Tohoku University. Research Profiles

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"S" Researcher - 43 Result(s)

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Hormone Actions in Human Breast Carcinoma

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Features

Breast cancer is one of the most common malignancies in women worldwide. Therefore, it is very important to investigate biological features of breast carcinoma in order to improve clinical outcome of the patients. It is well known that estrogens play important roles in the development of human breast carcinomas, and endocrine therapies are frequently used in these patients to block the intratumoral estrogen actions. In the Division of Pathology and Histotechnology, we analyze hormone actions in breast carcinoma by pathological methods as well as various molecular biological techniques.

Targeted Application(s)/Industry

It will be possible to newly develop diagnostic techniques regarding prediction of prognosis and/or effectiveness of treatment in breast cancer patients.

Pathology and Histotechnology, Graduate School of Medicine
SUZUKI, Takashi, Professor MD, PhD

Development of Fish iPS Cell Technology

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In order to utilize for the development of fish iPS cells, we established experimental systems to monitor cellular multipotency using zebrafish and medaka transgenic lines which express GFP fluorescence under the regulation of oct4 promoter. Because fish has strong fin regenerative activity after amputation, and GFP positive cells appear during fin regeneration, fin is expected to be suitable for iPS cell preparation. In addition, we ascertained that MC-LGNSO, a commercially available minicircle DNA developed for human iPS cell preparation, works well in fish cells. By using transgenic lines and the minicircle DNA, we are now trying to establish iPS cells from regenerating fin cells.

Targeted Application(s)/Industry

We expect that in fish, iPS cell technology is applicable to innovative new technologies in aquaculture: i.e. generation of iPS cells from selected fish strains and production of clone individuals of the selected lines, and cryopreservation of important fish strains as cell lines.

Graduate School of Agricultural Science
SUZUKI, Tohru, Professor PhD

Research on the metamorphic development and pluripotency of cells in fish

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We have been investigating the molecular control mechanisms of fish metamorphosis and pluripotency of embryonic cells using flounder and fugu as important species in aquaculture, and also zebrafish and medaka of model organisms. We recently discovered that the Nodal pathway, which is known to control the sidedness of internal organs, fixes the laterality of flounder eye-sidedness. In the study of pluripotency, we established transgenic lines in which pluripotency of cells can be monitored by GFP fluorescence.

Graduate School of Agricultural Science
SUZUKI, Tohru, Professor PhD