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Research Themes - 230 Result(s)

 D

Developmental and clinilal pragmatics in Asian languages

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概要

We conduct collaborative studies examining the lifelong development of language use, which reflects human mental states and individual differences. These studies include participants ranging from children to older adults with diverse backgrounds and conditions.

従来技術との比較

We investigate the mechanisms by which the way we use language can bring joy and anger to others, and its developmental change and individual differences. To this end, we examine subjective experiences of language use, actual language behavior, and the underlying brain activity and physiological responses, while also analyzing individual differences through neuropsychological assessments.

特徴・独自性
  • Rather than focusing on language abilities such as vocabulary knowledge and grammatical functions, we try to reveal the development and diversity of pragmatic competence, which integrates human emotional, cognitive, and sensorimotor functions. We consider this integrative approach to be a distinctive feature of our lab.
実用化イメージ

Our potential contribution lies in developing better ways to deliver services or products by evaluating the effects of the language used in messaging.

Researchers

Graduate School of Arts and Letters

Sachiko Kiyama

DIFFERENTIATION INDUCING METHOD ENABLING TUMORIGENESIS OF IPS CELLS TO BE SUPPRESSED

特徴・独自性
  • The present invention relates to a technique for differentiating iPS cells into target differentiated cells while suppressing tumorigenesis in the iPS cells. In use of a statin and a differentiation inducer, iPS cells are differentiated into target differentiated cells, whereby iPS cells can be differentiated into differentiated cells in which tumorigenesis is suppressed.
実用化イメージ

Researchers

Graduate School of Dentistry

Hiroshi Egusa

Discovery of diagnostic markers by metabolomics

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特徴・独自性
  • Losing cholesterol homeostasis with inborn errors of metabolisms or hepatobiliary diseases makes a change to in vivo cholesterol metabolism profile and causes the emergence of increased metabolites as conjugates in blood and urine. We have developed an LC/ESI-MS/MS method using fragment patterns characteristic of conjugation types for group-specific and comprehensive analysis of conjugated cholesterol metabolites. This method can contribute for an efficient discovery of diagnostic marker candidates toward various diseases.
実用化イメージ

After availability verification of candidates as diagnostic markers, it will be required screening tests. We have potential to collaborate with company for development of bioassay systems using antibodies or enzymes.

Researchers

Tohoku University Hospital

Nariyasu Mano

Dry-Contact Ultrasonic Technique

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特徴・独自性
  • A new dry-contact technique for transduction of broadband, high-frequency ultrasound via a solid layer inserted between water and the sample, whereat the pressure of about 0.1 MPa is applied at the layer/sample interface by evacuating air between them, has been developed. Based on the technique, acoustic imaging of an electronic package is realized under the dry environment (Fig. 1). Typically, the polymer films are used as the intermediate layer for water protection of the sample, and by utilizing the acoustic resonance phenomenon among water, film and the sample, higher quality acoustic image of the testing sample than that for the water immersion case can be recorded without getting the sample wet (Fig. 2). Moreover, thin materials, e.g., polymer film (Fig. 3), etc. can be characterized by analyzing the acoustic resonance phenomenon among the three media. We hope to conduct collaborative research with a willing company for a practical application of this technology in industry.
実用化イメージ

Researchers

Graduate School of Engineering

Hironori Tohmyoh

 E

Eco-Material Processing

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特徴・独自性
  • The major subject of our group is ferrous process metallurgy including thermodynamics of metals, alloys and molten slags, high temperature heterogeneous kinetics, phase equilibria of complex oxide systems and so on. We are interested in physic-chemical fundamentals of processing of metals, slags, scrap and waste. Recently our research interests are extended to multidisciplinary area so-called "Industrial Ecology" by the combination of process metallurgy, LCA (life cycle assessment) and social science such as econometrics.
実用化イメージ

Typically our research group is aggressively working in the area of material flow analysis of critical metals considering the quality of recycled materials. Currently our major research partners are steel and non-ferrous industries, while we do hope to collaborate with waste treatment company, mineral industry and an administrative organ.

Researchers

New Industry Creation Hatchery Center

Tetsuya Nagasaka

Economics of Aging

特徴・独自性
  • I investigate on the economics of aging, the optimal social welfare policy, low fertility and so on not based on the historical and systematic approach but based on the neo-classical economic theory. I also use econometric method and statistical approach. I often estimate the future projections of the population, public finance, magnitude of private markets, the results of public policies.
  • I also research on the comparative studies on East Asia (Japan, China, Korea, Taiwan) and European (especially Scandinavian countries). I provide statistic data and information on the economic and political systems on the aging in Japan.
実用化イメージ

The future estimation on the financial status , market caused by low fertility and aging. The effective management of the medical institutions, social welfare systems, gender equality societies for the central and local government, research institutions, public enterprises, and financial Institutions.

Researchers

Graduate School of Economics and Management

Hiroshi Yoshida

Electrical Spin Generation and Manipulation in Semiconductors

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特徴・独自性
  • Since spin orbit interactions caused by the structural inversion asymmetry and the bulk inversion asymmetry induce an effective magnetic field in III-Vsemiconductor heterostructures, it is possible to realize the new functional devices based on the electrical control of the spin precession. We study the electrical spin generation by using spatial modulation of spin orbit interaction, which demonstrates Stern-Gerlach spin filter in semiconductors, and research ultra-fast spin dynamics by using time resolved Kerr rotation microscopy. We also investigate a spin MOSFET based on the perpendicular magnetic materials and electric-field induced magnetization control. We can reduce the leak current and the signal delay in the logic circuit. With the non-volatility of the ferromagnetic source and drain electrodes, random access memory is also enabled by using the spin MOSFET structure.
実用化イメージ

Target application will be low power logic devices and non-volatile memory based on electron spins and also future metal-based spintronic devices.

Researchers

Graduate School of Engineering

Makoto Koda

Electronic properties of nanostructures and nanodevices

特徴・独自性
  • 1) We investigate interesting properties of nanostructures and develop materials and devices utilizing nanostructures.
  • 2) We have techniques and skills on low-noise electric measurements, cryogenics, nanofabrication, and data informatics. We are open to new collaborations.
実用化イメージ

Researchers

Advanced Institute for Materials Research

Tomohiro Otsuka

Emergence in collective electrons in organic molecular materials

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特徴・独自性
  • The main research subjects in this group are the experimental investigations of the organic molecular conductors. The characteristic properties of the organic materials are multiple flexibilities owing to the assemble structure of nanometer-size molecules. This flexbility comes up recently for developing the organic electronic devices. We explore the fundamental electronic properties of the organic molecular materials which have wide range of the ground states from superconductivity to insulating states resulting from the strongly correlated electrons in the molecular pi-orbital. Such features are closely connected to flexible and multiple degrees of freedom in charge, spin, molecular latticeand molecules themselves. We are actively studying on the interesting and important issues in the condensed matter physics from the viewpoints of the characteristic flexbility of the organic molecular materials. We are prepared to provide academic consultations to companies interested in our research.
実用化イメージ

Researchers

Institute for Materials Research

Takahiko Sasaki

Establishment of Minimally Invasive Cell Therapy for Diabetes by Introducing Interdisciplinary Approach

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特徴・独自性
  • The islet transplantation is the ideal "minimum invasive" cell transplant therapy for the severe diabetic patients who are suffering with controlling the blood glucose levels. In this project, we try to have a cross organization among the advanced technologies in islet transplantation as one of the typical cases. Our chief objective is to construct the center of medical cell-engineering therapy as successful examples in Tohoku University. We are convinced that technical innovation through this project could contribute much more to the activation of medical industry based upon cell therapy.
実用化イメージ

We have already established effective academic-industrial alliances regarding our several projects including a development of new type of cell-isolation enzyme. However, we are still looking for possible candidates concerning a special device for cell transplantation and medical grade-pathogen free animals.

Researchers

Graduate School of Medicine

Masafumi Goto

Evaluating the Effects and Social Implementation of Community Sheds

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概要

To prevent loneliness and social isolation in middle-aged and older adults, this study aims to introduce the community-based initiative “Community Shed,” which originated in Australia, into Japan and to scientifically examine its effects. As the number of older adults living alone increases and more people lose a sense of purpose in life, Community Sheds are attracting attention as places that foster social connections and promote the formation of ikigai (a sense of meaning in life). This study is grounded in the theory of the “Social Cure,” which posits that group membership enhances health and well-being.

従来技術との比較

Conventional interventions have been effective in addressing objective indicators of social isolation but have shown only limited impact in alleviating subjective feelings of loneliness, and they have insufficiently addressed the social structures that generate isolation. In Japan in particular, the isolation of older men after retirement has become a serious issue, with few opportunities available for creating new purposes in life or for seeking consultation. Community Sheds aim not merely to provide opportunities for social interaction but to focus on the quality of social connections and the construction of social identity (a sense of belonging). They are designed to offer a space for autonomous and self-directed activities through which participants can cultivate both a sense of purpose and a sense of belonging.

特徴・独自性
  • In collaboration with the Japan Community Shed Association and JST-RISTEX, pilot Community Sheds have been established in Japan, including “Yoroya” in Mizukami Village, Kumamoto Prefecture, and “Pokke Kotan” in Nishi Ward, Sapporo City, where their effectiveness is being evaluated. The results so far indicate reductions in feelings of loneliness, improvements in perceived physical health and cognitive function, and an expansion of group memberships and supportive relationships. Building on these findings, this project aims to develop a sustainable, Japan-specific system to prevent unwanted isolation and loneliness.
実用化イメージ

In collaboration with the Japan Community Shed Association and JST-RISTEX, we are promoting the establishment and evaluation of pilot Community Sheds in Japan, such as “Yoroya” in Mizukami Village, Kumamoto Prefecture, and “Pokke Kotan” in Nishi Ward, Sapporo City. These initiatives have demonstrated positive outcomes, including reductions in participants’ feelings of loneliness, improvements in perceived physical health and cognitive function, and an expansion of group memberships and supportive relationships. Building on these achievements, we aim to develop a sustainable, Japan-specific system to prevent unwanted isolation and loneliness.

Researchers

Graduate School of Education

Ayahito Ito

Exercising "Cultured" Myotubes!

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特徴・独自性
  • We succeeded in generating highly developed cultured C2C12 myotubes by manipulating intracellular Ca2+ transients with electric pulse stimulation (EPS), that are endowed with similar properties to in vivo skeletal muscle in terms of (1) excitation-induced contractile activity as a result of de novo sarcomere formation, (2) higher energy expenditure (as assessed by AMPK activation), and (3) improved insulin responsiveness (as assessed by exofacial myc-GLUT4 translocation assay).
実用化イメージ

Taking advantage of our “in vitro Exercise Model", our innovation will be an excellent alternative for the animal experimentation that can be applicable for a wide array of skeletal muscle research including drug screen.

Researchers

Graduate School of Biomedical Engineering

Makoto Kanzaki

Extraction of cellulose nanofibers (CNFs) from sea pineapples' shells and application for energy materials

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概要

The sea pineapple is the only animal that produces cellulose, and its shells, excluding the edible parts, are treated as industrial waste. By removing proteins and other components from the sea squirt shells and fibrillating them, cellulose nanofibers (CNFs) can be extracted. We have focused on the fact that CNFs derived from sea squirt shells have a higher degree of crystallinity and greater mechanical strength compared to those from wood, and we are exploring various applications of this material. Furthermore, since the material transforms into high-quality carbon upon calcination, we successfully developed "nano-blood carbon catalysts" by mixing it with dried blood powder and calcining the mixture. These catalysts are being applied in fuel cells, water electrolysis, and metal-air batteries.

従来技術との比較

CNFs derived from sea pineapple's shells have a higher degree of crystallinity compared to those from wood and provide longer fibers, resulting in high strength. When calcined, they transform into high-performance carbon.

特徴・独自性
  • We are the only research laboratory that has consistently developed a process for the simple and large-scale purification of CNFs derived from sea pineapple's shells, along with the creation of film materials that leverage their unique properties (mechanical, engineering, surface science, electrical, and thermal characteristics), as well as the development of carbonized materials.
実用化イメージ

We offer materials derived from sea pineapples' shell CNFs, as well as their carbonized products and catalysts. Please feel free to consult us regarding material supply, carbonization processes, or the utilization of catalysts.

Researchers

Advanced Institute for Materials Research

Hiroshi Yabu

 F

Fabrication of Imitative Stress Corrosion Cracking Specimens for the Development of Nondestructive Evaluation Techniques

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特徴・独自性
  • The emergence of stress corrosion cracking is one of the most important issues from the viewpoint of aging management and maintenance of nuclear power plants. There is a large discrepancy between stress corrosion cracking and other cracks such as fatigue cracks from the viewpoint of nondestructive testing and evaluations, which requires suitable specimens containing stress corrosion cracking for the development of nondestructive testing and evaluation techniques and also for personnel training. However, artificially introducing stress corrosion cracking needs large cost and long time. Furthermore, several studies have pointed out that such articial stress corrosion cracking is not always similar to natural ones. On the basis of the background above, we develop a method to fabricate "imitative" stress corrosion cracking specimens using diffusion bonding.
実用化イメージ

The method enables one to introduce a region whose response is almost identical to actual stress corrosion cracking from the viewpoint of nondestructive testing. Whereas the dimension of the region is accurately controllable, the method requires much less cost and time comparing the conventional ones using corrosive environment. Patent is already applied for.

Researchers

Graduate School of Engineering

Noritaka Yusa

Fabrication of The Novel Designed Nanodrugs Composed of Poorly Water-Soluble Compounds

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特徴・独自性
  • One of our major research focuses is to design the novel drug nanoparticles, so called “Nano-prodrugs”, and to apply them as anticancer drugs or eye drops with excellent delivery efficiency. Nano-prodrugs are constructed by synthetic prodrugs molecules which contains poorly water-soluble substituent. They could be fabricated to nanoparticles with 100 nm or less in size by our reprecipitation technique, which has been used to create organic nanomaterials. We are aiming at practical application of our Nano-prodrugs in the near future.
実用化イメージ

Our reprecipitation technique for fabricating organic nanomaterials is a versatile technique that can be applied to various organic molecules as well as drug compounds. We hope to conduct collaborative research with a willing company on controlling and evaluating properties of the organic nanoparticles.

Researchers

Institute of Multidisciplinary Research for Advanced Materials

Hitoshi Kasai

First-Principles Simulations of Laser-Induced Electron and Atomic Dynamics

概要

When light, such as a laser, is irradiated onto matter, the dynamics of atoms and electrons within the material are driven. We have been studying these driven atomic and electronic dynamics using microscopic simulations based on quantum mechanics. Furthermore, through these simulation approaches, we are also studying the microscopic physical processes underlying light-induced phenomena.

従来技術との比較

In conventional materials science calculations, first-principles simulations based on density functional theory have been widely used to study the equilibrium properties of matter. However, such equilibrium approaches are not well suited to capturing the dynamics driven by light within materials. Our research method employs time-dependent density functional theory, which can handle material dynamics, thereby going beyond equilibrium descriptions and enabling precise analysis of nonequilibrium phenomena, nonlinear effects, and ultrafast processes driven by light.

特徴・独自性
  • * First-principles calculations for optical science
  • * Real-time simulations of nonequilibrium dynamics of electrons and atoms
  • * Clarifying microscopic mechanisms behind macroscopic phenomena induced by light
実用化イメージ

We are developing theoretical and computational methods to accurately describe the nonlinear and nonequilibrium dynamics of atoms and electrons driven by light. We are also conducting research aimed at creating new science and technology based on light-driven phenomena. We hope that our research will contribute to the social implementation of new scientific and technological advances.

Researchers

Graduate School of Science

Shunsuke Sato

Food Palatability, Product Usability, and Preference; An Approach from Psychology and Neuroscience.

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特徴・独自性
  • My research interest is peoples' perception of external stimulus. Based on these researches and our knowledge, I can offer you an idea of the products that give consumers satisfaction. Also on the basis of psychological and neuro-scientifc experiences and knowledges, I can offer you a transdisciplinary approaches on human perception, cognition, emotion and decision making.
実用化イメージ

Marketing and developing of the products such as foods, beverages, fabric softeners, perfumes, body deodorants etc. The knowledges and research tools are also useful in regulating the malodor in the air pollution, in developing the public services and in elevating public quality of life.

Researchers

Graduate School of Arts and Letters

Nobuyuki Sakai

Forecasting eruption transition through geologic and petrologic approaches

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特徴・独自性
  • 1) In addition to geophysical observations, recent advances in volcanic stratigraphy and petrology would make us possible to forecast the transition of volcanic eruptions. We have been developing near-real-time volcanology based on the erupted materials in an early eruption stage.
  • 2) Automation of textural analyses of erupted materials, Risk assessment of volcanic eruption based on eruption stratigraphy
実用化イメージ

Researchers

Graduate School of Science

Michihiko Nakamura

Fuel Cell and Energy Storage Using Ion Conduction in Ceramics

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特徴・独自性
  • Solid oxide fuel cell is a highly efficient power generation system operating at high temperatures using ion conducting ceramics. We conduct basic and multi-aspect research on the electrochemical and mechanical behaviors of the materials for further improving the efficiency, cost, and reliability of solid oxide fuel cells. We are also interested in the reverse operation of fuel cells which enables the storage of the electricity from renewable sources into hydrogen or methane, etc.
実用化イメージ

Researchers

Graduate School of Environmental Studies

Tatsuya Kawada

Functional and Molecular Imaging with Positron Emission Tomography (PET)

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特徴・独自性
  • Using positron emission tomography (PET), we can measure the regional metabolism, perfusion and signal transmission between neurotransmitters and receptors in various organ systems of living humans and animals, such as the brain and heart. Recent technical developments have shown that the mind, or at least some parts of it, can be demonstrated by "imaging".
実用化イメージ

Our group has had considerable achievements in clinical research on drug effects and side effects, elucidation of underlying mechanism of alternative and complementary therapies, as well as exercise physiology.

Researchers

Research Center for Accelerator and Radioisotope Science

Manabu Tashiro