Tohoku University. Research Profiles

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"N" Researcher - 23 Result(s)

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Analysis and Function Elucidation of Fine Clusters and Defects in Materials Invisible by Electron Microscopy

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It is well known that nano-scale impurity/solute clusters, defects, defect clusters and their complexes affect the mechanical and electrical properties in materials. However, it is very difficult to observe these objects even by state-of-the-art electron microscopes. We overcome the difficulty by employing noble two techniques: laser three-dimensional atom probe (3D-AP) technique and positron annihilation spectroscopy (PAS). Laser 3D-AP can map out each atom in various materials (metals, semiconductors, insulators) in three-dimensional real space with nearly atomic scale resolution. PAS can detect vacancy-type defects and defect-impurity complexes very sensitively.

Targeted Application(s)/Industry

By combining these methods, we are going to reveal the functions of the fine impurity clusters and defects to the materials: developments of new nano-structured materials, the mechanism of degradation of aged structural materials, the fall in the yield of semiconductor device production, and developments of quantum devices etc.

Institute for Materials Research
NAGAI, Yasuyoshi, Professor PhD

English Vocabulary and Word-Formation: Synchronic and Diachronic Approaches

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My main research fields are English vocabulary, word-formation, and morphology. English is unique in possessing very rich amount of high-quality corpora and also in functioning the first ‘world language' in history, engendering dialects of non-native speakers all over the world. Using these original features as our data source allows us to watch and experience the process of how words and morphemes appear, grow, mature, and disappear.

Targeted Application(s)/Industry

My research could be useful for those interested in i) Construction and development of English dictionaries and corpora, ii) machine translation and language processing, iii) English education, and iv) coinages and naming in English

Graduate School of Information Sciences
NAGANO, Akiko, Associate Professor

Eco-Material Processing

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The major subject of our group is ferrous process metallurgy including thermodynamics of metals, alloys and molten slags, high temperature heterogeneous kinetics, phase equilibria of complex oxide systems and so on. We are interested in physic-chemical fundamentals of processing of metals, slags, scrap and waste. Recently our research interests are extended to multidisciplinary area so-called "Industrial Ecology" by the combination of process metallurgy, LCA (life cycle assessment) and social science such as econometrics.

Targeted Application(s)/Industry

Typically our research group is aggressively working in the area of material flow analysis of critical metals considering the quality of recycled materials. Currently our major research partners are steel and non-ferrous industries, while we do hope to collaborate with waste treatment company, mineral industry and an administrative organ.

Department of Metallurgy, Graduate School of Engineering
NAGASAKA, Tetsuya, Professor Doctor of Engieering

Assessment of Physical Activities Using Wearable Sensors

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Maintaining appropriate amount of physical activity is essential for health and disease prevention. Gait is the most common type of physical activity in everyday life. Monitoring the amount of physical activity in everyday lives may benefit mainly those who are at threat of metabolic syndrome and overweight. Towards better estimation of the amount of physical activity utilizing wearable sensors, we focused on taking running and walking economy into account. The relationship between step length and oxygen uptake was first determined. Step length estimation with moderate accuracy was accomplished using acceleration signals during walking. Step length was then taken into energy expenditure calculation as one of the variables.

Targeted Application(s)/Industry

Together with the basic version of the current locomotion monitoring system capable of counting staircase climbing up & down, we managed to upgrade our locomotion monitoring system into 3 dimensional.

Graduate School of Biomedical Engineering
NAGATOMI, Ryoichi, Professor

Development of Intelligent Molecules for the Regulation of Gene Expression in Cells

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The artificial control of gene expression by synthetic oligodeoxynucleotides (ODNs) has been the subject of considerable interest. In particular, ODNs conjugated with a cross-linking agent have been expected to enhance the inhibitory effect. Recently, microRNAs (miRNA) endogenously expressed small regulatory non-coding RNAs, are recognized as playing a critical role in regulating gene expression and the great concerns have been raised about efficient antisense oligonucleotides against miRNAs. We have already demonstrated that ODNs bearing a 2-amino-6-vinylpurine (2-AVP) derivative exhibited efficient interstrand cross-linking to cytosine selectively. The unique structural features of AVP are to possess both the hydrogen bond donor-acceptor sites as recognition sites and the vinyl group as a reactive moiety in a single molecule. Recently, we have developed of the novel cross-linking agents, which are designed based on the unique structure of AVP. These derivatives can react to thymine at the complementary site with highly selective and efficient under neutral conditions. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Targeted Application(s)/Industry

Institute of Multidisciplinary Research for Advanced Materials
NAGATSUGI, Fumi, Professor PHD

Photo-Functional Advanced Materials for Nanofabrication by Nanoimprint Lithography

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Nakagawa group has dedicated to pursue scientific principles for molecular control of interface function occurring at polymer/other material interfaces and to put them into practice in nanoimprint lithography promising as a next generation nanofabrication tool. We are developing advanced photo-functional materials such as sticking molecular layers for "fix by light", UV-curable resins and antisticking molecular layers for "preparation by light", fluorescent resist materials for "inspection by light", and hybrid optical materials "available to light" and new research tools such as mechanical measurement systems to evaluate release property of UV-curable resins.

Targeted Application(s)/Industry

Our research aims at creating new devices to control photon, electron, and magnetism.

Institute of Multidisciplinary Research for Advanced Materials
NAKAGAWA, Masaru, Professor Doctor of Engineering

Changing Corporate In-Service Training

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We have developed a system named PF-NOTE that the system uses video cameras, clickers and a computer to bookmark an audience's clicker feedback into simultaneously recorded video. We are also doing research for creating effective education or learning programs by using the developed system. The system has been mainly used for reflective learning, and we have found that this system is effective in various situations for both teacher and learners, such as practice teaching for early career teachers, developing presentation skills, and developing discussion skills.

Targeted Application(s)/Industry

We offer PF-NOTE system(s) and education/learning program(s) to companies that are of particular interest with respect to communication skills training, passing skills to the younger generation of employees, observation skill training and job interview training.

Graduate School of Educational Informatics Research Division
NAKAJIMA, Taira, Associate Professor

Forecasting eruption transition through geologic and petrologic approaches

Features

1) In addition to geophysical observations, recent advances in volcanic stratigraphy and petrology would make us possible to forecast the transition of volcanic eruptions. We have been developing near-real-time volcanology based on the erupted materials in an early eruption stage.
2) Automation of textural analyses of erupted materials, Risk assessment of volcanic eruption based on eruption stratigraphy

Targeted Application(s)/Industry

Department of Earth Science, Graduate school of Science
NAKAMURA, Michihiko, Professor Doctor of Science

Experimental Nuclear Physics

Features

1) Study of strangeness nuclear physics and hypernuclei with high energy electron/photon beams

2)加速器研究施設で収集される大量のデータ解析技術、
  荷電粒子、高エネルギー光子の測定技術、

Targeted Application(s)/Industry

Department of Physics, Graduate School of Science
NAKAMURA, Satoshi N., Professor Doctor of Science

Analysis of Biological Signals and Visualization

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Recent development of sensor technology and ICT have enabled collection and acculumation of huge amount and wide variety of biological data. We have been investigating analysis and processing methods of the biological data for supporting clinical diagnosis and health care. For example, development of extraction algorithm of fetal electrocardiogram from maternal abdominal siglnals, and estimation and visualization algorithms of status of autonomic functions based on diverse biological signals.

Targeted Application(s)/Industry

System development of biosignal anaysis, visualization, and diagnosis.
Development of monitoring and evaluation methods of alertness and sleepiness of traffic driver and workers.
Shift work scheduling based on circadian clock.

Graduate School of Information Sciences
NAKAO, Mitsuyuki, Professor Doctor of Engineering

Integrated Design for Sustainable Energy Systems

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The concept of LCS (low carbon society) is a unique approach having multi-dimensional considerations such as social, economic and environmental dimensions. The LCS aims at an extensive restructuring of worldwide energy supply/demand network system by not only replacing the conventional parts with the new ones, but also integrating all the necessary components and designing absolutely different energy networks. An energy-economic model is a tool for decision making for a variety of purposes, such as energy security planning, climate policy analysis, and technology innovation assessment.

Targeted Application(s)/Industry

Applying this model derives political measures, such as investment in R&D. It is also useful for guiding development policies under the concept of sustainability. In finding suitable energy-economic models for specific purposes, it is important to apply an adequate tool to consider geographical regions in focus, time horizon, energy classification, and economic parameters.

Department of Management Science and Technology , Graduate School of Engineering
NAKATA, Toshihiko, Professor Doctor of Engineering

Regulation of ABC Transporters in Colorectal Cancer

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Colorectal cancer (CRC) is one of the most common types of cancer worldwide. Surgical resection is the only curative treatment available for primary CRC. We determined the gene expression profiles for ATP binding cassette (ABC) transporters by RNA sequencing in matched colon cancer and normal colon tissue specimens in order to provide insight into the regulatory mechanisms underlying expression of transporters related to colon carcinogenesis. The expression of ABCC3 was repressed by Wnt signaling pathway, suggesting downregulation of ABCC3 might contribute oncogenesis.

Targeted Application(s)/Industry

Recently, we easily obtain comprehensive data including transcriptome and other omics data. These data are expected to help find a target for drug development, expecting that pharmaceutical industry interpret and extract new knowledge from them.

Graduate School of Medicine
NAKAYAMA, Keiko, Professor Medical Doctor

Elucidation of oncogenesis by Fbxw7

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In life science research field, it is noteworthy issue how information in genome is interpreted and is transferred to functional molecules. However, during these 10 years, we convinced that the amount of proteins, final functional molecules was regulated by not only by production but also by degradation. For examples, the amount of c-Myc, which promotes cell cycle and inhibits cell death, increase in many types of cancer by failure of protein degradation.
We have generated model mice in which function of Fbxw7, inducer of c-Myc degradation is suppressed. We observed promotion of oncogenesis in these mice, suggesting that Fbxw7 is oncosuppressor gene. In other words, Fbxw7 has a great potential to regulate oncogenesis or progress of cancer. These molecules specified the target proteins for proteolysis suggesting that modification of these molecules leads to develop oncosuppressive therapy. We hope to conduct collaborative research with a willing company for a practical application of this knowledge in industry.

Targeted Application(s)/Industry

Graduate School of Medicine
NAKAYAMA, Keiko, Professor Medical Doctor

Philosophy of Science and Technology, Science and Technology Studies (STS)

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My research area is mainly phenomenology, philosophy of technology, and applied ethics (engineering ethics etc.). Technological Artifacts mediate human activities. So designing artifacts is in itself an ethical behavior. Analysing the ontological structure of the artifacts, describing the epistemological propcess of desingning activities, evaluating the social and ethical influence of artifacts are main issues in philosophy of technology. On the basis of such philosophical investigations, we can develope ethical studies concerining how engineerss, companies can recognize ethical issues in a networks of meanings , how they can make ethical decision among engineers and users.

Targeted Application(s)/Industry

I hope to conduct cooperative research on ethical education of engineers, as well as on human-machine interaction.

Graduate School of Arts and Letters
NAOE, Kiyotaka, Professor PhD

Performance enhancement and application development of energy harvesting materials by microstructure design

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To realize IoT society, it is required the sensors, which function without battery charge. We study on energy harvesting materials using our knowledge about materials mechanics and numerical simulation such as finite element method. We recently address to develop energy harvesting devices, which can recovery the unharnessed energy around us as electrical energy.

Targeted Application(s)/Industry

Department of Materials Processing, Graduate School of Engineering
NARITA, Fumio, Professor Doctor of Engineering

Nonprofit Organizations and Social Capital

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Nonprofit organizations strive to solve community and social problems and to create new social values. Nonprofit organizations have the role to create citizenship and social capital - trust, norms and networks - in community. Social capital, an invisible and soft capital has increasingly become important to a sustainable management of an organization.
We hope to conduct collaborative research with willing corporations and organizations for measuring social capital at community/organizational levels and for making practical proposals on how to create and utilize social capital with viewpoints of partnership with nonprofit organizations and human resource development.

Graduate School of Economics and Management
NISHIDE, Yuko, Professor Doctor of International Public Policy

Religion, language, society, and life in ancient India

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Targeted Application(s)/Industry

Faculty of Arts and Letters
NISHIMURA, Naoko, Associate Professor Doctor of Philosophy

Bio-Hybrid MEMS for Medical, Environmental and Food Engineering

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We have developed original manufacturing techniques for bio-hybrid MEMSs that utilize special functions of bio-elements, proteins and living cells, for molecular selective sensing and power generation from natural fuels.
(1) Conducting polymer electrodes printed on hydrogels (image 1)
(2) Dynamic control of bio-adhesion by electrochemical means (image 2)
(3) Micro Biofuel Cells with flexible enzyme electrode patches (image 3)

Targeted Application(s)/Industry

We hope to conduct collaborative research with a willing company for a practical application of these technologies in industry.

Department of Bioengineering and Robotics, Graduate School of Engineering
NISHIZAWA, Matsuhiko, Professor Doctor of Engineering

Electrical Detection of Magnetization Process in Nano-Scale Ferromagnet

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A nano-scale ferromagnet has onion and vortex states in its magnetization. Especially the vortex state is important since the stray field from the ferromagnet is suppressed. It is expected to apply it to high density non-volatile memory because of two different magnetized orientations, clock-wise and counter clock-wise directions. We have experimentally and theoretically confirmed that the chirality of the vortex state can be detected with an electrical way (Fig. 1). Furthermore, by putting a single nano-scale ferromagnet on top of a semiconductor Hall bar, we have demonstrated that the magnetization reversal process can be electrically detected with a very high sensitivity even without using SQUID (Fig. 2).

Targeted Application(s)/Industry

As an example of applications, the method is applicable to magnetic sensor with high sensitivity and high density non-volatile memory. We are prepared to provide academic consultations to companies interested in our research.

Department of Materials Science, Graduate School of Engineering
NITTA, Junsaku, Professor Doctor of Engineering

The Novel Ultrasound Irradiation Device

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Dr. Katsunori Nonogaki has developed the novel ultrasound irradiation device, which can improve the autonomic nervous system activity and peripheral circulation. In addition, the ultrasoud device can improve hypertension and hyperglycemia within 20 min in subjects with drug-resistant hypertension and diabetes. Our initial device was approved in Japan (226AIBZX00028000). This device will be avaliable for the treatment of 1) muscle pain, 2) the autonomic neural dysfunction and stress-related disorders, 3) hypertention, and 4) diabetes. Moreover, the device will be usefull for your healthy life and aging care.

Targeted Application(s)/Industry

Our aims are to export the device internationally. We seek the investment and international business partners.

Department of Diabetes Technology, Graduate School of Biomedical Engineering
NONOGAKI, Katsunori, Professor MD, PhD