Tohoku University. Research Profiles

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"S" Researcher - 43 Result(s)

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Visualization of Biological Microstructure with High Frequency Ultrasound and Photoacoustic Imaging

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Features

"Features"
High-resolution imaging of biological tissue is non-invasively obtained with high frequency ultrasound. We have developed some ultrasound microscope systems which realized the resolution of 15-micron with 100 MHz and resolution to visualize a single cell with GHz range ultrasound. Ultrasonic imaging provides not only tissue morphology but also information on tissue elasticity. Recently, we have developed a real-time three-dimensional photoacoustic imaging system for visualization of subcutaneous micro vasculature and oxygen saturation.
"Targeted Application(s)/Industry"
High frequency ultrasound and photoacoustic imaging is repeatedly and non-invasively applied for early diagnosis of atherosclerosis, skin aging and tissue metabolism. They are useful for efficacy assessment of cosmetics and pharmaceuticals. High frequency ultrasound is also applied in the industrial areas where thickness measurement of opaque film or bilayer thin coating with the precision of 0.1 micron is required.

Targeted Application(s)/Industry

Biomedical Imaging Laboratory, Graduate School of Biomedical Engineering
SAIJO, Yoshifumi, Professor PhD (Medicine)

Development of preventive medicine for aortic aneurysm and dissection of Marfan syndrome

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Marfan’s syndrome (MF) is a severe, systemic disorder of connective tissue formation. A variety of MFS therapies have been developed, including surgical therapy for aortic root aneurysm and dissection (AAD) that are life-threatening, traditional medical therapies such as β-adrenergic receptor or angiotensin II receptor blockers for slow aortic growth and to decrease the risk of AAD. However these treatments did not prevent tissue destruction in the AAD of MF. To develop preventive strategy for AAD, it will be necessary to identify molecular mechanisms of microfibril formation and an appropriate fibrillin-1 microfibril associated molecule. Recently, ADAMTSL6β, which is a microfibril-associated extracellular matrix protein contributes the regeneration of microfibril by promoting fibrillin-microfibril assembly. We try to develop ADAMTSL6β as a preventive medicine for AAD of MF by regeneration of fibrillin-1 microfibril assembly.

Targeted Application(s)/Industry

Graduate School of Dentistry, Division of Operative Dentistry, Department of Restorative Dentistry
SAITO, Masahiro, Professor Doctor of Dentistry

Carbon Nanotubes

Features

We investigate the physical properties of carbon nanotubes, graphene and two-dimensional materials.

Targeted Application(s)/Industry

Department of Physics
SAITO, Riichiro, Professor Doctor of Science

Blockchain-based Approachs for High Secure P2P-type Decentralized Cloud Storage and Practical Smart Contract for Trading Personal Data

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We are developing a decentralized P2P (Peer to Peer) type cloud storage that realizes innovative level of security by use of surplus storages of P2P nodes with the Blockchain technology. The developed storage can avoid the risk of large-scale information leakage of stored data due to the weakness of the central server. By using our cryptographic currency for rewards and usage fees in the storage, fair storage usage of all users can also be achieved.
In addition, We are developing a unique smart contract technology for practical decentralized trading of personal data among an unspecified number of users.

Targeted Application(s)/Industry

We hope to conduct collaborative researches with companies developing Bitcoin 2.0 type application (e.g. smart contract, Fintech) based on the Blockchain technology, the Internet of Things (IoT) technology, Medical Database for practical use.

Center for Information Technology in Education
SAKAI, Masao, Associate Professor Doctor of Engineering

Food Palatability, Product Usability, and Preference; An Approach from Psychology and Neuroscience.

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My research interest is peoples' perception of external stimulus. Based on these researches and our knowledge, I can offer you an idea of the products that give consumers satisfaction. Also on the basis of psychological and neuro-scientifc experiences and knowledges, I can offer you a transdisciplinary approaches on human perception, cognition, emotion and decision making.

Targeted Application(s)/Industry

Marketing and developing of the products such as foods, beverages, fabric softeners, perfumes, body deodorants etc. The knowledges and research tools are also useful in regulating the malodor in the air pollution, in developing the public services and in elevating public quality of life.

Department of Psychology, Graduate School of Arts and Letters
SAKAI, Nobuyuki, Professor PhD of Human Sciences

Development of Innovative Green Nanodevices Using Damage-Free Processes

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We developed an entirely new concept of "bio-template ultimate process technology" and realized fabrication of uniform, size-controllable, defect-free, high-density and regularly-distributed quantum dot array on surface of arbitrary material. The quantum dot array can be applied to high efficiency and inexpensive quantum dot solar cells, high luminescence quantum dot lasers, high-speed graphene / germanium transistors, and so on, i.e., energy-generating, energy-storing, and low-energy-consumption devices.

Targeted Application(s)/Industry

We can accept collaborative researches on nanodevices such as quantum dot solar cells or lasers, low-energy-consumption devices such as graphene transistor and germanium transistor, and fundamental technologies such as plasma/beam processes, thin film deposition, doping, and surface treatment.

Green Nanotechnology Laboratory, Innovative Energy Research Center, Institute of Fluid Science
SAMUKAWA, Seiji, Professor Doctor of Engineering

Emergence in collective electrons in organic molecular materials

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The main research subjects in this group are the experimental investigations of the organic molecular conductors. The characteristic properties of the organic materials are multiple flexibilities owing to the assemble structure of nanometer-size molecules. This flexbility comes up recently for developing the organic electronic devices. We explore the fundamental electronic properties of the organic molecular materials which have wide range of the ground states from superconductivity to insulating states resulting from the strongly correlated electrons in the molecular pi-orbital. Such features are closely connected to flexible and multiple degrees of freedom in charge, spin, molecular latticeand molecules themselves. We are actively studying on the interesting and important issues in the condensed matter physics from the viewpoints of the characteristic flexbility of the organic molecular materials. We are prepared to provide academic consultations to companies interested in our research.

Low Temperature Condensed State Physics, Institute for Materials Research
SASAKI, Takahiko, Professor Dr. Eng.

Development of Passive Millimeter-wave Imaging Device for Practical Applications

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Millimeter wave (MM-wave) which is one of the electromagnetic wave transparent the clothes, the fire and the wall etc. and all natural materials including objects in clothes always radiate the electromagnetic wave as the thermal noise. Using these characteristics of MM-wave, imaging of concealed objects in clothes can be accomplished in a noninvasive and noncontact manner. This technique is called Passive Millimeter Wave (PMMW) Imaging technique and we have developed a PMMW imaging device for security applications.

The wave length of MM-wave frequency range is from 1 mm to 10 mm and the spatial resolution of images in MM-wave range is low compared with sub-millimeter (terahertz) range or Infra-Red range, however, higher transmittance through clothes can be obtained compared with higher frequency range. Furthermore, low noise amplifier (LNA) exists which could be the advantage of MM-wave compared with higher frequency ranges.

Now the device was developed for the purpose of keeping safe and secure aircrafts and ships etc., we hope to conduct collaborative research with a willing company for a practical application of this technology in industrial fields such as the fire rescue, the police equipment and the medical devices.

Graduate school of Engineering
SATO, Hiroyasu, Assistant Professor Doctor of Engineering

Radar Remote Sensing

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We are developing new electromagnetic methodologies including radar and electromagnetic induction techniques, applying to natural resources survey and environmental monitoring. Currently, we are working for topics such as space borne and air borne microwave remote sensing sensors (SAR), Ground Penetrating Radar (GPR), Electromagnetic Induction methods (Metal detector) and their applications to subsurface sensing and humanitarian demining, and borehole radar for hydro geology. One of our sensors, ALIS which is a GPR system for land mine detection has been successfully operated in real mine field in Cambodia. These technologies using applied electromagnetics can be applied to other fields. We are seeking for industries which have interests in subsurface sensing and detection.

Targeted Application(s)/Industry

•Development and Application of Ground Penetrating Radar (GPR ) , EMI methods
(Ground water, soil moisture, landmine, explosive detection, archaeological survey, NDI)
Space borne and air borne Synthetic Aperture Radar (SAR) (Environmental monitoring, identification of vegetation, identification of targets)
Development and Application of Ground Based Synthetic Aperture Radar (GB-SAR) (Land slide monitoring, Tsunami, NDI)

Center for Northeast Asian Studies
SATO, Motoyuki, Professor Doctor of Engineering

Landmine detection sensor

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ALIS is a hand-held dual sensor system, which consists of a metal detector and a ground-penetrating radar (GPR). The most unique feature of ALIS is its visualiza- tion function of the metal detector and GPR. Operators can easily identify buried mines on the visualized image.
The full features of a state-of-the-art metal detector are available, for example the soil compensation function and the pinpointing capability. The GPR antennas are integrated into search head together with metal detector coils. The control unit holds all the electronics and a rechargeable battery. The color LCD display provides the survey results both from the metal detector and the GPR as images. Audio alert is also available for the metal detector indication.

Targeted Application(s)/Industry

Center for Northeast Asian Studies
SATO, Motoyuki, Professor Doctor of Engineering

Hardware Development of Brain Computer and its Application to Visual Information Processing

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Toward realizing a high-performance neuromorphic vision processing system, our research involves a neural network model of spatial perception based on motion-stereo vision and its implementation on a very large scale integrated circuit (VLSI). Important parameters for spatial perception such as time-to-contact, orientation, and the shortest distance to plane surfaces of a target object are recognized by using the model without knowing moving direction and velocity of the object. We have developed a VLSI capable of performing visual perception based on the model with low power consumption, reduced less than 1/100 compared with a commercial CPU.

Targeted Application(s)/Industry

Targeted applications include a drone flying autonomously equipped with collision avoidance system by visual perception. Targeted industry includes infrastructure inspection, agriculture, logistics, and so on.

Research Institute of Electrical Communication
SATO, Shigeo, Professor Ph.D (Information Science)

Nanoparticle synthesis by femtosecond laser pulses

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By using femtosecond laser pulses, nanoparticles of noble metals (gold, platinum, silver, palladium etc.) are synthesized. Particles with the size of a few nanometers are fabricated by simply irradiating metal ion solution with the laser pulses. This process needs no reducing agent and is able to synthesize alloy nanoparticles of noble metals. The collection of nanoparticles is easy because the process is performed in liquid. We are prepared to provide academic consultations to companies interested in our research.

Targeted Application(s)/Industry

Institute of Multidisciplinary Research for Advanced Materials
SATO, Shunichi, Professor Doctor of Engineering

Development of Vector Beam and its Application to Nanoimaging

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Vector beams are very attractive because of their unique features such as small spot formation and strong longitudinal electric field near focus. We are developing a variety of generation methods of vector beams including Laguerre-Gaussian and Bessel-Gaussian beams and their higher order transverse modes. For instance, a smaller spot by approximately 30 % than that by a linearly polarized beam has been demonstrated and applied for nanoimaging.

Targeted Application(s)/Industry

Confocal scanning microscpy will benefit from vector beams as enhancement of spatial resolution. Otherwise, precision nano-processing will be possible. We are prepared to provide academic consultations to companies interested in our research.

Institute of Multidisciplinary Research for Advanced Materials
SATO, Shunichi, Professor Doctor of Engineering

Development of next-generation sterilization method by a plasma flow at atmospheric pressure

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Plasma sterilization has been developed as an alternative sterilization method due to its chemical activity, operation at low temperature and atmospheric pressure, low power consumption, low cost and safety. We have studied a mechanism of chemical species generation and transport in a plasma flow and, the sterilization efficacy and mechanism for several plasma sources at atmospheric pressure, such as a microwave plasma flow, a dielectric barrier discharge in a tube and a water vapor plasma flow. We already clarified that the damages of outer membrane and destructions of the cytoplasmic membrane of Escherichia coli by exposure to the microwave plasma flow. Fig. 1 shows the effect of plasma exposure on the E. coli. When the E. coli was exposed to the plasma, the height of the E. coli decreased and the potassium leakage of cytoplasmic material increased. For sterilization in a tube, we also clarified that an induced flow in the narrow tube by DBD transports chemical species and sterilize the whole inside surface of a tube as shown in Fig. 2. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Institute of Fluid Science
SATO, Takehiko, Professor Doctor of Engineering

Neutron scattering study on macroscopic quantum phenomena

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In contrast to other scattering techniques, such as x-ray and electron diffractions, neutron scattering has the following advantages: 1) light atoms, such as H and Li, can be detected; 2) electron spins can be detected; 3) low energy excitations can be investigated. Using the neutron scattering technique, we search for macroscopic quantum phenomena in many-body electron systems, such as macroscopic singlet ground states in the quantum frustrated magnets and spin-fluctuation-mediated unconventional superconductors.

Targeted Application(s)/Industry

As noted above, neutron scattering can be used for investigating magnetic structure, spin dynamics, light atom positions in crystalline materials and their dynamics. Hence, this technique is very useful when those pieces of information are to be known.

Institute of Multidisciplinary Research for Advanced Materials
SATO, Taku J, Professor Doctor of Science

Regulation of Angiogenesis

Features

Angiogenesis, i.e., the formation of new capillaries, takes place under pathophysiological conditions including cancers, ocular neovascular diseases and atherosclerosis. Anti-angiogenic drugs have been developed, and are now in clinical use. However, because of side effects due to the damage to vascular endothelial cells, the development of anti-angiogenic drugs with different modalities is anticipated. We have isolated vasohibin-1 (VASH1) as a novel angiogenesis inhibitor expressed by endothelial cells (ECs), and vasohibin-2 (VASH2) as its homologue having pro-angiogenic activity.

Targeted Application(s)/Industry

We are planning to develop strategies of VASH1 potentiation and VASH2 inhibition. For VASH1 potentiation, we are planning to use recombinant VASH1 protein or search low molecular weight substances having VASH1 like activity. For VASH2 inhibition, we are succeeded in the development of neutralizing anti-human VASH2 monoclonal antibody.

Institute of Development, Aging and Cancer
SATO, Yasufumi, Professor M.D.,PhD

Suppression of Intergranular Degradation of Polycrystalline Materials by Grain Boundary Engineering

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Intergranular degradation often results in decreased lifetime, reliability and economical efficiency of polycrystalline materials. In spite of persistent efforts to prevent such degradation, its complete suppression has not yet been achieved. Grain boundary studies have revealed that coincidence-site-lattice (CSL) boundaries have stronger resistance to intergranular degradations than random boundaries. The concept of ‘grain boundary design and control' has been refined as grain boundary engineering (GBE). GBEed materials which are characterized by high frequencies of CSL boundaries are resistant to intergranular degradations. Our group has achieved very high frequencies of CSL boundaries in commercial stainless steels by GBE. GBEed stainless steels showed significantly stronger resistance to intergranular corrosion (see Figs. 1 and 2), weld-decay, knife-line attack, stress corrosion cracking, liquid-metal embrittlement, radiation damage, etc. and much longer creep life (see Fig. 3) than the unGBEed ones.

Targeted Application(s)/Industry

By using this GBE processing, we expect to conduct effective collaborative research in related fields.

Department of Materials Processing, Graduate School of Engineering
SATO, Yutaka, Professor Ph.D.

Design and control of new weld interface during welding of dissimilar materials

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Welding of dissimilar materials is an important process to manufacture the future structures and devices, but it is hard to produce the high-performance welds because the excessive reaction at the weld interface deteriorates the weld properties. Our group attempts to develop the new dissimilar welding process to yield the new interface with the aimed properties through design and control of interfacial reaction as well as usage of solid-state welding processes, such as friction stir welding and ultrasonic welding.

Targeted Application(s)/Industry

We hope to have collaborative researches with willing companies for practical application of welding of dissimilar materials, including metal/metal and metal/thermoplastic composite, in transportation, infrastructure, and energy industries.

Department of Materials Processing, Graduate School of Engineering
SATO, Yutaka, Professor Ph.D.

Mathematical Biology

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Principal subject of our study is the mathematical model analysis to make clear or present the point at issue for scientific discussion about real biological/social phenomena, or to promote the advanced theoretical research: what theoretical problem about target phenomenon is treated, how the problem is mathematically modeled, what mathematical analysis is applied for the model, and how the mathematical result is lead to the discussion in biological/social science.

Targeted Application(s)/Industry

Graduate School of Information Sciences
SENO, Hiromi, Professor Doctor of Science