Research Profiles

JP

"M" Researcher - 37 Result(s)

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Development of a Novel Therapy for Amyotrophic Lateral Sclerosis (ALS) Using Hepatocyte Growth Factor (HGF)

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特徴・独自性
  • Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by systematic motor neuron degeneration. Approximately 20% cases of familial ALS are caused by mutations in the superoxide dismutase 1 (SOD1) gene. We developed transgenic rats that express a human SOD1 gene with two different ALS-linked mutations (G93A or H46R) showing progressive motor neuron degeneration and paralysis. The larger size of the rat ALS models as compared with existing mouse models will facilitate studies on neuroprotective and neuro-regenerative strategy involving manipulations of cerebrospinal fluid and spinal cord.
実用化イメージ

Hepatocyte growth factor (HGF) is one of the most potent survival-promoting factors for motor neurons. Continuous intrathecal infusion of human recombinant HGF (hrHGF) attenuated loss of spinal motor neurons, astrocytosis, and microglial activation, leading to prolonged survival in the ALS rats. Safety and toxicology testing of the hrHGF protein in non-human primates should prompt further clinical trials in human ALS patients.

Researchers

Graduate School of Medicine

Masashi Aoki

Amyotrophic lateral sclerosis (ALS),Muscular dystrophy,Distal myopathy with rimmed vacuoles (DMRV)/ hereditary inclusion body myopathy (hIBM)

 
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特徴・独自性
  • Distal myopathy with rimmed vaculoles (DMRV) / hereditary inclusion body myopathy (hIBM) is an autosomal recessive disorder characterized clinically by the preferential involvement of the tibialis anterior muscle. It is known that the disease gene underlying DMRV is GNE, encoding glucosamine (UDP-N-acetyl)-2- epimerase and N-acetylmannosamine kinase, two essential enzymes in sialic acid biosynthesis. Decreased sialic acid production causes muscle degeneration. Muscle atrophy and weakness are completely prevented in a mouse model of DMRV after treatment with sialic acid metabolites orally.
  • The aim of this study is to investigate pharmacokinetics and safety of N-acetylneuraminic acid (figure) in patients with DMRV. N-acetylneuraminic acid and N-glycolylneuraminic acid in serum and urine are measured before and after oral administration of N-acetylneuraminic acid. We are prepared to provide academic consultations to companies interested in our research.
実用化イメージ

Researchers

Graduate School of Medicine

Masashi Aoki

Lethal effects of blue light on insects

 
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特徴・独自性
  • We revealed the strong lethal effect of short-wavelength visible light (blue light: 400–500 nm) on insects. That is, we found that blue light irradiation by using a common light-emitting diode (LED) can kill the eggs, larvae, pupae, and adults of various orders of insects. Our findings will provide clean and safe pest-control technique as well as important information on the hazards of exposure to visible light.
実用化イメージ

Researchers

Graduate School of Agricultural Science

Masatoshi Hori

Development of the cyclotron accelerator and its application

 
 
 
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特徴・独自性
  • We develop technology of the cyclotron accelerator and its application as follows. 1)Ion source (particularly heavy ion source), 2)design of ion optics, 3)device control system for the cyclotron, 4)RF system, 5)detectors for charged particles, gamma ray, and neutron, 6) radiation test by ion and neutron beam.
実用化イメージ

We have beam lines dedicated to the neutron irradiation and the ion irradiation, respectively. We can provide fast neutron beam (20-70 MeV), and various ion beam such as p, alpha, and heavy ions up to Xe. We also develop a neutron imaging technique using fast neutron.

Researchers

Cyclotron and Radioisotope Center

Masatoshi Itoh

Universal Design in Language Use

 
 
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特徴・独自性
  • My current research topic is "universal design in language use," with special reference to order in language and thought. In particular, I am investigating (1) similarities and differences in neural processing of languages with different basic word orders, (2) to what extent the order in non-verbal thought is affected by the order in language, and vice versa, and (3) what is the optimal order in human language and human thought, if any.
実用化イメージ

Although I am conducting basic research, I believe it helps develop (1) effective language teaching/learning methods, (2) rehabilitation programs for aphasia, (3) dynamic preservation of endangered languages/dialects, and so on.

Researchers

Graduate School of Arts and Letters

Masatoshi Koizumi

Creation of a high functional bio-interface using laser fabrication

 
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特徴・独自性
  • 　Using laser fabrication, we are developing techniques to enhance material surface properties and functionality. For example, to create a functional interface, we aim to clarify, by way of simulation and experimentation, the phenomenon that occurs when the surface of a material is irradiated using a laser beam.
  • 　We expect that the results of our research will be widely applicable, including biomedical devices.
  • ■　Creation of biocompatible surfaces
  • 　Materials used for artificial organs, vessels, and other bio-implants require excellent tissue and cell biocompatibility. Therefore, we are exploring the creation of biocompatible surfaces using a new laser irradiation process in this study.
  • 　We have succeeded in imparting a biologically active function to titanium-based materials by applying the laser irradiation technique. When such a material that has a biologically active function is inserted in a living body, hydroxyapatite (the principal constituent of bones and teeth) precipitates on the surface. Using the laser irradiation technique, we can manufacture bone-adherent implants, and we envisage their application to artificial joints or dental implants.
  • 　This research aims to discover such breakthrough solutions for biomedical applications using the laser irradiation technique.
実用化イメージ

Researchers

Green Goals Initiative

Masayoshi Mizutani

Applying Blended Learning to Special Needs Education

 
 
 
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特徴・独自性
  • I am interested in the human communication process and the man-machine interaction in some educational situation. I conducted interviews, questionnaires, behavior observations and experiments of students with special educational needs, their parents and teachers to investigate the needs, accessibility, usability, efficacy and its factors of blended learning and digital learning materials.
実用化イメージ

The outcomes of our research will make contribution to the design and development of teaching/learning materials and methods.

Researchers

Graduate School of Education

Masayuki Kumai

Optimizing everything / Optimal Society

 
 
 
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特徴・独自性
  • Aiming at developing practical quantum optimization technology known as quantum annealing, we are working on exploring basic technologies that can overcome the limitations and applications in collaboration with multiple companies. The advantage of the method is that it can be used simply by formulating a cost function that draws the goal to be optimized once, but we are not limited to the original method. We extend it by considering a much easier problem, sequential optimization by learning, black box optimization, etc.. In particular, it is being applied to automated driving, logistics in factories, and evacuation guidance during disasters.
実用化イメージ

Applications to route search problems such as automatic driving of various vehicles, evacuation route guidance at the time of disaster, process scheduling and a large number of combination problems. We can provide a solution to combinatorial optimization in each industry. (Transportation / distribution, manufacturing, materials, drug discovery, etc.)

Researchers

Graduate School of Information Sciences

Masayuki Ohzeki

Bio-Hybrid MEMS for Medical, Environmental and Food Engineering

 
 
 
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特徴・独自性
  • We have developed original manufacturing techniques for bio-hybrid MEMSs that utilize special functions of bio-elements, proteins and living cells, for molecular selective sensing and power generation from natural fuels.
  • (1) Conducting polymer electrodes printed on hydrogels (image 1)
  • (2) Dynamic control of bio-adhesion by electrochemical means (image 2)
  • (3) Micro Biofuel Cells with flexible enzyme electrode patches (image 3)
実用化イメージ

We hope to conduct collaborative research with a willing company for a practical application of these technologies in industry.

Researchers

Graduate School of Engineering

Matsuhiko Nishizawa

Forecasting eruption transition through geologic and petrologic approaches

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特徴・独自性
  • 1) In addition to geophysical observations, recent advances in volcanic stratigraphy and petrology would make us possible to forecast the transition of volcanic eruptions. We have been developing near-real-time volcanology based on the erupted materials in an early eruption stage.
  • 2) Automation of textural analyses of erupted materials, Risk assessment of volcanic eruption based on eruption stratigraphy
実用化イメージ

Researchers

Graduate School of Science

Michihiko Nakamura

Multicultural collaboration and Human Rights Education

 
 
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特徴・独自性
  • In this research, students from various backgrounds study human rights together to see whether human rights could be the universal topic for students to start and developing their discussions. Thus, this research is trying to observe students' behavior and check their study outcome.
実用化イメージ

It would be great if I could collaborate with any researchers or associations to do comparative research under the topics of human rights or creating collaborative relationships among students from various backgrounds.

Researchers

Institute for Excellence in Higher Education

Mino Takamatsu

Construction of Monitoring Systems for Genetic Diversity in Aquatic Organisms

 
 
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特徴・独自性
  • Maintaining genetic diversity within a species is a major issue to conserve biodiversity and sustainable use. To monitor genetic diversity in natural and captive populations using adequate genetic markers is the most important step. We have focused aquatic organisms and studied the genetic diversity using an array of DNA analyses. Our research interest includes 1) genetic structure and phylogeography of natural populations in marine and freshwater organisms and 2) genetic management of commercially important species to contribute the stock enhancement programs.
実用化イメージ

Our skill can be applied to environmental assessment and fish resource management. We are collaborating with national institutes and giving advice to private environmental assessment companies.

Researchers

Graduate School of Agricultural Science

Minoru Ikeda

Peptide and Protein Designs for Unexplored Fileds

 
 
 
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特徴・独自性
  • I am proposing methodologies to design recombinant peptides and proteins with appropriate structures and functions in the medicinal, environmental, material, and nanotechnological fields, with molecular evolutional and domain shuffling engineering. At present, we have constructed the methodologies for efficient renaturation of functional proteins from inclusion bodies expressed in bacteria, generation of peptides and proteins with the function of biomineralization, generation of peptides and proteins with affinity for inorganic materials to spontaneously make linkages between various nanomaterials, and high enhancement of cellulolytic enzyme activity induced by nanoclustering design on nanomaterials.
実用化イメージ

We hope the business partners in the in the medicinal, environmental, material, and nanotechnological fields would be interested in my approaches and we could conduct effective collaboration research with them.

Researchers

Graduate School of Engineering

Mitsuo Umetsu

Analysis of Biological Signals and Visualization

 
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特徴・独自性
  • Recent development of sensor technology and ICT have enabled collection and acculumation of huge amount and wide variety of biological data. We have been investigating analysis and processing methods of the biological data for supporting clinical diagnosis and health care. For example, development of extraction algorithm of fetal electrocardiogram from maternal abdominal siglnals, and estimation and visualization algorithms of status of autonomic functions based on diverse biological signals.
実用化イメージ

System development of biosignal anaysis, visualization, and diagnosis.
Development of monitoring and evaluation methods of alertness and sleepiness of traffic driver and workers.
Shift work scheduling based on circadian clock.

Researchers

Unprecedented-scale Data Analytics Center

Mitsuyuki Nakao

Material Design for Solution of Energy and Environmental Problems by Multi-Physics and Multi-Scale Simulation

 
 
 
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特徴・独自性
  • In order to solve the energy and environmental problems, the development of the high-functional and high-performance materials is required in a wide variety of research fields such as fuel cell, Li-ion battery, tribology etc. Especially, the recent material technologies constitute of multi-physics and multi-scale phenomena including chemical reaction, friction, impact, stress, fluid, photon, electron, heat, electric and magnetic fields etc. on nano- and macro-scales. Therefore, Kubo laboratory is pioneering the development of multi-physics and multi-scale simulator on the basis of quantum chemistry and is utilizing supercomputers "Fugaku" and "MASAMUNE-IMR" for realizing the theoretical material design with high-accuracy.
実用化イメージ

We utilize our developed multi-physics and multi-scale simulation technology on the basis of quantum chemistry for acceelerating the material development in a wide variety of private companies of automotive, machinery, power, electronics, material, metal, chemistry etc. and then contribute to solving the energy and environmental problems.

Researchers

Institute for Materials Research

Momoji Kubo

Brain Mechanism Realizing Human Mind

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特徴・独自性
  • I am investigating the brain mechanism of human mind. Specifically, my target is the internal schema that dissociate the self and other in the following three layers: physical, interpersonal, and social domains.
実用化イメージ

  • Improvement of the interface of the system
  • Clarifying the neuro-cognitive mechanism of the effect on the customer
  • New concept of the customer satisfaction

Researchers

Institute of Development, Aging and Cancer

Motoaki Sugiura

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