduate School of Information Sciences
KATO, Nei, Professor Doctor of Engineering

Production of Tumor-Specific Monoclonal Antibodies

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Podoplanin (PDPN/Aggrus/T1α), a platelet aggregation-inducing mucin-like sialoglycoprotein, is highly expressed in many cancers and normal tissues. A neutralizing monoclonal antibody (mAb; NZ-1) can block the association between podoplanin and C-type lectin-like receptor-2 (CLEC-2) and inhibit podoplanin-induced cancer metastasis, but NZ-1 reacts with podoplanin-expressing normal cells such as lymphatic endothelial cells. Recently, we established a platform to produce cancer-specific mAbs (CasMabs). The newly established LpMab-2 mAb reacted with podoplanin-expressing cancer cells but not with normal cells, as shown by flow cytometry and immunohistochemistry; therefore, LpMab-2 is an anti-podoplanin CasMab that is expected to be useful for molecular targeting therapy against podoplanin-expressing cancers.

Targeted Application(s)/Industry

We can produce cancer-specific mAbs (CasMabs) against all membranous proteins. CasMabs are expected to be useful for molecular targeting therapy without side effects.

Graduate School of Medicine
KATO, Yukinari, Professor M.D.,PhD