Tohoku University. Research Profiles

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"D" Theme - 73 Result(s)

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Development of the e-voting system

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A purpose of this study is to make the environment where many Japaneses are easy to vote for, using ICT. In Japan, it is difficult to introduce the e-election system. This is because there is legitimate limitation. So we turn to case study to discover means to overcome the problem.

Targeted Application(s)/Industry

Graduate School of Infomation Sciences
KAWAMURA Kazunori, Associate Professor Master of Law

Development of the high-quality and low-power display system for ultra-realistic communications

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Recently, with a spread of high definition video streaming services and ubiquitous network, development of high-quality, ultra-realistic and low-power display systems has been demanded. We have been studying physical properties of liquid crystal materials, precise control technique of polarization, high performance liquid crystal display (LCD) devices and its application to the advanced display systems for the realization of new media such as electric paper display and digital signage display, and low-energy society. We established a polarization control technology which realizes a precise control of polarization with liquid crystal materials. By using this world-leading technology, we have been studying the control of the surface alignment of liquid crystal molecules and developed a wide-viewing angle and fast switching liquid crystal display, ultra-high definition field-sequential-color display (Fig. 1), ultra-low power reflective full-color display (Fig. 2) and large-size high-quality display system.
We are also studying the ultra-realistic display systems such as a spatial 3D display and a multiple directional viewing display based on the precise light control technique as a next generation interactive communication technologies (Fig.3). We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Graduate School of Engineering
ISHINABE Takahiro, Associate Professor Doctor of Engineering

Development of the method of Baby Borehole Hydraulic Fracturing, BABHY

Features

For the effective measurement of the reopening pressure in hydraulic fracturing, it is necessary to use the testing equipment with sufficiently small compliance. This limitation makes it difficult to apply the hydraulic fracturing for the measurement of the maximum stress, because the compliance of conventional equipments is generally so large. Taking account of this situation, we proposed a new concept which allows us to do the in-situ tests of hydraulic fracturing for stress measurement at so deep depths as more than 1 km. We call the concept the Baby Borehole Hydrofracturing, BABHY for short. In order to put the new concept into practice, we developed the BABHY sonde and finally we succeeded to carry out hydraulic fracturing test by using the tools in a vertical borehole of 811 m depth. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Large-Scale Environmental Fluid Dynamics Laboratory, Complex Flow Division, Institute of Fluid Science
ITO Takatoshi, Professor Doctor of Engineering

Development of the next generation anti-HIV agents

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HIV infection is one of most serious concern in infectious diseases. We will perform anti-HIV assays for unmet medical needs in control of HIV infections with established novel assays. We have developed reverse transcriptase inhibitor that has novel mechanism of inhibition, translocation-inhibition (J Biol Chem, 2009). Dr Kodama participated in the primary screening and development of a new HIV integrase inhibitor, elvitegravir (J Virol 2009), and a unique reverse transcriptase inhibitor, islatravir, which phase III clinical trials by the Merck & Co., Inc. will complete, soon. We have a representative resistant HIV strain-library for anti-HIV screening and several target oriented high through-put screening systems.

Targeted Application(s)/Industry

We can establish high through-put screening for new targets, so please consult with us individually. We are open to joint development requiring BSL3/P3 experimental facilities and academic guidance including other microorganisms.

International Research Institute of Disaster Science
KODAMA Eiichi, Professor MD, PhD

Development of the Nickel-Free Dental Magnetic Attachment Using the Magnetic Shielding Material which Lost its Magnetism by Nitrogen-Solid Solution

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In the dental magnetic attachments which retain dentures, superstructures of dental implants, and so on, the non-magnetic stainless steel containing nickel is used in order to reinforce their retentive force by a magnetic circuit. The surface layer of magnetic stainless steel which loses its magnetism by nitrogen-solid solution obtained from heating in nitrogen gas at high temperature, enable to form a magnetic circuit, which does not contain nickel at all, and to reduce its components and manufacturing processes. The method using the nitrogen-solid solution in this study is warrantable to manufacture the nickel-free dental magnetic attachment with high safety.

Targeted Application(s)/Industry

The nickel-free magnetic attachment realizes a retainer with higher safety, and can expect the application to medical and dental care for clinical uses, such as not only a denture but a dental implant, an epithese, and so on with easy desorption.

Division of Dental Biomaterials, Graduate School of Dentistry
TAKADA Yukyo, Associate Professor Doctor of Engineering

Development of Vector Beam and its Application to Nanoimaging

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Vector beams are very attractive because of their unique features such as small spot formation and strong longitudinal electric field near focus. We are developing a variety of generation methods of vector beams including Laguerre-Gaussian and Bessel-Gaussian beams and their higher order transverse modes. For instance, a smaller spot by approximately 30 % than that by a linearly polarized beam has been demonstrated and applied for nanoimaging.

Targeted Application(s)/Industry

Confocal scanning microscpy will benefit from vector beams as enhancement of spatial resolution. Otherwise, precision nano-processing will be possible. We are prepared to provide academic consultations to companies interested in our research.

Institute of Multidisciplinary Research for Advanced Materials
SATO Shunichi, Professor Doctor of Engineering

Development of Wearable Motion Measurement System for Motor Rehabilitation and Healthcare

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In order to realize wealthy and vibrant local communities, it is desired that people in the community are healthy. However, the amount of the daily activity decreases as they get older, which increases the risks of the fall by weakened lower limb muscles and of the cerebrovascular disease, and so on. Therefore, for the elderly people, there is increased need of the walking training and the movement assistance in daily life, and of the rehabilitation aid.
In this study, focusing on the motor function of the lower limbs that is important for independent activities of daily living and that relates to the health maintenance, development of assistive technologies for decreased gait ability or for dysfunction of lower limbs are performed based on the technologies of electronics and signal processing. Especially, the wearable sensor system using gyroscopes and accelerometers are developed to measure kinetic information, and then the evaluation system for the gait ability and the lower limbs motor function is developed in this study.

Targeted Application(s)/Industry

The goal of this study is to realize simple and convenient measurement and accumulation of various information of gait, to visualize the obtained data for determination of training effect and evaluation of motor function, and to provide appropriate training program for each subject.

Graduate School of Biomedical Engineering
WATANABE Takashi, Professor Doctor of Engineering

DIFFERENTIATION INDUCING METHOD ENABLING TUMORIGENESIS OF IPS CELLS TO BE SUPPRESSED

Features

The present invention relates to a technique for differentiating iPS cells into target differentiated cells while suppressing tumorigenesis in the iPS cells. In use of a statin and a differentiation inducer, iPS cells are differentiated into target differentiated cells, whereby iPS cells can be differentiated into differentiated cells in which tumorigenesis is suppressed.

Targeted Application(s)/Industry

Graduate School of Dentistry Division of Molecular and Regenerative Prosthodontics
EGUSA Hiroshi, Professor D.D.S., Ph.D.

Digitizing Democracy in Japan

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The global pandemic is forcing democracies around the world to hold non-contact elections. Internet voting is considered a viable option, but there is little chance of introducing it in Japan. Similarly, while there is an urgent need to implement online parliament to reduce the risk of infection, only a minority of parliaments are willing to do so. In this study, we will identify the factors that hinder the digitalization of democracy and pursue the possibility of social implementation in Japan.

Targeted Application(s)/Industry

This study can contribute to election commission practices and vendor voting terminal development.

GSIS
KAWAMURA Kazunori, Associate Professor PhD of Information Sciences

Discovery of diagnostic markers by metabolomics

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Losing cholesterol homeostasis with inborn errors of metabolisms or hepatobiliary diseases makes a change to in vivo cholesterol metabolism profile and causes the emergence of increased metabolites as conjugates in blood and urine. We have developed an LC/ESI-MS/MS method using fragment patterns characteristic of conjugation types for group-specific and comprehensive analysis of conjugated cholesterol metabolites. This method can contribute for an efficient discovery of diagnostic marker candidates toward various diseases.

Targeted Application(s)/Industry

After availability verification of candidates as diagnostic markers, it will be required screening tests. We have potential to collaborate with company for development of bioassay systems using antibodies or enzymes.

Tohoku University Hospital
MANO Nariyasu, Professor Doctor of Pharmaceutical Sciences

Drug Delivery System for Retinal Protection

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Intravitreal injection of some drugs to treat retinal diseases has been successfully reported. However, there is a possibility of severe side effects, such as infection. So we have developed a transscleral drug delivery system by using non-biodegradable device, which enabled sustained drug delivery to the retina. Because of the nature of the device, we can deliver the multi-drug independently. We have performed our work in collaboration with Department of Bioengineering and Robotics.

Targeted Application(s)/Industry

Using this drug delivery device, we may be able to apply our system not only to the retinal diseases but also to other diseases.
For clinical application, we hope the collaboration with companies and organizations from the points of materials and original drug delivery to the focal regions.

Division of Clinical Cell Therapy, Graduate School of Medicine
ABE Toshiaki, Professor MD

Drug Development for Fundamental Treatment of Alzheimer's Disease

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Background: Alzheimer's disease (AD) is a neurodegenerative disorder with a large unmet medical need. Recently, our pilot clinical study suggested the possibility that 1-year oral administration of decocted nobiletin-rich Citrus reticulata peel could be of benefit for improving the cognition of patients with AD, with the following pharmacological features: 1) this Kampo medicine includes a large amount of nobiletin that can rescue the memory impairment and prevents hippocampal amyloid beta accumulation in APP-Tg mice, as originally reported by us, and 2) the medicine reversed impaired learning and memory to a greater degree than nobiletin in animal, to which sinensetin, another constituent contributes in large part.
Research plan: We thus try to identify endogenous molecules that can bind selectively to nobiletin and sinensetin in hippocampal neurons, and to further synthesize novel compounds that are capable of more potently improving learning and memory impairment in animals than both natural compounds.

Targeted Application(s)/Industry

Our research goal is discovery of the drugs for fundamental treatment of AD. I hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Department of Pharmacotherapy, Graduate School of Pharmaceutical Sciences
YAMAKUNI Tohru, PhD

Dry-Contact Ultrasonic Technique

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A new dry-contact technique for transduction of broadband, high-frequency ultrasound via a solid layer inserted between water and the sample, whereat the pressure of about 0.1 MPa is applied at the layer/sample interface by evacuating air between them, has been developed. Based on the technique, acoustic imaging of an electronic package is realized under the dry environment (Fig. 1). Typically, the polymer films are used as the intermediate layer for water protection of the sample, and by utilizing the acoustic resonance phenomenon among water, film and the sample, higher quality acoustic image of the testing sample than that for the water immersion case can be recorded without getting the sample wet (Fig. 2). Moreover, thin materials, e.g., polymer film (Fig. 3), etc. can be characterized by analyzing the acoustic resonance phenomenon among the three media. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.

Graduate School of Engineering
TOHMYOH Hironori, Professor Doctor of Engineering