"D" Theme - 58 Result(s)

 D

Development of Potential Thermoelectric Materials

NEXT
PREV
特徴・独自性
  • We have been exploring novel thermoelectric materials. Functions of a solid substance primarily depend on the electronic structure, directly derived from its crystal structure. Through high-quality structure analyses using neutron and X-ray diffraction, combined with first-principles calculations, we have been fabricating materials with desired functions. To date, more than 40 novel materials have been discovered based on our guiding principles.
実用化イメージ

For developing future device technologies, challenges on thin-film thermionic multilayers and organic thermoelectric materials are currently underway.

Researchers

Graduate School of Engineering

Yuzuru Miyazaki

Development of preventive medicine for aortic aneurysm and dissection of Marfan syndrome

NEXT
PREV
特徴・独自性
  • Marfan’s syndrome (MF) is a severe, systemic disorder of connective tissue formation. A variety of MFS therapies have been developed, including surgical therapy for aortic root aneurysm and dissection (AAD) that are life-threatening, traditional medical therapies such as β-adrenergic receptor or angiotensin II receptor blockers for slow aortic growth and to decrease the risk of AAD. However these treatments did not prevent tissue destruction in the AAD of MF. To develop preventive strategy for AAD, it will be necessary to identify molecular mechanisms of microfibril formation and an appropriate fibrillin-1 microfibril associated molecule. Recently, ADAMTSL6β, which is a microfibril-associated extracellular matrix protein contributes the regeneration of microfibril by promoting fibrillin-microfibril assembly. We try to develop ADAMTSL6β as a preventive medicine for AAD of MF by regeneration of fibrillin-1 microfibril assembly.
実用化イメージ

Researchers

Graduate School of Dentistry

Masahiro Saito

Development of Recombinant Inbred Mice with a Genetic Predisposition to Collagen Disease

NEXT
PREV
特徴・独自性
  • Eleven strains of recombinant inbred (RI) mice derived from MRL/lpr and C3H/lpr mice were established. This RI is the only one in the world that randomly develops lesions such as nephritis, arthritis, sialadenitis, vasculitis, and production of autoantibodies in each strain. The genomes of the two strains of mice are randomly held in homozygous condition, and the phenotypes of each strain and the effects of administered drugs could be compared based on their genotype maps. It is possible to identify the regions of gene loci involved in the phenotype and drug sensitivity.
実用化イメージ

Development of diagnostic and therapeutic agents for autoimmune diseases. It can be applied to the elucidation of the mechanism of onset of immunological adverse events caused by immune checkpoint inhibitors and the development of drugs to prevent the onset of such events, and industry-academia collaboration with pharmaceutical companies, test reagent companies, etc. is possible.

Researchers

Graduate School of Biomedical Engineering

Tetsuya Kodama

Development of Recycling Technology for High-Water Content Sludge by Using Fiber Materials

NEXT
PREV
特徴・独自性
  • The recycling rate of construction muds and sludge is very low because the water content of these muds is very high and direct reuse of them is very difficult. Therefore, a new recycling technology for high-water content sludge has been developed in this laboratory. This technology is called "Fiber-Cement-Stabilized Soil Method", and it uses fiber materials and cement. The main feature of this method is to mix the fiber materials with the sludge, and the fiber materials included in the soil produce several geotechnical merits.
実用化イメージ

The modified soils produced by this method can be used as ground materials for reinforced embankment of the river bank and soil structures because they have several features such as high failure strength, high failure strain high durability for drying and wetting and high dynamic strength.

Researchers

Graduate School of Environmental Studies

Hiroshi Takahashi

Development of Sensors and Measuring Systems for Ultra-Precision Manufacturing and Nanomanufacturing

NEXT
PREV
特徴・独自性
  • The research is being focused on measurement of surface forms of precision workpieces and stage motions of precision machines, which are important items for ultra-precision manufacturing and nanomanufacturing. Optical sensors are being developed for measurement of angle and displacement, which are fundamental quantities for manufacturing. Technologies for improvement of the sensor sensitivity and bandwidth, reduction of the sensor size as well as new multi-axis sensing methods are being The research is being focused on measurement of surface forms of precision workpieces and stage motions of precision machines. Optical sensors are being developed for measurement of angle and displacement. A number of scanning-type measuring systems for precision measurement of surface forms and stage motions are also being developed. Error separation algorithms and systems for straightness and roundness, which are the most fundamental geometries treated in ultra-precision manufacturing, are being investigated. Novel systems based on scanning probe microscopy are under development for micro- and nano-structures as well as freeform optics in responding to new and important challenges from ultra-precision manufacturing and nanomanufacturing.
実用化イメージ

The multi-axis optical displacement and angle sensors developed in the laboratory are expected to measure motions of semiconductor/IC manufacturing and inspection equipment, precision machine tools, ultra-precision measuring instrument. The surface profile measurement systems are expected t play an important role in ultra-precision manufacturing and nanomanufacturing industries.

Researchers

Graduate School of Engineering

I Ko

newDevelopment of single-channel multi-gas sensing materials based on response behavior

NEXT
PREV
概要

This technology is related to the development of a “response-behavior selective” type gas sensor that can discriminate multiple gases in a single sensor channel. The VO₂(M1) phase shows different response behavior (upward/downward) to gases such as ammonia (NH₃) and hydrogen sulfide (H₂S), enabling highly accurate identification even in gas mixtures. It can be operated at room temperature and is expected to be applied in the healthcare field.

従来技術との比較

Conventional semiconductor gas sensors rely on “response-intensity selectivity,” making it difficult to distinguish between gases with similar properties. In addition, detection of multiple gases requires a multi-channel configuration, which poses challenges to device miniaturization and low power consumption. This technology enables multi-gas discrimination with a single channel, achieving high selectivity while minimizing interference.

特徴・独自性
  • We propose a new sensing concept called “response behavior-selectivity,” in which identification is based on the directionality of the gas response (forward/reverse). Theoretical calculations predict the response behavior, which can be controlled by doping elements, which is unique to this technology. Furthermore, flexible sensor chips can be fabricated, making them suitable for wearable devices.
実用化イメージ

Potential applications include smart diapers that identify defecation and urination, health monitoring by exhalation, and VOC detection. In the future, we will promote development toward practical applications while further downsizing the device and improving the efficiency of signal transmission by linking it with MEMS technology and IoT.

Researchers

Institute of Multidisciplinary Research for Advanced Materials

Yin Shu

Development of Solid-State-Ionics Materials for Energy Conversion, Storage and Utilization

NEXT
PREV
特徴・独自性
  • Our focus is on the development of solid-state-ionics materials to be used for a variety of energy conversion systems. To further improve the performance of fuel cells and lithium batteries, novel ionic conductors and mixed conductors with high ionic conductivity and chemical stability are highly demanded. We have been developing such the materials based on defect chemistry and thermodynamics of ceramics, and trying to apply those materials to actual energy conversion devices.
実用化イメージ

To date, a hydrogen production system utilizing oxygen permeable membranes and an all-solid-state battery have been prepared.

Researchers

Graduate School of Engineering

Hitoshi Takamura

Development of Sustainable Integrated Multiphase Energy System

NEXT
PREV
特徴・独自性
  • Our laboratory is focusing in the development of innovative multiphase fluid dynamic methods based on the multiscale integration of massively parallel supercomputing and advanced measurements, and research related to creation of environmentally conscious energy systems. Furthermore, we promote basic research for the creation of risk management science and associated new multiphase flow system directly linked to sustainable energy represented by a high-density hydrogen storage technology.
実用化イメージ

P2P Hydrogen supply chain, Elastohydrodynamic lubrication, Supercomputing of Laser melting and sputter particle formation, High pressure diecast computing / Automotive industry, Additive manufacturing

Researchers

Institute of Fluid Science

Jun Ishimoto

Development of Terahertz Semiconductor Devices Using Novel Nano-Heterostructures and Materials and their ICT Applications

NEXT
PREV
特徴・独自性
  • Terahertz coherent electromagnetic waves are expected to explore the potential application fields of future information and communications technologies. We are developing novel, ultra-broadband integrated signal-processing devices/systems operating in the terahertz frequency regime employing novel semiconductor nano-heterostructures and materials. We are challenging to develop room-temperature operating coherent and intense laser transistors and fast-response and highly sensitive detectors working for the next-generation beyond-5G terahertz wireless communications as well as safety and security terahertz imaging applications.
  • A. Ultimately-fast terahertz transistors utilizing graphene, carbon-based new material, and compound semiconductor heterojunction material systems:
  • Graphene-based novel terahertz photonics devices, breaking through the limit on conventional technology. Recently we have succeeded in single-mode terahertz lasing in a dual-gate graphene-channel laser transistor device at 100K. Moreover, we have succeeded in room-temperature terahertz coherent amplification in a dual-grating-gate graphene channel transistor promoted by current-driven graphene Dirac plasmon instability. The obtained maximal gain of 9% is four times as high as the quantum efficiency limit when terahertz photons interact directly with graphene electrons without excitation of graphene plasmons. These will be big steps towards realization of an intense, room-temperature operating graphene plasmonic terahertz laser transistors.
  • B. Frequency-tunable plasmon-resonant terahertz emitter and detectors and metamaterial circuits:
  • By using an original dual-grating-gate high-electron mobility transistor (DGG-HEMT) structure with InP-based material systems record-breaking ultrahigh-sensitive detection of terahertz radiation have been realized at room temperature.
実用化イメージ

By making full use of these world-leading device/circuit technologies, we are exploring future ultra-broadband 6G- and 7G-class wireless communication systems as well as spectroscopic/imaging systems for safety and security. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Researchers

Research Institute of Electrical Communication

Taiichi Otsuji

Development of the cyclotron accelerator and its application

NEXT
PREV
特徴・独自性
  • We develop technology of the cyclotron accelerator and its application as follows. 1)Ion source (particularly heavy ion source), 2)design of ion optics, 3)device control system for the cyclotron, 4)RF system, 5)detectors for charged particles, gamma ray, and neutron, 6) radiation test by ion and neutron beam.
実用化イメージ

We have beam lines dedicated to the neutron irradiation and the ion irradiation, respectively. We can provide fast neutron beam (20-70 MeV), and various ion beam such as p, alpha, and heavy ions up to Xe. We also develop a neutron imaging technique using fast neutron.

Researchers

Research Center for Accelerator and Radioisotope Science

Masatoshi Itoh

Development of the high-quality and low-power display system for ultra-realistic communications

NEXT
PREV
特徴・独自性
  • Recently, with a spread of high definition video streaming services and ubiquitous network, development of high-quality, ultra-realistic and low-power display systems has been demanded. We have been studying physical properties of liquid crystal materials, precise control technique of polarization, high performance liquid crystal display (LCD) devices and its application to the advanced display systems for the realization of new media such as electric paper display and digital signage display, and low-energy society. We established a polarization control technology which realizes a precise control of polarization with liquid crystal materials. By using this world-leading technology, we have been studying the control of the surface alignment of liquid crystal molecules and developed a wide-viewing angle and fast switching liquid crystal display, ultra-high definition field-sequential-color display (Fig. 1), ultra-low power reflective full-color display (Fig. 2) and large-size high-quality display system.
  • We are also studying the ultra-realistic display systems such as a spatial 3D display and a multiple directional viewing display based on the precise light control technique as a next generation interactive communication technologies (Fig.3). We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.
実用化イメージ

Researchers

Graduate School of Engineering

Takahiro Ishinabe

Development of the method of Baby Borehole Hydraulic Fracturing, BABHY

特徴・独自性
  • For the effective measurement of the reopening pressure in hydraulic fracturing, it is necessary to use the testing equipment with sufficiently small compliance. This limitation makes it difficult to apply the hydraulic fracturing for the measurement of the maximum stress, because the compliance of conventional equipments is generally so large. Taking account of this situation, we proposed a new concept which allows us to do the in-situ tests of hydraulic fracturing for stress measurement at so deep depths as more than 1 km. We call the concept the Baby Borehole Hydrofracturing, BABHY for short. In order to put the new concept into practice, we developed the BABHY sonde and finally we succeeded to carry out hydraulic fracturing test by using the tools in a vertical borehole of 811 m depth. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.
実用化イメージ

Researchers

Institute of Fluid Science

Takatoshi Ito

Development of the next generation anti-HIV agents

NEXT
PREV
特徴・独自性
  • HIV infection is one of most serious concern in infectious diseases. We will perform anti-HIV assays for unmet medical needs in control of HIV infections with established novel assays. We have developed reverse transcriptase inhibitor that has novel mechanism of inhibition, translocation-inhibition (J Biol Chem, 2009). Dr Kodama participated in the primary screening and development of a new HIV integrase inhibitor, elvitegravir (J Virol 2009), and a unique reverse transcriptase inhibitor, islatravir, which phase III clinical trials by the Merck & Co., Inc. will complete, soon. We have a representative resistant HIV strain-library for anti-HIV screening and several target oriented high through-put screening systems.
実用化イメージ

We can establish high through-put screening for new targets, so please consult with us individually. We are open to joint development requiring BSL3/P3 experimental facilities and academic guidance including other microorganisms.

Researchers

International Research Institute of Disaster Science

Eiichi Kodama

Development of Wearable Motion Measurement System for Motor Rehabilitation and Healthcare

NEXT
PREV
特徴・独自性
  • In order to realize wealthy and vibrant local communities, it is desired that people in the community are healthy. However, the amount of the daily activity decreases as they get older, which increases the risks of the fall by weakened lower limb muscles and of the cerebrovascular disease, and so on. Therefore, for the elderly people, there is increased need of the walking training and the movement assistance in daily life, and of the rehabilitation aid.
  • In this study, focusing on the motor function of the lower limbs that is important for independent activities of daily living and that relates to the health maintenance, development of assistive technologies for decreased gait ability or for dysfunction of lower limbs are performed based on the technologies of electronics and signal processing. Especially, the wearable sensor system using gyroscopes and accelerometers are developed to measure kinetic information, and then the evaluation system for the gait ability and the lower limbs motor function is developed in this study.
実用化イメージ

The goal of this study is to realize simple and convenient measurement and accumulation of various information of gait, to visualize the obtained data for determination of training effect and evaluation of motor function, and to provide appropriate training program for each subject.

Researchers

Graduate School of Biomedical Engineering

Takashi Watanabe

DIFFERENTIATION INDUCING METHOD ENABLING TUMORIGENESIS OF IPS CELLS TO BE SUPPRESSED

特徴・独自性
  • The present invention relates to a technique for differentiating iPS cells into target differentiated cells while suppressing tumorigenesis in the iPS cells. In use of a statin and a differentiation inducer, iPS cells are differentiated into target differentiated cells, whereby iPS cells can be differentiated into differentiated cells in which tumorigenesis is suppressed.
実用化イメージ

Researchers

Graduate School of Dentistry

Hiroshi Egusa

Discovery of diagnostic markers by metabolomics

NEXT
PREV
特徴・独自性
  • Losing cholesterol homeostasis with inborn errors of metabolisms or hepatobiliary diseases makes a change to in vivo cholesterol metabolism profile and causes the emergence of increased metabolites as conjugates in blood and urine. We have developed an LC/ESI-MS/MS method using fragment patterns characteristic of conjugation types for group-specific and comprehensive analysis of conjugated cholesterol metabolites. This method can contribute for an efficient discovery of diagnostic marker candidates toward various diseases.
実用化イメージ

After availability verification of candidates as diagnostic markers, it will be required screening tests. We have potential to collaborate with company for development of bioassay systems using antibodies or enzymes.

Researchers

Tohoku University Hospital

Nariyasu Mano

Dry-Contact Ultrasonic Technique

NEXT
PREV
特徴・独自性
  • A new dry-contact technique for transduction of broadband, high-frequency ultrasound via a solid layer inserted between water and the sample, whereat the pressure of about 0.1 MPa is applied at the layer/sample interface by evacuating air between them, has been developed. Based on the technique, acoustic imaging of an electronic package is realized under the dry environment (Fig. 1). Typically, the polymer films are used as the intermediate layer for water protection of the sample, and by utilizing the acoustic resonance phenomenon among water, film and the sample, higher quality acoustic image of the testing sample than that for the water immersion case can be recorded without getting the sample wet (Fig. 2). Moreover, thin materials, e.g., polymer film (Fig. 3), etc. can be characterized by analyzing the acoustic resonance phenomenon among the three media. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.
実用化イメージ

Researchers

Graduate School of Engineering

Hironori Tohmyoh