"D" Theme - 73 Result(s)
D
Development of next-generation sterilization method by a plasma flow at atmospheric pressureFeaturesPlasma sterilization has been developed as an alternative sterilization method due to its chemical activity, operation at low temperature and atmospheric pressure, low power consumption, low cost and safety. We have studied a mechanism of chemical species generation and transport in a plasma flow and, the sterilization efficacy and mechanism for several plasma sources at atmospheric pressure, such as a microwave plasma flow, a dielectric barrier discharge in a tube and a water vapor plasma flow. We already clarified that the damages of outer membrane and destructions of the cytoplasmic membrane of Escherichia coli by exposure to the microwave plasma flow. Fig. 1 shows the effect of plasma exposure on the E. coli. When the E. coli was exposed to the plasma, the height of the E. coli decreased and the potassium leakage of cytoplasmic material increased. For sterilization in a tube, we also clarified that an induced flow in the narrow tube by DBD transports chemical species and sterilize the whole inside surface of a tube as shown in Fig. 2. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry. |
Development of Novel Bone Substitute Biomaterials Showing Highly Osteoconductive PropertyFeaturesNovel bone substitute biomaterials should have a property not only to support cellular attachment on the material surfaces but also activate cellular function of osteoblasts that promote regeneration of bone tissue. Our laboratory successfully developed such materials composed of octacalcium phosphate (OCP) (Suzuki O et al. Dent Mater J 39:187, 2020. doi: 10.4012/dmj.2020-001), obtained by a restricted synthesis condition originally developed, with specific crystal characteristics, and various natural polymers, such as gelatin, collagen, alginate and hyaluronic acid. The materials consist from OCP and these polymers are capable of enhancing new bone formation concomitant with their own biodegradations. The concept to develop such materials is that (1) design of reaction of calcium phosphate ceramics and the synthesis; (2) design of material strength to meet the mechanical stress from living body; (3) selection of natural and synthetic polymer materials for the calcium phosphate ceramics. Targeted Application(s)/IndustryWe are prepared to provide academic consultations to companies interested in our research. Division of Craniofacial Function Engineering, Graduate School of Dentistry
SUZUKI Osamu, Professor
Doctor in Medical Sciencese
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Development of Novel Scintillator and Piezoelectric CrystalsFeaturesOur research target is mainly focused on the topic of development of novel scintillator crystals, piezoelectric crystals, growth technology, characterization and its device application. Targeted Application(s)/IndustryFor the purpose of "real" contribution to human culture, we are always carrying out our research activity considering the industrial application. This point is unique feature of our attitude toward science. Research Laboratory on Advanced Crystal Engineering, Institute for Materials Research
YOSHIKAWA Akira, Professor
Doctor of Science
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Development of Open Nanoporous Base and Half Metals, Metalloids and their AlloysFeaturesNanoporous metals have drawn considerable attention due to their highly functional properties. They are generally produced by selective dissolution of elements from a multicomponent alloy (known as the dealloying method). As this method is based on differences in the electrode potential of each element present in the alloy, and this potential is high for noble metals, porous structure can be obtained only for noble metals. Recently we have found a new, simple and easy dealloying method without using aqueous solution, which enable us to develop an open nanoporous non-oxidized metallic material even with base metals (such as Ti, Ni, Cr, Fe, Mo, etc), metalloids and their alloys. Targeted Application(s)/IndustryThis technique is very powerful for developing new functional electrodes, catalysts, filters as well for removing toxic metallic element from the surface of biomaterials containing the toxic element. |
Development of Optical Sysytems for Noninvasive Treatment and DiagnosisFeaturesOptical fiber-based endoscopic systems for non-invasive treatment and diagnosis are developed. The fiber transmits high-powered laser light for treatment and low-powered light for diagnosis. We develop treatment and diagnosis systems utilizing not only common glass-based optical fibers but hollow-optical fibers. Hollow optical fibers deliver high-powered infrared lasers and light with wide range of wavelength from ultraviolet and far infrared. Targeted Application(s)/IndustryOur potential collaborators will be medical device manufactures, as well as any electronic device, communication device, and measurement instrument manufactures considering new entry to the field. |
Development of Passive Millimeter-wave Imaging Device for Practical ApplicationsFeaturesMillimeter wave (MM-wave) which is one of the electromagnetic wave transparent the clothes, the fire and the wall etc. and all natural materials including objects in clothes always radiate the electromagnetic wave as the thermal noise. Using these characteristics of MM-wave, imaging of concealed objects in clothes can be accomplished in a noninvasive and noncontact manner. This technique is called Passive Millimeter Wave (PMMW) Imaging technique and we have developed a PMMW imaging device for security applications. Graduate school of Engineering
SATO Hiroyasu, Assistant Professor
Doctor of Engineering
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Development of PHD-Targeted Drug for Ischemic InjuryFeaturesAll the living organisms generate energy from molecular oxygen to maintain their own lives. Once the concentration of oxygen falls down, life activity gets severely hampered and it could sometimes cause death. Typical examples that are related to local hypoxia are ischemic heart disease, stroke and kidney disease. Targeted Application(s)/IndustryCurrently, we have several compounds that inhibit the PHD. We want to commercialize in conjunction with pharmaceutical companies in Japan and overseas, advancing our non-clinical studies for clinical development. Division of Molecular Medicine and Therapy, United Centers for Advanced Research and Translational Medicine (ART), Graduate School of Medicine
MIYATA Toshio, Professor
M.D., PhD
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Development of Potential Thermoelectric MaterialsFeaturesWe have been exploring novel thermoelectric materials. Functions of a solid substance primarily depend on the electronic structure, directly derived from its crystal structure. Through high-quality structure analyses using neutron and X-ray diffraction, combined with first-principles calculations, we have been fabricating materials with desired functions. To date, more than 40 novel materials have been discovered based on our guiding principles. Targeted Application(s)/IndustryFor developing future device technologies, challenges on thin-film thermionic multilayers and organic thermoelectric materials are currently underway. |
Development of preventive medicine for aortic aneurysm and dissection of Marfan syndromeFeaturesMarfan’s syndrome (MF) is a severe, systemic disorder of connective tissue formation. A variety of MFS therapies have been developed, including surgical therapy for aortic root aneurysm and dissection (AAD) that are life-threatening, traditional medical therapies such as β-adrenergic receptor or angiotensin II receptor blockers for slow aortic growth and to decrease the risk of AAD. However these treatments did not prevent tissue destruction in the AAD of MF. To develop preventive strategy for AAD, it will be necessary to identify molecular mechanisms of microfibril formation and an appropriate fibrillin-1 microfibril associated molecule. Recently, ADAMTSL6β, which is a microfibril-associated extracellular matrix protein contributes the regeneration of microfibril by promoting fibrillin-microfibril assembly. We try to develop ADAMTSL6β as a preventive medicine for AAD of MF by regeneration of fibrillin-1 microfibril assembly. Targeted Application(s)/IndustryGraduate School of Dentistry, Division of Operative Dentistry, Department of Restorative Dentistry
SAITOU Masahiro, Professor
Doctor of Dentistry
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Development of Production System of Valuable Proteins Using a Koji-Mold, Aspergillus Oryzae, as a HostFeaturesBecause a koji-mold, Aspergillus oryzae, has an ability to secret a higher amount of proteins and is regarded as a safe microorganism, it has been expected as a promising host for production of useful proteins derived from plants and animals. However, Aspergillus oryzae produces various proteolytic enzymes that could degrade heterologous proteins produced, and hence we constructed mutant strains in which a transcription factor gene involved in proteolytic enzyme production was disrupted. In addition, codon optimization of heterologous gene resulted in a significant increase in the stability of heterologous gene transcripts. These attempts would lead to an increase in the amount of valuable proteins produced. Targeted Application(s)/IndustryThe technology could be applied to the high-level production of pharmaceutical proteins and industrially useful enzymes. We look forward to developing the collaborative project with enzyme and pharmaceutical industries. |
Development of Recombinant Inbred Mice with a Genetic Predisposition to Collagen DiseaseFeaturesEleven strains of recombinant inbred (RI) mice derived from MRL/lpr and C3H/lpr mice were established. This RI is the only one in the world that randomly develops lesions such as nephritis, arthritis, sialadenitis, vasculitis, and production of autoantibodies in each strain. The genomes of the two strains of mice are randomly held in homozygous condition, and the phenotypes of each strain and the effects of administered drugs could be compared based on their genotype maps. It is possible to identify the regions of gene loci involved in the phenotype and drug sensitivity. Targeted Application(s)/IndustryDevelopment of diagnostic and therapeutic agents for autoimmune diseases. It can be applied to the elucidation of the mechanism of onset of immunological adverse events caused by immune checkpoint inhibitors and the development of drugs to prevent the onset of such events, and industry-academia collaboration with pharmaceutical companies, test reagent companies, etc. is possible. Graduate School of Biomedical Engineering
KODAMA Tetsuya, Professor
PhD (Engineering), PhD (Medicine)
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Development of Recycling Technology for High-Water Content Sludge by Using Fiber MaterialsFeaturesThe recycling rate of construction muds and sludge is very low because the water content of these muds is very high and direct reuse of them is very difficult. Therefore, a new recycling technology for high-water content sludge has been developed in this laboratory. This technology is called "Fiber-Cement-Stabilized Soil Method", and it uses fiber materials and cement. The main feature of this method is to mix the fiber materials with the sludge, and the fiber materials included in the soil produce several geotechnical merits. Targeted Application(s)/IndustryThe modified soils produced by this method can be used as ground materials for reinforced embankment of the river bank and soil structures because they have several features such as high failure strength, high failure strain high durability for drying and wetting and high dynamic strength. Graduate School of Environmental Studies
TAKAHASHI Hiroshi, Professor
Doctor of Engineering
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Development of Renewable Energy Systems for Sustainable Development SocietyFeaturesDevelopment of renewable energy systems as well as research on high efficient energy conversion systems is a key technology to solve the global-scale environmental destruction and energy problems. We are working on the research on the advanced technology of renewable energy such as solar energy and hydrogen. Topics of research are two of the following roughly separately.
(1) Development of highly effective thermal energy systems and energy saving systems by using spectral control of thermal radiation.
(2) Aiming at the achievement of the hydrogen energy society, we develop new energy conversion devices based on solid state ionics, and perform feasible studies for solid oxide fuel cells (SOFCs) based on mechanics of materials. Targeted Application(s)/IndustryHigh temperature solar absorption materials
High effieciency solar-termophotovoltaic (STPV) system
Small power source for mobile electric devices based on micro-SOFC
New energy harvesting devices in harsh environment Department of Mechanical Systems and Design, Graduate School of Engineering
YUGAMI Hiroo, Professor
Doctor of Engineering
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Development of rocking isolation bearing system (RIBS) and fundamental study of application to bridgesFeaturesAs an idea motivated by the damage mode of the conventional pin bearing that actually occurred, we propose "a new seismic isolation bearing system". In order to clarify the reasonable implementation methodology and structural details that can drastically improve the seismic performance of bridge structures, a fundamental study will be conducted on the dynamic characteristics of bridges featuring such a RIBS by using an idealized mathematical model. Targeted Application(s)/IndustryWe aim to develop a new type of seismic isolation bearing used in bridge structures. For example, the bearing can be used to replace a damaged bearing after a strong earthquake or to build a new bridge. School of Engineering, Department of Civil and Environmental Engineering
HE Xinhao, Assistant Professor
Ph.D (Eng.)
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Development of Sensors and Measuring Systems for Ultra-Precision Manufacturing and NanomanufacturingFeaturesThe research is being focused on measurement of surface forms of precision workpieces and stage motions of precision machines, which are important items for ultra-precision manufacturing and nanomanufacturing. Optical sensors are being developed for measurement of angle and displacement, which are fundamental quantities for manufacturing. Technologies for improvement of the sensor sensitivity and bandwidth, reduction of the sensor size as well as new multi-axis sensing methods are being The research is being focused on measurement of surface forms of precision workpieces and stage motions of precision machines. Optical sensors are being developed for measurement of angle and displacement. A number of scanning-type measuring systems for precision measurement of surface forms and stage motions are also being developed. Error separation algorithms and systems for straightness and roundness, which are the most fundamental geometries treated in ultra-precision manufacturing, are being investigated. Novel systems based on scanning probe microscopy are under development for micro- and nano-structures as well as freeform optics in responding to new and important challenges from ultra-precision manufacturing and nanomanufacturing. Targeted Application(s)/IndustryThe multi-axis optical displacement and angle sensors developed in the laboratory are expected to measure motions of semiconductor/IC manufacturing and inspection equipment, precision machine tools, ultra-precision measuring instrument. The surface profile measurement systems are expected t play an important role in ultra-precision manufacturing and nanomanufacturing industries. |
Development of Soft Magnetic Materials and Magnet Consisting of Complete Rare-Earth Free Elements Both with Ultimately-High-Efficient Types Contributing to Energy- and Resource-Saving by Precise Controlling their NanostructuresFeaturesFeatures and Originalities Targeted Application(s)/Industry |
Development of Solid-State-Ionics Materials for Energy Conversion, Storage and UtilizationFeaturesOur focus is on the development of solid-state-ionics materials to be used for a variety of energy conversion systems. To further improve the performance of fuel cells and lithium batteries, novel ionic conductors and mixed conductors with high ionic conductivity and chemical stability are highly demanded. We have been developing such the materials based on defect chemistry and thermodynamics of ceramics, and trying to apply those materials to actual energy conversion devices. Targeted Application(s)/IndustryTo date, a hydrogen production system utilizing oxygen permeable membranes and an all-solid-state battery have been prepared. Department of Materials Science, Graduate School of Engineering
TAKAMURA Hitoshi, Professor
Doctor of Engineering
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Development of Sustainable Integrated Multiphase Energy SystemFeaturesOur laboratory is focusing in the development of innovative multiphase fluid dynamic methods based on the multiscale integration of massively parallel supercomputing and advanced measurements, and research related to creation of environmentally conscious energy systems. Furthermore, we promote basic research for the creation of risk management science and associated new multiphase flow system directly linked to sustainable energy represented by a high-density hydrogen storage technology. Targeted Application(s)/IndustryP2P Hydrogen supply chain, Elastohydrodynamic lubrication, Supercomputing of Laser melting and sputter particle formation, High pressure diecast computing / Automotive industry, Additive manufacturing |
Development of Terahertz Semiconductor Devices Using Novel Nano-Heterostructures and Materials and their ICT ApplicationsFeaturesTerahertz coherent electromagnetic waves are expected to explore the potential application fields of future information and communications technologies. We are developing novel, ultra-broadband integrated signal-processing devices/systems operating in the terahertz frequency regime employing novel semiconductor nano-heterostructures and materials. Frequency-tunable plasmon-resonant terahertz emitter and detectors and metamaterial circuits. By using an original dual-grating-gate high-electron mobility transistor (DGG-HEMT) structure with InP-based material systems record-breaking ultrahigh-sensitive detection and coherent monochromatic emission of terahertz radiation have been realized at room temperature. These devices work for terahertz imaging and spectroscopy. Targeted Application(s)/IndustryBy making full use of these world-leading device/circuit technologies, we are exploring future ultra-broadband 6G- and 7G-class wireless communication systems as well as spectroscopic/imaging systems for safety and security. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry. Research Institute of Electrical Communication
OTSUJI Taiichi, Professor
Doctor of Engineering
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Development of the cyclotron accelerator and its applicationFeaturesWe develop technology of the cyclotron accelerator and its application as follows. 1)Ion source (particularly heavy ion source), 2)design of ion optics, 3)device control system for the cyclotron, 4)RF system, 5)detectors for charged particles, gamma ray, and neutron, 6) radiation test by ion and neutron beam. Targeted Application(s)/IndustryWe have beam lines dedicated to the neutron irradiation and the ion irradiation, respectively. We can provide fast neutron beam (20-70 MeV), and various ion beam such as p, alpha, and heavy ions up to Xe. We also develop a neutron imaging technique using fast neutron. |
