Tohoku University. Research Profiles

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"D" Theme - 78 Result(s)

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Development of Early Diagnosis and Treatment System for Lymph Node Metastasis

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Animal studies of lymph node metastasis are constrained by limitations in the techniques available for noninvasive monitoring of the progression of lymph node metastasis, as well as difficulties in the establishment of appropriate animal models. To overcome these challenges, this study has developed a mouse model of inter-lymph-node metastasis via afferent lymphatic vessels for use in the development of imaging modalities and treatment methods.

Targeted Application(s)/Industry

Non-invasive equipments for early diagnosis and treatment of lymph node metastasis.

Graduate School of Biomedical Engineering
KODAMA, Tetsuya, Professor PhD(Engineering), PhD(Medicine)

Development of Electronic Instruments (Radio, Infrared, Optical, and Digital), Extensible Unit, and Embedded Software for Spacecraft

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We have performed the development of the radio wave receivers, radars, infrared & optical cameras / spectrometers, and digital instruments for various space projects. (Ex. KAGUYA [Lunar orbiter], BepiColombo [Mercury orbiter], Exceed [EUV space telescope], Reimei [Small aurora-observatory], ERG [radiation belt], JUICE [Jupiter], the International Space Station [by atmospheric camera IMAP], several sounding rockets and high-altitude balloon experiments.)

Targeted Application(s)/Industry

By historical reasons, the developments of these analog / digital circuits, FPGA, embedded software, extensible mechanics have mainly been with companies and engineers in Kanto and Chubu areas. We hope to find the counter companies / persons in Sendai / Miyagi / Tohoku areas.

Department of Geophysics, Graduate School of Science
KASABA, Yasumasa, Professor PhD (Electronics)

Development of Entangled Photon Sources

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The quantum information and communication technology (QICT) is expected to overcome the difficulties that classical information technology is confronted with. Quantum entanglement carried by photons is one of the most fundamental resources in QICT. We have been developing efficient, high-quality entangled photon sources utilizing semiconductor materials and quasi-phase-matched optical nonlinear devices, with a number of patents awarded.

Targeted Application(s)/Industry

We hope to conduct collaborative research with a willing company for a practical application of this technology.

Research Institute of Electrical Communication
EDAMATSU, Keiichi, Professor Doctor of Science

Development of Fall-Prevention Footwear Based on Mechanical Analysis of Slip-Related Falls

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The number of fatalities due to falling accidents indoor/outdoor has increased in Japan as well as in other advanced countries. The fatalities due to falling accidents in a year have exceeded those due to traffic accidents in Japan recently. Because more than 80% of the fatalities are elderly people, it is considered an urgent issue to prevent their falling. We have conducted researches on falling during walking due to induced slip, in the contact interface of shoe sole and floor, through tribological and biomechanical approaches. We clarified the required values of static friction coefficient (figure 1), between shoe sole and floor, and how to gait to prevent slipping through kinetic analysis of gait. We also succeeded in the development of a unique footwear outsole having the high-grip property (figure 2) and high slip-resistant concrete pavement blocks (figure 3) through the collaboration with regional companies. We have recently conducted research and development of footwear that is able to prevent falls due to balance loss after slipping.

Targeted Application(s)/Industry

Products for fall prevention in daily life or in work site. Evaluation of slip resistance of footwear and floor materials.

Graduate School of Engineering
YAMAGUCHI, Takeshi, Associate Professor Doctor of Engineering

Development of Fish iPS Cell Technology

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In order to utilize for the development of fish iPS cells, we established experimental systems to monitor cellular multipotency using zebrafish and medaka transgenic lines which express GFP fluorescence under the regulation of oct4 promoter. Because fish has strong fin regenerative activity after amputation, and GFP positive cells appear during fin regeneration, fin is expected to be suitable for iPS cell preparation. In addition, we ascertained that MC-LGNSO, a commercially available minicircle DNA developed for human iPS cell preparation, works well in fish cells. By using transgenic lines and the minicircle DNA, we are now trying to establish iPS cells from regenerating fin cells.

Targeted Application(s)/Industry

We expect that in fish, iPS cell technology is applicable to innovative new technologies in aquaculture: i.e. generation of iPS cells from selected fish strains and production of clone individuals of the selected lines, and cryopreservation of important fish strains as cell lines.

Graduate School of Agricultural Science
SUZUKI, Tohru, Professor PhD

Development of Frequency Tunable Coherent TERAHERTZ Light Sources and their Potential Applications

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Terahertz wave (THz) is quite new electromagnetic wave. THz wave is expected to show wide variety of important practical applications. In view of the scientific fields, THz spectroscopy can reveal quite new inter-molecular vibration. We successfully realized the THz wave emission via both non-linear optical effects of NIR laser light and the high frequency semiconductor device operations. The frequency region realized is ranging between 0.03THz and a few 10 THz. It is also noted that the device assembly of THz semiconductor devices and the crystal growth of non-linear optical crystal have been performed in our laboratory.

Targeted Application(s)/Industry

Applications
Non-destructive and non-contact defect recognition of building blocks and water diffusion recognition in polymers, paints, woods and concrete, adhesion failure of ceramics tiles on concrete walls, chirality discrimination of medicines, hydro-oxide formation of medicines, recognition of polytypes of organic and nonorganic crystalline compounds, THz spectroscopic imaging using specific molecular vibrations

Industry
Civil and architecture engineering, Metal construction like bridge, tunnel construction, automobile and train, semiconductor fabrication, electronic device fabrication, medicine, chemical engineering.

Department of Materials Science and Engineering, Graduate School of Engineering
OYAMA, Yutaka, Professor Doctor of Engineering

Development of Geothermal Energy and Geosphere Environmental Informatics

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My research field is Geothermal Geology, Resource Geology and Environmental Geology. I am conducting exploration of heat source, hydrothermal alteration and characterization of geothermal reservoir by geological techniques. I study water-rock interaction and fluid dynamics in reservoirs on the basis of hydrothermal experiments under sub- to supercritical conditions and numerical simulation. Additionally, risk assessment of soil, river water in terms of heavy metal pollution.

Targeted Application(s)/Industry

I am conducting international collaboration with respect to geothermal geology, mining geology, and geoengineering related to risk assessment of geosphere environment.

Graduate School of Environmental Studies
TSUCHIYA, Noriyoshi, Professor Doctor of Engineering

Development of Grass-field Shorthorn Cattle and it's Innocative Green-Technology for Sustainable and Improving Beef Production

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Grass-field Shorthorn Cattle(trademark registration No. 5270386 Fig.1)that possess a loss of functional myostatin result in the double-muscled phenotype with generalized hyperplasia and hypertrophy of the muscle. The cattle were developed form Japanese Shorthorn Cattle, and have superior carcass characteristics including a larger proportion of muscle (about 50% more muscle mass than normal-muscled cattle), lower proportions of fat and more tender meat (Fig. 2). The increased lean beef production shows that Grass-field Shorthorn Cattle are estimated to be a hopeful breed as meat cattle in days to come. Therefore, we are studying the further development of Grass-field Shorthorn Cattle and it’s whole mechanisms of increased muscle muss (Fig.3) as a new breed to reduce the environmental loading on beef production. The goal of our research is to establish innovative Green-Technology for sustainable and improving beef production of GSC and to utilize them for practical use.

Graduate School of Agricultural Science
ASO, Hisashi, Professor Doctor of Medicine

Development of healthy longevity meal and health supplement based on the Japanese diet

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We studied the health function of the Japanese diet, and clarified that the Japanese diet from 1975 has the function of reducing stress, obesity, diabetes, fatty liver, dementia, cancer, and aging speed. And, with various evaluation systems, we clarified the characteristics of 1975 Japanese diet (Fig.1). The various findings obtained in this research are a considerable advantage in developing health foods, which helps to develop healthy longevity meals and health supplements.

Targeted Application(s)/Industry

In addition to research on functionality of foods, the identification of functional ingredients by simultaneous analysis of meals and ingredients (Fig.2) and the identification of ingredients that improve the balance of intestinal flora better (Fig.3) are also possible.

Graduate School of Agriculture
TSUDUKI, Tsuyoshi, Associate Professor Doctor of Agriculture

Development of high performance and high functional materials by Compression Shearing MEthod (COSME)

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The compression shearing process is a new technology that enables consolidating of powder materials at temperatures ranging from room temperature to about 300 ° C. This method can consolidate powder to bulk material at temperatures below the melting point without binders or additives that make materials difficult to recycle. It is an innovative technology that has the potential to be applied to materials that were difficult to consolidate using conventional powder metallurgy methods and a new concept material process. We are actively working on this research on both basics and applications and would like to apply this technology to material bonding and material coating in the future.

Targeted Application(s)/Industry

Institute of Fluid Science
MIKI, Hiroyuki, Associate Professor Doctor of Science

Development of High Performance Carbon Nanotube-Alumina Composite

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One of the important challenges in the development of carbon nanotubes (CNTs) reinforced ceramic composites is uniform dispersion of CNTs in the matrix. The mechanical properties of CNT/ceramics composites have been limited to date due to the formation of CNT agglomerates in the composite. We have successfully produced CNT/alumina composites with world top class strength and toughness, by employing a newly developed CNTs dispersion technique based on a flocculation method. The processing method developed in this study enables us to prepare high performance CNT materials using a pressureless sintering method.

Targeted Application(s)/Industry

The possible applications of the CNT/alumina composites developed in this study include tribological materials (ball bearing), biomaterials (artificial hip joint), micro-actuator materials utilizing electrostrictive effects, electromagnetic wave absorber, particularly in the frequency range of several GHz and several ten GHz.

Graduate School of Engineering
HASHIDA, Toshiyuki, Professor Doctor of Engineering

Development of High Sensitive Magnetic Sensor Operating at Room Temperature with Tunnel Magnetoresistance Devices

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Recently, many tunnel magnetoresistance devices with high magnetoresistance effect are reported. These are expected to be applied to high sensitive magnetic sensors. There are many magnetic sensors with variety of the mechanism, in order to meet the demand of the very wide range of sensing magnetic field. However, there is no magnetic sensor which has high sensitivity, easy to use, operation at room temperature and low cost. Only a magnetic sensor with tunnel magnetoresistance devices can satisfy all the demand in principle. As the device has very wide range of the sensing magnetic field, it can be designed for any demand to the sensors.

Targeted Application(s)/Industry

For example, this device can sense a bio-magnetic field easily at room temperature, so that it could be replaced SQUID device, which is popular now but is very expensive and not easy to use personally. Therefore, by using this device, we expect we can conduct effective collaborative research in medical field.

Department of Applied Physics, Graduate School of Engineering
ANDO, Yasuo, Professor Doctor of Engineering

Development of Immunobiotic Evaluation System for Functional Feeds as a Livestock Animal Model

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Pattern recognition receptor (PRR) family plays an important role in the defense through recognition of pathogen-associated molecular patterns or microorganisms-associated molecular patterns (PAMPs/MAMPs).
Some functional feed materials are thought to regulate intestinal immunity by contact and stimulation of epithelial cells and immunocompetent cells via PRRs in the gastrointestinal tract and induction of cytokine production. In this "new world" of feed immunology, however, much remains unknown about the underlying mechanisms of intestinal immunity because of lack of appropriate intestinal immunoassay system for livestock animals.
We have advanced application of originally established porcine and bovine intestinal epitheliocytes (PIE, BIE) cell lines (see photo) for evaluation of immunobiotics and immunogenics exerting anti-inflammatory responses both in PIE cell monolayer and co-culture system with porcine peyer's patch immune cells as a peyer's patch culture model (see illustration).

Targeted Application(s)/Industry

This evaluation system may also contribute to elucidate immunoregulatory mechanism of immunobiotics and immunogenics mediated by pattern recognition receptors essential to future development of not only immunobiotic feeds but also vaccines using immunobiotics to prevent specific diseases. This can benefit mankind by offering immunobiotic feeds as a safer alternative to conventional antibiotic drug therapy.

Graduate School of Agricultural Science
KITAZAWA, Haruki, Associate Professor Doctor of Agriculture

Development of Innovative Casting Technology

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In casting process, molten metal is poured into a mold and solidified for making complex shaped metallic product that is used in a variety field of industries. Major research field of my research laboratory is the innovative casting technology, that is, the research on computer simulation technology for prediction of typical casting defects (shrinkage, segregation and so on), and the semi-sold die casting process for light metals. Applications of the casting technology are based on the needs from the industries. Not only hardware technology but also software technology are fully used for the establishment of the cutting edge casting technology.

Targeted Application(s)/Industry

Followings are targeted applications of co-operative research with industries.
1.Casting CAE(Computer Aided Engineering)system (Fig.1)
2.Quick, simple and easy semi-solid metallic slurry making method (Fig. 2)
3.Macro-segregation simulation technology (Fig.3)
4.Advanced casting CAE technology based on particle method

Graduate School of Engineering
ANZAI, Koichi, Professor Doctor of Engineering

Development of Innovative Green Nanodevices Using Damage-Free Processes

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We developed an entirely new concept of "bio-template ultimate process technology" and realized fabrication of uniform, size-controllable, defect-free, high-density and regularly-distributed quantum dot array on surface of arbitrary material. The quantum dot array can be applied to high efficiency and inexpensive quantum dot solar cells, high luminescence quantum dot lasers, high-speed graphene / germanium transistors, and so on, i.e., energy-generating, energy-storing, and low-energy-consumption devices.

Targeted Application(s)/Industry

We can accept collaborative researches on nanodevices such as quantum dot solar cells or lasers, low-energy-consumption devices such as graphene transistor and germanium transistor, and fundamental technologies such as plasma/beam processes, thin film deposition, doping, and surface treatment.

Green Nanotechnology Laboratory, Innovative Energy Research Center, Institute of Fluid Science
SAMUKAWA, Seiji, Professor Doctor of Engineering

Development of Intelligent Molecules for the Regulation of Gene Expression in Cells

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The artificial control of gene expression by synthetic oligodeoxynucleotides (ODNs) has been the subject of considerable interest. In particular, ODNs conjugated with a cross-linking agent have been expected to enhance the inhibitory effect. Recently, microRNAs (miRNA) endogenously expressed small regulatory non-coding RNAs, are recognized as playing a critical role in regulating gene expression and the great concerns have been raised about efficient antisense oligonucleotides against miRNAs. We have already demonstrated that ODNs bearing a 2-amino-6-vinylpurine (2-AVP) derivative exhibited efficient interstrand cross-linking to cytosine selectively. The unique structural features of AVP are to possess both the hydrogen bond donor-acceptor sites as recognition sites and the vinyl group as a reactive moiety in a single molecule. Recently, we have developed of the novel cross-linking agents, which are designed based on the unique structure of AVP. These derivatives can react to thymine at the complementary site with highly selective and efficient under neutral conditions. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Targeted Application(s)/Industry

Institute of Multidisciplinary Research for Advanced Materials
NAGATSUGI, Fumi, Professor PHD

Development of Interconnect Materials and Processes for High Performance and High Reliability Electric Devices

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Electronic products can be operated not only by semiconductors but also by metal interconnections attached to the semiconductors. Required properties for the metal interconnections are ohmic contact, diffusion barrier property, adhesion with semiconductors, and low resistivity, corrosion resistance, process reliability. Our group has committed ourselves to develop new metals and processes to meet the needs of wide-ranged device producers with consideration of cost performance. Topics of our research include (1) Cu alloys to self-form a diffusion barrier layer in multilayer interconnection of Si devices, (2) Cu alloys to form a reaction-doping layer in IGZO oxide semiconductors, (3) Nb alloys to achieve mechanical and thermal reliability with good ohmic property for SiC power devices, (4) Cu alloys for transparent conductive oxide such as ITO, (5) screen-printable Cu paste lines for solar cells, etc..

Targeted Application(s)/Industry

Our research efforts are targeted at metallization and interconnections for advanced LSI, flat panel displays, touch panels, power modules, solar cells, and other electronic devices. Collaborators include material producers, equipment vendors, and device producers in the entire value chain of electronic products.

Department of Materials Science, Graduate School of Engineering
KOIKE, Junichi, Professor PhD

Development of Miniature and Highly-Functional Photonic Devices Using Ultrafine Microstructures

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In our laboratory, miniature and highly-functional photonic devices based on new optical phenomena caused by the interaction of ultrafine microstructures with light have been studied. In addition, development of new production technology to overcome the problems that have been obvious from the practical application viewpoint of nanophotonic devices has been performed.

  • -Main research topics--
MEMS tunable metamaterials for optical control.
Structural color filters using subwavelength gratings for the applications of display and spectroscopic analyzers.
Surface-smoothing technology using surface self-diffusion.
Study of low loss silicon nanophotonic devices.

Targeted Application(s)/Industry

We aim to realize optical filters, optical resonators, and color filters, by using above technologies. Also, development of nano-photonic elements fabricated by a nanoimprint technology has been progressed.
We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Graduate School of Engineering
KANAMORI, Yoshiaki, Professor Doctor of Engineering